Prescription onlyLower-cost generic available



  • Cream, gel, or ointment
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Treats acne and sun damage.

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Prescription onlyLower-cost generic available

Our bottom line

Renova (Tretinoin) isn't a cure for fine lines and wrinkles, but it's clinically proven to improve them.


  • You only need to apply it once a day, usually in the evening.
  • Most people who reported having skin irritation said that it was mild.
  • Part of a complete program to help you take better care of your skin.
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  • It may take up to 6 months to see the full benefit for facial wrinkles.
  • Not a good choice for women who want to become or are pregnant
  • Can change the color and texture of your skin if used long-term.
  • You need to be careful about avoiding any sunlight or artificial tanning while using it.
  • It doesn't work for deep wrinkles.

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What to expect when you take Renova (Tretinoin)

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Tips from our pharmacists
  • Works best as part of a complete skin care program (including SPF) to protect your skin from sun damage.
  • Renova doesn't permanently erase or improve significant skin changes such as deep wrinkles.
  • Apply a very small amount (pea-size) on entire face once a day at bedtime.
  • You'll need to use Renova regularly for at least 3 to 4 months before you see improvement. Once you stop, the improvement may slowly disappear.
  • Renova wasn't studied in people with skin cancer or serious damage from the sun (actinic keratosis) so it's not known if this would benefit.
  • Not safe to use during pregnancy. Even though Renova is applied to the skin, a small amount is absorbed and harmful to your unborn baby.
  • Some medicines you take by mouth can make you more sensitive to sunlight and combine with effects of Renova. Check with your doctor or pharmacist before you take any new medicines.
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Side effects for Renova (Tretinoin)

From clinical trials of Renova / Any condition (0.02%)  ( 339)

  • Mild skin reactionsMild skin reactions100% for Renova vs.0% for placebo
  • Severe local irritationSevere local irritation7% for Renova vs.1% for placebo
  • Any side effectAny side effect4% for Renova vs.0% for placebo
  • Skin hypo- or hyperpigmentationSkin hypo- or hyperpigmentation2% for Renova vs.0% for placebo

Risks and Warnings for Renova (Tretinoin)

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    • Higher risk if:
    • Using other medicines or products that irritate the skin
    • Eczema
    • Extreme temperatures (hot or cold)

    Renova (Tretinoin) may cause skin redness, burning, peeling or swelling. Be careful using Renova (Tretinoin) if you have a condition called eczema, because your skin may already be red, itchy and irritated.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Renova (Tretinoin)

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The FDA category for this medication is C. It is advised that you: Weigh risks vs. benefits