Prescription onlyNo lower cost generic available

Rituxan Alternatives

(Rituximab)

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Compare Rituxan (Rituximab) to alternatives

These medications are comparable to Rituxan (Rituximab) or used for similar purposes.

Rituxan
(Rituximab)

Enbrel
(Etanercept)

Remicade
(Infliximab)

Orencia
(Abatacept)

Imbruvica
(Ibrutinib)

Humira
(Adalimumab)

Cyclophosphamide

Calms down your immune system. Rituxan (Rituximab) is effective for treating multiple types of cancer and arthritis. That said, you'll need to watch for possibly serious side effects, especially infusion reactions.Calms down your immune system. Enbrel (Etanercept) is very effective at calming down your immune system, but it's expensive, you have to take into account the hassle of injections and traveling with the medication.Calms down your immune system. Remicade (Infliximab) is very effective at calming down your immune system, but you have to get each dose at your doctor's office and watch out for serious side effects.Orencia (Abatacept) decreases inflammation in rheumatoid arthritis. Orencia (Abatacept) slows the progress of rheumatoid arthritis, but can also have serious side effects.Coming soon.Calms down your immune system. Humira (Adalimumab) is very effective at calming down your immune system, but it's expensive, you have to take into account the hassle of injections and traveling with the medication.Coming soon.
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Reviews & ratings
Button Group. All currently active
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Reviews for Enbrel (Etanercept)
58%
9% vs. Rituxan (Rituximab)
52%
15% vs. Rituxan (Rituximab)
19%
19% vs. Rituxan (Rituximab)
Reviews for Remicade (Infliximab)
77%
+10% vs. Rituxan (Rituximab)
65%
2% vs. Rituxan (Rituximab)
13%
13% vs. Rituxan (Rituximab)

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Not enough reviews for this drug. Help someone out, leave a review!

Reviews for Humira (Adalimumab)
59%
8% vs. Rituxan (Rituximab)
49%
18% vs. Rituxan (Rituximab)
26%
26% vs. Rituxan (Rituximab)

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Side effects
RituxanEnbrelRemicadeOrenciaImbruvicaHumiracyclophosphamide
  • Low blood phosphate 11%
  • Acute infusion reactions 8%
  • Cardiac side effect 1%
More Rituxan side effects »
  • Injection site reactions 26%
  • Any infection 11%
  • Positive anti-double-stranded dna antibodies 11%
  • Upper respiratory infections 8%
  • Non-upper respiratory infections 6%
  • Positive ana 6%
  • Itching 1%
  • Rash 1%
More Enbrel side effects »
  • Infusion reaction 13%
  • Infections 11%
More Remicade side effects »
  • Headache 5%
  • High blood pressure 3%
  • Common cold 3%
  • Indigestion 2%
  • Dizziness 2%
  • Back pain 1%
  • Rash 1%
  • Pain in extremity 1%
  • Cough 1%
  • Urinary tract infection 1%
More Orencia side effects »

We haven’t found good data for Imbruvica side effects.

FDA side effect reports for Imbruvica »
  • Injection site reactions 6%
  • Rash 6%
  • Positive titers 5%
  • Upper respiratory infection 4%
  • Headache 4%
  • Abdominal pain 3%
  • Urinary tract infection 3%
  • High blood pressure 2%
  • Alkaline phosphatase increased 2%
  • High blood lipid levels 2%
More Humira side effects »

We haven’t found good data for cyclophosphamide side effects.

FDA side effect reports for cyclophosphamide »
How it works
RituxanEnbrelRemicadeOrenciaImbruvicaHumiracyclophosphamide
Rituxan (Rituximab) is a monoclonal antibody. It targets a specific protein on white blood cells that makes it easier for your immune system to find and destroy cancerous cells. It also relieves symptoms and slows the progression of Rheumatoid Arthritis.Enbrel (Etanercept) is a biologic response modifier. It works in the immune system to block a protein called TNF (tumor necrosis factor). Blocking TNF relieves symptoms and prevents disease progression.Remicade (Infliximab) is a biologic response modifier. It works in the immune system to block a protein called TNF (tumor necrosis factor). Blocking TNF relieves symptoms and prevents disease progression.Orencia (Abatacept) is called a DMARD, a disease-modifying antirheumatic drug. It prevents your body from activating cells that cause inflammation.Coming soon.Humira (Adalimumab) is a biologic response modifier. It works in the immune system to block a protein called TNF (tumor necrosis factor). Blocking TNF relieves symptoms and prevents disease progression.Coming soon.
Type of medication
RituxanEnbrelRemicadeOrenciaImbruvicaHumiracyclophosphamide
Immunosuppressant
Immunomodulator
Antirheumatic
Biological response modifier
Anticancer
Biological response modifier
Prescription only
Immunosuppressant
Immunomodulator
Antirheumatic
Biological response modifier
Prescription only
Immunosuppressant
Immunomodulator
Antirheumatic
Biological response modifier
Prescription only
Immunosuppressant
Immunomodulator
Antirheumatic
Biological response modifier
Prescription only
Coming soon.
Immunosuppressant
Immunomodulator
Antirheumatic
Biological response modifier
Prescription only
Coming soon.
Available as
RituxanEnbrelRemicadeOrenciaImbruvicaHumiracyclophosphamide
  • Infusion (IV)
  • Injection
  • Injection
  • Injection
  • Pill
  • Injection
  • Pill
  • Injection
Used for (click to learn more)
RituxanEnbrelRemicadeOrenciaImbruvicaHumiracyclophosphamide
  • Chronic lymphoid leukemia
  • Acute lymphoid leukemia Acute myeloid leukemia Breast cancer Burkitt's lymphoma Chronic lymphoid leukemia Chronic myeloid leukemia Hodgkin's disease
Risk factors for serious side effects
RituxanEnbrelRemicadeOrenciaImbruvicaHumiracyclophosphamide
    • Taking other immunosuppressant drugs
    • Age 60 or older
    • Weak immune system
    • Taking Rituxan (Rituximab) with immunosuppressant drugs (if using for RA)
    • Taking Rituxan (Rituximab) with chemotherapy (if using for NHL or CLL
    • Stem cell transplant
      • Taking Rituxan (Rituximab) for Non-Hodgkin's Lymphoma (NHL)
      • Rapidly growing tumors
      • History of heart problems
      • Drug interactions
      • Start of therapy with Rituxan (Rituximab)
        Detailed Rituxan (Rituximab) risks & warnings »
        Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.
        Pregnancy category
        RituxanEnbrelRemicadeOrenciaImbruvicaHumiracyclophosphamide
        CFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        BFDA pregnancy category (Probably safe)

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        See the FDA package insert
        BFDA pregnancy category (Probably safe)

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        See the FDA package insert
        CFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        DFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        BFDA pregnancy category (Probably safe)

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        See the FDA package insert
        DFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        Alcohol
        No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.
        Food
        No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.
        Kidneys and liver
        • Discuss with your doctor the serious heart, kidney, liver, or stomach problems that can happen while on Rituxan (Rituximab).
        • Tumor lysis syndrome (TLS) happens when cancer cells are broken down very quickly and damage the kidneys. The damage can be so bad that people need dialysis. If you're taking Rituxan (Rituximab) for a cancer condition your doctor can give you medicines and take measures to prevent this reaction.
        No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.
        Sex
        No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.
        Sleep
        No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.
        Weight
        • Rituxan (Rituximab) can increase your risk of serious or life-threatening bacterial, fungal and viral infections including sepsis. In some cases infections can be reactivated from an inactive virus in your body like tuberculosis (TB) or hepatitis B virus (HBV). You may need to take medicine for TB before you can begin taking Rituxan (Rituximab). If you develop symptoms of cough, fever, chills, muscle aches, feel very tired, or you notice dark urine, yellowing of skin/eyes, appetite/weight loss, vomiting, change in stool color, stomach discomfort, and skin rash, tell your doctor and get medical care right away.
        No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.
        Upsides and benefits
        RituxanEnbrelRemicadeOrenciaImbruvicaHumiracyclophosphamide
        • Treats leukemia, lymphoma, and blood vessel inflammation.
        • Also treats moderate to severe rheumatoid arthritis that hasn't responded to anti-TNF treatment (but you'll need to take methotrexate too).
        • The chance of having a reaction to the infusion is highest during your first dose, but the risk decreases each time you get Rituxan (Rituximab). It usually happens within 30 minutes to 2 hours after starting the infusion.
        • Rituxan (Rituximab) is a targeted therapy that works differently than chemotherapy. Both work well when they're taken together, especially when treating CLL and NHL.
        • Treats certain types of arthritis conditions caused by an overactive immune system.
        • Enbrel is the first biologic approved for moderate to severe rheumatoid arthritis.
        • It has an established safety profile for treatment of rheumatoid arthritis (RA).
        • Available as a single-use syringe and SureClick auto-injector pen which may be more convenient and easier for some people to use.
        • People taking Enbrel for rheumatoid arthritis showed significant improvement and were able to reduce the dose or stop immunosuppressant medicines.
        • Remicade has almost two decades of clinical trial data and real-life experience with millions of people who have used it.
        • Initial dosing to introduce Remicade to your body might be a hassle, but then you only need to take it every 6-8 weeks depending on your condition.
        • Treats certain types of arthritis and gastrointestinal conditions caused by an overactive immune system.
        • Helps minimize joint damage, lowers symptoms, and prevents future problems.
        • In a 2-year study that used IV Orencia (Abatacept) with methotrexate, more than half of the people had remission and the majority felt significantly better.
        • People taking [name-common] had no new joint damage after two years.
        • Taking Orencia (Abatacept) allows RA patients to use less prednisone, a steroid that has many side effects.
        • Orencia (Abatacept) can be used without other medications for RA.
        Coming soon.
        • Most people feel it's worth the hassle.
        • Once you've learned the correct way to use Humira, you can inject the medicine yourself without going to your doctor's office.
        • It's available in a single-use pen (Humira Pen) that may be more convenient and easier for some people to use.
        • It's an alternative for people with Crohn's disease who stopped getting better on other TNF-blockers or had side effects that made them switch.
        • Treats certain types of arthritis and gastrointestinal conditions caused by an overactive immune system.
        Coming soon.
        Downsides and risks
        RituxanEnbrelRemicadeOrenciaImbruvicaHumiracyclophosphamide
        • Only your doctor or other trained medical staff can administer Rituxan (Rituximab), so you'll need to go into an office or clinic for every dose.
        • Not the best choice if you have heart problems.
        • Rituxan (Rituximab) can stay in your body for up to 6 months after you complete treatment. Men and women who are able to have children need to use birth control for up to one year after finishing Rituxan (Rituximab).
        • Discuss with your doctor the serious heart, kidney, liver, or stomach problems that can happen while on Rituxan (Rituximab).
        • Enbrel lowers your ability to fight infection and can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
        • You're first dose of Enbrel will need to be given at your doctor's office. If you decide not to self-inject and don't have someone to do it for you, you'll need to continue to see your doctor for each dose.
        • It's an injection.
        • It's expensive because there's no generic available yet.
        • You'll need to properly dispose of the needle, syringes, or Pen in a special (FDA-approved) sharps container.
        • Because it needs to be refrigerated until you use it, if you're traveling, you'll need to carry it in a cooler with an ice pack.
        • You have to get every dose through an IV infusion at your doctor's office.
        • Remicade has a higher risk of serious infusion-related side effects during or after it's given since it's injected right into your veins. Your doctor can prescribe medication before your dose that may lower this risk.
        • Remicade lowers your ability to fight infection and can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
        • Not the best choice if you have heart failure.
        • Talk to your baby's doctor if you're pregnant or breast-feeding. When women in a study took Remicade (Infliximab), the medicine was found in their breast milk 2 to 3 days after each dose, and in the baby's blood 6 months after they were born.
        • It's expensive because there's no generic available yet.
        • You'll have to get your blood tested regularly while taking Orencia (Abatacept).
        • You'll probably have to take other medications to help treat your RA symptoms.
        • Orencia (Abatacept) is pretty expensive.
        • The IV infusion form of Orencia (Abatacept) can cause a reaction, which ranges from a slight itching or warm feeling to more serious complications like low blood pressure and chest pain.
        • Because RA is chronic disease, you'll likely take Orencia (Abatacept) for many years.
        Coming soon.
        • Humira lowers your ability to fight infection and can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
        • You're first dose of Humira will need to be given at your doctor's office. If you decide not to self-inject and don't have someone to do it for you, you'll need to continue to see your doctor for each dose.
        • It's an injection.
        • It's expensive because there's no generic available yet.
        • You'll need to properly dispose of the needle, syringes, or Pen in a special (FDA-approved) sharps container.
        • Because it needs to be refrigerated until you use it, if you're traveling, you'll need to carry it in a cooler with an ice pack.
        Coming soon.
        Tips from our pharmacists for people taking the medication
        RituxanEnbrelRemicadeOrenciaImbruvicaHumiracyclophosphamide
        • Rituxan (Rituximab) is given as an IV infusion by trained medical staff in a clinic or hospital.
        • You'll need to be monitored in the clinic in case you have a serious or life-threatening reaction during the infusion, but you can take other medications that'll lower your risk of this happening.
        • It's very important that you read the Medication Guide before you start taking Rituxan (Rituximab).
        • Rituxan (Rituximab) lowers your immune system's ability to fight infections, so it's important to let your doctor know if you notice a fever, a cough that doesn't go away, or flu-like symptoms.
        • Use effective birth control while you're taking Rituxan (Rituximab) and for 12 months after you finish treatment.
        • Don't get live vaccines while you're taking Rituxan (Rituximab).
        • Enbrel (Etanercept) is available as a single-use prefilled syringe, single-use prefilled SureClick Autoinjector, and multiple-use vial. You and your doctor can discuss which is best for you.
        • The autoinjector can be stored at room temperature for up to 14 days and can't be refrigerated again.
        • Enbrel (Etanercept) is a medication that's injected under the skin (subcutaneous). Your doctor can give you your first dose, then let you self-inject it once so you learn how to do it correctly.
        • Enbrel (Etanercept) lowers the your immune system's ability to fight infections, so it's important to let your doctor know if you come down with a fever, cough, or notice flu-like symptoms.
        • You'll need to have a TB test before you start using Enbrel (Etanercept).
        • Don't inject Enbrel (Etanercept) into skin that's red, bruised, or irritated. Rotate your injection areas to avoid skin reactions.
        • Tell your doctor if you have an allergy to latex since the syringe needle cover has latex in it.
        • As with all injection medicines, store away from children and throw used syringes away in a protective container, and not in the trash.
        • Remicade (Infliximab) is a medication that's given as an infusion at your doctor's office or clinic.
        • It's very important to read the patient Medication Guide when you first start using Remicade (Infliximab).
        • It's possible to get an allergic reaction to Remicade (Infliximab) either immediately during the treatment or a several days after stopping it. Your doctor can give you medicines that'll lower this risk.
        • You'll need to have a TB test before you start taking Remicade (Infliximab) and periodically during treatment.
        • Remicade (Infliximab) lowers your immune system's ability to fight infections, so it's important to let your doctor know if you notice a fever, cough, or flu-like symptoms. Children seem to get more infections than adults, so keep a close eye on them.
        • If you have a young child, let their doctor know if you were on Remicade (Infliximab) while pregnant or nursing. It can increase their risk of infections for several months after your last dose and can delay their vaccine schedule.
        • Keep the Orencia (Abatacept) self-injection refrigerated, but let it rest at room temperature for 30 to 60 minutes before using it.
        • Each time you use Orencia (Abatacept), be sure to rotate the sites you chose to inject it in. Don't inject it where your skin is tender, bruised, red, or scaly.
        • If you decide to go with the IV version of Orencia (Abatacept), you will only need to get infusions once a month. The self-injections however need to be taken once a week.
        • If you get the IV infusion, stay hydrated, try to relax, and ask your nurse to apply dry heat (instant warm packs) to your arm to help find your good veins.
        Coming soon.
        • Humira (Adalimumab) is a medication that's injected under the skin (subcutaneous). Your doctor can give you your first dose, then let you self-inject it once so you learn how to do it correctly.
        • Humira (Adalimumab) lowers the your immune system's ability to fight infections, so it's important to let your doctor know if you come down with a fever, cough, or notice flu-like symptoms.
        • You'll need to have a TB test before you start using Humira (Adalimumab).
        • Don't inject Humira (Adalimumab) into skin that's red, bruised, or irritated. Rotate your injection areas to avoid skin reactions.
        • Tell your doctor if you have an allergy to latex since the syringe needle cover has latex in it.
        • As with all injection medicines, store away from children and throw used syringes away in a protective container, and not in the trash.
        Coming soon.
        Learn more
        More about RituxanSide effectsReviews & ratingsAlternativesFDA package insert
        More about EnbrelSide effectsReviews & ratingsFDA package insert
        More about RemicadeSide effectsReviews & ratingsFDA package insert
        More about OrenciaSide effectsReviews & ratingsFDA package insert
        More about ImbruvicaSide effectsReviews & ratingsFDA package insert
        More about HumiraSide effectsReviews & ratingsFDA package insert
        More about cyclophosphamideSide effectsFDA package insert