Prescription onlyClass: Autoimmune

Rituxan Alternatives

(rituximab)

Prescription onlyClass: Autoimmune
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Compare Rituxan (rituximab) to alternatives

These medications are comparable to Rituxan (rituximab) or used for similar purposes.

Rituxan
(rituximab)

Enbrel
(etanercept)

Remicade
(infliximab)

Orencia
(abatacept)

Simponi
(golimumab)

Imbruvica
(ibrutinib)

Humira
(adalimumab)

Cytoxan
(cyclophosphamide)

Calms down your immune system. Rituxan (Rituximab) is effective for treating multiple types of cancer and arthritis. That said, you'll need to watch for possibly serious side effects, especially infusion reactions.Calms down your immune system to prevent joint damage. Enbrel (etanercept) effectively calms down your immune system, but it puts you at risk of serious infections.Calms down your immune system. Remicade (infliximab) is an effective treatment for many autoimmune diseases, but you can have serious side effects.Calms down the immune system and prevents joint damage. Orencia (abatacept) slows the progress of rheumatoid arthritis, but can also cause serious side effects.Calms down the immune system. Simponi (golimumab) effectively calms down your immune system, but it is given as a shot and puts you at risk of serious infections like tuberculosis or hepatitis B.Coming soon.Calms down the immune system. Humira (adalimumab) is good for treating many autoimmune conditions, but it can also cause serious side effects.Treats various cancers and kidney disorders. As with all chemotherapy, Cytoxan (cyclophosphamide) has many side effects but is also very effective against different cancers.
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Reviews & ratings
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Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Rituxan (rituximab)?
Worth itNot sureNot worth it
Reviews for Enbrel
62%
-12% worse vs. Rituxan
53%
-3% worse vs. Rituxan
17%
+17% better vs. Rituxan
Have you used Enbrel (etanercept)?
Worth itNot sureNot worth it
Reviews for Remicade
76%
-26% worse vs. Rituxan
62%
-12% worse vs. Rituxan
15%
+15% better vs. Rituxan
Have you used Remicade (infliximab)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Orencia (abatacept)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Simponi (golimumab)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Imbruvica (ibrutinib)?
Worth itNot sureNot worth it
Reviews for Humira
60%
-10% worse vs. Rituxan
51%
-1% worse vs. Rituxan
26%
+26% better vs. Rituxan
182 reviews
Have you used Humira (adalimumab)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Cytoxan (cyclophosphamide)?
Worth itNot sureNot worth it
Side effects
RituxanEnbrelRemicadeOrenciaSimponiImbruvicaHumiracyclophosphamide
  • Fever 60%
  • Lung disorder 31%
  • Cardiac disorder 28%
  • Chills 13%
  • Any infection 62%
  • Infusion reaction 12%
  • Any serious infection 11%
  • Cardiac side effect 1%
  • Tested positive for haca 23%
More Rituxan side effects »
  • Infections 11%
  • Upper airway infections 8%
  • Injection site reactions 26%
  • Non-upper respiratory infections 6%
  • Rash 1%
  • Fever 3%
  • Itchiness 1%
More Enbrel side effects »
  • Upper airway infection 7%
  • Nausea 1%
  • Headache 4%
  • Sinus infection 6%
  • Sore throat 4%
  • Coughinng 4%
  • Abdominal pain 4%
  • Bronchitis 1%
  • Rash 5%
More Remicade side effects »
  • Headache 5%
  • Common cold 3%
  • Dizziness 2%
  • Cough 1%
  • Back pain 1%
  • High blood pressure 3%
  • Indigestion 2%
  • Urinary tract infection 1%
  • Rash 1%
  • Pain in arms or legs 1%
More Orencia side effects »
  • Common cold 3%
  • Injection site reaction 4%
  • Viral infections (such as influenza and herpes) 2%
  • Increased liver function test (alt) 1%
  • Increased liver function test (ast) 1%
  • High blood pressure 1%
  • Bronchitis 1%
  • Superficial fungal infections 1%
  • Tingling sensation 1%
  • Dizziness 1%
More Simponi side effects »

We haven’t found good data for Imbruvica side effects.

FDA side effect reports for Imbruvica »
  • Upper airway infection 4%
  • Rash 6%
  • Headache 4%
  • Sinus infection 2%
  • Nausea 1%
  • Injection site reactions 7%
  • Urinary tract infection 3%
  • Flu syndrome 1%
  • Stomach pain 3%
  • High cholesterol 2%
More Humira side effects »

The cyclophosphamide FDA package insert doesn’t have numbers about how common side effects are.

More about cyclophosphamide side effects »
How it works
RituxanEnbrelRemicadeOrenciaSimponiImbruvicaHumiracyclophosphamide
Rituxan (Rituximab) is a monoclonal antibody. It targets a specific protein on white blood cells that makes it easier for your immune system to find and destroy cancerous cells. It also relieves symptoms and slows the progression of Rheumatoid Arthritis.Enbrel (etanercept) blocks a protein called TNF (tumor necrosis factor) in the immune system which lowers inflammation, relieves symptoms and prevents disease progression.Remicade (infliximab) blocks a protein in your immune system called TNF (tumor necrosis factor) that causes inflammation.Orencia (abatacept) is a biologic DMARD (disease-modifying anti-rheumatic drug) - sometimes just called a "biologic". It prevents your body from activating the cells that cause inflammation.Simponi (golimumab) blocks a protein called TNF (tumor necrosis factor) that revs up the immune system. Blocking TNF lowers inflammation, relieves symptoms and prevents disease progression. Simponi (golimumab) is also known as a biologic DMARD (disease-modifying anti-rheumatic drug) - or just a "biologic" - when used to treat rheumatoid arthritis.Coming soon.Humira (adalimumab) is a TNF blocker which stops inflammation.Cytoxan (cyclophosphamide) works by stopping cancer cells from multiplying.
Type of medication
RituxanEnbrelRemicadeOrenciaSimponiImbruvicaHumiracyclophosphamide
Prescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription only
Available as
RituxanEnbrelRemicadeOrenciaSimponiImbruvicaHumiracyclophosphamide
  • Infusion (iv)
  • Injection
  • Injection
  • Infusion
  • Injection
  • Injection
  • Pill
  • Injection
  • Pill
  • Injection
Used for
RituxanEnbrelRemicadeOrenciaSimponiImbruvicaHumiracyclophosphamide
  • Chronic Lymphoid Leukemia
Risk factors for serious side effects
RituxanEnbrelRemicadeOrenciaSimponiImbruvicaHumiracyclophosphamide
  • Taking other immunosuppressant drugs
  • Age 60 or older
  • Weak immune system
  • Taking Rituxan (Rituximab) with immunosuppressant drugs (if using for RA)
  • Taking Rituxan (Rituximab) with chemotherapy (if using for NHL or CLL
Detailed Rituxan (rituximab) risks & warnings »
  • Latex allergy
  • History of heart failure
  • Taking other immunosuppressant drugs
  • Age 65 or older
Detailed Enbrel (etanercept) risks & warnings »
  • Taking other immunosuppressant drugs
  • Age 65 or older
  • Comorbidities
  • History of malignancy
Detailed Remicade (infliximab) risks & warnings »
  • Using TNF inhibitors
  • Taking immunosuppressive medications
  • History of repeat infections
  • Adults with rheumatoid arthritis taking TNF inhibitors
  • COPD
Detailed Orencia (abatacept) risks & warnings »
  • Taking other immunosuppressant drugs
  • Age 65 or older
  • Active, chronic, or recurrent infection
  • History of malignancy
Detailed Simponi (golimumab) risks & warnings »
    Coming soon.
    • Taking other immunosuppressant medications such as Kineret or Orencia
    • Age 65 or older
    • Active, chronic, or recurrent infection
    • Comorbidities
    • Taking other immunosuppressant medications, such as azathiprine or 6-mercaptopurine, at the same time as Humira (adalimumab)
    Detailed Humira (adalimumab) risks & warnings »
    • Dehydration
    • Urinary tract infections
    • Previous liver disease
    • Previous radiation to abdomen
    • Poor prognosis
    Detailed Cytoxan (cyclophosphamide) risks & warnings »
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Kidneys and liver
    RituxanEnbrelRemicadeOrenciaSimponiImbruvicaHumiracyclophosphamide
    • Discuss with your doctor the serious heart, kidney, liver, or stomach problems that can happen while on Rituxan (Rituximab).
    No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.
    • Cytoxan (cyclophosphamide) can cause kidney or bladder problems or make you at risk of getting kidney infections. To stop this from happening, you should drink plenty of liquids and urinate often. If you have pink or red urine or pain on urination, tell your doctor right away.
    • Effective when used in combination with other anticancer agents or by itself against blood cancers and a kidney disease known as minimal change nephrotic syndrome.
    • Cytoxan (cyclophosphamide) can seriously damage the kidneys.
    Weight
    RituxanEnbrelRemicadeOrenciaSimponiImbruvicaHumiracyclophosphamide
    No weight related info.No weight related info.
    • Although rare, Remicade (infliximab) can hurt your liver. If you have appetite/weight loss, stomach discomfort, vomiting, or dark urine, talk to your doctor. If you have yellowing of skin/eyes, talk to your doctor right away.
    No weight related info.No weight related info.No weight related info.No weight related info.
    • Cytoxan (cyclophosphamide) can cause liver damage. You're more likely to have this if you're taking certain other chemotherapy drugs or getting radiation throughout your entire body. If you have sudden weight gain, swelling of your stomach, fluid build up in your abdomen, yellowing skin or eyes, dark urine or pale stools, talk to your doctor right away.
    Upsides and benefits
    RituxanEnbrelRemicadeOrenciaSimponiImbruvicaHumiracyclophosphamide
    • Treats leukemia, lymphoma, and blood vessel inflammation.
    • Also treats moderate to severe rheumatoid arthritis that hasn't responded to anti-TNF treatment (but you'll need to take methotrexate too).
    • The chance of having a reaction to the infusion is highest during your first dose, but the risk decreases each time you get Rituxan (Rituximab). It usually happens within 30 minutes to 2 hours after starting the infusion.
    • Rituxan (Rituximab) is a targeted therapy that works differently than chemotherapy. Both work well when they're taken together, especially when treating CLL and NHL.
    • People taking Enbrel (etanercept) for rheumatoid arthritis showed significant improvement and were able to reduce the dose or stop their other RA medicines.
    • Enbrel (etanercept) can work for you even if other medications didn't help your rheumatoid arthritis.
    • Enbrel (etanercept) is the first biologic approved for moderate to severe rheumatoid arthritis. Since it has been around for a long time, its side effects are well known.
    • Many people have only minor or no side effects.
    • It's available as a pre-filled syringe and SureClick auto-injector pen which some people find more convenient and easier to use.
    • People taking Remicade (infliximab) for ulcerative colitis, Crohn's disease, rheumatoid arthritis and other autoimmune conditions had more clinical response, clinical remission and symptom improvement compared to people who did not take Remicade (infliximab).
    • People who were also taking steroids for treatment were able to discontinue steroid use while taking Remicade (infliximab).
    • Remicade (infliximab) has almost two decades of clinical trial data and real-life experience with many people who have used it.
    • After the initial dosing, you only need to take Remicade (infliximab) every 6-8 weeks, depending on your condition.
    • Compared to other medications used to treat autoimmune conditions, Remicade (infliximab) has not been associated with as many harmful effects during pregnancy and breastfeeding.
    • In a 2-year study that used IV Orencia (abatacept) with methotrexate, more than half of the people had remission and the majority felt significantly better.
    • Helps minimize joint damage, lowers symptoms, and prevents future problems. People taking Orencia (abatacept) had no new joint damage after two years.
    • Taking Orencia (abatacept) allows RA patients to use less prednisone, a steroid that has many side effects.
    • You can give yourself Orencia (abatacept) subcutaneously on your own at home rather than visiting a clinic or hospital.
    • Available in a prefilled autoinjector for convenient use.
    • Simponi (golimumab) is only injected once a month.
    • Simponi (golimumab) comes in a prefilled syringe or autoinjector. You won't need to measure out the medication.
    • While taking Simponi (golimumab), you may continue to use other drugs prescribed by your doctor that help treat your condition, such as NSAIDS (like ibuprofen) and steroids.
    Coming soon
    • Humira (adalimumab) is effective in reducing symptoms in all of its approved indications.
    • You can give yourself Humira (adalimumab) on your own at home rather than visiting a clinic or hospital.
    • Humira (adalimumab) treats many different autoimmune conditions.
    • Available in a single-use pen (Humira Pen) that may be more convenient and easier for some people to use.
    • Effective when used in combination with other anticancer agents or by itself against blood cancers and a kidney disease known as minimal change nephrotic syndrome.
    • Cytoxan (cyclophosphamide) is one of the most well-known medications for cancer, so doctors know what to expect.
    • Available in generic and in both a pill or as an injection.
    Downsides and risks
    RituxanEnbrelRemicadeOrenciaSimponiImbruvicaHumiracyclophosphamide
    • Only your doctor or other trained medical staff can administer Rituxan (Rituximab), so you'll need to go into an office or clinic for every dose.
    • Not the best choice if you have heart problems.
    • Rituxan (Rituximab) can stay in your body for up to 6 months after you complete treatment. Men and women who are able to have children need to use birth control for up to one year after finishing Rituxan (Rituximab).
    • Discuss with your doctor the serious heart, kidney, liver, or stomach problems that can happen while on Rituxan (Rituximab).
    • Enbrel (etanercept) raises your risk of serious or life-threatening infections, including tuberculosis (TB).
    • Enbrel (etanercept) can increase the risk of lymphoma, leukemia and other cancers.
    • May not be the best choice if you have a history of heart failure or nervous system problems like multiple sclerosis.
    • You'll need to have regular blood tests before and during treatment to make sure you don't have any problems taking Enbrel (etanercept).
    • You could get injection site reactions such as redness, swelling, rash, itching, or bruising.
    • You have to receive this medication at your doctor's office or clinic. You might need to be tested regularly for tuberculosis.
    • Remicade (infliximab) lowers your ability to fight infection and can cause serious illness. The risk is greater if you take other drugs that lower your immune system, or have a history of diabetes or tuberculosis.
    • Remicade (infliximab) can in some cases worsen symptoms of heart failure or neurologic conditions. People 65 years and older may have more side effects from this medication.
    • In rare cases, Remicade (infliximab) has been associated with cancers in children and adolescents.
    • No generic available, so it can be costly.
    • Orencia (abatacept) can be costly.
    • The IV infusion form of Orencia (abatacept) can cause a reaction, which ranges from a slight itching or warm feeling to more serious side effects such as low blood pressure and chest pain.
    • The IV infusion form of Orencia (abatacept) contains maltose, a type of sugar, that can give false high blood sugar readings with certain types of blood sugar monitors on the day of Orencia (abatacept) infusion. The self-injection subcutaneous form does not contain maltose. Talk to your doctor if you have diabetes.
    • If you need TNF inhibitors as part of your treatment, it is not recommended to take Orencia (abatacept). If you have COPD, you are at higher risk of side effects.
    • Orencia (abatacept) lowers your ability to fight infection. Your risk can increase if you take medications that lower your immune system or have an active infection. You may need to get tested for tuberculosis before starting Orencia (abatacept).
    • Like other immunosuppressive drugs, Simponi (golimumab) can awaken (reactivate) infections.
    • Simponi (golimumab) can increase the risk of lymphoma, leukemia, and other cancers.
    • Not the best choice if you have a history of heart failure or nervous system problems like multiple sclerosis.
    • You'll need to have regular blood tests before and during treatment to make sure you don't have any problems taking Simponi (golimumab).
    Coming soon
    • Not first-choice treatment for rheumatoid arthritis.
    • Humira (adalimumab) is an injection and not an oral medication.
    • Humira (adalimumab) is expensive because there's no generic available yet.
    • Humira (adalimumab) lowers your ability to fight infection and in some cases can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
    • You'll need to properly dispose of the needle, syringes, or Pen in a sharps container.
    • Humira (adalimumab) needs to be refrigerated until you use it, so if you're traveling, you'll need to carry it in a cooler with an ice pack.
    • Cytoxan (cyclophosphamide) can seriously damage the kidneys.
    • Cytoxan (cyclophosphamide) can cause many different side effects throughout the body.
    • Cytoxan (cyclophosphamide) is more likely to cause nausea and vomiting compared to other chemotherapy drugs.
    • Cytoxan (cyclophosphamide) can cause infertility.
    Tips from our pharmacists for people taking the medication
    RituxanEnbrelRemicadeOrenciaSimponiImbruvicaHumiracyclophosphamide
    • Rituxan (Rituximab) is given as an IV infusion by trained medical staff in a clinic or hospital.
    • You'll need to be monitored in the clinic in case you have a serious or life-threatening reaction during the infusion, but you can take other medications that'll lower your risk of this happening.
    • It's very important that you read the Medication Guide before you start taking Rituxan (Rituximab).
    • Rituxan (Rituximab) lowers your immune system's ability to fight infections, so it's important to let your doctor know if you notice a fever, a cough that doesn't go away, or flu-like symptoms.
    • Use effective birth control while you're taking Rituxan (Rituximab) and for 12 months after you finish treatment.
    • Don't get live vaccines while you're taking Rituxan (Rituximab).
    • Enbrel (etanercept) is available as an injection and a SureClick Autoinjector. You and your doctor can discuss which is best for you.
    • Enbrel (etanercept) is a medication that's injected under the skin (subcutaneous). Your doctor can give you your first dose, then let you self-inject it once you learn how to do it correctly.
    • Enbrel (etanercept) lowers your immune system's ability to fight infections including tuberculosis (TB), fungal, viral, and bacterial infections. Your doctor will check for TB and hepatitis B before starting Enbrel (etanercept). Let your doctor know if you come down with a fever, cough, or notice flu-like symptoms before or during treatment.
    • Enbrel (etanercept) can cause redness, rash, swelling, itching, or bruising at the site of injection. Do not inject into skin that's already red, bruised, or irritated. Rotate your injection areas to avoid skin reactions.
    • Keep Enbrel (etanercept) refrigerated, but let it rest at room temperature for 30 to 60 minutes before using it. Enbrel (etanercept) should not be used if kept at room temperature for longer than 14 days.
    • You should not receive certain vaccinations with Enbrel (etanercept). Discuss with your doctor about your vaccine history and whether you need to receive any vaccines before treatment.
    • Remicade (infliximab) can in some cases cause a serious allergic reaction either immediately or several days after the treatment. Your doctor can give you medicines that will lower this risk.
    • Your doctor will test you for tuberculosis before taking Remicade (infliximab) and regularly during treatment.
    • Remicade (infliximab) lowers your immune system's ability to fight infections, so it's important to let your doctor know if you notice a fever, cough, or flu-like symptoms.
    • You should not receive any live vaccines while taking Remicade (infliximab). Tell your doctor that you are taking Remicade (infliximab) before receiving any vaccines.
    • If you have any signs or new or worsening symptoms such as heart, neurological, or autoimmune conditions, talk to your doctor. Tell your doctor about symptoms such as bruising or bleeding.
    • If you are using the IV version of Orencia (abatacept), you will only need to get infusions once a month (after the first initial doses). It takes about 30 minutes to give the full dose of medicine. Stay hydrated and ask your nurse to apply dry heat (instant warm packs) to your arm to help find your good veins.
    • The self-injections are taken once a week. You or your caregiver should receive training on the proper way to prepare and inject Orencia (abatacept).
    • Keep the Orencia (abatacept) self-injection refrigerated, and let it rest at room temperature for 30 minutes before using it.
    • Each time you use Orencia (abatacept), it's important to rotate the sites you chose to inject it in. Don't inject Orencia (abatacept) into skin that's red, bruised, or irritated.
    • Talk with your doctor before getting any vaccines. Use of this drug may either raise the chance of an infection or make the vaccine not work as well.
    • As with all injection medicines, store it securely away from children and throw away used syringes in an FDA-approved sharps disposal container, never in the trash.
    • Simponi (golimumab) is an immunosuppressant medication that's injected under the skin (subcutaneous) once a month.
    • Simponi (golimumab) lowers your ability to fight infections, so it's important to let your doctor know if you have a fever, cough, or flu-like symptoms.
    • Tell your doctor if you have an allergy to latex since the syringe needle cover has latex in it.
    • Each time you use Simponi (golimumab), it's important to rotate the sites you chose to inject it in (either your abdomen, thigh, or upper arm). Don't inject Simponi (golimumab) into skin that's red, bruised, or irritated.
    • Keep it refrigerated, and let it sit at room temperature for about 30 minutes before injecting yourself. Do not shake the Simponi (golimumab) autoinjector at any time.
    • People taking Simponi (golimumab) should not get live vaccines. Talk to your doctor before receiving any vaccines.
    Coming soon
    • Humira (adalimumab) is a medication that's injected under the skin. Your doctor can give you your first dose, then you can inject yourself at home once you feel comfortable doing so on your own.
    • Humira (adalimumab) lowers your ability to fight infections, so it's important to let your doctor know if you have a fever, cough, or flu-like symptoms.
    • Tell your doctor if you have an allergy to latex since the syringe needle cover has latex in it.
    • Each time you use Humira (adalimumab), it's important to rotate the sites you chose to inject it in. Don't inject Humira (adalimumab) into skin that's red, bruised, or irritated.
    • As with all injection medicines, store securely away from children and throw away used syringes in an FDA-approved sharps disposal container, and not in the trash.
    • This medication comes in an injection or pill. You and your doctor will decide what form is most appropriate for you.
    • Drink plenty of fluids to prevent urinary problems.
    • You should protect yourself and your sexual partners from getting pregnant while taking Cytoxan (cyclophosphamide) for at least 4 months if you're a male or a year if you're female.
    • You're more likely to get sick or heal slower while taking Cytoxan (cyclophosphamide). Talk to your doctor before getting any vaccines.
    • Talk to your doctor if you start having breathing problems that don't go away.
    Learn more
    More about RituxanSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Rituxan (rituximab)?
    Worth itNot sureNot worth it
    More about EnbrelSide effectsReviews & ratingsFDA package insert
    Have you used Enbrel (etanercept)?
    Worth itNot sureNot worth it
    More about RemicadeSide effectsReviews & ratingsFDA package insert
    Have you used Remicade (infliximab)?
    Worth itNot sureNot worth it
    More about OrenciaSide effectsReviews & ratingsFDA package insert
    Have you used Orencia (abatacept)?
    Worth itNot sureNot worth it
    More about SimponiSide effectsFDA package insert
    Have you used Simponi (golimumab)?
    Worth itNot sureNot worth it
    More about ImbruvicaSide effectsReviews & ratingsFDA package insert
    Have you used Imbruvica (ibrutinib)?
    Worth itNot sureNot worth it
    More about HumiraSide effectsReviews & ratingsFDA package insert
    Have you used Humira (adalimumab)?
    Worth itNot sureNot worth it
    More about cyclophosphamideSide effectsFDA package insert
    Have you used Cytoxan (cyclophosphamide)?
    Worth itNot sureNot worth it