Over-the-counterLower-cost generic availableClass: Respiratory

Robitussin Nighttime Multi-Symptom Cold Cf

(acetaminophen / diphenhydramine / phenylephrine)

Over-the-counterLower-cost generic availableClass: Respiratory
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Relieves cold symptoms and helps you sleep.

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Our bottom line

Robitussin Nighttime Multi-Symptom Cold Cf (Acetaminophen / Diphenhydramine / Phenylephrine) is good for treating multiple cold symptoms, but it won't relieve coughing.

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Upsides

  • Robitussin Nighttime Multi-Symptom Cold Cf (Acetaminophen / Diphenhydramine / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, watery eyes, a fever, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.

Downsides

  • Robitussin Nighttime Multi-Symptom Cold Cf (Acetaminophen / Diphenhydramine / Phenylephrine) doesn't stop coughing.
  • The antihistamine (diphenhydramine) can make you feel groggy the next morning.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
How it works

Robitussin Nighttime Multi-Symptom Cold Cf (Acetaminophen / Diphenhydramine / Phenylephrine) is a combination medicine that treats cold symptoms. Acetaminophen relieves pain and reduces fever. Phenylephrine is a decongestant that clears your sinuses. Diphenhydramine is an antihistamine that treats runny nose and watery eyes and helps you sleep.

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Side effect rates for Robitussin Nighttime Multi-Symptom Cold Cf (acetaminophen / diphenhydramine / phenylephrine)

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These are side effects of Robitussin Nighttime Multi-Symptom Cold Cf (acetaminophen / diphenhydramine / phenylephrine) reported to the FDA by people taking it, and by doctors and pharmacists.
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Risks and Warnings for Robitussin Nighttime Multi-Symptom Cold Cf (acetaminophen / diphenhydramine / phenylephrine)

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    • Higher risk if:
    • Drinking more than 3 alcoholic beverages a day
    • Taking with other Tylenol-containing medicines
    • History of liver disease

    Robitussin Nighttime Multi-Symptom Cold Cf (Acetaminophen / Diphenhydramine / Phenylephrine) contains acetaminophen, also known as Tylenol or APAP, and is a common ingredient in many other over-the-counter medicines. Taking too much acetaminophen causes liver damage that can be permanent and life-threatening. In case of an overdose, call your local Poison Control Center and get medical attention immediately.

Common concerns from people taking Robitussin Nighttime Multi-Symptom Cold Cf (acetaminophen / diphenhydramine / phenylephrine)

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Pregnancy
Kidneys and liver
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
Pain
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.