Prescription onlyClass: Neuro/psych



Prescription onlyClass: Neuro/psych
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Treats bipolar disorder and schizophrenia.

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Our bottom line

While Saphris (asenapine) has fewer side effects compared with other medicines that treat bipolar disorder and schizophrenia, it can be more expensive.

Price and discounts
Prices and coupons for 30 (10mg) orally disintegrating tabs of asenapine


  • Saphris (asenapine) can be used to treat bipolar disorder in children age 10 or older, and schizophrenia in children age 12 or older.
  • You don't need water to take Saphris (asenapine); the pill dissolves in your mouth right away.
  • Compared to other medicines, the side effects of Saphris (asenapine) are milder.


  • Saphris (asenapine) is only available as a brand name.
  • Compared to other medicines, Saphris (asenapine) can cause changes in your hormones and make you sleepy.
  • You have to take Saphris (asenapine) twice a day, which can be hard to remember.
How it works

While it's not clear how Saphris (asenapine) helps to treat bipolar disorder or schizophrenia, it changes the amount of dopamine and serotonin in the brain, two chemicals that are known to regulate mood.

What to expect when you take Saphris (asenapine) for Schizophrenia

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Side effect rates for Saphris (asenapine)

324 From clinical trials of Saphris / Bipolar disorder, adjunct (Twice daily, 5 or 10 mg)
  • Sleepiness
  • Trouble sleeping
  • Difficulty controlling movements
  • Numbness in the mouth
  • Fatigue
  • Dizziness
  • Indigestion
  • Swelling in the arms and legs
  • Weight gain
  • High blood pressure

Risks and Warnings for Saphris (asenapine)

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    • Higher risk if:
    • People age 65 or older with dementia and psychosis

    Older people who have dementia and psychosis have a higher risk of death if they take antipsychotic medicines like Saphris (asenapine). They shouldn't be given this medicine.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Saphris (asenapine)

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  • People on medicines like Saphris (asenapine) have had weight gain and higher blood sugar to the point of having diabetes. Your doctor will work with you to stop that from happening.