Prescription onlyClass: Neuro/psych



Prescription onlyClass: Neuro/psych
Back to: Full Site NavigationSkip to: side effects sectionSkip to: What to expect sectionSkip to: Risks and warnings sectionSkip to: Common concerns from users and pharmacists

Treats fibromyalgia.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

While Savella (milnacipran) is one of the only medicines approved to treat fibromyalgia, it can be very expensive, and requires a strict schedule to take it correctly.

Price and discounts
Best available price for 60 (50mg) tablets of savella
What is GoodRx?


  • Savella (milnacipran) is considered a first choice medicine for treating fibromyalgia.
  • There are programs to make the copay for Savella (milnacipran) more affordable.
  • Savella (milnacipran) can be taken with or without food.


  • Savella (milnacipran) is only available as a brand name so it can have a very high copay.
  • You have to take it based on a very strict schedule, which can be confusing during the first month.
  • Taking Savella (milnacipran) by itself usually isn't enough to get relief from fibromyalgia.
How it works

Savella (milnacipran) is a serotonin and norepinephrine reuptake inhibitor. While it's not clear how Savella (milnacipran) treats fibromyalgia, it raises the amount of serotonin and norepinephrine in the brain, which might play a role in pain relief.

What to expect when you take Savella (milnacipran) for Fibromyalgia

Skip what to expect section. Skip to Risks & Warnings section.
Skip side effects section. Skip to What to Expect and Pharmacists Tips section.

Side effect rates for Savella (milnacipran)

2209 From clinical trials of Savella / Fibromyalgia
  • Nausea
  • Headache
  • Constipation
  • Trouble sleeping
  • Hot flashes
  • Dizziness
  • Excess sweating
  • Vomiting
  • Heart pounding or racing sensation
  • Colds or flu

Risks and Warnings for Savella (milnacipran)

Skip risks section. Skip to common concerns section.
    • Higher risk if:
    • People under age 24
    • History of depression or suicide attempts

    Savella (milnacipran) is similar to other drugs in its class based on how it works in the body, and may raise the risk of suicide when starting it. This is more likely if you're under age 24 and if you have depression. If you have depression, or think you might have depression, talk to your doctor first before you start taking Savella (milnacipran), especially if you're already taking medicines to treat it.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Savella (milnacipran)

Final section. Do you want to return to drug navigation?
  • Savella (milnacipran) can be taken with or without food.
  • If you're on blood thinners, taking Savella (milnacipran) might make you more likely to bleed. Make sure your doctor knows you're on blood thinners. Your doctor might make changes in how you take those medicines, or your doctor might have you take something else for your fibromyalgia.