Prescription onlyLower-cost generic availableClass: Mental health

Seroquel

(quetiapine)

Prescription onlyLower-cost generic availableClass: Mental health
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Helps control your thoughts and mood.

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Our bottom line

Seroquel (Quetiapine) is good for treating psychosis and mania. Fewer side effects than most antipsychotics, but might be less effective for people over age 40 with schizophrenia.

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Upsides

  • Effective at relieving psychotic symptoms and manic episodes.
  • Antipsychotic medicines are all about equally effective.
  • Fewer side effects than most antipsychotic medicines.
  • Less likely to cause heart problems compared to some antipsychotics.
  • Compared to other antipsychotics, the least likely to cause Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
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Downsides

  • In studies, less effective for people over age 40 for schizophrenia.
  • Sometimes causes weight gain, sleepiness, and low blood pressure.
  • You might need routine blood tests to check how the medicine is affecting your body.
  • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
How it works

Seroquel (Quetiapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.

What to expect when you take Seroquel (quetiapine) for Schizophrenia

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Side effect rates for Seroquel (quetiapine)

399 From clinical trials of Seroquel / Adjunct therapy for bipolar I disorder (mania)
  • Drowsiness
  • Dry mouth
  • Headache
  • Muscle weakness
  • Constipation
  • Dizziness
  • Tremor
  • Abdominal pain
  • Positional low blood pressure
  • Weight gain

Risks and Warnings for Seroquel (quetiapine)

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    • Higher risk if:
    • Elderly patients with dementia

    Older patients with dementia-related psychosis have a higher risk of death when treated with antipsychotic medications. Seroquel (Quetiapine) is not approved to treat dementia-related psychosis.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Seroquel (quetiapine)

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Pregnancy
Alcohol
  • Take it at night-it makes you sleepy. Do not drink a lot of alcohol; it makes the dry mouth worse and affects your mood the next day in a negative way. DO NOT miss a dose. You will experience withdrawal symptoms very quickly.
  • Don't drink too much alcohol when taking seroquel as it affects it's performance
  • Drinking alcohol whilst on this medication can lead to "black outs"... and you can wake up the next day in fear/panicking but not knowing why (a sense of dread). Also, it gives you seroquel munchies. the munchies are very real!!!!!
Food
  • Seroquel (Quetiapine) can increase your blood sugar and cholesterol. Seroquel (Quetiapine) is more likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
  • Seroquel (Quetiapine) can cause you to gain weight. Seroquel (Quetiapine) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
  • Had a little weight gain and had to control the increase in appetite and not be urged to eat junk food
Pain
  • It made me drowsy at night with some discomfort with joint pain about 15% of the time
Sleep
  • Can cause dizziness, drowsiness, and low blood pressure.
  • To avoid sleepiness take it in the night.
  • It made me drowsy at night with some discomfort with joint pain about 15% of the time
  • Makes you super drowsy so take it at night and sometimes follows into the next morning. I call it the seroquel hangover. Don't stay up too late after you take it because you will eat everything in sight. I call that the seroquel munchies :)
Weight
  • Sometimes causes weight gain, sleepiness, and low blood pressure.
  • May cause weight gain and worsen cholesterol or blood sugar.
  • Seroquel (Quetiapine) can cause you to gain weight. Seroquel (Quetiapine) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
  • May cause weight gain.
  • Drug is infamous for weight gain and I did gain about 30 pounds when taking it HOWEVER I wasn't exactly looking after my diet or exercise. My suggestion is to be sure you're taking care of yourself when you start it and that will make it easier to tell if IT is causing weight gain.
  • Weight gain galore!!