Serzone

(nefazodone)

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Treats depression.

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Our bottom line

Serzone (nefazodone) is usually used with other medicines to treat depression, but it is more likely to cause liver damage.

Quick facts about nefazodone
  • Drug class: Neuro/psych
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (nefazodone)

Upsides

  • Serzone (nefazodone) is a good choice to take with other medicines for depression if they haven't worked by themselves.
  • Serzone (nefazodone) is available in generic.

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Downsides

  • While Serzone (nefazodone) is available as a generic, it's not considered a first or second choice medicine for depression because it is more likely to cause liver damage than other similar medicines.
  • Serzone (nefazodone) is usually taken 2 times a day; the first choice medicines are only taken 1 time a day.
  • It can take up to 3 months before you notice the full effects of Serzone (nefazodone).
  • Compared to other similar medicines, Serzone (nefazodone) has a lot of interactions with other drugs, so your doctor might have to adjust the doses of your other medicines.

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How it works

Serzone (nefazodone) is a serotonin reuptake inhibitor. Serzone (nefazodone) raises the amount of serotonin in the brain, which helps to regulate your mood.

Quick facts about nefazodone
  • Drug class: Neuro/psych
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (nefazodone)

Used for

Dosage forms

  • Pill
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What to expect when you take Serzone (nefazodone) for Depression

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Side effect rates for Serzone (nefazodone)

From 787 clinical trials of nefazodone when taken for depression (300-600mg/day)
  • Headache
  • Dry mouth
  • Sleepiness
  • Nausea
  • Dizziness
  • Constipation
  • Weakness
  • Trouble sleeping
  • Lightheadedness
  • Indigestion

Risks and Warnings for Serzone (nefazodone)

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    • Higher risk if:
    • People under age 24

    People who take medicines similar to Serzone (nefazodone) are at higher risk for suicide. This is more likely to happen in people under age 24. Talk to your doctor right away if you feel your mood begins to darken or you want to hurt yourself or other people.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Serzone (nefazodone)

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Pregnancy
Interactions
  • Compared to other similar medicines, Serzone (nefazodone) has a lot of interactions with other drugs, so your doctor might have to adjust the doses of your other medicines.
Pain
  • Talk to your doctor right away if you notice yellowing in the whites of your eyes or your skin, a high fever, pain in your stomach, or dark urine.