Prescription onlyLower-cost generic available

Zocor

(Simvastatin)

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Lowers cholesterol.

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Prescription onlyLower-cost generic available

Our pharmacists’ bottom line

Zocor (Simvastatin) is a good medication to improve your cholesterol. Statin side effects can be difficult to deal with, but the benefits might outweigh the risks.

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  • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
  • Can lower the risk of heart attack, stroke, and death, particularly if you have diabetes, high blood pressure, obesity, or a history of smoking.
  • Statins can cause digestive problems, blood sugar problems, muscle aches and stiffness, muscle injury, kidney damage, and liver damage. Some people have to stop taking this medicine because of these problems.
  • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
  • Not safe to use if you're pregnant.

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Side effects for Zocor (Simvastatin)

From clinical trials of Simvastatin / High cholesterol ( 4646)

  • Upper respiratory infectionsUpper respiratory infections9% for Simvastatin vs.0% for placebo
  • Abdominal painAbdominal pain7% for Simvastatin vs.0% for placebo
  • ConstipationConstipation7% for Simvastatin vs.0% for placebo
  • HeadacheHeadache7% for Simvastatin vs.0% for placebo
  • BronchitisBronchitis7% for Simvastatin vs.6% for placebo
  • Abnormal heart rhythmAbnormal heart rhythm6% for Simvastatin vs.5% for placebo
  • NauseaNausea5% for Simvastatin vs.0% for placebo
  • Scaly, itchy rashScaly, itchy rash5% for Simvastatin vs.3% for placebo
  • Upset stomachUpset stomach5% for Simvastatin vs.2% for placebo
  • VertigoVertigo5% for Simvastatin vs.4% for placebo

What to expect when you take Zocor (Simvastatin) for High cholesterol

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Tips from our pharmacists
  • Lowers bad cholesterol and triglycerides, and raises good cholesterol.
  • Most people reach their target cholesterol levels in 4 to 6 weeks.
  • Avoid grapefruit and grapefruit juice while taking this medicine.
  • Tell your doctor if you develop sudden muscle pain, fever, or weakness.
  • Tell your doctor if you notice dark urine or yellowing of the eyes or skin.
  • Certain medications can interact with this drug. Talk to your doctor or pharmacist.

Risks and Warnings for Zocor (Simvastatin)

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    • Higher risk if:
    • Kidney disease
    • High dose of Zocor (Simvastatin)
    • Combining Zocor (Simvastatin) with certain cholesterol-lowering drugs
    • Older age and female gender

    There are rare cases of muscle damage leading to kidney failure in people taking Zocor (Simvastatin). The risk is greater in people with kidney disease or thyroid disease, are older and female and taking certain cholesterol-lowering medication combinations. Tell your doctor if you develop sudden muscle pain, weakness or fever and there is no known cause.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Zocor (Simvastatin)

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The FDA category for this medication is X. It is advised that you: Unsafe
Pregnancy
Alcohol
  • Upsides and downsides from our pharmacists
  • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
  • Risks from our pharmacists
  • There are reports of liver damage in people who take Zocor (Simvastatin), especially if they are heavy alcohol drinkers or have a history of liver disease. If you notice dark urine or yellowing of the eyes or skin, tell your doctor. Your doctor may also want to check your liver function periodically.
Kidneys & liver
  • Upsides and downsides from our pharmacists
  • Statins can cause digestive problems, blood sugar problems, muscle aches and stiffness, muscle injury, kidney damage, and liver damage. Some people have to stop taking this medicine because of these problems.
  • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
  • Risks from our pharmacists
  • There are rare cases of muscle damage leading to kidney failure in people taking Zocor (Simvastatin). The risk is greater in people with kidney disease or thyroid disease, are older and female and taking certain cholesterol-lowering medication combinations. Tell your doctor if you develop sudden muscle pain, weakness or fever and there is no known cause.
  • Combining certain medications can increase the risk of muscle pain (myopathy), muscle damage (rhabdomyolysis) and kidney damage. Talk to your doctor or pharmacist when taking any new medications.