Sovaldi (Sofosbuvir) is an effective medicine to treat chronic hepatitis C infection, but it can be expensive.
Harvoni (ledipasvir / sofosbuvir) is a combination pill for hepatitis C that you only need to take once a day. Depending on the amount of liver damage you have, it's sometimes taken together with another medicine called ribavirin.
- Most people who take Sovaldi (Sofosbuvir) together with other antiviral medicines have good results, with no HCV found in their blood three months later.
- Can take Sovaldi (Sofosbuvir) for a shorter amount of time than other hepatitis C medications.
- Effective in people who have both hepatitis C and HIV infection, liver cancer, or who are waiting for a liver transplant.
- Harvoni (ledipasvir / sofosbuvir) is a simple hepatitis C treatment that can cure 96% to 99% of those with genotype 1 who have had no prior treatment. Most people only have to take 1 pill a day for either 12 or 24 weeks.
- The most common side effects are mild to moderate tiredness and headache.
- Harvoni (ledipasvir / sofosbuvir) is also a good option for people taking HIV medications since it doesn't have drug interactions with most of these medicines.
- Harvoni (ledipasvir / sofosbuvir) is approved for the treatment of hepatitis C in some people with severe liver disease and liver transplants.
- Harvoni (ledipasvir / sofosbuvir) is also one of the first drugs approved to treat hepatitis C in children ages 12 to 17.
- Women shouldn't become pregnant while taking HCV medications and will need to take monthly pregnancy tests while on this.
- Requires routine blood tests to check liver function.
- There are many interactions between Sovaldi (Sofosbuvir) and other drugs and herbal supplements. Talk to your doctor or pharmacist before starting new medications.
- Can only be used in people age 18 years and older.
- There's no generic available, so it can be very expensive.
- Harvoni (ledipasvir / sofosbuvir) needs an acidic stomach to be absorbed properly. This means that heartburn medications can affect how Harvoni (ledipasvir / sofosbuvir) works, so talk to you doctor or pharmacist before starting any.
- Harvoni (ledipasvir / sofosbuvir) can cause serious drops in heart rate when it’s taken with amiodarone. If you have to take them together, your heart rate needs to be checked regularly.
- You should be tested for hepatitis B before starting Harvoni (ledipasvir / sofosbuvir), since untreated hepatitis B can become active again with medications that treat hepatitis C.
- If you have severe liver disease or have a liver transplant, you'll have to take Harvoni (ledipasvir / sofosbuvir) with another medicine called ribavirin.
- Talk to your doctor if you're currently on rosuvastatin, as you shouldn’t take it with Harvoni (ledipasvir / sofosbuvir).
- Hepatitis C infection genotype 1, 4, 5, and 6
- Harm to fetus
Women of childbearing age
- Hepatitis B reactivation
History of hepatitis B infection
- Slow heart rate
...and 3 more risk factors
- Drug interactions
...and 1 more risk factors
- Ribavirin combination treatment
Taking ribavirin with Harvoni (ledipasvir / sofosbuvir)