Prescription onlyClass: Infection

Sovaldi Alternatives

(sofosbuvir)

Prescription onlyClass: Infection
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Compare Sovaldi (sofosbuvir) to alternatives

These medications are comparable to Sovaldi (sofosbuvir) or used for similar purposes.

Sovaldi
(sofosbuvir)

Harvoni
(ledipasvir / sofosbuvir)

Incivek
(telaprevir)

Victrelis
(boceprevir)

Treats hepatitis C infection. Sovaldi (Sofosbuvir) is an effective medicine to treat chronic hepatitis C infection, but it can be expensive.Treats hepatitis C. Harvoni (ledipasvir / sofosbuvir) is a combination pill for hepatitis C that you only need to take once a day. Depending on the amount of liver damage you have, it's sometimes taken together with another medicine called ribavirin.Coming soon.Coming soon.
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Reviews & ratings
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Have you used Sovaldi (sofosbuvir)?
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Have you used Harvoni (ledipasvir / sofosbuvir)?
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Have you used Incivek (telaprevir)?
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Have you used Victrelis (boceprevir)?
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Side effects
SovaldiHarvoniIncivekVictrelis

We haven’t found good data for Sovaldi side effects.

FDA side effect reports for Sovaldi »
  • Weakness / lack of energy 8%
  • Headache 12%
  • Tiredness 17%
  • Muscle pain 9%
  • Irritability 7%
  • Cough 4%
  • Dizziness 5%
  • Shortness of breath 2%
  • Nausea 6%
  • Diarrhea 4%
More Harvoni side effects »

We haven’t found good data for Incivek side effects.

FDA side effect reports for Incivek »

We haven’t found good data for Victrelis side effects.

FDA side effect reports for Victrelis »
How it works
SovaldiHarvoniIncivekVictrelis
Sovaldi (Sofosbuvir) is an antiviral medicine. It prevents the hepatitis C virus (HCV) from making copies of itself.Harvoni (ledipasvir / sofosbuvir) is a combination of 2 antiviral medications that stop the hepatitis C virus from making copies of itself in the body.Coming soon.Coming soon.
Type of medication
SovaldiHarvoniIncivekVictrelis
Prescription onlyPrescription only
Available as
SovaldiHarvoniIncivekVictrelis
  • Pill
  • Pill
  • Pill
  • Pill
Used for
SovaldiHarvoniIncivekVictrelis
  • Hepatitis C Infection Genotype 1 4 5 And 6
  • Hepatitis C
  • Hepatitis C
Risk factors for serious side effects
SovaldiHarvoniIncivekVictrelis
  • Women of childbearing age
Detailed Sovaldi (sofosbuvir) risks & warnings »
  • History of hepatitis B infection
  • Amiodarone
  • Beta blockers
  • Heart disease
  • Liver disease
Detailed Harvoni (ledipasvir / sofosbuvir) risks & warnings »
    Coming soon.
      Coming soon.
      Pregnancy

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      Interactions
      SovaldiHarvoniIncivekVictrelis
      • Many medicines interact with Sovaldi (Sofosbuvir). You may need your dose adjusted or take an alternative medicine to avoid significant reactions. Let your doctor and pharmacist know if you're taking a new prescription or over-the-counter medicine, such as St John's wort.
      • There are many interactions between Sovaldi (Sofosbuvir) and other drugs and herbal supplements. Talk to your doctor or pharmacist before starting new medications.
      • Harvoni (ledipasvir / sofosbuvir) can interact with other medicines, making it not work as well. Make sure your doctor and pharmacist know all of the medications you're taking, including prescription, over-the-counter, and supplements. Your doctor might have to change your other medicines while you're taking Harvoni (ledipasvir / sofosbuvir).
      No interactions related info.No interactions related info.
      Food
      SovaldiHarvoniIncivekVictrelis
      • Can be taken with or without food. Try to take Sovaldi (Sofosbuvir) around the same time each day. Don't take more than 1 tablet a day.
      No food related info.No food related info.No food related info.
      Kidneys and liver
      SovaldiHarvoniIncivekVictrelis
      No kidneys and liver related info.
      • If you have severe liver disease or have a liver transplant, you'll have to take Harvoni (ledipasvir / sofosbuvir) with another medicine called ribavirin.
      No kidneys and liver related info.No kidneys and liver related info.
      Upsides and benefits
      SovaldiHarvoniIncivekVictrelis
      • Most people who take Sovaldi (Sofosbuvir) together with other antiviral medicines have good results, with no HCV found in their blood three months later.
      • Can take Sovaldi (Sofosbuvir) for a shorter amount of time than other hepatitis C medications.
      • Effective in people who have both hepatitis C and HIV infection, liver cancer, or who are waiting for a liver transplant.
      • Harvoni (ledipasvir / sofosbuvir) is a simple hepatitis C treatment that can cure 96% to 99% of those with genotype 1 who have had no prior treatment. Most people only have to take 1 pill a day for either 12 or 24 weeks.
      • The most common side effects are mild to moderate tiredness and headache.
      • Harvoni (ledipasvir / sofosbuvir) is also a good option for people taking HIV medications since it doesn't have drug interactions with most of these medicines.
      • Harvoni (ledipasvir / sofosbuvir) is approved for the treatment of hepatitis C in some people with severe liver disease and liver transplants.
      • Harvoni (ledipasvir / sofosbuvir) is also one of the first drugs approved to treat hepatitis C in children ages 12 to 17.
      Coming soonComing soon
      Downsides and risks
      SovaldiHarvoniIncivekVictrelis
      • Women shouldn't become pregnant while taking HCV medications and will need to take monthly pregnancy tests while on this.
      • Requires routine blood tests to check liver function.
      • There are many interactions between Sovaldi (Sofosbuvir) and other drugs and herbal supplements. Talk to your doctor or pharmacist before starting new medications.
      • Can only be used in people age 18 years and older.
      • There's no generic available, so it can be very expensive.
      • Harvoni (ledipasvir / sofosbuvir) needs an acidic stomach to be absorbed properly. This means that heartburn medications can affect how Harvoni (ledipasvir / sofosbuvir) works, so talk to you doctor or pharmacist before starting any.
      • Harvoni (ledipasvir / sofosbuvir) can cause serious drops in heart rate when it’s taken with amiodarone. If you have to take them together, your heart rate needs to be checked regularly.
      • You should be tested for hepatitis B before starting Harvoni (ledipasvir / sofosbuvir), since untreated hepatitis B can become active again with medications that treat hepatitis C.
      • If you have severe liver disease or have a liver transplant, you'll have to take Harvoni (ledipasvir / sofosbuvir) with another medicine called ribavirin.
      • Talk to your doctor if you're currently on rosuvastatin, as you shouldn’t take it with Harvoni (ledipasvir / sofosbuvir).
      Coming soonComing soon
      Tips from our pharmacists for people taking the medication
      SovaldiHarvoniIncivekVictrelis
      • Sovaldi (Sofosbuvir) shouldn't be taken by itself. It should be used with antiviral medications like Ribavirin, and for some people, Peginterferon Alfa. You should stop taking Sovaldi (Sofosbuvir) if you stop taking the other antiviral medicines.
      • The other antiviral medicines taken with Sovaldi (Sofosbuvir) can cause birth defects. Both women and men must use two forms of contraception during treatment and for 6 months after.
      • Depending on the type of hepatitis C infection, you'll take Sovaldi (Sofosbuvir) for either 12 or 24 weeks. Don't stop early or make any changes without first talking to your doctor.
      • Can be taken with or without food. Try to take Sovaldi (Sofosbuvir) around the same time each day. Don't take more than 1 tablet a day.
      • It's important to take Harvoni (ledipasvir / sofosbuvir) as your doctor and pharmacist tell you to. If you miss a dose and there are at least 6 hours until you are supposed to take the next one, take the missed dose as soon as you remember. Otherwise, skip the missed dose and take your next dose at the regular time.
      • Harvoni (ledipasvir / sofosbuvir) can be taken with or without food, but should be taken at the same time every day.
      • Harvoni (ledipasvir / sofosbuvir) is absorbed best in an acidic stomach environment. If you need to treat heartburn, use an antacid like Tums and separate when you take it from Harvoni (ledipasvir / sofosbuvir) by at least 4 hours. Talk to your doctor if you need to take something stronger.
      • Headaches are a possible side effect. You can use over-the-counter acetaminophen (Tylenol) to treat them, but be sure to take less than 2000 mg a day to prevent further liver damage.
      • Don’t stop taking Harvoni (ledipasvir / sofosbuvir) without first talking with your doctor or pharmacist.
      Coming soonComing soon
      Learn more
      More about SovaldiSide effectsAlternativesFDA package insert
      Have you used Sovaldi (sofosbuvir)?
      Worth itNot sureNot worth it
      More about HarvoniSide effectsFDA package insert
      Have you used Harvoni (ledipasvir / sofosbuvir)?
      Worth itNot sureNot worth it
      More about IncivekSide effectsReviews & ratingsFDA package insert
      Have you used Incivek (telaprevir)?
      Worth itNot sureNot worth it
      More about VictrelisSide effectsFDA package insert
      Have you used Victrelis (boceprevir)?
      Worth itNot sureNot worth it