Sovaldi (Sofosbuvir)

Prescription only

Harvoni (ledipasvir / sofosbuvir)

Prescription only
1 of 4 alternatives
Treats hepatitis C infection.

Sovaldi (Sofosbuvir) is an effective medicine to treat chronic hepatitis C infection, but it can be expensive.

Treats hepatitis C.

Harvoni (ledipasvir / sofosbuvir) is a combination pill for hepatitis C that you only need to take once a day. Depending on the amount of liver damage you have, it's sometimes taken together with another medicine called ribavirin.

  • Most people who take Sovaldi (Sofosbuvir) together with other antiviral medicines have good results, with no HCV found in their blood three months later.
  • Can take Sovaldi (Sofosbuvir) for a shorter amount of time than other hepatitis C medications.
  • Effective in people who have both hepatitis C and HIV infection, liver cancer, or who are waiting for a liver transplant.
  • Harvoni (ledipasvir / sofosbuvir) is a simple hepatitis C treatment that can cure 96% to 99% of those with genotype 1 who have had no prior treatment. Most people only have to take 1 pill a day for either 12 or 24 weeks.
  • The most common side effects are mild to moderate tiredness and headache.
  • Harvoni (ledipasvir / sofosbuvir) is also a good option for people taking HIV medications since it doesn't have drug interactions with most of these medicines.
  • Harvoni (ledipasvir / sofosbuvir) is approved for the treatment of hepatitis C in some people with severe liver disease and liver transplants.
  • Harvoni (ledipasvir / sofosbuvir) is also one of the first drugs approved to treat hepatitis C in children ages 12 to 17.
  • Women shouldn't become pregnant while taking HCV medications and will need to take monthly pregnancy tests while on this.
  • Requires routine blood tests to check liver function.
  • There are many interactions between Sovaldi (Sofosbuvir) and other drugs and herbal supplements. Talk to your doctor or pharmacist before starting new medications.
  • Can only be used in people age 18 years and older.
  • There's no generic available, so it can be very expensive.
  • Harvoni (ledipasvir / sofosbuvir) needs an acidic stomach to be absorbed properly. This means that heartburn medications can affect how Harvoni (ledipasvir / sofosbuvir) works, so talk to you doctor or pharmacist before starting any.
  • Harvoni (ledipasvir / sofosbuvir) can cause serious drops in heart rate when it’s taken with amiodarone. If you have to take them together, your heart rate needs to be checked regularly.
  • You should be tested for hepatitis B before starting Harvoni (ledipasvir / sofosbuvir), since untreated hepatitis B can become active again with medications that treat hepatitis C.
  • If you have severe liver disease or have a liver transplant, you'll have to take Harvoni (ledipasvir / sofosbuvir) with another medicine called ribavirin.
  • Talk to your doctor if you're currently on rosuvastatin, as you shouldn’t take it with Harvoni (ledipasvir / sofosbuvir).
Used for
  • Hepatitis C infection genotype 1, 4, 5, and 6
Dosage forms
  • Pill
  • Pill
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Side effects
The Sovaldi (Sofosbuvir) FDA package insert doesn’t have numbers about how common side effects are.
The Harvoni (ledipasvir / sofosbuvir) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Harm to fetus

    Women of childbearing age

See more detailed risks and warnings
  • Hepatitis B reactivation

    History of hepatitis B infection

  • Slow heart rate


    ...and 3 more risk factors

  • Drug interactions

    Taking rifampin

    ...and 1 more risk factors

  • Ribavirin combination treatment

    Taking ribavirin with Harvoni (ledipasvir / sofosbuvir)

See more detailed risks and warnings