4.2/ 7 average rating with 50 reviewsforStelara

Stelara
Alternatives

(Ustekinumab)

Stelara (Ustekinumab)

Prescription only

Cimzia (certolizumab)

Prescription only
1 of 5 alternatives
Treats moderate to severe psoriasis.

Stelara (Ustekinumab) works for two psoriatic conditions. It may be somewhat of a hassle because of the injection, but after the first two doses, you only need to take it every 12 weeks.

Calms the immune system and prevents joint damage.

Cimzia (certolizumab) effectively calms down your immune system, but you have to be comfortable receiving injections.

Upsides
  • Stelara (Ustekinumab) works throughout your whole body (systemic therapy) and may be better than just applying medicine to your skin (local therapy) for moderate or severe plaque psoriasis that covers large areas or many areas of your body.
  • It's used alone or together with another medicine called methotrexate for better results to treat active psoriatic arthritis.
  • Initial dosing might be a hassle, but then you only have to take it every 12 weeks.
  • People treated with Stelara (Ustekinumab) for psoriatic arthritis felt better and had more physical improvement compared to not using the medicine (placebo).
  • People taking Cimzia (certolizumab) for Crohn's disease, rheumatoid arthritis and other autoimmune conditions had greater clinical response compared to people who did not take Cimzia (certolizumab).
  • Compared to some other drugs used to treat autoimmune conditions, Cimzia (certolizumab) has not been associated with as many harmful effects during pregnancy and breastfeeding.
  • You can give yourself Cimzia (certolizumab) on your own at home rather than visiting a clinic or hospital.
  • After the initial dosing, you need to take Cimzia (certolizumab) every 4 weeks.
  • Cimzia (certolizumab) has been on the market for almost 10 years.
Downsides
  • It's an injection.
  • Stelara (Ustekinumab) lowers your ability to fight infection and can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
  • You have to get your first dose of Stelara (Ustekinumab) at your doctor's office. If you decide not to self-inject and don't have someone to do it for you, you'll need to continue to see your doctor for each dose.
  • You'll need to properly dispose of the needle and syringes in a special (FDA-approved) sharps container.
  • Because Stelara (Ustekinumab) needs to be refrigerated until you use it, if you're traveling, you'll need to carry it in a cooler with an ice pack.
  • Cimzia (certolizumab) lowers your ability to fight infection and in some cases can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, or had tuberculosis (TB) in the past.
  • Can in some cases cause bladder infections, rash and respiratory infections (cold or flu)
  • In rare cases, Cimzia (certolizumab) has been associated with cancers in children and adolescents.
  • Can increase your risk of side effects if you have a history of heart failure, nervous system conditions, or hepatitis B.
  • There's no generic available and it can be expensive.
Used for
Dosage forms
  • Injection
  • Injection
Price
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Reviews
50 
48%
think this treatment is worth it
42%
think this treatment works well
20%
think this treatment is a hassle

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Side effects
1possible side effects
  • Immunogenicity
    6%
See more detailed side effects
The Cimzia (certolizumab) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Serious Infections

    Taking other immunosuppressant drugs

    ...and 2 more risk factors

  • Malignancy

    Age 60 or older

    ...and 2 more risk factors

  • Nervous system effects

    Preeclampsia/eclampsia

    ...and 3 more risk factors

See more detailed risks and warnings
  • Serious infections

    Taking other immunosuppressant medications such as methotrexate or steroids

    ...and 3 more risk factors

  • Cancers

    Taking other immunosuppressant medications, such as azathiprine or 6-mercaptopurine, at the same time as Cimzia (certolizumab)

    ...and 2 more risk factors

  • Heart problems

    History of heart failure

  • Nervous system effects

    Multiple sclerosis

    ...and 1 more risk factors

See more detailed risks and warnings