Prescription onlyNo lower cost generic available

Stelara Alternatives

(Ustekinumab)

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Compare Stelara (Ustekinumab) to alternatives

These medications are comparable to Stelara (Ustekinumab) or used for similar purposes.

Stelara
(Ustekinumab)

Cimzia
(Certolizumab)

Enbrel
(Etanercept)

Humira
(Adalimumab)

Remicade
(Infliximab)

Treats moderate to severe psoriasis. Stelara (Ustekinumab) works for two psoriatic conditions. It may be somewhat of a hassle because of the injection, but after the first two doses, you only need to take it every 12 weeks.Reduces inflammation. Cimzia (Certolizumab) is an effective medicine to calm down your immune system, but it can be expensive and it requires a lot of monitoring while you're taking it.Calms down your immune system. Enbrel (Etanercept) is very effective at calming down your immune system, but it's expensive, you have to take into account the hassle of injections and traveling with the medication.Calms down your immune system. Humira (Adalimumab) is very effective at calming down your immune system, but it's expensive, you have to take into account the hassle of injections and traveling with the medication.Calms down your immune system. Remicade (Infliximab) is very effective at calming down your immune system, but you have to get each dose at your doctor's office and watch out for serious side effects.
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Reviews & ratings
Button Group. All currently active
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4.021739130434782Stelara
Reviews for Stelara (Ustekinumab)
43%
of people say Stelara (Ustekinumab) is worth it
39%
say it works well
22%
say it's a big hassle

Not enough reviews for this drug. Help someone out, leave a review!

Reviews for Enbrel (Etanercept)
58%
+15% vs. Stelara (Ustekinumab)
52%
+13% vs. Stelara (Ustekinumab)
19%
+3% vs. Stelara (Ustekinumab)
Reviews for Humira (Adalimumab)
59%
+16% vs. Stelara (Ustekinumab)
49%
+10% vs. Stelara (Ustekinumab)
26%
4% vs. Stelara (Ustekinumab)
Reviews for Remicade (Infliximab)
77%
+34% vs. Stelara (Ustekinumab)
65%
+26% vs. Stelara (Ustekinumab)
13%
+9% vs. Stelara (Ustekinumab)
Side effects
StelaraCimziaEnbrelHumiraRemicade
  • Headache 2%
  • Nausea 2%
  • Joint pain 2%
  • Dizziness 1%
  • Itching 1%
  • Back pain 1%
  • Throat pain 1%
  • Fatigue 1%
More Stelara side effects »
  • Upper respiratory infections 7%
  • Common cold 4%
  • Ear, nose, or throat infection 4%
  • High blood pressure 3%
  • Back pain 3%
  • Joint pain 2%
  • Acute bronchitis 2%
  • Rash 2%
  • Sore throat 2%
  • Urinary tract infections 1%
More Cimzia side effects »
  • Injection site reactions 26%
  • Any infection 11%
  • Positive anti-double-stranded dna antibodies 11%
  • Upper respiratory infections 8%
  • Non-upper respiratory infections 6%
  • Positive ana 6%
  • Itching 1%
  • Rash 1%
More Enbrel side effects »
  • Injection site reactions 6%
  • Rash 6%
  • Positive titers 5%
  • Upper respiratory infection 4%
  • Headache 4%
  • Abdominal pain 3%
  • Urinary tract infection 3%
  • High blood pressure 2%
  • Alkaline phosphatase increased 2%
  • High blood lipid levels 2%
More Humira side effects »
  • Infusion reaction 13%
  • Infections 11%
More Remicade side effects »
How it works
StelaraCimziaEnbrelHumiraRemicade
Stelara (Ustekinumab) is a biologic response modifier, or biologic. It blocks two immune system proteins called IL-12 and IL-23. This slows down new skin cell formation, and lowers inflammation for people with psoriasis or psoriatic arthritis.Cimzia (Certolizumab) is a monoclonal antibody. It lowers inflammation in the body by blocking a protein called TNF (tumor necrosis factor).Enbrel (Etanercept) is a biologic response modifier. It works in the immune system to block a protein called TNF (tumor necrosis factor). Blocking TNF relieves symptoms and prevents disease progression.Humira (Adalimumab) is a biologic response modifier. It works in the immune system to block a protein called TNF (tumor necrosis factor). Blocking TNF relieves symptoms and prevents disease progression.Remicade (Infliximab) is a biologic response modifier. It works in the immune system to block a protein called TNF (tumor necrosis factor). Blocking TNF relieves symptoms and prevents disease progression.
Type of medication
StelaraCimziaEnbrelHumiraRemicade
Immunosuppressant
Immunomodulator
Antipsoriatic
Biological response modifier
Prescription only
Immunosuppressant
Immunomodulator
Antirheumatic
Biological response modifier
Prescription only
Immunosuppressant
Immunomodulator
Antirheumatic
Biological response modifier
Prescription only
Immunosuppressant
Immunomodulator
Antirheumatic
Biological response modifier
Prescription only
Immunosuppressant
Immunomodulator
Antirheumatic
Biological response modifier
Prescription only
Available as
StelaraCimziaEnbrelHumiraRemicade
  • Injection
  • Injection
  • Injection
  • Injection
  • Injection
Used for (click to learn more)
StelaraCimziaEnbrelHumiraRemicade
Risk factors for serious side effects
StelaraCimziaEnbrelHumiraRemicade
  • Taking other immunosuppressant drugs
  • Age 60 or older
  • Weak immune system
      • Age 60 or older
      • Long-term use of drugs that suppress the immune system
      • History of PUVA (photochemotherapy)
      • Preeclampsia/eclampsia
      • Acute hypertension
      • Taking other drugs that suppress the immune system
      • Taking cytotoxic chemotherapy
          Detailed Stelara (Ustekinumab) risks & warnings »
          Coming soon.Coming soon.Coming soon.Coming soon.
          Pregnancy category
          StelaraCimziaEnbrelHumiraRemicade
          BFDA pregnancy category (Probably safe)

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          See the FDA package insert
          BFDA pregnancy category (Probably safe)

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          See the FDA package insert
          BFDA pregnancy category (Probably safe)

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          See the FDA package insert
          BFDA pregnancy category (Probably safe)

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          See the FDA package insert
          BFDA pregnancy category (Probably safe)

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          See the FDA package insert
          Alcohol
          No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.
          Food
          No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.
          Kidneys and liver
          No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.
          Sex
          No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.
          Sleep
          No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.
          Weight
          • Stelara (Ustekinumab) can increase your risk of serious bacterial, fungal and viral infections. In some cases infections can be reactivated from an inactive virus in your body like tuberculosis (TB). You may need to take medicine for TB before you can begin taking Stelara (Ustekinumab). If you develop symptoms of cough, fever, chills, muscle aches, feel very tired, or you notice dark urine, yellowing of skin/eyes, appetite/weight loss, vomiting, change in stool color, stomach discomfort, and skin rash, tell your doctor and get medical care right away.
          • Tell your doctor if you have night sweats, persistent fever, fatigue, weight loss, or swollen lymph nodes.
          No specific weight-related info.No specific weight-related info.No specific weight-related info.
          Upsides and benefits
          StelaraCimziaEnbrelHumiraRemicade
          • Stelara (Ustekinumab) works throughout your whole body (systemic therapy) and may be better than just applying medicine to your skin (local therapy) for moderate or severe plaque psoriasis that covers large areas or many areas of your body.
          • It's used alone or together with another medicine called methotrexate for better results to treat active psoriatic arthritis.
          • Initial dosing might be a hassle, but then you only have to take it every 12 weeks.
          • People treated with Stelara (Ustekinumab) for psoriatic arthritis felt better and had more physical improvement compared to not using the medicine (placebo).
          • In studies, people with RA (rheumatoid arthritis) taking methotrexate had improved symptoms when Cimzia (Certolizumab) was added to methotrexate.
          • Cimzia (Certolizumab) is as effective as other similar medicines for Crohn's disease. It can be an option for people taking other RA medications that have too many side effects of don't work anymore.
          • Cimzia (Certolizumab) lasts longer in the body than other RA medications, letting it work longer.
          • Available in a prefilled syringe. This can make it easier to give yourself the injection.
          • Treats certain types of arthritis conditions caused by an overactive immune system.
          • Enbrel is the first biologic approved for moderate to severe rheumatoid arthritis.
          • It has an established safety profile for treatment of rheumatoid arthritis (RA).
          • Available as a single-use syringe and SureClick auto-injector pen which may be more convenient and easier for some people to use.
          • People taking Enbrel for rheumatoid arthritis showed significant improvement and were able to reduce the dose or stop immunosuppressant medicines.
          • Most people feel it's worth the hassle.
          • Once you've learned the correct way to use Humira, you can inject the medicine yourself without going to your doctor's office.
          • It's available in a single-use pen (Humira Pen) that may be more convenient and easier for some people to use.
          • It's an alternative for people with Crohn's disease who stopped getting better on other TNF-blockers or had side effects that made them switch.
          • Treats certain types of arthritis and gastrointestinal conditions caused by an overactive immune system.
          • Remicade has almost two decades of clinical trial data and real-life experience with millions of people who have used it.
          • Initial dosing to introduce Remicade to your body might be a hassle, but then you only need to take it every 6-8 weeks depending on your condition.
          • Treats certain types of arthritis and gastrointestinal conditions caused by an overactive immune system.
          Downsides and risks
          StelaraCimziaEnbrelHumiraRemicade
          • Stelara (Ustekinumab) lowers your ability to fight infection and can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
          • You have to get your first dose of Stelara (Ustekinumab) at your doctor's office. If you decide not to self-inject and don't have someone to do it for you, you'll need to continue to see your doctor for each dose.
          • You'll need to properly dispose of the needle and syringes in a special (FDA-approved) sharps container.
          • Because Stelara (Ustekinumab) needs to be refrigerated until you use it, if you're traveling, you'll need to carry it in a cooler with an ice pack.
          • It's an injection.
          • Can lower your immune system's ability to fight infections. You can get serious infections such as TB (tuberculosis) and infections caused by viruses, fungi, or bacteria.
          • Can have a higher risk for causing bladder infections, rash, and upper respiratory infections (cold or flu) compared to other similar medicines.
          • Cimzia (Certolizumab) can increase the risk of lymphoma, leukemia, and other cancers.
          • Requires routine tests to check for infections.
          • Not a good choice if you have a history of heart failure, nervous system problems, or hepatitis B.
          • There's no generic available and it can be very expensive.
          • Enbrel lowers your ability to fight infection and can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
          • You're first dose of Enbrel will need to be given at your doctor's office. If you decide not to self-inject and don't have someone to do it for you, you'll need to continue to see your doctor for each dose.
          • It's an injection.
          • It's expensive because there's no generic available yet.
          • You'll need to properly dispose of the needle, syringes, or Pen in a special (FDA-approved) sharps container.
          • Because it needs to be refrigerated until you use it, if you're traveling, you'll need to carry it in a cooler with an ice pack.
          • Humira lowers your ability to fight infection and can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
          • You're first dose of Humira will need to be given at your doctor's office. If you decide not to self-inject and don't have someone to do it for you, you'll need to continue to see your doctor for each dose.
          • It's an injection.
          • It's expensive because there's no generic available yet.
          • You'll need to properly dispose of the needle, syringes, or Pen in a special (FDA-approved) sharps container.
          • Because it needs to be refrigerated until you use it, if you're traveling, you'll need to carry it in a cooler with an ice pack.
          • You have to get every dose through an IV infusion at your doctor's office.
          • Remicade has a higher risk of serious infusion-related side effects during or after it's given since it's injected right into your veins. Your doctor can prescribe medication before your dose that may lower this risk.
          • Remicade lowers your ability to fight infection and can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
          • Not the best choice if you have heart failure.
          • Talk to your baby's doctor if you're pregnant or breast-feeding. When women in a study took Remicade (Infliximab), the medicine was found in their breast milk 2 to 3 days after each dose, and in the baby's blood 6 months after they were born.
          • It's expensive because there's no generic available yet.
          Tips from our pharmacists for people taking the medication
          StelaraCimziaEnbrelHumiraRemicade
          • Stelara (Ustekinumab) is an immunosuppressant medication that's injected under the skin (subcutaneous).
          • Your doctor will give your first dose then let you self-inject once you learn how to do it correctly.
          • It's very important you read the Medication Guide especially if you're giving yourself injections.
          • Usual dosing to build up the medicine in your body is a starting dose, then 4 weeks, then 12 weeks. Maintenance dosing is every 12 weeks.
          • You'll need to have a TB test before you start injecting Stelara (Ustekinumab).
          • Tell your doctor if you have an allergy to latex. The prefilled syringe needle cover contains a latex product.
          • Don't use/inject if the medicine contains any particles or is discolored.
          • Rotate your injection areas using front of the thigh, outer area of upper arms or lower part of your belly (not around belly button). Don't inject into skin that's red, bruised or irritated.
          • Stelara (Ustekinumab) can increase your risk of common infections, reactivate infections hidden in your body, and in some people, cause rare infections.
          • Serious and life-threatening nervous system and allergic reactions can happen immediately, days or months after starting Stelara (Ustekinumab). Stelara (Ustekinumab) can increase your risk of certain skin cancer.
          • Dispose of used syringes in a protective (Sharps) container. DON'T throw in the trash.
          • Don't get any live vaccines while you're taking Stelara (Ustekinumab). If you need to get a vaccine, ask your doctor first.
          • Cimzia (Certolizumab) is a medicine that's injected just under the skin (subcutaneous). It can be given in your doctor's office or you can do it yourself at home.
          • It can take multiple doses before you start to see any effects, so don't change your dose without talking to your doctor.
          • Tell your doctor if you have night sweats, persistent fever, fatigue, weight loss, or swollen lymph nodes.
          • You'll need to have a TB (tuberculosis) test before you start Cimzia (Certolizumab) and periodically during treatment.
          • Don't get any live vaccines while you're taking Cimzia (Certolizumab) since they may not work as well. Wait at least 3 months after you've stopped taking Cimzia (Certolizumab) before getting a live vaccine.
          • Enbrel (Etanercept) is available as a single-use prefilled syringe, single-use prefilled SureClick Autoinjector, and multiple-use vial. You and your doctor can discuss which is best for you.
          • The autoinjector can be stored at room temperature for up to 14 days and can't be refrigerated again.
          • Enbrel (Etanercept) is a medication that's injected under the skin (subcutaneous). Your doctor can give you your first dose, then let you self-inject it once so you learn how to do it correctly.
          • Enbrel (Etanercept) lowers the your immune system's ability to fight infections, so it's important to let your doctor know if you come down with a fever, cough, or notice flu-like symptoms.
          • You'll need to have a TB test before you start using Enbrel (Etanercept).
          • Don't inject Enbrel (Etanercept) into skin that's red, bruised, or irritated. Rotate your injection areas to avoid skin reactions.
          • Tell your doctor if you have an allergy to latex since the syringe needle cover has latex in it.
          • As with all injection medicines, store away from children and throw used syringes away in a protective container, and not in the trash.
          • Humira (Adalimumab) is a medication that's injected under the skin (subcutaneous). Your doctor can give you your first dose, then let you self-inject it once so you learn how to do it correctly.
          • Humira (Adalimumab) lowers the your immune system's ability to fight infections, so it's important to let your doctor know if you come down with a fever, cough, or notice flu-like symptoms.
          • You'll need to have a TB test before you start using Humira (Adalimumab).
          • Don't inject Humira (Adalimumab) into skin that's red, bruised, or irritated. Rotate your injection areas to avoid skin reactions.
          • Tell your doctor if you have an allergy to latex since the syringe needle cover has latex in it.
          • As with all injection medicines, store away from children and throw used syringes away in a protective container, and not in the trash.
          • Remicade (Infliximab) is a medication that's given as an infusion at your doctor's office or clinic.
          • It's very important to read the patient Medication Guide when you first start using Remicade (Infliximab).
          • It's possible to get an allergic reaction to Remicade (Infliximab) either immediately during the treatment or a several days after stopping it. Your doctor can give you medicines that'll lower this risk.
          • You'll need to have a TB test before you start taking Remicade (Infliximab) and periodically during treatment.
          • Remicade (Infliximab) lowers your immune system's ability to fight infections, so it's important to let your doctor know if you notice a fever, cough, or flu-like symptoms. Children seem to get more infections than adults, so keep a close eye on them.
          • If you have a young child, let their doctor know if you were on Remicade (Infliximab) while pregnant or nursing. It can increase their risk of infections for several months after your last dose and can delay their vaccine schedule.
          Learn more
          More about StelaraSide effectsReviews & ratingsAlternativesFDA package insert
          More about CimziaSide effectsReviews & ratingsFDA package insert
          More about EnbrelSide effectsReviews & ratingsFDA package insert
          More about HumiraSide effectsReviews & ratingsFDA package insert
          More about RemicadeSide effectsReviews & ratingsFDA package insert