Prescription onlyLower-cost generic availableClass: Pain


(buprenorphine / naloxone)

Prescription onlyLower-cost generic availableClass: Pain
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Treats drug dependence.

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Our bottom line

Suboxone (Buprenorphine / Naloxone) works well to reduce cravings and treat opioid dependence. It's most effective if you have an addiction to heroin or short-acting-opioids.

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  • Effective at preventing abuse or misuse in people who are addicted to opioids. Works best for people addicted to short-acting opioids or heroin.
  • Your doctor can adjust the dose to a level that controls withdrawal symptoms until you're stable. Studies show the right dose depends on the person and how the drug works for them.
  • Fewer side effects and drug interactions compared to other similar medicines.
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  • Not as good for people who are dependent on long-acting opioids or Methadone because of the risk of a long withdrawal.
  • Like all opioids, it can cause slowed breathing, coma, and death from overdose, especially if you mix with other nervous system depressants like pain medicine or alcohol.
  • You have to be very careful with your dose. Changing the size or strength of a film can affect the amount of drug absorbed into your body, and could cause under- or over-dosing.
  • The film can cause reduced sensation in your mouth, painful burning tongue, or burning mouth syndrome.
How it works

Suboxone (Buprenorphine / Naloxone) is a combination medicine with two parts that work together to treat opioid dependence. Buprenorphine is an opioid pain reliever (similar to morphine). Naloxone mildly counteracts the pain reliever, so it's added to prevent overuse or abuse of this medication.

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Side effect rates for Suboxone (buprenorphine / naloxone)

214 From clinical trials of Suboxone / Opioid dependence (16 mg buprenorphine/4 mg naloxone)
  • Headache
  • Withdrawal syndrome
  • Pain
  • Nausea
  • Sweating
  • Sleep difficulty
  • Constipation
  • Pain abdomen
  • Widening of blood vessels
  • Chills

Risks and Warnings for Suboxone (buprenorphine / naloxone)

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    • Higher risk if:
    • Cardiovascular disease
    • dehydration
    • taking drugs that lower blood pressure

    Suboxone (Buprenorphine / Naloxone) can cause severe low blood pressure, fainting, and a drop blood pressure when you change positions, called orthostatic hypotension. You might be more sensitive if you're already taking medicine to lower your blood pressure so be careful. It's important that you tell your doctor about these symptoms before changing your dose or stopping your medication suddenly.

Common concerns from people taking Suboxone (buprenorphine / naloxone)

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  • Fewer side effects and drug interactions compared to other similar medicines.
  • Don't mix with alcohol or other sedating drugs.
  • Some medicines can affect enzymes that break down Suboxone (Buprenorphine / Naloxone). Certain drugs to treat infections, HIV, and seizures can change the amount of Suboxone (Buprenorphine / Naloxone) in the body. Tell your doctor about any medications you are taking and if you notice muscle aches, restlessness, anxiety, tearing eyes, runny nose, excessive sweating, yawning or inability to sleep. These may be symptoms of withdrawal.
  • The film can cause reduced sensation in your mouth, painful burning tongue, or burning mouth syndrome.
  • Other than Methadone, best medication without increasing and tolerance for my Chronic Pain EVER!!!
  • Wanted off of 4 yrs of pain pill scripts for Fibromyalgia. Got sick. This also helps with pain. Very expensive if insurance doesnt cover it.
  • Can make you drowsy and dizzy.