Prescription onlyLower-cost generic availableClass: Autoimmune

Azulfidine Alternatives

(sulfasalazine)

Prescription onlyLower-cost generic availableClass: Autoimmune
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Compare Azulfidine (sulfasalazine) to alternatives

These medications are comparable to Azulfidine (sulfasalazine) or used for similar purposes.

Azulfidine
(sulfasalazine)

Lialda
(mesalamine)

Colazal
(balsalazide)

Reduces inflammation. Azulfidine (Sulfasalazine) is used for moderate to severe inflammatory bowel conditions, and with other meds for treating rheumatoid arthritis.Treats inflammatory bowel disease. Lialda (Mesalamine) is an effective first-line medicine for inflammatory bowel disease. There isn't a generic version and you'll have to take it multiple times a day.Coming soon.
Reviews & ratings
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Have you used Azulfidine (sulfasalazine)?
Worth itNot sureNot worth it

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Have you used Lialda (mesalamine)?
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Have you used Colazal (balsalazide)?
Worth itNot sureNot worth it
Side effects
SulfasalazineAsacolColazal

We haven’t found good data for Sulfasalazine side effects.

FDA side effect reports for Sulfasalazine »
  • Abdominal pain 4%
  • Eructation 1%
  • Pain 6%
  • Sore throat 2%
  • Back pain 2%
More Asacol side effects »

We haven’t found good data for Colazal side effects.

FDA side effect reports for Colazal »
How it works
SulfasalazineAsacolColazal
Azulfidine (Sulfasalazine) is an anti-inflammatory drug that reduces inflammation and pain. It treats inflammatory bowel diseases and rheumatoid arthritis.Lialda (Mesalamine) is an anti-inflammatory medication. Researchers don't know exactly how Lialda (Mesalamine) works in the colon, but it seems to lower the chemicals in the body that cause inflammation.Coming soon.
Type of medication
SulfasalazineAsacolColazal
Prescription onlyPrescription only
Available as
SulfasalazineAsacolColazal
  • Pill
  • Extended release
  • Pill
  • Extended release
  • Enema
  • Suppository
  • Pill
Used for
SulfasalazineAsacolColazal
  • Ulcerative Colitis Mild To Moderate
Risk factors for serious side effects
SulfasalazineAsacolColazal
    Detailed Azulfidine (sulfasalazine) risks & warnings »
    • Asthma
    • Rhinitis
    • Nasal polyps
    • Aspirin allergy
    • NSAID allergy
    Detailed Lialda (mesalamine) risks & warnings »
      Coming soon.
      Pregnancy

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      Food
      SulfasalazineAsacolColazal
      • Swallow tablets whole, and take after a meal with a full glass of water.
      No food related info.No food related info.
      Kidneys and liver
      SulfasalazineAsacolColazal
      • Severe hypersensitivity reactions can include internal organ involvement, such as hepatitis (liver), nephritis (kidney), myocarditis (heart), blood abnormalities, or pneumonitis (lungs).
      • Azulfidine (Sulfasalazine) isn't a good option if you have kidney or liver disease.
      • Lialda (Mesalamine) is broken down by the kidney and liver. If you have kidney or liver problems, talk to your doctor because you may need to take a different dose of the medication.
      • Rarely, Lialda (Mesalamine) can cause liver injury, hepatitis, and liver failure. Let your doctor know and get medical attention if you notice yellowing skin or eyes.
      • Not a good option if you have kidney disease.
      No kidneys and liver related info.
      Upsides and benefits
      SulfasalazineAsacolColazal
      • When taken consistently, Azulfidine (Sulfasalazine) can control your symptoms of ulcerative colitis and other bowel diseases.
      • Azulfidine (Sulfasalazine) is usually used in combination with other medications to control rheumatoid arthritis.
      • Effective first-line medication for treating and lowering the symptoms of mild inflammatory bowel disease.
      • About half the people who have mild to moderate colon inflammation and take Lialda (Mesalamine) will see improvement.
      • Available in tablets, capsules, enemas, and suppositories.
      • Certain forms of Lialda (Mesalamine) can be used during pregnancy. Talk to your doctor if you're pregnant, or plan on becoming pregnant, and you want to take Lialda (Mesalamine).
      Coming soon
      Downsides and risks
      SulfasalazineAsacolColazal
      • You need to have blood tests every 3 months when taking Azulfidine (Sulfasalazine).
      • Azulfidine (Sulfasalazine) isn't a good option if you have kidney or liver disease.
      • Can't take Azulfidine (Sulfasalazine) if you are allergic to aspirin or sulfa medications.
      • Azulfidine (Sulfasalazine) shouldn't be used if you are breastfeeding.
      • No generic versions are available for the tablets, capsules, and suppositories (meaning it could be somewhat expensive).
      • Doesn't work well for severe colon inflammation.
      • You may need to take Lialda (Mesalamine) three or four times a day.
      • Not a good option if you have kidney disease.
      Coming soon
      Tips from our pharmacists for people taking the medication
      SulfasalazineAsacolColazal
      • Don't use if you are allergic to sulfa drugs or aspirin.
      • Swallow tablets whole, and take after a meal with a full glass of water.
      • Drink at least six glasses of water daily while on this.
      • Continue to take Azulfidine (Sulfasalazine) even once you feel better.
      • Read the information that come with your medication in the drugstore since there are many conditions you should be aware of before taking Azulfidine (Sulfasalazine).
      • Can cause an orange color in your urine or skin.
      • Don't take Lialda (Mesalamine) if you're allergic to aspirin. Talk to your doctor or pharmacist about any drug allergies you have before starting Lialda (Mesalamine).
      • Taking antacids with Lialda (Mesalamine) can make your inflammation worse. Talk to your doctor before you make any changes.
      • You can sunburn more easily when taking Lialda (Mesalamine). Use sunscreen and protective clothing when you go outdoors.
      • Don't break, chew, or crush the tablets because they're coated and won't work as well.
      • The suppositories should be kept in for at least 1 to 3 hours to get the most benefit.
      Coming soon
      Learn more
      More about SulfasalazineSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Azulfidine (sulfasalazine)?
      Worth itNot sureNot worth it
      More about AsacolSide effectsReviews & ratingsFDA package insert
      Have you used Lialda (mesalamine)?
      Worth itNot sureNot worth it
      More about ColazalSide effectsReviews & ratingsFDA package insert
      Have you used Colazal (balsalazide)?
      Worth itNot sureNot worth it