Azulfidine (Sulfasalazine)

Prescription only

Lialda (Mesalamine)

Prescription only
1 of 3 alternatives
Reduces inflammation.

Azulfidine (Sulfasalazine) is used for moderate to severe inflammatory bowel conditions, and with other meds for treating rheumatoid arthritis.

Treats inflammatory bowel disease.

Lialda (Mesalamine) is an effective first-line medicine for inflammatory bowel disease. There isn't a generic version and you'll have to take it multiple times a day.

  • When taken consistently, Azulfidine (Sulfasalazine) can control your symptoms of ulcerative colitis and other bowel diseases.
  • Azulfidine (Sulfasalazine) is usually used in combination with other medications to control rheumatoid arthritis.
  • Effective first-line medication for treating and lowering the symptoms of mild inflammatory bowel disease.
  • About half the people who have mild to moderate colon inflammation and take Lialda (Mesalamine) will see improvement.
  • Available in tablets, capsules, enemas, and suppositories.
  • Certain forms of Lialda (Mesalamine) can be used during pregnancy. Talk to your doctor if you're pregnant, or plan on becoming pregnant, and you want to take Lialda (Mesalamine).
  • You need to have blood tests every 3 months when taking Azulfidine (Sulfasalazine).
  • Azulfidine (Sulfasalazine) isn't a good option if you have kidney or liver disease.
  • Can't take Azulfidine (Sulfasalazine) if you are allergic to aspirin or sulfa medications.
  • Azulfidine (Sulfasalazine) shouldn't be used if you are breastfeeding.
  • No generic versions are available for the tablets, capsules, and suppositories (meaning it could be somewhat expensive).
  • Doesn't work well for severe colon inflammation.
  • You may need to take Lialda (Mesalamine) three or four times a day.
  • Not a good option if you have kidney disease.
Used for
Dosage forms
  • Pill
  • Extended release
  • Pill
  • Extended release
  • Enema
  • Suppository
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Side effects
The Azulfidine (Sulfasalazine) FDA package insert doesn’t have numbers about how common side effects are.
10possible side effects
  • Headache
  • Abdominal pain
  • Eructation
  • Pain
  • Nausea
  • Pharyngitis
  • Dizziness
  • Asthenia
  • Diarrhea
  • Back pain
See more detailed side effects
Risks and warnings
See more detailed risks and warnings
  • Serious allergic reactions


    ...and 4 more risk factors

  • Serious allergic reactions

    Phenylketonuria (PKU)

  • Worsening kidney or liver function

    Kidney problems

    ...and 1 more risk factors

  • Blood disorders

    Age 65 or older

  • Liver toxicity

    Liver problems

  • Worsening of colitis

    Taking Lialda (Mesalamine) at the start of treatment

See more detailed risks and warnings