Prescription onlyLower-cost generic availableClass: Neuro/psych



Prescription onlyLower-cost generic availableClass: Neuro/psych
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Improves your mood.

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Our bottom line

Surmontil (trimipramine) is good at treating depression, but it can cause more side effects, like sleepiness and weight gain, compared to other medicines.

Price and discounts
Best available price for 30 (100mg) capsules of trimipramine


  • Surmontil (trimipramine) is part of the first choice medicines to treat depression.
  • Available in generic and in three different strengths.
  • Can be taken once a day, usually before you go to bed.
  • Can be taken with or without food.


  • You might not notice changes in your mood until you've taken Surmontil (trimipramine) for several weeks.
  • Stopping Surmontil (trimipramine) suddenly without telling your doctor can be dangerous.
  • Surmontil (trimipramine) can cause more side effects than other medicines used to treat depression.
How it works

Surmontil (trimipramine) is a tricyclic antidepressant. It raises the amount of serotonin and norepinephrine in the brain, 2 chemicals that are known to regulate mood.

What to expect when you take Surmontil (trimipramine) for Depression

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Side effect rates for Surmontil (trimipramine)

Risks and Warnings for Surmontil (trimipramine)

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    • Higher risk if:
    • People under age 24

    Taking Surmontil (trimipramine) can make you more likely to harm yourself or commit suicide, especially if you are under age 24 and during the first few weeks of taking the medicine. Surmontil (trimipramine) isn’t approved for children under age 18. If your mood darkens and you want to hurt yourself or other people, call your doctor or go to the emergency room right away.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Surmontil (trimipramine)

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  • Can be taken with or without food.