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Theraflu Nighttime Severe Cold And Cough Alternatives

(Acetaminophen / Diphenhydramine / Phenylephrine)

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Compare Theraflu Nighttime Severe Cold And Cough (Acetaminophen / Diphenhydramine / Phenylephrine) to alternatives

These medications are comparable to Theraflu Nighttime Severe Cold And Cough (Acetaminophen / Diphenhydramine / Phenylephrine) or used for similar purposes.

Theraflu Nighttime Severe Cold And Cough
(Acetaminophen / Diphenhydramine / Phenylephrine)

Alka-Seltzer Plus Cold And Cough
(Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine)

Alka-Seltzer Plus Night Severe Cold And Flu
(Acetaminophen / Doxylamine / Dextromethorphan / Phenylephrine)

Nyquil Cold And Flu
(Acetaminophen / Dextromethorphan / Doxylamine)

Advil Pm
(Diphenhydramine / Ibuprofen)

Tylenol Pm
(Acetaminophen / Diphenhydramine)

Relieves cold and flu symptoms, and helps you sleep. Theraflu Nighttime Severe Cold And Cough (Acetaminophen / Diphenhydramine / Phenylephrine) is good for treating multiple cold and flu symptoms, but it won't relieve coughing.Relieves coughing and cold symptoms. Alka-Seltzer Plus Cold And Cough (Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine) is good for multiple cold symptoms, but it's more medicine than you need if you only have one symptom.Relieves cold and flu symptoms, and helps you sleep. Alka-Seltzer Plus Night Severe Cold And Flu (Acetaminophen / Doxylamine / Dextromethorphan / Phenylephrine) is good for multiple cold symptoms at night, but it's more medicine than you need if you only have one symptom.Relieves cold and flu symptoms, and helps you sleep. Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a useful combination medicine that relieves cold and flu symptoms and will help you sleep. Make sure you really need all of its ingredients.Relieves pain and helps you sleep. Advil Pm (Diphenhydramine / Ibuprofen) works well at relieving pain and also helps you sleep.Relieves pain and helps you sleep. Tylenol Pm (Acetaminophen / Diphenhydramine) works well at relieving pain and also helps you sleep.
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Reviews & ratings
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Reviews for Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine)
83%
+58% vs. Theraflu Nighttime Severe Cold And Cough (Acetaminophen / Diphenhydramine / Phenylephrine)
42%
+42% vs. Theraflu Nighttime Severe Cold And Cough (Acetaminophen / Diphenhydramine / Phenylephrine)
6%
+19% vs. Theraflu Nighttime Severe Cold And Cough (Acetaminophen / Diphenhydramine / Phenylephrine)

Not enough reviews for this drug. Help someone out, leave a review!

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Side effects
Theraflu Nighttime Severe Cold and CoughAlka-Seltzer Plus Cold and CoughAlka-Seltzer Plus Night Severe Cold and FluNyquil Cold and FluAdvil PMTylenol PM

We haven’t found good data for Theraflu Nighttime Severe Cold and Cough side effects.

FDA side effect reports for Theraflu Nighttime Severe Cold and Cough »

We haven’t found good data for Alka-Seltzer Plus Cold and Cough side effects.

FDA side effect reports for Alka-Seltzer Plus Cold and Cough »

We haven’t found good data for Alka-Seltzer Plus Night Severe Cold and Flu side effects.

FDA side effect reports for Alka-Seltzer Plus Night Severe Cold and Flu »

We haven’t found good data for Nyquil Cold and Flu side effects.

FDA side effect reports for Nyquil Cold and Flu »

We haven’t found good data for Advil PM side effects.

FDA side effect reports for Advil PM »

We haven’t found good data for Tylenol PM side effects.

FDA side effect reports for Tylenol PM »
How it works
Theraflu Nighttime Severe Cold and CoughAlka-Seltzer Plus Cold and CoughAlka-Seltzer Plus Night Severe Cold and FluNyquil Cold and FluAdvil PMTylenol PM
Theraflu Nighttime Severe Cold And Cough (Acetaminophen / Diphenhydramine / Phenylephrine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Phenylephrine is a decongestant that clears your sinuses. Diphenhydramine is an antihistamine that treats runny nose and watery eyes and helps you sleep.Alka-Seltzer Plus Cold And Cough (Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine) is a combination medicine that treats cold and flu symptoms. Aspirin relieves pain and reduces fever. Chlorpheniramine is an antihistamine that treats runny nose and watery eyes. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses.Alka-Seltzer Plus Night Severe Cold And Flu (Acetaminophen / Doxylamine / Dextromethorphan / Phenylephrine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses. Doxylamine is an antihistamine that relieves a runny nose and makes you very sleepy.Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Doxylamine is an antihistamine that relieves a runny nose and makes you very sleepy.Advil Pm (Diphenhydramine / Ibuprofen) is a combination medicine that treats cold and flu symptoms. Ibuprofen is an NSAID that relieves pain and reduces fever. Diphenhydramine is an antihistamine that treats runny nose and watery eyes and helps you sleep.Tylenol Pm (Acetaminophen / Diphenhydramine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Diphenhydramine is an antihistamine that treats runny nose and watery eyes and helps you sleep.
Type of medication
Theraflu Nighttime Severe Cold and CoughAlka-Seltzer Plus Cold and CoughAlka-Seltzer Plus Night Severe Cold and FluNyquil Cold and FluAdvil PMTylenol PM
Pain reliever
Acetaminophen (APAP)
Antihistamine
1st generation
DecongestantOver-the-counter
Pain reliever
Salicylate
Antihistamine
1st generation
Cough suppressantDecongestantOver-the-counter
Pain reliever
Acetaminophen (APAP)
Antihistamine
Ethanolamine derivative
Cough suppressantDecongestantOver-the-counter
Pain reliever
APAP
Cough suppressantAntihistamine
Ethanolamine derivative
Over-the-counter
Antihistamine
1st generation
Pain reliever
NSAID
Over-the-counter
Pain reliever
Acetaminophen (APAP)
Antihistamine
1st generation
Over-the-counter
Available as
Theraflu Nighttime Severe Cold and CoughAlka-Seltzer Plus Cold and CoughAlka-Seltzer Plus Night Severe Cold and FluNyquil Cold and FluAdvil PMTylenol PM
  • Powder
  • Pill
  • Effervescent tablet
  • Powder
  • Pill
  • Liquid
  • Pill
  • Pill
Used for (click to learn more)
Theraflu Nighttime Severe Cold and CoughAlka-Seltzer Plus Cold and CoughAlka-Seltzer Plus Night Severe Cold and FluNyquil Cold and FluAdvil PMTylenol PM
Risk factors for serious side effects
Theraflu Nighttime Severe Cold and CoughAlka-Seltzer Plus Cold and CoughAlka-Seltzer Plus Night Severe Cold and FluNyquil Cold and FluAdvil PMTylenol PM
  • Drinking more than 3 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • History of phenylketonuria (PKU)
  • History of high blood pressure
  • Taking MAO inhibitors
  • Taking with alcohol
  • Taking with other medicines that make you less alert
  • History of falls
  • Age 65 or older
  • Taking other drugs that make you drowsy or dizzy
  • Women of childbearing age
Detailed Theraflu Nighttime Severe Cold And Cough (Acetaminophen / Diphenhydramine / Phenylephrine) risks & warnings »
Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.
Pregnancy category
Theraflu Nighttime Severe Cold and CoughAlka-Seltzer Plus Cold and CoughAlka-Seltzer Plus Night Severe Cold and FluNyquil Cold and FluAdvil PMTylenol PM
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
Alcohol
No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.
  • Avoid using alcohol and other drugs that make you drowsy.
  • Don't take Advil Pm (Diphenhydramine / Ibuprofen) with alcohol or other drugs that make you sleepy.
  • Don't take Tylenol Pm (Acetaminophen / Diphenhydramine) with alcohol or other drugs that make you sleepy.
Food
No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.
  • Contains ibuprofen, so take it with food to avoid stomach problems and ulcers.
No specific food-related info.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.
Sex
No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.
Sleep
  • Diphenhydramine (the antihistamine) will make you drowsy, but phenylephrine (the decongestant) can make you restless. Depending on how the medicine affects you, don't take it immediately before going to bed.
  • Diphenhydramine, also known as Benadryl, is an antihistamine in Theraflu Nighttime Severe Cold And Cough (Acetaminophen / Diphenhydramine / Phenylephrine) that can make you feel dizzy or drowsy. People who are at a higher risk of falls should avoid using Theraflu Nighttime Severe Cold And Cough (Acetaminophen / Diphenhydramine / Phenylephrine).
No specific sleep-related info.
  • The antihistamine (doxylamine) can help you sleep.
  • The antihistamine (doxylamine) will help you sleep.
  • Avoid using alcohol and other drugs that make you drowsy.
  • Isn't habit-forming like some other pain medicines and sleep aids.
  • Diphenhydramine makes you tired, so take Advil Pm (Diphenhydramine / Ibuprofen) before you go to sleep.
  • Isn't habit-forming like some other pain medicines and sleep aids.
  • Diphenhydramine makes you tired, so take Tylenol Pm (Acetaminophen / Diphenhydramine) before you go to sleep.
Weight
No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.
Upsides and benefits
Theraflu Nighttime Severe Cold and CoughAlka-Seltzer Plus Cold and CoughAlka-Seltzer Plus Night Severe Cold and FluNyquil Cold and FluAdvil PMTylenol PM
  • Theraflu Nighttime Severe Cold And Cough (Acetaminophen / Diphenhydramine / Phenylephrine) is a combination medicine that relieves multiple cold and flu symptoms. It's good to use if you have a stuffy nose, watery eyes, a fever, and pain.
  • Since you're taking this with water, it can help you stay hydrated.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • Alka-Seltzer Plus Cold And Cough (Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • Phenylephrine (the decongestant ingredient) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • Dextromethorphan (the cough suppressant ingredient) works well and has very few side effects.
  • Alka-Seltzer Plus Night Severe Cold And Flu (Acetaminophen / Doxylamine / Dextromethorphan / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The antihistamine (doxylamine) can help you sleep.
  • The cough medicine (dextromethorphan) works well and has very few side effects.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have watery eyes, a cough, fever, and pain.
  • The antihistamine (doxylamine) will help you sleep.
  • The cough medicine (dextromethorphan) works well and has very few side effects.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • Advil Pm (Diphenhydramine / Ibuprofen) works well when you have a cold or the flu, but can also be used for backaches, minor arthritis, and joint pain.
  • Can be used for anyone 12 years or older.
  • Isn't habit-forming like some other pain medicines and sleep aids.
  • Tylenol Pm (Acetaminophen / Diphenhydramine) works well when you have a cold or the flu, but can also be used for backaches, minor arthritis, and joint pain.
  • Can be used for anyone 12 years or older.
  • Isn't habit-forming like some other pain medicines and sleep aids.
Downsides and risks
Theraflu Nighttime Severe Cold and CoughAlka-Seltzer Plus Cold and CoughAlka-Seltzer Plus Night Severe Cold and FluNyquil Cold and FluAdvil PMTylenol PM
  • Theraflu Nighttime Severe Cold And Cough (Acetaminophen / Diphenhydramine / Phenylephrine) doesn't stop coughing, but drinking warm water will help sooth your throat.
  • The antihistamine (diphenhydramine) can make you feel groggy the next morning.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • The aspirin in Alka-Seltzer Plus Cold And Cough (Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine) interacts with many other drugs and health conditions.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • The pain reliever (ibuprofen) can interact with other medications and make health problems like stomach bleeding and ulcers worse.
  • The antihistamine (diphenhydramine) can make you feel groggy the next morning.
  • Can only take one dose in 24 hours.
  • Can increase the risk of falls, so elderly people shouldn't use it.
  • The antihistamine (diphenhydramine) can make you feel groggy the next morning.
  • Can increase the risk of falls, so elderly people shouldn't use it.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • Can only take one dose in 24 hours.
Tips from our pharmacists for people taking the medication
Theraflu Nighttime Severe Cold and CoughAlka-Seltzer Plus Cold and CoughAlka-Seltzer Plus Night Severe Cold and FluNyquil Cold and FluAdvil PMTylenol PM
  • Starts working in about 30 minutes.
  • Dissolve 1 packet in a cup of hot water and use every 4 hours as needed. Don't use more than 5 packets in 24 hours.
  • Diphenhydramine (the antihistamine) will make you drowsy, but phenylephrine (the decongestant) can make you restless. Depending on how the medicine affects you, don't take it immediately before going to bed.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Let your doctor know if your symptoms don't improve in a few days.
  • Alka-Seltzer Plus Cold And Cough (Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine) starts working in about 30 minutes.
  • Chlorpheniramine (the antihistamine in Alka-Seltzer Plus Cold And Cough (Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine)) can make you sleepy, so avoid activities that require you to be fully alert until you know how it affects you.
  • Phenylephrine (the decongestant ingredient) can make you restless, so don't take it too close to bedtime.
  • Don't take Alka-Seltzer Plus Cold And Cough (Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine) if you're pregnant.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
  • Alka-Seltzer Plus Night Severe Cold And Flu (Acetaminophen / Doxylamine / Dextromethorphan / Phenylephrine) comes as a powder packet you can dissolve in hot water and drink.
  • Doxylamine (the antihistamine ingredient) can make you tired, so take it close to bedtime.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
  • Follow age-specific dosing instructions on how much to take. Don't take more than recommended on the package.
  • Avoid using alcohol and other drugs that make you drowsy.
  • Doxylamine (the antihistamine ingredient) can make you tired, so take it close to bedtime.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
  • Contains ibuprofen, so take it with food to avoid stomach problems and ulcers.
  • Diphenhydramine makes you tired, so take Advil Pm (Diphenhydramine / Ibuprofen) before you go to sleep.
  • Don't take Advil Pm (Diphenhydramine / Ibuprofen) with alcohol or other drugs that make you sleepy.
  • Don't take Advil Pm (Diphenhydramine / Ibuprofen) if you're pregnant.
  • Diphenhydramine makes you tired, so take Tylenol Pm (Acetaminophen / Diphenhydramine) before you go to sleep.
  • Don't take Tylenol Pm (Acetaminophen / Diphenhydramine) with alcohol or other drugs that make you sleepy.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Let your doctor know if your symptoms don't improve in a few days.
Learn more
More about Theraflu Nighttime Severe Cold and CoughSide effectsReviews & ratingsAlternativesFDA package insert
More about Alka-Seltzer Plus Cold and CoughSide effectsReviews & ratingsFDA package insert
More about Alka-Seltzer Plus Night Severe Cold and FluSide effectsReviews & ratingsFDA package insert
More about Nyquil Cold and FluSide effectsReviews & ratingsFDA package insert
More about Advil PMSide effectsReviews & ratingsFDA package insert
More about Tylenol PMSide effectsReviews & ratingsFDA package insert