Theraflu Nighttime Severe Cold And Cough
Alternatives

(Acetaminophen / Diphenhydramine / Phenylephrine)

Theraflu Nighttime Severe Cold And Cough (Acetaminophen / Diphenhydramine / Phenylephrine)

Over-the-counter
Relieves cold and flu symptoms, and helps you sleep.

Theraflu Nighttime Severe Cold And Cough (Acetaminophen / Diphenhydramine / Phenylephrine) is good for treating multiple cold and flu symptoms, but it won't relieve coughing.

Relieves coughing and cold symptoms.

Alka-Seltzer Plus Cold And Cough (Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine) is good for multiple cold symptoms, but it's more medicine than you need if you only have one symptom.

Upsides
  • Theraflu Nighttime Severe Cold And Cough (Acetaminophen / Diphenhydramine / Phenylephrine) is a combination medicine that relieves multiple cold and flu symptoms. It's good to use if you have a stuffy nose, watery eyes, a fever, and pain.
  • Since you're taking this with water, it can help you stay hydrated.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • Alka-Seltzer Plus Cold And Cough (Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • Phenylephrine (the decongestant ingredient) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • Dextromethorphan (the cough suppressant ingredient) works well and has very few side effects.
Downsides
  • Theraflu Nighttime Severe Cold And Cough (Acetaminophen / Diphenhydramine / Phenylephrine) doesn't stop coughing, but drinking warm water will help sooth your throat.
  • The antihistamine (diphenhydramine) can make you feel groggy the next morning.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • The aspirin in Alka-Seltzer Plus Cold And Cough (Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine) interacts with many other drugs and health conditions.
Used for
Dosage forms
  • Powder
  • Pill
  • Effervescent tablet
No pricing information available
No pricing information available
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Side effects
The Theraflu Nighttime Severe Cold And Cough (Acetaminophen / Diphenhydramine / Phenylephrine) FDA package insert doesn’t have numbers about how common side effects are.
The Alka-Seltzer Plus Cold And Cough (Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Liver damage

    Drinking more than 3 alcoholic beverages a day

    ...and 2 more risk factors

  • Brain damage from too much phenylalanine

    History of phenylketonuria (PKU)

  • High blood pressure

    History of high blood pressure

    ...and 1 more risk factors

  • Driving impairment

    Taking with alcohol

    ...and 1 more risk factors

  • Increased falls

    History of falls

    ...and 2 more risk factors

  • Harm to unborn babies

    Women of childbearing age

See more detailed risks and warnings
  • Stomach bleeding

    History of stomach bleeding or ulcers

    ...and 3 more risk factors

  • Driving impairment

    Taking with alcohol

    ...and 1 more risk factors

  • Harm to unborn babies

    Women of childbearing age

  • Reye's syndrome

    Age 18 years or younger

  • High blood pressure

    History of high blood pressure

    ...and 1 more risk factors

  • Serotonin syndrome

    Using other medications that affect serotonin

See more detailed risks and warnings