Prescription onlyLower-cost generic availableClass: Neuro/psych



Prescription onlyLower-cost generic availableClass: Neuro/psych
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Treats schizophrenia.

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Our bottom line

Taking Mellaril (thioridazine) is one of many options to treat schizophrenia if other medicines haven't worked, but there are some side effects which can be dangerous.


  • Available in generic.
  • Compared to other similar medicines, Mellaril (thioridazine) is less likely to cause problems controlling your movements.
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  • Mellaril (thioridazine) is only recommended for schizophrenia if other medicines haven't worked because the side effects can be very dangerous.
  • You have to take Mellaril (thioridazine) numerous times a day which can make it hard to remember.
  • Mellaril (thioridazine) can interfere with your heartbeat, so your doctor might have you do annual tests with your heart to make sure it's healthy.
How it works

Mellaril (thioridazine) is a typical antipsychotic that lowers levels of dopamine in the brain. In schizophrenia, it's believed the brain produces too much dopamine.

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Dosage forms
  • Pill

What to expect when you take Mellaril (thioridazine) for Schizophrenia

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Side effect rates for Mellaril (thioridazine)

Risks and Warnings for Mellaril (thioridazine)

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    • Higher risk if:
    • History of heartbeat problems
    • Taking medicines for depression
    • Taking beta blockers

    Rarely, Mellaril (thioridazine) can cause problems with the heartbeat that can be deadly. This is more likely to happen if you've had problems with your heartbeat before, or if you're taking certain medicines for depression or beta blockers. Your doctor will check your heart to make sure it's healthy enough before you start Mellaril (thioridazine). Go to the emergency room right away if you feel dizzy, faint or notice an irregular heartbeat. Talk to your pharmacist to make sure there aren't any interactions with your other medicines and Mellaril (thioridazine).

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Mellaril (thioridazine)

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  • Don't drink alcohol while taking Mellaril (thioridazine).
  • You can take Mellaril (thioridazine) with or without food. Take it with food if you get an upset stomach.
  • Mellaril (thioridazine) can make you feel sleepy the first few days that you take it, and you might be more likely to fall and hurt yourself. This can be worse if you drink alcohol or take narcotics for pain or other medical issues. Don't drive or do anything requiring concentration until you know how Mellaril (thioridazine) affects you. Be very careful getting up if you've been sitting or lying down for a while, and brace yourself and sit down if you do feel dizzy.