Prescription onlyLower-cost generic availableClass: Neuro/psych


(imipramine hydrochloride)

Prescription onlyLower-cost generic availableClass: Neuro/psych
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Improves your mood and stops bedwetting in children.

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Our bottom line

Tofranil (imipramine hydrochloride) is one of the first choice medicines used to treat depression, but it can cause weight gain and sleepiness.

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Best available price for 30 (25mg) tablets of imipramine-hydrochloride
What is GoodRx?


  • Tofranil (imipramine hydrochloride) is part of the first choice of medicines used to treat depression.
  • Available in generic.
  • Tofranil (imipramine hydrochloride) is usually taken only once a day.
  • Available in 3 different strengths.


  • Tofranil (imipramine hydrochloride) can lower your sex drive and cause more weight gain than other similar medicines for depression.
  • You might be more sensitive to the sun and have a higher risk for heat stroke while taking Tofranil (imipramine hydrochloride).
  • If you have a history of heart conditions, your symptoms might get worse with Tofranil (imipramine hydrochloride). Talk to your doctor to see if Tofranil (imipramine hydrochloride) is right for you.
How it works

Tofranil (imipramine hydrochloride) is a tricyclic antidepressant. It raises the amount of serotonin and norepinephrine in the brain, 2 chemicals that are known to regulate mood. It's not known exactly how Tofranil (imipramine hydrochloride) treats bedwetting.

What to expect when you take Tofranil (imipramine hydrochloride) for Bedwetting

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Side effect rates for Tofranil (imipramine hydrochloride)

Risks and Warnings for Tofranil (imipramine hydrochloride)

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    • Higher risk if:
    • Under age 24

    Taking Tofranil (imipramine hydrochloride) can make you more likely to harm yourself or commit suicide, especially if you are younger and during the first few weeks of taking the medicine. If you or your child feel like they want to hurt themselves while taking Tofranil (imipramine hydrochloride), call the doctor right away.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Tofranil (imipramine hydrochloride)

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  • Don't drink alcohol while taking Tofranil (imipramine hydrochloride).
  • Tofranil (imipramine hydrochloride) can make you feel sleepy, so don't drive or do anything requiring concentration until you know how it affects you.
  • Compared to other medicines for depression, Tofranil (imipramine hydrochloride) can make you more likely to gain weight and have changes in blood sugar. If you have diabetes, your doctor might need to change the doses of your medications to make sure your blood sugar stays controlled. Talk to your doctor to see if you should take another medicine besides Tofranil (imipramine hydrochloride).