Prescription onlyLower-cost generic availableClass: Neuro/psych


(imipramine pamoate)

Prescription onlyLower-cost generic availableClass: Neuro/psych
Back to: Full Site NavigationSkip to: side effects sectionSkip to: What to expect sectionSkip to: Risks and warnings sectionSkip to: Common concerns from users and pharmacists

Improves your mood.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Tofranil-PM (imipramine pamoate) is one of the first choice medicines used to treat depression, but it can cause weight gain and sleepiness.

Price and discounts
What is GoodRx?


  • Tofranil-PM (imipramine pamoate) is part of the first choice of medicines used to treat depression.
  • Available in generic.
  • Tofranil-PM (imipramine pamoate) is usually taken only once a day.
  • Available in 3 different strengths.


  • Tofranil-PM (imipramine pamoate) can lower your sex drive and cause more weight gain than other similar medicines for depression.
  • You might be more sensitive to the sun and have a higher risk for heat stroke while taking Tofranil-PM (imipramine pamoate).
  • If you have a history of heart conditions, your symptoms might get worse with Tofranil-PM (imipramine pamoate). Talk to your doctor to see if Tofranil-PM (imipramine pamoate) is right for you.
How it works

Tofranil-PM (imipramine pamoate) is a tricyclic antidepressant. It regulates mood by raising the amount of serotonin and norepinephrine in the brain.

What to expect when you take Tofranil-PM (imipramine pamoate) for Depression

Skip what to expect section. Skip to Risks & Warnings section.
Skip side effects section. Skip to What to Expect and Pharmacists Tips section.

Side effect rates for Tofranil-PM (imipramine pamoate)

Risks and Warnings for Tofranil-PM (imipramine pamoate)

Skip risks section. Skip to common concerns section.
    • Higher risk if:
    • Under age 24

    Taking Tofranil-PM (imipramine pamoate) can make you more likely to harm yourself or commit suicide, especially if you are younger and during the first few weeks of taking the medicine. If you or your child feel like they want to hurt themselves while taking Tofranil-PM (imipramine pamoate), call the doctor right away.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Tofranil-PM (imipramine pamoate)

Final section. Do you want to return to drug navigation?
  • Don't drink alcohol while taking Tofranil-PM (imipramine pamoate).
  • Tofranil-PM (imipramine pamoate) can make you feel sleepy, so don't drive or do anything requiring concentration until you know how it affects you.
  • Compared to other medicines for depression, Tofranil-PM (imipramine pamoate) can make you more likely to gain weight and have changes in blood sugar. If you have diabetes, your doctor might need to change the doses of your medications to make sure your blood sugar stays controlled. Talk to your doctor to see if you should take another medicine besides Tofranil-PM (imipramine pamoate).