Prescription onlyLower-cost generic available

Qudexy Xr


  • Pill
  • Extended release capsule
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Prevents seizures and migraine headaches.

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Prescription onlyLower-cost generic available

Our bottom line

Qudexy Xr (Topiramate) is useful for preventing seizures and migraines, and doesn't require blood tests while you're on it.


  • Used on its own or with other antiepileptic medicines to lower the frequency of seizures, especially for people with tonic-clonic or partial seizures, or Lennox-Gestaut syndrome.
  • Helpful in preventing frequent migraine headaches.
  • Doesn't need routine blood tests.
What do people say?
48 reviews


  • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
  • A few people will get kidney stones.
  • Not safe to use if you're pregnant.

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What to expect when you take Qudexy Xr (Topiramate) for Seizures

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Tips from our pharmacists
  • For the first week, avoid activities that require you to be alert.
  • Don't use if pregnant.
  • Can cause tingling skin sensations and reduced appetite.
  • Report any confusion, decreased sweating, fever, or changes in behavior or vision.
  • Takes 3 to 4 weeks to feel full effects on mood.
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Side effects for Qudexy Xr (Topiramate)

From clinical trials of Topamax / Adjunctive therapy for epilepsy, partial onset seizures (200mg per day)  ( 263)

  • DrowsinessDrowsiness15% for Topamax vs.9% for placebo
  • NervousnessNervousness13% for Topamax vs.7% for placebo
  • FatigueFatigue11% for Topamax vs.13% for placebo
  • NervousnessNervousness9% for Topamax vs.2% for placebo
  • ConfusionConfusion9% for Topamax vs.4% for placebo
  • FatigueFatigue9% for Topamax vs.4% for placebo
  • Low mood disorderLow mood disorder9% for Topamax vs.6% for placebo
  • Loss of appetiteLoss of appetite9% for Topamax vs.7% for placebo
  • Tingling sensationTingling sensation9% for Topamax vs.2% for placebo
  • Weight decreaseWeight decrease8% for Topamax vs.4% for placebo

Manufacturers don’t say how common these side effects are

  • Mood problems

Risks and Warnings for Qudexy Xr (Topiramate)

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    • Higher risk if:
    • History of depression

    Qudexy Xr (Topiramate) may increase the risk of suicidal thoughts or behavior. Watch for worsening depression or any unusual changes in mood or behavior, especially during the first few months of treatment or when the dose changes. Report anything concerning to a doctor immediately.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Qudexy Xr (Topiramate)

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The FDA category for this medication is D. It is advised that you: Weigh risks vs. benefits
Kidneys and liver
  • Upsides and downsides from our pharmacists
  • A few people will get kidney stones.
  • Risks from our pharmacists
  • Qudexy Xr (Topiramate) may increase your risk for kidney stones. Stay well-hydrated to lower your risk.
  • 1-It will affect concentration so take at night 2- It will affect your kidneys so get bloodwork done regularly 3- It will affect your mood at high doses
  • I can't have an orgasm on that pill
  • Upsides and downsides from our pharmacists
  • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
  • Went from 4-5 migraines a week to 1-2 a month. Have the tingling and did experiencing weight loss; tingling in feet comes and goes, never completely gone for years now. Overall would take the 'pins and needles' over a migraine.
  • Caused abdominal pain, diarrhea and weight loss for the first month. Caused cognitive problems - couldn't concentrate and would completely blank on certain words, specifically names.
  • Pros: 50 mg Topamax per day seemed to make my 3-6 migraines per month shallower, shorter, and less painful. I also lost weight - nice! However, I stopped taking it after a year because it was making me too tired and depressed.