Prescription onlyLower-cost generic available

Qudexy Xr


  • Pill
  • Extended release capsule
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Prevents seizures and migraine headaches.

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Prescription onlyLower-cost generic available

Our pharmacists’ bottom line

Qudexy Xr (Topiramate) is useful for preventing seizures and migraines, and doesn't require blood tests while you're on it.

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  • Used on its own or with other antiepileptic medicines to lower the frequency of seizures, especially for people with tonic-clonic or partial seizures, or Lennox-Gestaut syndrome.
  • Helpful in preventing frequent migraine headaches.
  • Doesn't need routine blood tests.
  • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
  • A few people will get kidney stones.
  • Not safe to use if you're pregnant.

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Side effects for Qudexy Xr (Topiramate)

From clinical trials of Topamax / Adjunctive therapy for epilepsy (200–400mg per day) ( 474)

  • DrowsinessDrowsiness28% for Topamax vs.12% for placebo
  • DizzinessDizziness25% for Topamax vs.15% for placebo
  • NervousnessNervousness16% for Topamax vs.6% for placebo
  • Lack of muscle coordinationLack of muscle coordination16% for Topamax vs.7% for placebo
  • FatigueFatigue15% for Topamax vs.13% for placebo
  • Vision abnormalVision abnormal13% for Topamax vs.2% for placebo
  • Speech disorders/related speech problemsSpeech disorders/related speech problems13% for Topamax vs.2% for placebo
  • Slowed-down thinking and movementsSlowed-down thinking and movements13% for Topamax vs.2% for placebo
  • Difficulty with memoryDifficulty with memory12% for Topamax vs.3% for placebo
  • ConfusionConfusion11% for Topamax vs.5% for placebo

What to expect when you start Qudexy Xr (Topiramate)

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Tips from our pharmacists
  • For the first week, avoid activities that require you to be alert.
  • Don't use if pregnant.
  • Can cause tingling skin sensations and reduced appetite.
  • Report any confusion, decreased sweating, fever, or changes in behavior or vision.
  • Takes 3 to 4 weeks to feel full effects on mood.

Risks and Warnings for Qudexy Xr (Topiramate)

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    • Higher risk if:
    • History of depression

    Qudexy Xr (Topiramate) may increase the risk of suicidal thoughts or behavior. Watch for worsening depression or any unusual changes in mood or behavior, especially during the first few months of treatment or when the dose changes. Report anything concerning to a doctor immediately.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Qudexy Xr (Topiramate)

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The FDA category for this medication is D. It is advised that you: Weigh risks vs. benefits
Kidneys & liver
  • Upsides and downsides from our pharmacists
  • A few people will get kidney stones.
  • Risks from our pharmacists
  • Qudexy Xr (Topiramate) may increase your risk for kidney stones. Stay well-hydrated to lower your risk.
  • 1-It will affect concentration so take at night 2- It will affect your kidneys so get bloodwork done regularly 3- It will affect your mood at high doses
    Age: 40
    Gender: woman
    Taken for: Migraine prevention
    Duration taken: two years or more
Weight gain or loss
  • Upsides and downsides from our pharmacists
  • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
  • Went from 4-5 migraines a week to 1-2 a month. Have the tingling and did experiencing weight loss; tingling in feet comes and goes, never completely gone for years now. Overall would take the 'pins and needles' over a migraine.
    Age: 37
    Gender: man
    Taken for: Migraine prevention
    Duration taken: two years or more
  • Caused abdominal pain, diarrhea and weight loss for the first month. Caused cognitive problems - couldn't concentrate and would completely blank on certain words, specifically names.
    Age: 32
    Gender: woman
    Taken for: Migraine prevention
    Duration taken: a few months
  • Pros: 50 mg Topamax per day seemed to make my 3-6 migraines per month shallower, shorter, and less painful. I also lost weight - nice! However, I stopped taking it after a year because it was making me too tired and depressed.
    Age: 46
    Gender: woman
    Taken for: Migraine prevention
    Duration taken: a year or so