Prescription onlyLower-cost generic availableClass: Neurology

Qudexy Xr Alternatives

(topiramate)

Prescription onlyLower-cost generic availableClass: Neurology
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Compare Qudexy Xr (topiramate) to alternatives

These medications are comparable to Qudexy Xr (topiramate) or used for similar purposes.

Qudexy Xr
(topiramate)

Lamictal
(lamotrigine)

Tegretol
(carbamazepine)

Neurontin
(gabapentin)

Imitrex
(sumatriptan)

Inderal
(propranolol)

Depacon
(valproate, valproic acid, or divalproex)

Prevents seizures and migraine headaches. Qudexy Xr (Topiramate) is useful for preventing seizures and migraines, and doesn't require blood tests while you're on it.Prevents seizures and stabilizes mood. Lamictal (Lamotrigine) is most useful for treating severe seizure disorders, and for bipolar disorder with more depression symptoms than manic symptoms. Just be careful to increase your dose slowly to avoid skin rash.Prevents seizures, stabilizes mood, and relieves nerve pain. Tegretol (Carbamazepine) is useful for preventing seizures and relieving certain types of nerve pain, but interacts with many drugs.Treats tingling and burning nerve pain. Neurontin (Gabapentin) is an old seizure disorder medicine that's now used to treat nerve-related pain caused by different conditions.Treats migraine headaches. Imitrex (Sumatriptan) is an excellent choice for acute migraine relief, but you might need another medication to prevent headaches.Lowers blood pressure and controls heart rate. Inderal (Propranolol) is good for treating many heart problems and other problems in the body, but it has more side effects than other beta blockers. You can't miss doses.Prevents seizures and stabilizes mood. Depacon (Valproate, Valproic Acid, Or Divalproex) is good long-term prevention for epilepsy, bipolar disorder, and migraines, but can cause weight gain.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.43Topamax
Reviews for Topamax
52%
of people (All ages) say Topamax is worth it
50%
say it works well
36%
say it's a big hassle
Have you used Qudexy Xr (topiramate)?
Worth itNot sureNot worth it
Reviews for Lamictal
66%
-14% worse vs. Topamax
58%
-8% worse vs. Topamax
18%
-18% worse vs. Topamax
184 reviews
Have you used Lamictal (lamotrigine)?
Worth itNot sureNot worth it
Reviews for Tegretol
56%
-4% worse vs. Topamax
43%
+7% better vs. Topamax
23%
-13% worse vs. Topamax
Have you used Tegretol (carbamazepine)?
Worth itNot sureNot worth it
Reviews for Neurontin
57%
-5% worse vs. Topamax
40%
+10% better vs. Topamax
19%
-17% worse vs. Topamax
620 reviews
Have you used Neurontin (gabapentin)?
Worth itNot sureNot worth it
Reviews for Imitrex
74%
-22% worse vs. Topamax
68%
-18% worse vs. Topamax
19%
-17% worse vs. Topamax
Have you used Imitrex (sumatriptan)?
Worth itNot sureNot worth it
Reviews for Propranolol
66%
-14% worse vs. Topamax
62%
-12% worse vs. Topamax
15%
-21% worse vs. Topamax
Have you used Inderal (propranolol)?
Worth itNot sureNot worth it
Reviews for Depakote
46%
+6% better vs. Topamax
40%
+10% better vs. Topamax
27%
-9% worse vs. Topamax
Have you used Depacon (valproate, valproic acid, or divalproex)?
Worth itNot sureNot worth it
Side effects
TopamaxLamictalTegretolNeurontinImitrexPropranololDepakote
  • Ear, nose, or throat infection 16%
  • Diarrhea 8%
  • Weight decrease 7%
  • Difficulty with concentration/attention 7%
  • Inflammation inside the nose 5%
  • Tingling sensation 3%
  • Infection 3%
  • Infection viral 3%
  • Rash 3%
  • Fatigue 17%
More Topamax side effects »
  • Dizziness 25%
  • Headache 9%
  • Double vision 21%
  • Lack of muscle coordination 16%
  • Nausea 9%
  • Blurred vision 11%
  • Inflammation inside the nose 5%
  • Drowsiness 7%
  • Sore throat 1%
  • Rash 5%
More Lamictal side effects »
  • Dizziness 32%
  • Drowsiness 19%
  • Nausea 18%
  • Vomiting 15%
  • Lack of muscle coordination 15%
  • Constipation 5%
  • Itching 6%
  • Dry mouth 5%
  • Muscle weakness 4%
  • Rash 3%
More Tegretol side effects »
  • Dizziness 21%
  • Drowsiness 16%
  • Leg or ankle swelling 6%
  • Muscle weakness 1%
  • Diarrhea 2%
  • Infection 2%
  • Dry mouth 3%
  • Constipation 2%
  • Accidental injury 2%
  • Vomiting 2%
More Neurontin side effects »
  • Pain and other pressure sensations 2%
  • Atypical sensations 1%
  • Paresthesia (all types) 1%
  • Sensation warm/cold 1%
  • Pain - location specified 1%
  • Malaise/fatigue 2%
  • Chest - pain/tightness/pressure and/or heaviness 1%
  • Neck/throat/jaw - pain/ tightness/pressure 2%
  • Other - pressure/tightness/ heaviness 1%
  • Vertigo 2%
More Imitrex side effects »
  • Dizziness 5%
  • Fatigue 2%
  • Constipation 3%
More Propranolol side effects »
  • Nausea 7%
  • Drowsiness 7%
  • Dizziness 8%
  • Vomiting 9%
  • Accidental injury 6%
  • Muscle weakness 3%
  • Abdominal pain 1%
  • Indigestion 1%
  • Any side effect 4%
  • Rash 3%
More Depakote side effects »
How it works
TopamaxLamictalTegretolNeurontinImitrexPropranololDepakote
Qudexy Xr (Topiramate) is an antiepileptic. Researchers don't know exactly how it works, but it seems to affect multiple parts of the brain to control seizures and migraines.Lamictal (Lamotrigine) is an antiepileptic. Researchers don't know exactly how it works, but it seems to calm nerve activity in the brain.Tegretol (Carbamazepine) is an antiepileptic. Researchers don't know exactly how it works, but it seems to block certain kinds of nerve activity to reduce seizures and pain.Neurontin (Gabapentin) is an antiepileptic and nerve pain reliever. Researchers don't know exactly how it works, but it has a similar structure to GABA, a neurotransmitter that calms nerves in the brain and spinal cord.Imitrex (Sumatriptan) is a triptan medication that treats migraine headaches. It releases serotonin, which lowers the inflammation that causes headaches.Inderal (Propranolol) is an alpha and beta blocker. It lowers blood pressure by slowing heart rate, relaxing blood vessels, and lowering the body's fight-or-flight response.Depacon (Valproate, Valproic Acid, Or Divalproex) is an antiepileptic. Researchers don't know exactly how it works. It seems to increase the amount of GABA, a chemical that calms nerves in the brain.
Type of medication
TopamaxLamictalTegretolNeurontinImitrexPropranololDepakote
Prescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription only
Available as
TopamaxLamictalTegretolNeurontinImitrexPropranololDepakote
  • Pill
  • Extended release capsule
  • Pill
  • Extended release
  • Chewable tablet
  • Dissolving tablet
  • Pill
  • Extended release
  • Chewable tablet
  • Oral suspension
  • Pill
  • Oral solution
  • Pill
  • Injection
  • Nasal spray
  • Pill
  • Extended release
  • Liquid
  • Pill
  • Extended release
  • Extended release capsule
  • Sprinkle
  • Liquid
Used for
TopamaxLamictalTegretolNeurontinImitrexPropranololDepakote
Risk factors for serious side effects
TopamaxLamictalTegretolNeurontinImitrexPropranololDepakote
  • History of depression
  • Children
  • History of metabolic disorders
  • People also taking Depakote
  • Low-carb diet
Detailed Qudexy Xr (topiramate) risks & warnings »
  • History of depression
  • People also taking Depakote
  • Taking more than the prescribed dose
  • Increasing the dose too quickly
  • Taking birth control pills
Detailed Lamictal (lamotrigine) risks & warnings »
  • People also taking Depakote
  • Asian ancestry
  • History of depression
  • European, Chinese, or Japanese ancestry
  • Age 65 years or older
Detailed Tegretol (carbamazepine) risks & warnings »
  • Children ages 3 to 12
  • Taking with alcohol or drugs
  • Stopping Neurontin (Gabapentin) suddenly
Detailed Neurontin (gabapentin) risks & warnings »
  • History of heart problems
  • High blood pressure
  • High cholesterol
  • Diabetes
  • Being overweight or obese
Detailed Imitrex (sumatriptan) risks & warnings »
  • Suddenly stopping Inderal (Propranolol)
  • Major surgery requiring anesthesia
  • Diabetes
  • Concurrent use of non-dihydropyridine calcium channel blockers, digoxin or clonidine
Detailed Inderal (propranolol) risks & warnings »
  • Children under age 2
  • History of metabolic disorders
  • History of depression
  • People also taking Topamax
Detailed Depacon (valproate, valproic acid, or divalproex) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
TopamaxLamictalTegretolNeurontinImitrexPropranololDepakote
No interactions related info.No interactions related info.
  • Interacts with many other medicines and supplements.
No interactions related info.No interactions related info.No interactions related info.No interactions related info.
Food
TopamaxLamictalTegretolNeurontinImitrexPropranololDepakote
No food related info.
  • Take with food to avoid upset stomach.
No food related info.
  • Take the extended-release tablet with food.
No food related info.No food related info.
  • Take with food to avoid upset stomach.
Kidneys and liver
TopamaxLamictalTegretolNeurontinImitrexPropranololDepakote
  • Qudexy Xr (Topiramate) may increase your risk for kidney stones. Stay well-hydrated to lower your risk.
  • A few people will get kidney stones.
No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.
  • Can cause liver damage, so it's probably not safe if you already have liver problems.
Pain
TopamaxLamictalTegretolNeurontinImitrexPropranololDepakote
No pain related info.No pain related info.No pain related info.
  • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
No pain related info.No pain related info.No pain related info.
Sleep
TopamaxLamictalTegretolNeurontinImitrexPropranololDepakote
No sleep related info.No sleep related info.No sleep related info.
  • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
  • Imitrex (Sumatriptan) can make you drowsy, so avoid activities that need you to be fully alert until you know how it affects you.
No sleep related info.No sleep related info.
Weight
TopamaxLamictalTegretolNeurontinImitrexPropranololDepakote
  • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
No weight related info.No weight related info.No weight related info.No weight related info.No weight related info.
  • May cause hair loss and weight gain.
  • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
Upsides and benefits
TopamaxLamictalTegretolNeurontinImitrexPropranololDepakote
  • Used on its own or with other antiepileptic medicines to lower the frequency of seizures, especially for people with tonic-clonic or partial seizures, or Lennox-Gestaut syndrome.
  • Helpful in preventing frequent migraine headaches.
  • Doesn't need routine blood tests.
  • Effective at lowering the frequency of seizures in people with epilepsy or Lennox-Gestaut syndrome. Typically used together with other medications for severe seizure disorders.
  • Works best for partial, tonic-clonic, and absence seizures.
  • A first-line treatment for bipolar disorder. Effective long-term treatment for stabilizing mood. Prevents both depressive and manic episodes, but the effect is greater for preventing depression.
  • Doesn't require routine blood tests.
  • Lowers the frequency of seizures, especially for people with tonic-clonic and partial seizures.
  • First-line option for trigeminal neuralgia (nerve pain involving the face, head, and neck), and can relieve other types of nerve pain.
  • May be helpful in stabilizing mood for people with bipolar disorder.
  • Originally used to treat epilepsy (partial seizures), but now it primarily treats neuropathic pain that's caused by nerve stimulation or damage.
  • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
  • It's available as a generic, so it's less expensive than similar medications.
  • Comes in several forms. Ask your doctor if you should use the pill, nasal spray, patch, or injection.
  • A combination of forms can be used if symptoms do not improve.
  • The nasal spray and injectable forms work very quickly.
  • It's generally safe to use if you are pregnant.
  • Comes in a generic form, so it can be pretty cheap.
  • A first-choice treatment to prevent chest pain (angina).
  • A first-choice treatment for heart failure, heart attack, heart valve disorders, and abnormal heart rhythm.
  • Also treats and prevents many non-heart problems, such as tremors, anxiety, migraines, and liver disease symptoms.
  • Lowers the frequency of seizures, especially for people with absence, tonic-clonic, and complex partial seizures.
  • One of the first-line options to stabilize mood for people with bipolar disorder.
  • Helpful in preventing frequent migraine headaches.
Downsides and risks
TopamaxLamictalTegretolNeurontinImitrexPropranololDepakote
  • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
  • A few people will get kidney stones.
  • Not safe to use if you're pregnant.
  • Can cause double vision, dizziness, sleepiness, and headache.
  • Has the risk of a rare but life-threatening rash.
  • Can make hormonal birth control less effective.
  • Might be less effective than other medicines for treating manic episodes (acute mania) in people with bipolar disorder.
  • Interacts with many other medicines and supplements.
  • Higher risk of skin reactions compared to other antiepileptic medicines, ranging from mild to life-threatening rash.
  • Can cause blurry vision, dizziness, and upset stomach.
  • Not safe to use if you're pregnant.
  • Requires routine blood tests to see how the medicine is affecting your body.
  • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
  • You can't skip or miss doses since suddenly stopping Neurontin (Gabapentin) can cause seizures. This is even more likely if you drink alcohol, so it might not be the best medication for heavy drinkers.
  • The oral and nasal versions of Imitrex (Sumatriptan) have an unpleasant after-taste.
  • Does not prevent migraine headaches; it only treats them once they start.
  • Must wait 1 hour before using second injection.
  • Can cause rebound (more) headaches if Imitrex (Sumatriptan) is used too often.
  • Need to have your blood pressure checked often, especially if you're pregnant.
  • Taking a beta blocker might make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some might not go away.
  • Has more side effects than some beta blockers because it crosses into the brain and central nervous system.
  • Not a first-choice treatment for high blood pressure according to the latest guidelines, except if you have heart failure or heart disease. As a second choice, your doctor might add it to medicines you're already taking if your blood pressure is still too high.
  • Can hide symptoms of low blood sugar if you're diabetic.
  • You can't miss doses. Stopping Propranolol suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
  • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
  • Can cause liver damage, so it's probably not safe if you already have liver problems.
  • Not safe to use if you're pregnant.
  • Requires routine blood tests to see how the medicine is affecting your body.
Tips from our pharmacists for people taking the medication
TopamaxLamictalTegretolNeurontinImitrexPropranololDepakote
  • For the first week, avoid activities that require you to be alert.
  • Don't use if pregnant.
  • Can cause tingling skin sensations and reduced appetite.
  • Report any confusion, decreased sweating, fever, or changes in behavior or vision.
  • Takes 3 to 4 weeks to feel full effects on mood.
  • Follow dose adjustments set by your doctor to minimize skin rash.
  • Take with food to avoid upset stomach.
  • Report rash, blurry vision, fever, persistent headache, or neck stiffness to your doctor.
  • Makes hormonal birth control less effective.
  • Takes 4 to 6 weeks to feel full effects on mood.
  • For the first week, avoid activities that require you to be alert.
  • Report skin rashes or blistering immediately.
  • Don't use if pregnant.
  • Requires routine blood tests.
  • Report confusion, persistent abdominal pain, yellowing of eyes/skin, or easy bruising to your doctor.
  • Takes up to 5 weeks to feel full effects on mood.
  • Side effects are common, but usually manageable.
  • Don't drive while taking Neurontin (Gabapentin) until you know how the medication affects you.
  • Neurontin and generic forms of Gabapentin have the same ingredients as Gralise and Horizant, but are dosed differently. Make sure you know which form you're taking since they are used for different purposes.
  • Take the extended-release tablet with food.
  • Stop taking Neurontin (Gabapentin) slowly over at least one week to avoid getting withdrawal symptoms.
  • Take it as soon as your headache starts.
  • If you use the nasal spray, be sure to blow your nose before using it.
  • If you use the patch, put it on a dry area free of scars, tattoos, or other cuts and scrapes. Be sure to press the button to activate it.
  • If you use the injection, you can use a second injection if you still have a headache after an hour. If you have symptoms 2 hours after the injection, switch to the pill version.
  • Imitrex (Sumatriptan) can make you drowsy, so avoid activities that need you to be fully alert until you know how it affects you.
  • Lie down in a dark room after taking Imitrex (Sumatriptan) to help ease the pain.
  • Can cause dizziness in the first few days.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Can cause insomnia and fatigue.
  • Can hide symptoms of low blood sugar. Be careful if you're diabetic.
  • Don't stop taking this medicine suddenly.
  • For the first week, avoid activities that require you to be alert.
  • Don't use if pregnant.
  • Requires routine blood tests.
  • Take with food to avoid upset stomach.
  • May cause hair loss and weight gain.
  • Different versions of Depakote have different dosing. Be careful.
  • Report confusion, persistent abdominal pain, yellowing of eyes/skin, or easy bruising to your doctor.
  • Takes 3 to 4 weeks to feel full effects on mood.
Learn more
More about TopamaxSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Qudexy Xr (topiramate)?
Worth itNot sureNot worth it
More about LamictalSide effectsReviews & ratingsFDA package insert
Have you used Lamictal (lamotrigine)?
Worth itNot sureNot worth it
More about TegretolSide effectsReviews & ratingsFDA package insert
Have you used Tegretol (carbamazepine)?
Worth itNot sureNot worth it
More about NeurontinSide effectsReviews & ratingsFDA package insert
Have you used Neurontin (gabapentin)?
Worth itNot sureNot worth it
More about ImitrexSide effectsReviews & ratingsFDA package insert
Have you used Imitrex (sumatriptan)?
Worth itNot sureNot worth it
More about PropranololSide effectsReviews & ratingsFDA package insert
Have you used Inderal (propranolol)?
Worth itNot sureNot worth it
More about DepakoteSide effectsReviews & ratingsFDA package insert
Have you used Depacon (valproate, valproic acid, or divalproex)?
Worth itNot sureNot worth it