Prescription onlyLower-cost generic available



  • Pill
  • Extended release
  • Extended release capsule
  • Dissolving tablet
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Treats moderate to severe pain.

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Prescription onlyLower-cost generic available

Our pharmacists’ bottom line

Ultram (Tramadol) works well to treat severe pain and mood changes. Although it's a little weaker than other opioids, it can still be addictive.

Prescription opioids are used to treat several kinds of pain - but they carry significant risks, including addiction. Learn more about these drugs and be sure to discuss the risks with your doctor.
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  • Relieves moderate to severe pain. It has been shown to work as well as other opioid pain medications.
  • Compared to typical opioids, it provides unique pain relief and effects on your mood when taken regularly.
  • Has a lower chance of causing breathing problems compared to other typical opioids.
  • Doesn't cause as much constipation as other opioid pain medicines. Staying hydrated and taking laxatives can help treat this side effect.
  • Some people think it's weaker than other opioid pain medications. It can also cause more upset stomach.
  • Like other opioid pain relievers, Tramadol has a high risk of addiction, abuse, misuse, overdose, and death. It should only be used for severe pain that requires daily, around-the-clock treatment once alternative treatments haven't worked.
  • It isn't used for short-term, as-needed pain relief.
  • It's a controlled substance regulated by the federal government. This means that your use of Ultram (Tramadol) will be tracked to prevent potential prescription abuse.
  • To get Ultram (Tramadol) in the pharmacy, you'll need to bring in a paper prescription directly from your doctor.

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Side effects for Ultram (Tramadol)

From clinical trials of Tramadol / Any condition 

  • Abdominal painAbdominal pain5% for Tramadol vs.0% for placebo
  • Feeling unwellFeeling unwell5% for Tramadol vs.0% for placebo
  • AnxietyAnxiety5% for Tramadol vs.0% for placebo
  • ConfusionConfusion5% for Tramadol vs.0% for placebo
  • Coordination disturbanceCoordination disturbance5% for Tramadol vs.0% for placebo
  • EuphoriaEuphoria5% for Tramadol vs.0% for placebo
  • Constricted pupilConstricted pupil5% for Tramadol vs.0% for placebo
  • NervousnessNervousness5% for Tramadol vs.0% for placebo
  • Sleep disorderSleep disorder5% for Tramadol vs.0% for placebo
  • Widening of blood vesselsWidening of blood vessels5% for Tramadol vs.0% for placebo

What to expect when you start Ultram (Tramadol)

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Tips from our pharmacists
  • Starts working in one hour and works best if you take it regularly.
  • Can make you dizzy or drowsy, so avoid activities that need you to be fully alert until you know how this medicine affects you.
  • Take Ultram (Tramadol) with food to avoid an upset stomach.
  • There are different doses for people who are older or who have liver or kidney disease, so work with your doctor to get the right dose.
  • Swallow the extended-release tablets whole. They're designed to release the drug slowly and breaking, crushing, or chewing them could cause a serious overdose.

Risks and Warnings for Ultram (Tramadol)

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    • Higher risk if:
    • Higher dose
    • Using other medicines that can cause seizures
    • History of seizures
    • Alcoholism
    • Eating disorders
    • Brain infections

    Ultram (Tramadol) can lower the brain's threshold for seizures in people with certain risk factors. Use with caution.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Ultram (Tramadol)

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The FDA category for this medication is C. It is advised that you: Weigh risks vs. benefits
  • Risks from our pharmacists
  • Serious side effects may include drug abuse, dependence, slowed breathing rate (respiratory depression), and death. Don't take more than your doctor prescribes or take with alcohol, illegal drugs, or other opioid pain relievers.
  • Tips from our pharmacists
  • Take Ultram (Tramadol) with food to avoid an upset stomach.
  • Take it as prescribed with food.
    Age: 26
    Gender: woman
    Taken for: Chronic pain
    Duration taken: two years or more
Kidneys & liver
  • Tips from our pharmacists
  • There are different doses for people who are older or who have liver or kidney disease, so work with your doctor to get the right dose.
  • I wished I would of looked at the side effect before taking it. Also that my doctor would of not prescribed for me, because I told him I only had one kidney.
    Age: 48
    Gender: woman
    Taken for: Moderate to severe pain after surgery
    Duration taken: less than a week
  • I wouldn't be able to function well without it due to pain. Thanks to it, I am so far avoiding extensive neck surgery, It also helps by serving as a mild antidepressant. If it effects you sexually, ask your doctor to add the antidepressant
    Age: 65
    Gender: man
  • Used to be easy to get now controlled. Minor to mild pain. Teeth,back minor aches, and mood enhancer if taken on time,no skip. Don't stop sudden or can cause seizures.Take day not while sleeping cause gives night sweats,& increases sexdrive
    Age: 34
    Gender: woman
    Taken for: Pain (moderate to moderately-severe)
  • It does make you itchy, and it may keep you from sleeping.
    Age: 45
    Gender: man
    Taken for: Pain (moderate to moderately-severe)
  • caused itching; couldn't sleep
    Age: 60
    Gender: man
    Taken for: Pain (moderate to moderately-severe)
    Duration taken: less than a week