Prescription onlyLower-cost generic availableClass: Neuro/psych

Parnate Alternatives

(tranylcypromine)

Prescription onlyLower-cost generic availableClass: Neuro/psych
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Compare Parnate (tranylcypromine) to alternatives

These medications are comparable to Parnate (tranylcypromine) or used for similar purposes.

Parnate
(tranylcypromine)

Nardil
(phenelzine)

Stabilizes your mood. Parnate (tranylcypromine) is not a first choice medicine to treat depression because of its side effects and interactions with other medicines and foods.Stabilizes your mood. Nardil (phenelzine) is not a first choice for treating depression, but it can be good if other medicines haven't worked. It can interact with a lot of medicines, and you have to avoid certain foods and alcohol.
Reviews & ratings
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Have you used Parnate (tranylcypromine)?
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Have you used Nardil (phenelzine)?
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Side effects
tranylcyprominephenelzine

The tranylcypromine FDA package insert doesn’t have numbers about how common side effects are.

More about tranylcypromine side effects »

The phenelzine FDA package insert doesn’t have numbers about how common side effects are.

More about phenelzine side effects »
How it works
tranylcyprominephenelzine
Parnate (tranylcypromine) is a monoamine oxidase inhibitor. It increases the amount of norepinephrine, dopamine, and serotonin in your body which are believed to regulate mood.Nardil (phenelzine) is a monoamine oxidase inhibitor. It raises the amount of certain chemicals in your body that are thought to regulate mood, such as norepinephrine, dopamine, and serotonin.
Type of medication
tranylcyprominephenelzine
Prescription onlyPrescription only
Available as
tranylcyprominephenelzine
  • Pill
  • Pill
Used for
tranylcyprominephenelzine
Risk factors for serious side effects
tranylcyprominephenelzine
  • People under age 24
  • Eating smoked meats, cheese, soy sauce, and fermented foods
  • Beer or wine
  • Excessive amount of chocolate and caffeine
  • Taking cough and cold medicines like dextromethorphan (Robitussin DM), pseudoephedrine (Sudafed)
Detailed Parnate (tranylcypromine) risks & warnings »
  • People under age 24
  • Eating smoked meats, cheese, soy sauce, or fermented foods
  • Drinking beer or wine
  • Consuming an excessive amount of chocolate or caffeine
  • Taking cough and cold medicines like dextromethorphan (Robitussin DM) or pseudoephedrine (Sudafed)
Detailed Nardil (phenelzine) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Interactions
tranylcyprominephenelzine
  • Parnate (tranylcypromine) interacts with many medicines that can make you more likely to have side effects, so you'll want to tell your doctor and pharmacist what else you're taking, even the supplements and over-the-counter medicines. Your doctor might have to change how you take your medicines so that you don't get side effects.
No interactions related info.
Alcohol
tranylcyprominephenelzine
  • Eating certain foods or drinking beer or wine while taking Parnate (tranylcypromine) can cause your blood pressure to become dangerously high. Talk to your doctor or go to the emergency room right away if you get a very bad headache, changes in your heart rate, neck stiffness or soreness, or nausea and vomiting.
  • Avoid alcohol and limit the amount of caffeine you take if you take Parnate (tranylcypromine).
  • Eating certain foods or drinking beer or wine while taking Nardil (phenelzine) can cause your blood pressure to become dangerously high. Talk to your doctor or go to the emergency room right away if you get a very bad headache, changes in your heart rate, neck stiffness or soreness, or nausea and vomiting.
  • Avoid alcohol and limit the amount of caffeine you take if you take Nardil (phenelzine).
Weight
tranylcyprominephenelzine
  • Parnate (tranylcypromine) doesn't cause weight gain.
  • Nardil (phenelzine) can cause weight gain.
Upsides and benefits
tranylcyprominephenelzine
  • If other medicines haven't worked to help your depression, Parnate (tranylcypromine) can be a good alternative.
  • Parnate (tranylcypromine) doesn't cause weight gain.
  • Parnate (tranylcypromine) doesn't make you feel sleepy.
  • Parnate (tranylcypromine) is available as generic.
  • Available in generic.
Downsides and risks
tranylcyprominephenelzine
  • You have to take Parnate (tranylcypromine) 2 to 3 times a day, which can be inconvenient.
  • If you take Parnate (tranylcypromine) any later than early afternoon, you might have problems sleeping.
  • Not recommended in children under 18 years of age.
  • Not a recommended first or second choice for depression because of the side effects and diet restrictions.
  • You'll need to restrict your diet because your blood pressure can get very high.
  • If you're switched to another antidepressant from Nardil (phenelzine), you'll have to wait at least 14 days before you can start, otherwise it can be very dangerous.
Tips from our pharmacists for people taking the medication
tranylcyprominephenelzine
  • If you're switching from Parnate (tranylcypromine) to another antidepressant, you have to wait at least 2 weeks after stopping Parnate (tranylcypromine) to safely start the new one.
  • Avoid smoked meats, cheese, soy sauce, and other fermented foods because Parnate (tranylcypromine) can raise your blood pressure.
  • You might not notice any changes in your mood until you've taken Parnate (tranylcypromine) for at least 2 to 4 weeks.
  • Don't stop taking Parnate (tranylcypromine) suddenly without talking to your doctor first.
  • Avoid alcohol and limit the amount of caffeine you take if you take Parnate (tranylcypromine).
  • Take your last daily dose of Parnate (tranylcypromine) in the early afternoon so you don't have problems falling asleep.
  • If you're switching from Nardil (phenelzine) to another antidepressant, you have to wait at least 2 weeks after stopping Nardil (phenelzine) to safely start the new one.
  • Avoid smoked meats, cheese, soy sauce, and other fermented foods because Nardil (phenelzine) can raise your blood pressure.
  • Nardil (phenelzine) can cause weight gain.
  • You might not notice any changes in your mood until you've taken Nardil (phenelzine) for at least 4 weeks.
  • Don't stop taking Nardil (phenelzine) suddenly without talking to your doctor first.
  • Avoid alcohol and limit the amount of caffeine you take if you take Nardil (phenelzine).
Learn more
More about tranylcypromineSide effectsAlternativesFDA package insert
Have you used Parnate (tranylcypromine)?
Worth itNot sureNot worth it
More about phenelzineSide effectsFDA package insert
Have you used Nardil (phenelzine)?
Worth itNot sureNot worth it