Prescription onlyLower-cost generic availableClass: Neuro/psych


(perphenazine / amitriptyline)

Prescription onlyLower-cost generic availableClass: Neuro/psych
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Treats people with anxiety and/or depression, and people with schizophrenia.

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Our bottom line

While Triavil (perphenazine / amitriptyline) can be used to treat people with depression, anxiety, and/or schizophrenia, the limited amount of available combinations makes it harder to customize the dosing.

Price and discounts
Prices and coupons for 60 (2mg/25mg) tablets of perphenazine / amitriptyline


  • The combination of medicines in Triavil (perphenazine / amitriptyline) is recommended for treating depression with psychotic features.
  • Available in generic.
  • Convenient to take 1 pill that contains 2 medications.


  • Some doctors believe it's better to take the 2 components of Triavil (perphenazine / amitriptyline) separately, since it's easier to customize.
  • You have to take Triavil (perphenazine / amitriptyline) 2 to 4 times a day, which can be hard to remember.
  • There are only 5 different combinations available, so customizing a dose can be hard.
How it works

Triavil (perphenazine / amitriptyline) is a combination of 2 medicines, amitriptyline and perphenazine, which work together to maintain a balance of chemicals in the brain to regulate your mood.

What to expect when you take Triavil (perphenazine / amitriptyline) for Anxiety, depression, and/or schizophrenia

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Side effect rates for Triavil (perphenazine / amitriptyline)

Risks and Warnings for Triavil (perphenazine / amitriptyline)

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    • Higher risk if:
    • Under age 24

    Taking Triavil (perphenazine / amitriptyline) can make you more likely to harm yourself or commit suicide, especially if you are younger and during the first few weeks of taking the medicine. If you or your child feel like they want to hurt themselves while taking Triavil (perphenazine / amitriptyline), call the doctor right away.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Triavil (perphenazine / amitriptyline)

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  • Don't drink alcohol or take opioids for pain relief with Triavil (perphenazine / amitriptyline), since the combination can slow your breathing.
  • Triavil (perphenazine / amitriptyline) can make you feel sleepy, so don't drive or do anything requiring concentration until you know how it affects you.