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Improves mood

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Our bottom line

Trintellix (Vortioxetine) is a new type of serotonin modulating antidepressant that can be tried when the other antidepressants don't work, but some people may find the side effects intolerable and the cost expensive.

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  • Relieves depression symptoms.
  • May improve memory.
  • Possibly less side effect on sex drive/enjoyment compared to other antidepressants.
  • Works differently than other serotonine modifying antidepressants.


  • Likely expensive since insurance may not cover it.
  • Stomach issues, particularly nausea, can be persistant for some people.
  • Higher likelihood of interaction with other medications.

What to expect when you take Trintellix (Vortioxetine) for Depression

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Side effect rates for Trintellix (Vortioxetine)

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These are side effects of Trintellix (Vortioxetine) reported to the FDA by people taking it, and by doctors and pharmacists.
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Common concerns from people taking Trintellix (Vortioxetine)

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  • Higher likelihood of interaction with other medications.
  • Make sure it doesn't interact with your other medications.
  • Take with food and/or at night to lessen stomach issues, such as nausea, diarrhea, gas.
  • Couldn't sleep with it