Prescription onlyNo lower cost generic available

Truvada Alternatives

(Emtricitabine / Tenofovir)

Prescription onlyNo lower cost generic available
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Compare Truvada (Emtricitabine / Tenofovir) to alternatives

These medications are comparable to Truvada (Emtricitabine / Tenofovir) or used for similar purposes.

Truvada
(Emtricitabine / Tenofovir)

Atripla
(Efavirenz / Emtricitabine / Tenofovir)

Emtriva
(Emtricitabine)

Viread
(Tenofovir)

Works with other medicines to treat HIV infection. Truvada (Emtricitabine / Tenofovir) is a popular combination medicine that has two drugs with the same mechanism of action to treat and prevent HIV infection.Treats HIV infection. Atripla (Efavirenz / Emtricitabine / Tenofovir) is effective at treating HIV infection and it’s easier to remember to take just one pill instead of three separate medicines.Works with other medicines to treat HIV infection. emtricitabine is currently one of the most popular drugs within the Nucleoside Reverse Transcriptase Inhibitor (NRTI) drug class.Works with other medicines to treat HIV infection. Also treats Hepatitis B Virus. tenofovir can be a good choice to take within the Nucleoside Reverse Transcriptase Inhibitor (NRTI) drug class. It may not be the best choice though for people with kidney problems.
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Reviews & ratings
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Have you used Truvada (Emtricitabine / Tenofovir)?
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Have you used Atripla (Efavirenz / Emtricitabine / Tenofovir)?
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Have you used Emtriva (Emtricitabine)?
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Have you used Viread (Tenofovir)?
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Side effects
TruvadaAtriplaEmtrivaViread
  • > 5% bone mineral density loss 7%
  • Abdominal pain 2%
  • Secondary syphilis 2%
  • Headache 1%
  • Bone fractures 1%
  • Weight decreased 1%
  • Syphilis 1%
More Truvada side effects »

The Atripla FDA package insert doesn’t have numbers about how common side effects are.

More about Atripla side effects »

We haven’t found good data for Emtriva side effects.

FDA side effect reports for Emtriva »

We haven’t found good data for Viread side effects.

FDA side effect reports for Viread »
How it works
TruvadaAtriplaEmtrivaViread
Truvada (Emtricitabine / Tenofovir) is a combination medication that stops the replication of the human immunodeficiency virus (HIV) within important cells of the body. Emtricitabine and tenofovir both prevent the virus from taking over normal functions of the cell for its own purposes.Atripla (Efavirenz / Emtricitabine / Tenofovir) is a combination pill that contains three antiretroviral (ARV) drugs: tenofovir and emtricitabine (two nucleoside reverse transcriptase inhibitors) and efavirenz (a non-nucleoside reverse transcriptase inhibitor). It prevents the HIV-1 virus from multiplying and producing new viruses.emtricitabine stops the replication of the human immunodeficiency virus (HIV) within important cells of the body by preventing the virus from taking over normal functions of the cell for its own purposes.tenofovir stops the replication of the human immunodeficiency virus (HIV) within important cells of the body by preventing the virus from taking over normal functions of the cell for its own purposes.
Type of medication
TruvadaAtriplaEmtrivaViread
Antiretroviral
Nucleoside reverse transcriptase inhibitor (NRTI)
Antiretroviral
Nucleoside reverse transcriptase inhibitor (NRTI)
Prescription only
Antiretroviral
Non-nucleoside reverse transcriptase inhibitor (NNRTI)
Antiretrovira
Nucleoside reverse transcriptase inhibitor (NRTI)
Antiretroviral
Nucleoside reverse transcriptase inhibitor (NRTI)
Prescription only
Coming soon.
Coming soon.
Available as
TruvadaAtriplaEmtrivaViread
  • Pill
  • Pill
  • Pill
  • Liquid
  • Pill
  • Liquid
Used for (click to learn more)
TruvadaAtriplaEmtrivaViread
  • HIV infection
  • HIV infection
Risk factors for serious side effects
TruvadaAtriplaEmtrivaViread
    • Infection with chronic hepatitis B and stopping Truvada (Emtricitabine / Tenofovir)
    • Taking high dose anti-inflammatory drugs (NSAIDs)
        • Undiscovered HIV infection
        Detailed Truvada (Emtricitabine / Tenofovir) risks & warnings »
        • History of mental illness.
        • History of using recreational drugs.
        • Starting Atripla (Efavirenz / Emtricitabine / Tenofovir) for the first few weeks.
        • Taking alcohol or other drugs that also affect your nervous system.
        • Prior bone fractures
        • Osteoporosis
        • Women
        • Obesity
        • Liver disease
        • History of liver disease
        • Taking alcohol or other drugs that can damage the liver.
        • Infected with hepatitis B.
        • Not taking Atripla (Efavirenz / Emtricitabine / Tenofovir) regularly
        • History of seizures.
            • Starting Atripla (Efavirenz / Emtricitabine / Tenofovir) in the first two weeks.
              • Kidney damage
              Detailed Atripla (Efavirenz / Emtricitabine / Tenofovir) risks & warnings »
              • Women
              • Obesity
              • Liver disease
                • HIV
                • Exposure to other infections
                • Start of a new HIV medication
                • Change in HIV therapy
                • HIV treatment
                Detailed Emtriva (Emtricitabine) risks & warnings »
                • Women
                • Obesity
                • Liver disease
                  • Kidney damage
                  • Prior bone fractures
                  • Osteoporosis
                  • HIV
                  • Exposure to other infections
                  • Start of a new HIV medication
                  • Change in HIV therapy
                  • HIV treatment
                  Detailed Viread (Tenofovir) risks & warnings »
                  Pregnancy

                  Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

                  Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                  Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

                  Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

                  Food
                  TruvadaAtriplaEmtrivaViread
                  No food related info.No food related info.
                  • Take with or without food once a day.
                  No food related info.
                  Kidneys and liver
                  TruvadaAtriplaEmtrivaViread
                  • Can cause unusual dreams, or kidney or liver damage.
                  • Truvada (Emtricitabine / Tenofovir) is removed from the body by the kidneys, so the dose of Truvada (Emtricitabine / Tenofovir) needs to be lowered if you have any kidney problems.
                  • Before starting Truvada (Emtricitabine / Tenofovir), your doctor will test you for hepatitis B to make sure you're not infected. People who've stopped Truvada (Emtricitabine / Tenofovir) and had chronic hepatitis B have suffered from liver damage and failure.
                  • People on Truvada (Emtricitabine / Tenofovir) have reported kidney damage, which can be made worse if you take high doses of anti-inflammatory drugs called NSAIDs (Motrin/Advil, Aleve, Mobic, Voltaren, etc.). Call your doctor if you develop bone pain, pain in your arms or legs, or pain or weakness in your muscles.
                  • Atripla (Efavirenz / Emtricitabine / Tenofovir) can cause kidney damage, increase your risk of depression, and shouldn't be taken if you have a history of seizures or osteoporosis.
                  • Atripla (Efavirenz / Emtricitabine / Tenofovir) can cause this rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use Atripla (Efavirenz / Emtricitabine / Tenofovir). It may not be a good choice for people with liver problems.
                  • Atripla (Efavirenz / Emtricitabine / Tenofovir) is removed from the body by the kidney. Kidney (renal) damage, including cases of renal failure and Fanconi syndrome (injury to the tubes inside of the kidney), has been reported with the use of Atripla (Efavirenz / Emtricitabine / Tenofovir). Your doctor must continually monitor the function of your kidneys while you are taking Atripla (Efavirenz / Emtricitabine / Tenofovir).
                  • emtricitabine is removed from the body by the kidneys, so the dose of emtricitabine needs to be lowered if you have any kidney problems.
                  • emtricitabine can cause this rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use emtricitabine. It may not be a good choice for people with liver problems.
                  • Severe worsening of Hepatitis B has been seen in patients who have stopped taking emtricitabine. Liver function should be closely watched in people who have both HIV and HBV.
                  • The dose of tenofovir depends on how your kidneys work. It is really important to consistently monitor them with your doctor.
                  • Don't take other drugs that can hurt your kidneys while taking tenofovir without talking to your doctor. That sadly includes non-steroidal anti-inflammatory drugs (NSAIDs), like aspirin, Advil, and Aleve.
                  • tenofovir can cause this rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use tenofovir. It may not be a good choice for people with liver problems.
                  • Severe worsening of Hepatitis B has been seen in patients who have stopped taking tenofovir. Liver function should be closely watched in people who have both HIV and HBV.
                  • tenofovir is removed from the body by the kidney. Kidney (renal) damage, including cases of renal failure and Fanconi syndrome (injury to the tubes inside of the kidney), has been reported with the use of tenofovir. Your doctor must continually monitor the function of your kidneys while you are taking tenofovir.
                  Sleep
                  TruvadaAtriplaEmtrivaViread
                  No sleep related info.
                  • You can experience some central nervous system side effects when starting Atripla (Efavirenz / Emtricitabine / Tenofovir), such as dizziness, trouble sleeping, difficulty concentrating, drowsiness, and strange dreams. Taking Atripla (Efavirenz / Emtricitabine / Tenofovir) at bedtime will help lower the risk of experiencing these side effects. If these symptoms don't go away and it bothers you, let your doctor know.
                  No sleep related info.No sleep related info.
                  Upsides and benefits
                  TruvadaAtriplaEmtrivaViread
                  • First-line treatment for preventing HIV infection in combination with other HIV medications.
                  • Only has to be taken once a day.
                  • Truvada (Emtricitabine / Tenofovir) prevents and treats HIV infection.
                  • Used for preventing HIV infection in case you've been accidentally exposed or if you're in danger of being exposed.
                  • Atripla (Efavirenz / Emtricitabine / Tenofovir) is very effective at treating HIV infection.
                  • Contains three medications in one tablet, so it’s convenient to take.
                  • Generally well-tolerated (not as many side effects) compared to other HIV drugs.
                  • Take with or without food once a day.
                  • emtricitabine can be taken as a capsule or liquid.
                  • The emtricitabine oral solution can be stored for up to 3 months in the refrigerator.
                  • emtricitabine is contained in the following combination products: Atripla, Complera, Stribild, and Truvada.
                  • Take tenofovir once a day, with or without food.
                  • For people who can't swallow the tablet, take the powder instead.
                  • tenofovir is used for HIV in kids 2 years and older, and chronic hepatitis B in kids 12 years and older.
                  Downsides and risks
                  TruvadaAtriplaEmtrivaViread
                  • Has to be taken at the same time every day or your body can become resistant to the medication.
                  • Can't be taken on its own to treat HIV.
                  • Can cause unusual dreams, or kidney or liver damage.
                  • Truvada (Emtricitabine / Tenofovir) is removed from the body by the kidneys, so the dose of Truvada (Emtricitabine / Tenofovir) needs to be lowered if you have any kidney problems.
                  • Can't be taken with any drugs containing lamivudine since both are so similar to each other.
                  • Important to take at the same time every day to make sure the virus doesn’t become resistant to the medication.
                  • Atripla (Efavirenz / Emtricitabine / Tenofovir) can cause kidney damage, increase your risk of depression, and shouldn't be taken if you have a history of seizures or osteoporosis.
                  • Women should avoid becoming pregnant while taking Atripla (Efavirenz / Emtricitabine / Tenofovir) and for 12 weeks after stopping Atripla (Efavirenz / Emtricitabine / Tenofovir).
                  • emtricitabine is removed from the body by the kidneys, so the dose of emtricitabine needs to be lowered if you have any kidney problems.
                  • Kids have a higher chance than adults of skin color changes on their hands and feet while taking emtricitabine.
                  • Can't be taken with any drugs containing lamivudine since both are so similar to each other.
                  • The tenofovir powder can't be mixed in a liquid, so mix into soft food like applesauce and yogurt.
                  • The dose of tenofovir depends on how your kidneys work. It is really important to consistently monitor them with your doctor.
                  Tips from our pharmacists for people taking the medication
                  TruvadaAtriplaEmtrivaViread
                  • Since Truvada (Emtricitabine / Tenofovir) is only taken once a day, try taking it at the same time as your other HIV medications.
                  • If being used for kids, the dose of Truvada (Emtricitabine / Tenofovir) will continue to change as they grow, so keep in touch with their doctor.
                  • Keep an eye out for any new symptoms or side effects you may start to feel while taking Truvada (Emtricitabine / Tenofovir) and report them to your doctor.
                  • Practice safe sex while taking Truvada (Emtricitabine / Tenofovir) since the medication will not stop you from passing HIV to other people.
                  • Take at bedtime on an empty stomach to lower possible side effects.
                  • Take at the same time every day.
                  • Can cause stomach upset, headache, nausea, difficulty sleeping, vivid dreams, or depression.
                  • Let your doctor know if you start to get a rash.
                  • Practice safe sex since Atripla (Efavirenz / Emtricitabine / Tenofovir) won't cure HIV or prevent it from being passed on to other people.
                  • Since emtricitabine is only taken once a day, take it at the same time as your other HIV medications.
                  • If being used for kids, the dose of emtricitabine will continue to change as they grow, so keep in touch with their doctor.
                  • Keep an eye out for any new symptoms or side effects you may start to feel while taking emtricitabine and report them to your doctor.
                  • Don't take other drugs that can hurt your kidneys while taking tenofovir without talking to your doctor. That sadly includes non-steroidal anti-inflammatory drugs (NSAIDs), like aspirin, Advil, and Aleve.
                  • People with HIV should be tested for Hepatitis B virus (HBV) before starting tenofovir.
                  • Similarly, patients with chronic hepatitis B, should be tested for HIV before starting tenofovir.
                  • Decreases in bone mineral density can happen while taking tenofovir.
                  • Work with your doctor to monitor your kidney function and bone mineral density regularly.
                  Learn more
                  More about TruvadaSide effectsReviews & ratingsAlternativesFDA package insert
                  Have you used Truvada (Emtricitabine / Tenofovir)?
                  Worth itNot sureNot worth it
                  More about AtriplaSide effectsReviews & ratingsFDA package insert
                  Have you used Atripla (Efavirenz / Emtricitabine / Tenofovir)?
                  Worth itNot sureNot worth it
                  More about EmtrivaSide effectsFDA package insert
                  Have you used Emtriva (Emtricitabine)?
                  Worth itNot sureNot worth it
                  More about VireadSide effectsFDA package insert
                  Have you used Viread (Tenofovir)?
                  Worth itNot sureNot worth it