Over-the-counterLower-cost generic availableClass: Respiratory

Tylenol Cold Multi-Symptom Daytime Alternatives

(acetaminophen / dextromethorphan / phenylephrine)

Over-the-counterLower-cost generic availableClass: Respiratory
Back to: Full Site Navigation

Compare Tylenol Cold Multi-Symptom Daytime (acetaminophen / dextromethorphan / phenylephrine) to alternatives

These medications are comparable to Tylenol Cold Multi-Symptom Daytime (acetaminophen / dextromethorphan / phenylephrine) or used for similar purposes.

Tylenol Cold Multi-Symptom Daytime
(acetaminophen / dextromethorphan / phenylephrine)

Advil Congestion Relief
(ibuprofen / phenylephrine)

Sudafed Pe Pressure Pain And Cough
(acetaminophen / dextromethorphan / phenylephrine)

Sudafed
(pseudoephedrine)

Tylenol Cold Multi-Symptom Daytime
(acetaminophen / dextromethorphan / phenylephrine)

Dayquil Cold And Flu
(acetaminophen / phenylephrine / dextromethorphan)

Theraflu Daytime Severe Cold And Cough
(acetaminophen / dextromethorphan / phenylephrine)

Alka-Seltzer Plus Day Cold And Flu
(acetaminophen / dextromethorphan / phenylephrine)

Sudafed Pe
(phenylephrine)

Advil Cold And Sinus
(ibuprofen / pseudoephedrine)

Delsym
(dextromethorphan)

Relieves cold and flu symptoms. Tylenol Cold Multi-Symptom Daytime (Acetaminophen / Dextromethorphan / Phenylephrine) is good for multiple cold symptoms, but it's more medicine than you need if you only have one symptom.Relieves pain and congestion. Advil Congestion Relief (Ibuprofen / Phenylephrine) is a good combination medicine to relieve pain and congestion, but it's more medicine than you need if you only have one symptom.Relieves coughing and cold symptoms. Sudafed Pe Pressure Pain And Cough (Acetaminophen / Dextromethorphan / Phenylephrine) is good for multiple cold symptoms, but it's more medicine than you need if you only have one symptom.Clears your sinuses. Sudafed (Pseudoephedrine) relieves stuffy nose, but it could keep you up at night. Don't forget your photo ID or you won't be able to buy it in the drugstore.Relieves cold and flu symptoms. Tylenol Cold Multi-Symptom Daytime (Acetaminophen / Dextromethorphan / Phenylephrine) is good for multiple cold symptoms, but it's more medicine than you need if you only have one symptom.Relieves cold and flu symptoms. Dayquil Cold And Flu (Acetaminophen / Phenylephrine / Dextromethorphan) is a useful combination medicine that relieves cold and flu symptoms, but make sure you really need all of its ingredients.Relieves cold and flu symptoms. Theraflu Daytime Severe Cold And Cough (Acetaminophen / Dextromethorphan / Phenylephrine) is good for treating multiple cold and flu symptoms, but it's more medicine than you need if you only have one symptom.Relieves cold and flu symptoms. Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine) is good for multiple cold symptoms, but it's more medicine than you need if you only have one symptom.Clears your sinuses. Sudafed Pe (Phenylephrine) is a good medication for relieving stuffy nose. It doesn't work as well as pseudoephedrine (Sudafed), but it has fewer side effects.Relieves sinus pain and congestion. Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) is a good combination medicine to relieve pain and congestion, but it's more medicine than you need if you only have one symptom.Relieves coughing. Delsym (Dextromethorphan) is a good option for treating dry cough. It's not safe to take with MAO inhibitors though.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
Reviews for Tylenol Cold Multi-Symptom Daytime (acetaminophen / dextromethorphan / phenylephrine)
Not enough review data. Review it!
of people (All ages) say Tylenol Cold Multi-Symptom Daytime (acetaminophen / dextromethorphan / phenylephrine) is worth it
Not enough review data. Review it!
say it works well
Not enough review data. Review it!
say it's a big hassle
Have you used Tylenol Cold Multi-Symptom Daytime (acetaminophen / dextromethorphan / phenylephrine)?
Worth itNot sureNot worth it
Reviews for Advil Congestion Relief (ibuprofen / phenylephrine)
73%
-27% worse vs. Tylenol Cold Multi-Symptom Daytime (acetaminophen / dextromethorphan / phenylephrine)
32%
-68% worse vs. Tylenol Cold Multi-Symptom Daytime (acetaminophen / dextromethorphan / phenylephrine)
7%
-7% worse vs. Tylenol Cold Multi-Symptom Daytime (acetaminophen / dextromethorphan / phenylephrine)
1125 reviews
Have you used Advil Congestion Relief (ibuprofen / phenylephrine)?
Worth itNot sureNot worth it
Reviews for Sudafed Pe Pressure Pain And Cough (acetaminophen / dextromethorphan / phenylephrine)
Not enough review data. Review it!
-100% worse vs. Tylenol Cold Multi-Symptom Daytime (acetaminophen / dextromethorphan / phenylephrine)
Not enough review data. Review it!
-100% worse vs. Tylenol Cold Multi-Symptom Daytime (acetaminophen / dextromethorphan / phenylephrine)
Not enough review data. Review it!
Same vs. Tylenol Cold Multi-Symptom Daytime (acetaminophen / dextromethorphan / phenylephrine)
Have you used Sudafed Pe Pressure Pain And Cough (acetaminophen / dextromethorphan / phenylephrine)?
Worth itNot sureNot worth it
Reviews for Sudafed (pseudoephedrine)
82%
-18% worse vs. Tylenol Cold Multi-Symptom Daytime (acetaminophen / dextromethorphan / phenylephrine)
45%
-55% worse vs. Tylenol Cold Multi-Symptom Daytime (acetaminophen / dextromethorphan / phenylephrine)
6%
-6% worse vs. Tylenol Cold Multi-Symptom Daytime (acetaminophen / dextromethorphan / phenylephrine)
1740 reviews
Have you used Sudafed (pseudoephedrine)?
Worth itNot sureNot worth it
Reviews for Dayquil Cold And Flu (acetaminophen / phenylephrine / dextromethorphan)
81%
-19% worse vs. Tylenol Cold Multi-Symptom Daytime (acetaminophen / dextromethorphan / phenylephrine)
38%
-62% worse vs. Tylenol Cold Multi-Symptom Daytime (acetaminophen / dextromethorphan / phenylephrine)
5%
-5% worse vs. Tylenol Cold Multi-Symptom Daytime (acetaminophen / dextromethorphan / phenylephrine)
1034 reviews
Have you used Dayquil Cold And Flu (acetaminophen / phenylephrine / dextromethorphan)?
Worth itNot sureNot worth it
Reviews for Theraflu Daytime Severe Cold And Cough (acetaminophen / dextromethorphan / phenylephrine)
Not enough review data. Review it!
-33% worse vs. Tylenol Cold Multi-Symptom Daytime (acetaminophen / dextromethorphan / phenylephrine)
Not enough review data. Review it!
-67% worse vs. Tylenol Cold Multi-Symptom Daytime (acetaminophen / dextromethorphan / phenylephrine)
Not enough review data. Review it!
-17% worse vs. Tylenol Cold Multi-Symptom Daytime (acetaminophen / dextromethorphan / phenylephrine)
Have you used Theraflu Daytime Severe Cold And Cough (acetaminophen / dextromethorphan / phenylephrine)?
Worth itNot sureNot worth it
Reviews for Alka-Seltzer Plus Day Cold And Flu (acetaminophen / dextromethorphan / phenylephrine)
Not enough review data. Review it!
-50% worse vs. Tylenol Cold Multi-Symptom Daytime (acetaminophen / dextromethorphan / phenylephrine)
Not enough review data. Review it!
-50% worse vs. Tylenol Cold Multi-Symptom Daytime (acetaminophen / dextromethorphan / phenylephrine)
Not enough review data. Review it!
-25% worse vs. Tylenol Cold Multi-Symptom Daytime (acetaminophen / dextromethorphan / phenylephrine)
Have you used Alka-Seltzer Plus Day Cold And Flu (acetaminophen / dextromethorphan / phenylephrine)?
Worth itNot sureNot worth it
Reviews for Sudafed Pe (phenylephrine)
44%
-56% worse vs. Tylenol Cold Multi-Symptom Daytime (acetaminophen / dextromethorphan / phenylephrine)
24%
-76% worse vs. Tylenol Cold Multi-Symptom Daytime (acetaminophen / dextromethorphan / phenylephrine)
10%
-10% worse vs. Tylenol Cold Multi-Symptom Daytime (acetaminophen / dextromethorphan / phenylephrine)
164 reviews
Have you used Sudafed Pe (phenylephrine)?
Worth itNot sureNot worth it
Reviews for Advil Cold And Sinus (ibuprofen / pseudoephedrine)
75%
-25% worse vs. Tylenol Cold Multi-Symptom Daytime (acetaminophen / dextromethorphan / phenylephrine)
34%
-66% worse vs. Tylenol Cold Multi-Symptom Daytime (acetaminophen / dextromethorphan / phenylephrine)
6%
-6% worse vs. Tylenol Cold Multi-Symptom Daytime (acetaminophen / dextromethorphan / phenylephrine)
1464 reviews
Have you used Advil Cold And Sinus (ibuprofen / pseudoephedrine)?
Worth itNot sureNot worth it
Reviews for Delsym (dextromethorphan)
63%
-37% worse vs. Tylenol Cold Multi-Symptom Daytime (acetaminophen / dextromethorphan / phenylephrine)
32%
-68% worse vs. Tylenol Cold Multi-Symptom Daytime (acetaminophen / dextromethorphan / phenylephrine)
12%
-12% worse vs. Tylenol Cold Multi-Symptom Daytime (acetaminophen / dextromethorphan / phenylephrine)
127 reviews
Have you used Delsym (dextromethorphan)?
Worth itNot sureNot worth it
Side effects
Tylenol Cold Multi-Symptom DaytimeAdvil Congestion ReliefSudafed PE Pressure Pain And CoughSudafedTylenol Cold Multi-Symptom DaytimeDayquil Cold And FluTheraflu Daytime Severe Cold And CoughAlka-Seltzer Plus Day Cold And FluPhenylephrineAdvil Cold And SinusDelsym

We haven’t found good data for Tylenol Cold Multi-Symptom Daytime side effects.

FDA side effect reports for Tylenol Cold Multi-Symptom Daytime »

We haven’t found good data for Advil Congestion Relief side effects.

FDA side effect reports for Advil Congestion Relief »

We haven’t found good data for Sudafed PE Pressure Pain And Cough side effects.

FDA side effect reports for Sudafed PE Pressure Pain And Cough »

We haven’t found good data for Sudafed side effects.

FDA side effect reports for Sudafed »

We haven’t found good data for Tylenol Cold Multi-Symptom Daytime side effects.

FDA side effect reports for Tylenol Cold Multi-Symptom Daytime »

We haven’t found good data for Dayquil Cold And Flu side effects.

FDA side effect reports for Dayquil Cold And Flu »

We haven’t found good data for Theraflu Daytime Severe Cold And Cough side effects.

FDA side effect reports for Theraflu Daytime Severe Cold And Cough »

We haven’t found good data for Alka-Seltzer Plus Day Cold And Flu side effects.

FDA side effect reports for Alka-Seltzer Plus Day Cold And Flu »

We haven’t found good data for Phenylephrine side effects.

FDA side effect reports for Phenylephrine »

We haven’t found good data for Advil Cold And Sinus side effects.

FDA side effect reports for Advil Cold And Sinus »

We haven’t found good data for Delsym side effects.

FDA side effect reports for Delsym »
How it works
Tylenol Cold Multi-Symptom DaytimeAdvil Congestion ReliefSudafed PE Pressure Pain And CoughSudafedTylenol Cold Multi-Symptom DaytimeDayquil Cold And FluTheraflu Daytime Severe Cold And CoughAlka-Seltzer Plus Day Cold And FluPhenylephrineAdvil Cold And SinusDelsym
Tylenol Cold Multi-Symptom Daytime (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses.Advil Congestion Relief (Ibuprofen / Phenylephrine) is a combination medicine that treats cold and allergy symptoms. Ibuprofen is an NSAID that relieves swelling, pain, and fever. Phenylephrine is a decongestant that clears your sinuses.Sudafed Pe Pressure Pain And Cough (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that treats cold symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses.Sudafed (Pseudoephedrine) is a decongestant. It narrows blood vessels and reduces swelling in your nasal passages to make breathing easier.Tylenol Cold Multi-Symptom Daytime (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses.Dayquil Cold And Flu (Acetaminophen / Phenylephrine / Dextromethorphan) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses.Theraflu Daytime Severe Cold And Cough (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses.Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses.Sudafed Pe (Phenylephrine) is a decongestant. It narrows blood vessels and reduces swelling in your nasal passages to make breathing easier.Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) is a combination medicine that relieves cold symptoms and sinus pressure. Ibuprofen (an NSAID) relieves pain and reduces fever. Pseudoephedrine (a decongestant) clears your sinuses.Delsym (Dextromethorphan) is a cough suppressant.
Type of medication
Tylenol Cold Multi-Symptom DaytimeAdvil Congestion ReliefSudafed PE Pressure Pain And CoughSudafedTylenol Cold Multi-Symptom DaytimeDayquil Cold And FluTheraflu Daytime Severe Cold And CoughAlka-Seltzer Plus Day Cold And FluPhenylephrineAdvil Cold And SinusDelsym
Over-the-counter
Over-the-counter
Over-the-counter
Prescription or OTC
Over-the-counter
Over-the-counter
Over-the-counter
Over-the-counter
Prescription or OTC
Over-the-counter
Over-the-counter
Available as
Tylenol Cold Multi-Symptom DaytimeAdvil Congestion ReliefSudafed PE Pressure Pain And CoughSudafedTylenol Cold Multi-Symptom DaytimeDayquil Cold And FluTheraflu Daytime Severe Cold And CoughAlka-Seltzer Plus Day Cold And FluPhenylephrineAdvil Cold And SinusDelsym
  • Pill
  • Liquid
  • Powder
  • Pill
  • Pill
  • Pill
  • Extended release
  • Liquid
  • Pill
  • Liquid
  • Powder
  • Pill
  • Liquid
  • Powder
  • Pill
  • Pill
  • Nasal spray
  • Eye drops
  • Suppository
  • Pill
  • Pill
  • Liquid extended release
Used for
Tylenol Cold Multi-Symptom DaytimeAdvil Congestion ReliefSudafed PE Pressure Pain And CoughSudafedTylenol Cold Multi-Symptom DaytimeDayquil Cold And FluTheraflu Daytime Severe Cold And CoughAlka-Seltzer Plus Day Cold And FluPhenylephrineAdvil Cold And SinusDelsym
Risk factors for serious side effects
Tylenol Cold Multi-Symptom DaytimeAdvil Congestion ReliefSudafed PE Pressure Pain And CoughSudafedTylenol Cold Multi-Symptom DaytimeDayquil Cold And FluTheraflu Daytime Severe Cold And CoughAlka-Seltzer Plus Day Cold And FluPhenylephrineAdvil Cold And SinusDelsym
  • Taking with alcohol
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • History of high blood pressure
  • Taking MAO inhibitors
Detailed Tylenol Cold Multi-Symptom Daytime (acetaminophen / dextromethorphan / phenylephrine) risks & warnings »
  • History of stomach bleeding or ulcers
  • Age 60 years or older
  • Taking aspirin, NSAIDs, or blood thinners
  • Drinking more than 3 alcoholic beverages a day
  • Women of childbearing age
Detailed Advil Congestion Relief (ibuprofen / phenylephrine) risks & warnings »
  • Taking with alcohol
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • History of high blood pressure
  • Taking MAO inhibitors
Detailed Sudafed Pe Pressure Pain And Cough (acetaminophen / dextromethorphan / phenylephrine) risks & warnings »
  • History of high blood pressure
  • History of heart problems
  • Age 65 years or older
  • History of seizures
  • Women of childbearing age
Detailed Sudafed (pseudoephedrine) risks & warnings »
  • Taking with alcohol
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • History of high blood pressure
  • Taking MAO inhibitors
Detailed Tylenol Cold Multi-Symptom Daytime (acetaminophen / dextromethorphan / phenylephrine) risks & warnings »
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • History of high blood pressure
  • Taking MAO inhibitors
Detailed Dayquil Cold And Flu (acetaminophen / phenylephrine / dextromethorphan) risks & warnings »
  • Drinking more than 3 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • History of chronic obstructive pulmonary disease (COPD)
  • History of smoking
Detailed Theraflu Daytime Severe Cold And Cough (acetaminophen / dextromethorphan / phenylephrine) risks & warnings »
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • History of high blood pressure
  • Taking MAO inhibitors
Detailed Alka-Seltzer Plus Day Cold And Flu (acetaminophen / dextromethorphan / phenylephrine) risks & warnings »
  • History of high blood pressure
  • Taking MAO inhibitors
  • History of heart problems
  • Age 65 years or older
  • Women of childbearing age
Detailed Sudafed Pe (phenylephrine) risks & warnings »
  • History of stomach bleeding or ulcers
  • Age 60 years or older
  • Taking aspirin, NSAIDs, or blood thinners
  • Drinking more than 3 alcoholic beverages a day
  • Women of childbearing age
Detailed Advil Cold And Sinus (ibuprofen / pseudoephedrine) risks & warnings »
  • Using other medications that affect serotonin
Detailed Delsym (dextromethorphan) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Interactions
Tylenol Cold Multi-Symptom DaytimeAdvil Congestion ReliefSudafed PE Pressure Pain And CoughSudafedTylenol Cold Multi-Symptom DaytimeDayquil Cold And FluTheraflu Daytime Severe Cold And CoughAlka-Seltzer Plus Day Cold And FluPhenylephrineAdvil Cold And SinusDelsym
No interactions related info.
  • The pain reliever (ibuprofen) can interact with other medications and make health problems like stomach bleeding and ulcers worse.
No interactions related info.No interactions related info.No interactions related info.No interactions related info.No interactions related info.No interactions related info.No interactions related info.
  • The pain reliever (ibuprofen) can interact with other medications and make health problems like stomach bleeding and ulcers worse.
No interactions related info.
Food
Tylenol Cold Multi-Symptom DaytimeAdvil Congestion ReliefSudafed PE Pressure Pain And CoughSudafedTylenol Cold Multi-Symptom DaytimeDayquil Cold And FluTheraflu Daytime Severe Cold And CoughAlka-Seltzer Plus Day Cold And FluPhenylephrineAdvil Cold And SinusDelsym
No food related info.No food related info.No food related info.No food related info.No food related info.No food related info.
  • Theraflu Daytime Severe Cold And Cough (Acetaminophen / Dextromethorphan / Phenylephrine) contains aspartame (phenylalanine). People who have phenylketonuria (PKU) can't break down the amino acid phenylalanine. It builds up and causes serious medical problems. If you have PKU, don't use this product.
No food related info.No food related info.No food related info.No food related info.
Kidneys and liver
Tylenol Cold Multi-Symptom DaytimeAdvil Congestion ReliefSudafed PE Pressure Pain And CoughSudafedTylenol Cold Multi-Symptom DaytimeDayquil Cold And FluTheraflu Daytime Severe Cold And CoughAlka-Seltzer Plus Day Cold And FluPhenylephrineAdvil Cold And SinusDelsym
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • Advil Congestion Relief (Ibuprofen / Phenylephrine) contains ibuprofen, an NSAID that can lower kidney function or cause damage. Taking the lowest dose for the shortest amount of time lowers your risk. Your doctor should check your kidney function if you take Advil Congestion Relief (Ibuprofen / Phenylephrine) for any amount of time.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
No kidneys and liver related info.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it is a very common ingredient in pain and cold/flu combination medicines.
No kidneys and liver related info.
  • Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) contains ibuprofen, an NSAID that can lower kidney function or cause damage. Taking the lowest dose for the shortest amount of time lowers your risk. Your doctor should check your kidney function if you take Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) for any amount of time.
No kidneys and liver related info.
Pain
Tylenol Cold Multi-Symptom DaytimeAdvil Congestion ReliefSudafed PE Pressure Pain And CoughSudafedTylenol Cold Multi-Symptom DaytimeDayquil Cold And FluTheraflu Daytime Severe Cold And CoughAlka-Seltzer Plus Day Cold And FluPhenylephrineAdvil Cold And SinusDelsym
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • The pain reliever (ibuprofen) can interact with other medications and make health problems like stomach bleeding and ulcers worse.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
No pain related info.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than to other pain medications like aspirin or ibuprofen.
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it is a very common ingredient in pain and cold/flu combination medicines.
No pain related info.
  • The pain reliever (ibuprofen) can interact with other medications and make health problems like stomach bleeding and ulcers worse.
No pain related info.
Sleep
Tylenol Cold Multi-Symptom DaytimeAdvil Congestion ReliefSudafed PE Pressure Pain And CoughSudafedTylenol Cold Multi-Symptom DaytimeDayquil Cold And FluTheraflu Daytime Severe Cold And CoughAlka-Seltzer Plus Day Cold And FluPhenylephrineAdvil Cold And SinusDelsym
No sleep related info.No sleep related info.No sleep related info.
  • It can affect the quality of your sleep, so you can't take it too close to going to bed.
No sleep related info.No sleep related info.No sleep related info.No sleep related info.No sleep related info.No sleep related info.No sleep related info.
Upsides and benefits
Tylenol Cold Multi-Symptom DaytimeAdvil Congestion ReliefSudafed PE Pressure Pain And CoughSudafedTylenol Cold Multi-Symptom DaytimeDayquil Cold And FluTheraflu Daytime Severe Cold And CoughAlka-Seltzer Plus Day Cold And FluPhenylephrineAdvil Cold And SinusDelsym
  • Tylenol Cold Multi-Symptom Daytime (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • Advil Congestion Relief (Ibuprofen / Phenylephrine) is a combination medicine that relieves multiple cold and allergy symptoms. It's good to use if you have a stuffy nose, sinus pressure, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • Sudafed Pe Pressure Pain And Cough (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • One of the best over-the-counter options to clear stuffy nose and help you breathe better.
  • Clears nasal congestion better than other decongestants like phenylephrine.
  • Can be helpful in relieving congestion-related headaches and pressure in your ears.
  • Available in regular and extended release forms.
  • Tylenol Cold Multi-Symptom Daytime (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • Dayquil Cold And Flu (Acetaminophen / Phenylephrine / Dextromethorphan) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • Theraflu Daytime Severe Cold And Cough (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that relieves multiple cold and flu symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • Since you're taking this with water, it can help you stay hydrated.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than to other pain medications like aspirin or ibuprofen.
  • Works to clear nasal congestion and helps you breathe better.
  • Helpful in relieving congestion-related headaches.
  • Has fewer side effects than other decongestants like pseudoephedrine.
  • It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • Doesn't give you rebound congestion (worse symptoms when you stop taking it) like nasal spray decongestants do.
  • Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) is a combination medicine that relieves cold symptoms. It's good to use if you have congestion, sore throat, headache, or fever.
  • Ibuprofen (a pain reliever) is more effective than acetaminophen at lowering fever and relieving sinus pain.
  • Pseudoephedrine (a decongestant) clears nose congestion to help you breathe better.
  • Good for treating dry cough.
  • Available in drugstores either by itself or in combination with other medications to treat cold and allergy symptoms.
  • Available as a liquid and a tablet.
  • Some products relieve cough for up to 12 hours.
Downsides and risks
Tylenol Cold Multi-Symptom DaytimeAdvil Congestion ReliefSudafed PE Pressure Pain And CoughSudafedTylenol Cold Multi-Symptom DaytimeDayquil Cold And FluTheraflu Daytime Severe Cold And CoughAlka-Seltzer Plus Day Cold And FluPhenylephrineAdvil Cold And SinusDelsym
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other oral decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • If you don't really need both of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • The pain reliever (ibuprofen) can interact with other medications and make health problems like stomach bleeding and ulcers worse.
  • It's not safe to take ibuprofen if you're pregnant since it increases the risk of heart defects in babies.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other oral decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • Pseudoephedrine (a decongestant) can make your heart race or make you feel anxious and restless.
  • It can affect the quality of your sleep, so you can't take it too close to going to bed.
  • Can raise blood pressure so check with your doctor before using it if you have high blood pressure or other heart conditions.
  • Sudafed (Pseudoephedrine) isn't as effective after using it for more than 4 days straight.
  • Need to show a photo ID to buy it in the drugstore and there is a limit on how much you can buy each visit.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other oral decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other oral decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it is a very common ingredient in pain and cold/flu combination medicines.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine (Sudafed).
  • You shouldn't use it if you have high blood pressure.
  • Can make your heart race or make you feel anxious and restless.
  • Shouldn't use it before you want to sleep.
  • Not as effective after using it for 4 days in a row.
  • If you don't need both of the medications in this combination, you'd be taking extra medicine and can have extra side effects for no reason.
  • The pain reliever (ibuprofen) can interact with other medications and make health problems like stomach bleeding and ulcers worse.
  • It's not safe to take ibuprofen if you're pregnant since it increases the risk of heart defects in babies.
  • Pseudoephedrine, the decongestant in Advil Cold And Sinus (Ibuprofen / Pseudoephedrine), can make your heart race or make you feel anxious and restless.
  • Can't take dextromethorphan if you're taking MAO inhibitors (drugs used to treat Parkinson's disease, depression, and other emotional conditions). If taken together, they will cause dangerously high blood pressure levels.
  • If you're taking this in combination with other cold and allergy medications, you should read labels closely to make sure you're not accidentally taking too much of a single ingredient.
Tips from our pharmacists for people taking the medication
Tylenol Cold Multi-Symptom DaytimeAdvil Congestion ReliefSudafed PE Pressure Pain And CoughSudafedTylenol Cold Multi-Symptom DaytimeDayquil Cold And FluTheraflu Daytime Severe Cold And CoughAlka-Seltzer Plus Day Cold And FluPhenylephrineAdvil Cold And SinusDelsym
  • Tylenol Cold Multi-Symptom Daytime (Acetaminophen / Dextromethorphan / Phenylephrine) starts working in about 30 minutes.
  • Phenylephrine, the decongestant, can make you restless, so don't take it too close to bedtime.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • If you get the liquid form, use the dosing cup to measure the exact amount of medicine you need.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
  • Starts working in 30 minutes.
  • Don't take it if you have an allergy to aspirin since ibuprofen can cause a similar reaction.
  • Phenylephrine (the decongestant ingredient) can make you restless, so don't take it too close to bedtime.
  • Follow age-specific dosing instructions on how much to take. Don't take more than what's recommended on the package.
  • Let your doctor know if your symptoms don't improve in a few days.
  • Starts working in about 30 minutes.
  • Phenylephrine, the decongestant, can make you restless, so don't take it too close to bedtime.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
  • Starts working in 30 minutes.
  • You need to show an ID to buy Sudafed (Pseudoephedrine) in the drugstore because it contains pseudoephedrine.
  • Follow age-specific dosing instructions on how much to take. Don't take more than recommended on the package.
  • Don't take Sudafed (Pseudoephedrine) too close to bedtime since it can keep you awake.
  • Can cause an irregular or fast heartbeat, and can raise your blood pressure.
  • Talk to your doctor if your symptoms don't get better in 1 week.
  • Tylenol Cold Multi-Symptom Daytime (Acetaminophen / Dextromethorphan / Phenylephrine) starts working in about 30 minutes.
  • Phenylephrine, the decongestant, can make you restless, so don't take it too close to bedtime.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • If you get the liquid form, use the dosing cup to measure the exact amount of medicine you need.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
  • Phenylephrine, the decongestant, can make you restless, so don't take it too close to bedtime.
  • If you get the liquid form, use the dosing cup to measure the exact amount of medicine you need.
  • Follow age-specific dosing instructions on how much to take.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
  • Starts working in about 30 minutes.
  • Dissolve 1 packet in a cup of hot water and use every 4 hours as needed. Don't use more than 5 packets in 24 hours.
  • Phenylephrine, the decongestant, can make you restless, so don't take it too close to bedtime.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Let your doctor know if your symptoms don't improve in a few days.
  • Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine) starts working in about 30 minutes.
  • Phenylephrine (the decongestant ingredient) can make you restless, so don't take it too close to bedtime.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
  • Starts working in 30 minutes.
  • Phenylephrine can make you restless, so don't take it too close to bedtime.
  • It's in other cold and flu combination medicines. Read labels closely so you don't accidentally double up and take too much of it in a day.
  • Follow age-specific dosing instructions on how much to take.
  • Let your doctor know if your symptoms don't improve in a few days.
  • Starts working in 30 minutes.
  • You need to show an ID to buy Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) in the drugstore because it contains pseudoephedrine.
  • Don't take it if you have an allergy to aspirin since ibuprofen can cause a similar reaction.
  • Take it after eating to avoid getting an upset stomach.
  • Can cause an irregular or fast heartbeat, and can raise your blood pressure.
  • Be careful taking Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) if you have a history of bleeding problems or ulcers since it can make them worse.
  • Talk to your doctor if symptoms don't get better in 1 week.
  • Cough suppressant starts working in 15 to 30 minutes.
  • Follow age-specific dosing instructions on how much to take. Don't take more than the recommended dose.
  • If your cough lasts more than 7 days, call your doctor.
Learn more
More about Tylenol Cold Multi-Symptom DaytimeSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Tylenol Cold Multi-Symptom Daytime (acetaminophen / dextromethorphan / phenylephrine)?
Worth itNot sureNot worth it
More about Advil Congestion ReliefSide effectsReviews & ratingsFDA package insert
Have you used Advil Congestion Relief (ibuprofen / phenylephrine)?
Worth itNot sureNot worth it
More about Sudafed PE Pressure Pain And CoughSide effectsFDA package insert
Have you used Sudafed Pe Pressure Pain And Cough (acetaminophen / dextromethorphan / phenylephrine)?
Worth itNot sureNot worth it
More about SudafedSide effectsReviews & ratingsFDA package insert
Have you used Sudafed (pseudoephedrine)?
Worth itNot sureNot worth it
More about Tylenol Cold Multi-Symptom DaytimeSide effectsReviews & ratingsFDA package insert
Have you used Tylenol Cold Multi-Symptom Daytime (acetaminophen / dextromethorphan / phenylephrine)?
Worth itNot sureNot worth it
More about Dayquil Cold And FluSide effectsReviews & ratingsFDA package insert
Have you used Dayquil Cold And Flu (acetaminophen / phenylephrine / dextromethorphan)?
Worth itNot sureNot worth it
More about Theraflu Daytime Severe Cold And CoughSide effectsReviews & ratingsFDA package insert
Have you used Theraflu Daytime Severe Cold And Cough (acetaminophen / dextromethorphan / phenylephrine)?
Worth itNot sureNot worth it
More about Alka-Seltzer Plus Day Cold And FluSide effectsReviews & ratingsFDA package insert
Have you used Alka-Seltzer Plus Day Cold And Flu (acetaminophen / dextromethorphan / phenylephrine)?
Worth itNot sureNot worth it
More about PhenylephrineSide effectsReviews & ratingsFDA package insert
Have you used Sudafed Pe (phenylephrine)?
Worth itNot sureNot worth it
More about Advil Cold And SinusSide effectsReviews & ratingsFDA package insert
Have you used Advil Cold And Sinus (ibuprofen / pseudoephedrine)?
Worth itNot sureNot worth it
More about DelsymSide effectsReviews & ratingsFDA package insert
Have you used Delsym (dextromethorphan)?
Worth itNot sureNot worth it