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Tylenol Cold Multi-Symptom Nighttime

(Acetaminophen / Dextromethorphan / Doxylamine / Phenylephrine)

  • Liquid
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Relieves cold and flu symptoms, and helps you sleep.

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Over-the-counterLower-cost generic available

Our pharmacists’ bottom line

Tylenol Cold Multi-Symptom Nighttime (Acetaminophen / Dextromethorphan / Doxylamine / Phenylephrine) is a useful combination medicine that relieves cold and flu symptoms and will help you sleep. Make sure you really need all of its ingredients.

  • Tylenol Cold Multi-Symptom Nighttime (Acetaminophen / Dextromethorphan / Doxylamine / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, watery eyes, a cough, fever, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The cough suppressant (dextromethorphan) works well and has very few side effects.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • The antihistamine (doxylamine) will help you sleep.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • Phenylephrine can keep you awake and doxylamine makes you sleepy, so it could affect you either way.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
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Side effects for Tylenol Cold Multi-Symptom Nighttime (Acetaminophen / Dextromethorphan / Doxylamine / Phenylephrine)

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These are side effects of Tylenol Cold Multi-Symptom Nighttime (Acetaminophen / Dextromethorphan / Doxylamine / Phenylephrine) reported to the FDA by people taking it, and by doctors and pharmacists.

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What to expect when you take Tylenol Cold Multi-Symptom Nighttime (Acetaminophen / Dextromethorphan / Doxylamine / Phenylephrine)

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Tips from our pharmacists
  • Doxylamine (the antihistamine ingredient) can make you tired, so take it close to bedtime.
  • Avoid using alcohol and other drugs that make you drowsy.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.

Risks and Warnings for Tylenol Cold Multi-Symptom Nighttime (Acetaminophen / Dextromethorphan / Doxylamine / Phenylephrine)

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    • Higher risk if:
    • Drinking more than 2 alcoholic beverages a day
    • Taking with other Tylenol-containing medicines
    • History of liver disease

    Tylenol Cold Multi-Symptom Nighttime (Acetaminophen / Dextromethorphan / Doxylamine / Phenylephrine) contains acetaminophen, also known as Tylenol or APAP, and is a common ingredient in many other over-the-counter medicines. Taking too much acetaminophen causes liver damage that can be permanent and life-threatening. In case of an overdose, call your local Poison Control Center and get medical attention immediately.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Tylenol Cold Multi-Symptom Nighttime (Acetaminophen / Dextromethorphan / Doxylamine / Phenylephrine)

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The FDA category for this medication is N. It is advised that you: Unknown
Pregnancy
Alcohol
  • Tips from our pharmacists
  • Avoid using alcohol and other drugs that make you drowsy.
Sleep
  • Upsides and downsides from our pharmacists
  • The antihistamine (doxylamine) will help you sleep.
  • Tips from our pharmacists
  • Avoid using alcohol and other drugs that make you drowsy.