Over-the-counterLower-cost generic availableClass: Respiratory

Tylenol Cold Multi-Symptom Nighttime

(acetaminophen / dextromethorphan / doxylamine / phenylephrine)

Over-the-counterLower-cost generic availableClass: Respiratory
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Relieves cold and flu symptoms, and helps you sleep.

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Our bottom line

Tylenol Cold Multi-Symptom Nighttime (Acetaminophen / Dextromethorphan / Doxylamine / Phenylephrine) is a useful combination medicine that relieves cold and flu symptoms and will help you sleep. Make sure you really need all of its ingredients.

Upsides

  • Tylenol Cold Multi-Symptom Nighttime (Acetaminophen / Dextromethorphan / Doxylamine / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, watery eyes, a cough, fever, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The cough suppressant (dextromethorphan) works well and has very few side effects.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • The antihistamine (doxylamine) will help you sleep.
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Downsides

  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • Phenylephrine can keep you awake and doxylamine makes you sleepy, so it could affect you either way.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
How it works

Tylenol Cold Multi-Symptom Nighttime (Acetaminophen / Dextromethorphan / Doxylamine / Phenylephrine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Doxylamine is an antihistamine that relieves a runny nose and makes you very sleepy. Phenylephrine is a decongestant that clears your sinuses.

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Used for
Dosage forms
  • Liquid
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Side effect rates for Tylenol Cold Multi-Symptom Nighttime (acetaminophen / dextromethorphan / doxylamine / phenylephrine)

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These are side effects of Tylenol Cold Multi-Symptom Nighttime (acetaminophen / dextromethorphan / doxylamine / phenylephrine) reported to the FDA by people taking it, and by doctors and pharmacists.
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Risks and Warnings for Tylenol Cold Multi-Symptom Nighttime (acetaminophen / dextromethorphan / doxylamine / phenylephrine)

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    • Higher risk if:
    • Drinking more than 2 alcoholic beverages a day
    • Taking with other Tylenol-containing medicines
    • History of liver disease

    Tylenol Cold Multi-Symptom Nighttime (Acetaminophen / Dextromethorphan / Doxylamine / Phenylephrine) contains acetaminophen, also known as Tylenol or APAP, and is a common ingredient in many other over-the-counter medicines. Taking too much acetaminophen causes liver damage that can be permanent and life-threatening. In case of an overdose, call your local Poison Control Center and get medical attention immediately.

Common concerns from people taking Tylenol Cold Multi-Symptom Nighttime (acetaminophen / dextromethorphan / doxylamine / phenylephrine)

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Pregnancy
Alcohol
  • Avoid using alcohol and other drugs that make you drowsy.
Kidneys and liver
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
Pain
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.