Over-the-counterLower-cost generic available

Tylenol Cold Multi-Symptom Nighttime Alternatives

(Acetaminophen / Dextromethorphan / Doxylamine / Phenylephrine)

  • Liquid
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Compare Tylenol Cold Multi-Symptom Nighttime (Acetaminophen / Dextromethorphan / Doxylamine / Phenylephrine) to alternatives

These medications are comparable to Tylenol Cold Multi-Symptom Nighttime (Acetaminophen / Dextromethorphan / Doxylamine / Phenylephrine) or used for similar purposes.

Tylenol Cold Multi-Symptom Nighttime
(Acetaminophen / Dextromethorphan / Doxylamine / Phenylephrine)

Nyquil Cold And Flu
(Acetaminophen / Dextromethorphan / Doxylamine)

Relieves cold and flu symptoms, and helps you sleep. Tylenol Cold Multi-Symptom Nighttime (Acetaminophen / Dextromethorphan / Doxylamine / Phenylephrine) is a useful combination medicine that relieves cold and flu symptoms and will help you sleep. Make sure you really need all of its ingredients.Relieves cold and flu symptoms, and helps you sleep. Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a useful combination medicine that relieves cold and flu symptoms and will help you sleep. Make sure you really need all of its ingredients.
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Reviews & ratings
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Reviews for Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine)
83%
+83% vs. Tylenol Cold Multi-Symptom Nighttime (Acetaminophen / Dextromethorphan / Doxylamine / Phenylephrine)
42%
+42% vs. Tylenol Cold Multi-Symptom Nighttime (Acetaminophen / Dextromethorphan / Doxylamine / Phenylephrine)
6%
6% vs. Tylenol Cold Multi-Symptom Nighttime (Acetaminophen / Dextromethorphan / Doxylamine / Phenylephrine)
Side effects
Tylenol Cold Multi-Symptom NighttimeNyquil Cold and Flu

We haven’t found good data for Tylenol Cold Multi-Symptom Nighttime side effects.

FDA side effect reports for Tylenol Cold Multi-Symptom Nighttime »

We haven’t found good data for Nyquil Cold and Flu side effects.

FDA side effect reports for Nyquil Cold and Flu »
How it works
Tylenol Cold Multi-Symptom NighttimeNyquil Cold and Flu
Tylenol Cold Multi-Symptom Nighttime (Acetaminophen / Dextromethorphan / Doxylamine / Phenylephrine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Doxylamine is an antihistamine that relieves a runny nose and makes you very sleepy. Phenylephrine is a decongestant that clears your sinuses.Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Doxylamine is an antihistamine that relieves a runny nose and makes you very sleepy.
Type of medication
Tylenol Cold Multi-Symptom NighttimeNyquil Cold and Flu
Pain reliever
APAP
Cough suppressantAntihistamine
Ethanolamine derivative
DecongestantOver-the-counter
Pain reliever
APAP
Cough suppressantAntihistamine
Ethanolamine derivative
Over-the-counter
Available as
Tylenol Cold Multi-Symptom NighttimeNyquil Cold and Flu
  • Liquid
  • Pill
  • Liquid
Used for (click to learn more)
Tylenol Cold Multi-Symptom NighttimeNyquil Cold and Flu
Risk factors for serious side effects
Tylenol Cold Multi-Symptom NighttimeNyquil Cold and Flu
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • History of high blood pressure
  • Taking MAO inhibitors
  • Taking with alcohol
  • Taking with other medicines that make you less alert
  • Women of childbearing age
  • Age 65 years or older
  • Glaucoma
  • Benign prostatic hypertrophy (BPH)
  • Using other medications that affect serotonin
Detailed Tylenol Cold Multi-Symptom Nighttime (Acetaminophen / Dextromethorphan / Doxylamine / Phenylephrine) risks & warnings »
Coming soon.
Pregnancy category
Tylenol Cold Multi-Symptom NighttimeNyquil Cold and Flu
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
Alcohol
  • Avoid using alcohol and other drugs that make you drowsy.
  • Avoid using alcohol and other drugs that make you drowsy.
Food
No specific food-related info.No specific food-related info.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.
Sex
No specific sex-related info.No specific sex-related info.
Sleep
  • The antihistamine (doxylamine) will help you sleep.
  • Avoid using alcohol and other drugs that make you drowsy.
  • The antihistamine (doxylamine) will help you sleep.
  • Avoid using alcohol and other drugs that make you drowsy.
Weight
No specific weight-related info.No specific weight-related info.
Upsides and benefits
Tylenol Cold Multi-Symptom NighttimeNyquil Cold and Flu
  • Tylenol Cold Multi-Symptom Nighttime (Acetaminophen / Dextromethorphan / Doxylamine / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, watery eyes, a cough, fever, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The cough suppressant (dextromethorphan) works well and has very few side effects.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • The antihistamine (doxylamine) will help you sleep.
  • Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have watery eyes, a cough, fever, and pain.
  • The cough medicine (dextromethorphan) works well and has very few side effects.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • The antihistamine (doxylamine) will help you sleep.
Downsides and risks
Tylenol Cold Multi-Symptom NighttimeNyquil Cold and Flu
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • Phenylephrine can keep you awake and doxylamine makes you sleepy, so it could affect you either way.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
Tips from our pharmacists for people taking the medication
Tylenol Cold Multi-Symptom NighttimeNyquil Cold and Flu
  • Doxylamine (the antihistamine ingredient) can make you tired, so take it close to bedtime.
  • Avoid using alcohol and other drugs that make you drowsy.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
  • Follow age-specific dosing instructions on how much to take. Don't take more than recommended on the package.
  • Doxylamine (the antihistamine ingredient) can make you tired, so take it close to bedtime.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Avoid using alcohol and other drugs that make you drowsy.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
Learn more
More about Tylenol Cold Multi-Symptom NighttimeSide effectsAlternativesFDA package insert
More about Nyquil Cold and FluSide effectsReviews & ratingsFDA package insert