Over-the-counterLower-cost generic availableClass: Respiratory

Tylenol Cold Multi-Symptom Nighttime Alternatives

(acetaminophen / dextromethorphan / doxylamine / phenylephrine)

Over-the-counterLower-cost generic availableClass: Respiratory
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Compare Tylenol Cold Multi-Symptom Nighttime (acetaminophen / dextromethorphan / doxylamine / phenylephrine) to alternatives

These medications are comparable to Tylenol Cold Multi-Symptom Nighttime (acetaminophen / dextromethorphan / doxylamine / phenylephrine) or used for similar purposes.

Tylenol Cold Multi-Symptom Nighttime
(acetaminophen / dextromethorphan / doxylamine / phenylephrine)

Nyquil Cold And Flu
(acetaminophen / dextromethorphan / doxylamine)

Relieves cold and flu symptoms, and helps you sleep. Tylenol Cold Multi-Symptom Nighttime (Acetaminophen / Dextromethorphan / Doxylamine / Phenylephrine) is a useful combination medicine that relieves cold and flu symptoms and will help you sleep. Make sure you really need all of its ingredients.Relieves cold and flu symptoms, and helps you sleep. Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a useful combination medicine that relieves cold and flu symptoms and will help you sleep. Make sure you really need all of its ingredients.
Reviews & ratings
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Have you used Tylenol Cold Multi-Symptom Nighttime (acetaminophen / dextromethorphan / doxylamine / phenylephrine)?
Worth itNot sureNot worth it
Reviews for Nyquil Cold And Flu
83%
-83% worse vs. Tylenol Cold Multi-Symptom Nighttime
42%
-42% worse vs. Tylenol Cold Multi-Symptom Nighttime
7%
+7% better vs. Tylenol Cold Multi-Symptom Nighttime
1188 reviews
Have you used Nyquil Cold And Flu (acetaminophen / dextromethorphan / doxylamine)?
Worth itNot sureNot worth it
Side effects
Tylenol Cold Multi-Symptom NighttimeNyquil Cold And Flu

We haven’t found good data for Tylenol Cold Multi-Symptom Nighttime side effects.

FDA side effect reports for Tylenol Cold Multi-Symptom Nighttime »

We haven’t found good data for Nyquil Cold And Flu side effects.

FDA side effect reports for Nyquil Cold And Flu »
How it works
Tylenol Cold Multi-Symptom NighttimeNyquil Cold And Flu
Tylenol Cold Multi-Symptom Nighttime (Acetaminophen / Dextromethorphan / Doxylamine / Phenylephrine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Doxylamine is an antihistamine that relieves a runny nose and makes you very sleepy. Phenylephrine is a decongestant that clears your sinuses.Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Doxylamine is an antihistamine that relieves a runny nose and makes you very sleepy.
Type of medication
Tylenol Cold Multi-Symptom NighttimeNyquil Cold And Flu
Over-the-counterOver-the-counter
Available as
Tylenol Cold Multi-Symptom NighttimeNyquil Cold And Flu
  • Liquid
  • Pill
  • Liquid
Used for
Tylenol Cold Multi-Symptom NighttimeNyquil Cold And Flu
Risk factors for serious side effects
Tylenol Cold Multi-Symptom NighttimeNyquil Cold And Flu
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • History of high blood pressure
  • Taking MAO inhibitors
Detailed Tylenol Cold Multi-Symptom Nighttime (acetaminophen / dextromethorphan / doxylamine / phenylephrine) risks & warnings »
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • Using other medications that affect serotonin
  • Taking with alcohol
Detailed Nyquil Cold And Flu (acetaminophen / dextromethorphan / doxylamine) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Alcohol
Tylenol Cold Multi-Symptom NighttimeNyquil Cold And Flu
  • Avoid using alcohol and other drugs that make you drowsy.
  • Avoid using alcohol and other drugs that make you drowsy.
Kidneys and liver
Tylenol Cold Multi-Symptom NighttimeNyquil Cold And Flu
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
Pain
Tylenol Cold Multi-Symptom NighttimeNyquil Cold And Flu
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
Upsides and benefits
Tylenol Cold Multi-Symptom NighttimeNyquil Cold And Flu
  • Tylenol Cold Multi-Symptom Nighttime (Acetaminophen / Dextromethorphan / Doxylamine / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, watery eyes, a cough, fever, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The cough suppressant (dextromethorphan) works well and has very few side effects.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • The antihistamine (doxylamine) will help you sleep.
  • Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have watery eyes, a cough, fever, and pain.
  • The cough medicine (dextromethorphan) works well and has very few side effects.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • The antihistamine (doxylamine) will help you sleep.
Downsides and risks
Tylenol Cold Multi-Symptom NighttimeNyquil Cold And Flu
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • Phenylephrine can keep you awake and doxylamine makes you sleepy, so it could affect you either way.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
Tips from our pharmacists for people taking the medication
Tylenol Cold Multi-Symptom NighttimeNyquil Cold And Flu
  • Doxylamine (the antihistamine ingredient) can make you tired, so take it close to bedtime.
  • Avoid using alcohol and other drugs that make you drowsy.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
  • Doxylamine (the antihistamine ingredient) can make you tired, so take it close to bedtime.
  • Follow age-specific dosing instructions on how much to take. Don't take more than recommended on the package.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Avoid using alcohol and other drugs that make you drowsy.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
Learn more
More about Tylenol Cold Multi-Symptom NighttimeSide effectsAlternativesFDA package insert
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More about Nyquil Cold And FluSide effectsReviews & ratingsFDA package insert
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