Over-the-counterLower-cost generic availableClass: Respiratory

Tylenol Pm 

(acetaminophen / diphenhydramine)

Over-the-counterLower-cost generic availableClass: Respiratory
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Relieves pain and helps you sleep.

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Our bottom line

Tylenol Pm (Acetaminophen / Diphenhydramine) works well at relieving pain and also helps you sleep.

Upsides

  • Tylenol Pm (Acetaminophen / Diphenhydramine) works well when you have a cold or the flu, but can also be used for backaches, minor arthritis, and joint pain.
  • Can be used for anyone 12 years or older.
  • Isn't habit-forming like some other pain medicines and sleep aids.

Downsides

  • The antihistamine (diphenhydramine) can make you feel groggy the next morning.
  • Can increase the risk of falls, so elderly people shouldn't use it.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • Can only take one dose in 24 hours.
How it works

Tylenol Pm (Acetaminophen / Diphenhydramine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Diphenhydramine is an antihistamine that treats runny nose and watery eyes and helps you sleep.

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Side effect rates for Tylenol Pm (acetaminophen / diphenhydramine)

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These are side effects of Tylenol Pm (acetaminophen / diphenhydramine) reported to the FDA by people taking it, and by doctors and pharmacists.
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Risks and Warnings for Tylenol Pm (acetaminophen / diphenhydramine)

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    • Higher risk if:
    • History of falls
    • Age 65 or older
    • Taking other drugs that make you drowsy or dizzy

    Diphenhydramine, also known as Benadryl, is an antihistamine in Tylenol Pm (Acetaminophen / Diphenhydramine) that can make you feel dizzy or drowsy. People who are at a higher risk of falls should avoid using Tylenol Pm (Acetaminophen / Diphenhydramine).

Common concerns from people taking Tylenol Pm (acetaminophen / diphenhydramine)

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Pregnancy
Kidneys and liver
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
Pain
  • Isn't habit-forming like some other pain medicines and sleep aids.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
Sleep
  • Diphenhydramine makes you tired, so take Tylenol Pm (Acetaminophen / Diphenhydramine) before you go to sleep.
  • This can leave you drowsy unless you have a good 7-8 hours to sleep