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Tylenol Pm Alternatives

(Acetaminophen / Diphenhydramine)

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Compare Tylenol Pm (Acetaminophen / Diphenhydramine) to alternatives

These medications are comparable to Tylenol Pm (Acetaminophen / Diphenhydramine) or used for similar purposes.

Tylenol Pm
(Acetaminophen / Diphenhydramine)

Advil Pm
(Diphenhydramine / Ibuprofen)

Relieves pain and helps you sleep. Tylenol Pm (Acetaminophen / Diphenhydramine) works well at relieving pain and also helps you sleep.Relieves pain and helps you sleep. Advil Pm (Diphenhydramine / Ibuprofen) works well at relieving pain and also helps you sleep.
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Side effects
Tylenol PMAdvil PM

We haven’t found good data for Tylenol PM side effects.

FDA side effect reports for Tylenol PM »

We haven’t found good data for Advil PM side effects.

FDA side effect reports for Advil PM »
How it works
Tylenol PMAdvil PM
Tylenol Pm (Acetaminophen / Diphenhydramine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Diphenhydramine is an antihistamine that treats runny nose and watery eyes and helps you sleep.Advil Pm (Diphenhydramine / Ibuprofen) is a combination medicine that treats cold and flu symptoms. Ibuprofen is an NSAID that relieves pain and reduces fever. Diphenhydramine is an antihistamine that treats runny nose and watery eyes and helps you sleep.
Type of medication
Tylenol PMAdvil PM
Pain reliever
Acetaminophen (APAP)
Antihistamine
1st generation
Over-the-counter
Antihistamine
1st generation
Pain reliever
NSAID
Over-the-counter
Available as
Tylenol PMAdvil PM
  • Pill
  • Pill
Used for (click to learn more)
Tylenol PMAdvil PM
Risk factors for serious side effects
Tylenol PMAdvil PM
  • History of falls
  • Age 65 or older
  • Taking other drugs that make you drowsy or dizzy
  • Drinking more than 3 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • Age 65 years or older
  • Glaucoma
  • Benign prostatic hypertrophy (BPH)
Detailed Tylenol Pm (Acetaminophen / Diphenhydramine) risks & warnings »
Coming soon.
Pregnancy category
Tylenol PMAdvil PM
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
Alcohol
  • Don't take Tylenol Pm (Acetaminophen / Diphenhydramine) with alcohol or other drugs that make you sleepy.
  • Don't take Advil Pm (Diphenhydramine / Ibuprofen) with alcohol or other drugs that make you sleepy.
Food
No specific food-related info.
  • Contains ibuprofen, so take it with food to avoid stomach problems and ulcers.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.
Sex
No specific sex-related info.No specific sex-related info.
Sleep
  • Isn't habit-forming like some other pain medicines and sleep aids.
  • Diphenhydramine makes you tired, so take Tylenol Pm (Acetaminophen / Diphenhydramine) before you go to sleep.
  • Diphenhydramine, also known as Benadryl, is an antihistamine in Tylenol Pm (Acetaminophen / Diphenhydramine) that can make you feel dizzy or drowsy. People who are at a higher risk of falls should avoid using Tylenol Pm (Acetaminophen / Diphenhydramine).
  • Isn't habit-forming like some other pain medicines and sleep aids.
  • Diphenhydramine makes you tired, so take Advil Pm (Diphenhydramine / Ibuprofen) before you go to sleep.
Weight
No specific weight-related info.No specific weight-related info.
Upsides and benefits
Tylenol PMAdvil PM
  • Tylenol Pm (Acetaminophen / Diphenhydramine) works well when you have a cold or the flu, but can also be used for backaches, minor arthritis, and joint pain.
  • Can be used for anyone 12 years or older.
  • Isn't habit-forming like some other pain medicines and sleep aids.
  • Advil Pm (Diphenhydramine / Ibuprofen) works well when you have a cold or the flu, but can also be used for backaches, minor arthritis, and joint pain.
  • Can be used for anyone 12 years or older.
  • Isn't habit-forming like some other pain medicines and sleep aids.
Downsides and risks
Tylenol PMAdvil PM
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • The antihistamine (diphenhydramine) can make you feel groggy the next morning.
  • Can increase the risk of falls, so elderly people shouldn't use it.
  • Can only take one dose in 24 hours.
  • The pain reliever (ibuprofen) can interact with other medications and make health problems like stomach bleeding and ulcers worse.
  • The antihistamine (diphenhydramine) can make you feel groggy the next morning.
  • Can only take one dose in 24 hours.
  • Can increase the risk of falls, so elderly people shouldn't use it.
Tips from our pharmacists for people taking the medication
Tylenol PMAdvil PM
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Diphenhydramine makes you tired, so take Tylenol Pm (Acetaminophen / Diphenhydramine) before you go to sleep.
  • Don't take Tylenol Pm (Acetaminophen / Diphenhydramine) with alcohol or other drugs that make you sleepy.
  • Let your doctor know if your symptoms don't improve in a few days.
  • Contains ibuprofen, so take it with food to avoid stomach problems and ulcers.
  • Diphenhydramine makes you tired, so take Advil Pm (Diphenhydramine / Ibuprofen) before you go to sleep.
  • Don't take Advil Pm (Diphenhydramine / Ibuprofen) with alcohol or other drugs that make you sleepy.
  • Don't take Advil Pm (Diphenhydramine / Ibuprofen) if you're pregnant.
Learn more
More about Tylenol PMSide effectsReviews & ratingsAlternativesFDA package insert
More about Advil PMSide effectsReviews & ratingsFDA package insert