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Tylenol Sinus

(Acetaminophen / Phenylephrine)

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Relieves pain and congestion.

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Over-the-counterLower-cost generic available

Our pharmacists’ bottom line

Tylenol Sinus (Acetaminophen / Phenylephrine) is a good combination medicine to relieve pain and congestion. Be careful to not take too much acetaminophen (APAP) each day.

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  • Tylenol Sinus (Acetaminophen / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a headache, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than to other pain medications like aspirin or ibuprofen.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it is a very common ingredient in pain and cold/flu combination medicines.
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Side effects for Tylenol Sinus (Acetaminophen / Phenylephrine)

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These are side effects of Tylenol Sinus (Acetaminophen / Phenylephrine) reported to the FDA by people taking it, and by doctors and pharmacists.

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What to expect when you start Tylenol Sinus (Acetaminophen / Phenylephrine)

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Tips from our pharmacists
  • Starts working in 30 minutes.
  • Phenylephrine (the decongestant ingredient) can make you restless, so don't take it too close to bedtime.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Follow age-specific dosing instructions on how much to take.
  • Let your doctor know if your symptoms don't improve in a few days.

Risks and Warnings for Tylenol Sinus (Acetaminophen / Phenylephrine)

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    • Higher risk if:
    • Drinking more than 2 alcoholic beverages a day
    • Taking with other Tylenol-containing medicines
    • History of liver disease

    Tylenol Sinus (Acetaminophen / Phenylephrine) contains acetaminophen, also known as Tylenol or APAP, and is a common ingredient in many other over-the-counter medicines. Taking too much acetaminophen causes liver damage that can be permanent and life-threatening. In case of an overdose, call your local Poison Control Center and get medical attention immediately.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Tylenol Sinus (Acetaminophen / Phenylephrine)

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The FDA category for this medication is N. It is advised that you: Unknown