Over-the-counterLower-cost generic availableClass: Respiratory

Tylenol Sinus Alternatives

(Acetaminophen / Phenylephrine)

Over-the-counterLower-cost generic availableClass: Respiratory
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Compare Tylenol Sinus (Acetaminophen / Phenylephrine) to alternatives

These medications are comparable to Tylenol Sinus (Acetaminophen / Phenylephrine) or used for similar purposes.

Tylenol Sinus
(Acetaminophen / Phenylephrine)

Advil Congestion Relief
(Ibuprofen / Phenylephrine)

Zyrtec D
(Cetirizine / Pseudoephedrine)

Sudafed
(Pseudoephedrine)

Allegra D
(Pseudoephedrine / Fexofenadine)

Advil Allergy And Congestion Relief
(Chlorpheniramine / Ibuprofen / Phenylephrine)

Benadryl
(Diphenhydramine)

Sudafed Pe
(Phenylephrine)

Nyquil Cold And Flu
(Acetaminophen / Dextromethorphan / Doxylamine)

Advil Cold And Sinus
(Ibuprofen / Pseudoephedrine)

Relieves pain and congestion. Tylenol Sinus (Acetaminophen / Phenylephrine) is a good combination medicine to relieve pain and congestion. Be careful to not take too much acetaminophen (APAP) each day.Relieves pain and congestion. Advil Congestion Relief (Ibuprofen / Phenylephrine) is a good combination medicine to relieve pain and congestion, but it's more medicine than you need if you only have one symptom.Relieves congestion and allergy symptoms. Zyrtec D (Cetirizine / Pseudoephedrine) relieves allergies and congestion without causing daytime sleepiness. It can keep you up at night if you take it too close to bedtime.Clears your sinuses. Sudafed (Pseudoephedrine) relieves stuffy nose, but it could keep you up at night. Don't forget your photo ID or you won't be able to buy it in the drugstore.Treats allergy symptoms and congestion. Allegra D (Pseudoephedrine / Fexofenadine) is a combination allergy medicine that's useful if you have congestion and runny nose.Relieves cold and allergy symptoms. Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine) is an okay combination medicine to relieve pain and congestion. The antihistamine can make you sleepy and the decongestant can keep you awake, so it could affect you either way.Treats allergy symptoms and helps you sleep. Benadryl (Diphenhydramine) is great for allergies, but curl up on the couch after taking it and get ready for a nap.Clears your sinuses. Sudafed Pe (Phenylephrine) is a good medication for relieving stuffy nose. It doesn't work as well as pseudoephedrine (Sudafed), but it has fewer side effects.Relieves cold and flu symptoms, and helps you sleep. Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a useful combination medicine that relieves cold and flu symptoms and will help you sleep. Make sure you really need all of its ingredients.Relieves sinus pain and congestion. Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) is a good combination medicine to relieve pain and congestion, but it's more medicine than you need if you only have one symptom.
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Reviews & ratings
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4.92Tylenol Sinus
Reviews for Tylenol Sinus (Acetaminophen / Phenylephrine)
74%
of people (All ages) say Tylenol Sinus (Acetaminophen / Phenylephrine) is worth it
31%
say it works well
5%
say it's a big hassle
1176 reviews
Have you used Tylenol Sinus (Acetaminophen / Phenylephrine)?
Worth itNot sureNot worth it
Reviews for Advil Congestion Relief (Ibuprofen / Phenylephrine)
73%
-1% worse vs. Tylenol Sinus (Acetaminophen / Phenylephrine)
32%
+1% better vs. Tylenol Sinus (Acetaminophen / Phenylephrine)
7%
-2% worse vs. Tylenol Sinus (Acetaminophen / Phenylephrine)
1125 reviews
Have you used Advil Congestion Relief (Ibuprofen / Phenylephrine)?
Worth itNot sureNot worth it
Reviews for Zyrtec D (Cetirizine / Pseudoephedrine)
75%
+1% better vs. Tylenol Sinus (Acetaminophen / Phenylephrine)
43%
+12% better vs. Tylenol Sinus (Acetaminophen / Phenylephrine)
9%
-4% worse vs. Tylenol Sinus (Acetaminophen / Phenylephrine)
927 reviews
Have you used Zyrtec D (Cetirizine / Pseudoephedrine)?
Worth itNot sureNot worth it
Reviews for Sudafed (Pseudoephedrine)
82%
+8% better vs. Tylenol Sinus (Acetaminophen / Phenylephrine)
45%
+14% better vs. Tylenol Sinus (Acetaminophen / Phenylephrine)
6%
-1% worse vs. Tylenol Sinus (Acetaminophen / Phenylephrine)
1740 reviews
Have you used Sudafed (Pseudoephedrine)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Allegra D (Pseudoephedrine / Fexofenadine)?
Worth itNot sureNot worth it
Reviews for Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine)
73%
-1% worse vs. Tylenol Sinus (Acetaminophen / Phenylephrine)
30%
-1% worse vs. Tylenol Sinus (Acetaminophen / Phenylephrine)
6%
-1% worse vs. Tylenol Sinus (Acetaminophen / Phenylephrine)
1437 reviews
Have you used Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine)?
Worth itNot sureNot worth it
Reviews for Benadryl (Diphenhydramine)
86%
+12% better vs. Tylenol Sinus (Acetaminophen / Phenylephrine)
59%
+28% better vs. Tylenol Sinus (Acetaminophen / Phenylephrine)
8%
-3% worse vs. Tylenol Sinus (Acetaminophen / Phenylephrine)
294 reviews
Have you used Benadryl (Diphenhydramine)?
Worth itNot sureNot worth it
Reviews for Sudafed Pe (Phenylephrine)
44%
-30% worse vs. Tylenol Sinus (Acetaminophen / Phenylephrine)
24%
-7% worse vs. Tylenol Sinus (Acetaminophen / Phenylephrine)
10%
-5% worse vs. Tylenol Sinus (Acetaminophen / Phenylephrine)
164 reviews
Have you used Sudafed Pe (Phenylephrine)?
Worth itNot sureNot worth it
Reviews for Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine)
83%
+9% better vs. Tylenol Sinus (Acetaminophen / Phenylephrine)
42%
+11% better vs. Tylenol Sinus (Acetaminophen / Phenylephrine)
7%
-2% worse vs. Tylenol Sinus (Acetaminophen / Phenylephrine)
1188 reviews
Have you used Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine)?
Worth itNot sureNot worth it
Reviews for Advil Cold And Sinus (Ibuprofen / Pseudoephedrine)
75%
+1% better vs. Tylenol Sinus (Acetaminophen / Phenylephrine)
34%
+3% better vs. Tylenol Sinus (Acetaminophen / Phenylephrine)
6%
-1% worse vs. Tylenol Sinus (Acetaminophen / Phenylephrine)
1464 reviews
Have you used Advil Cold And Sinus (Ibuprofen / Pseudoephedrine)?
Worth itNot sureNot worth it
Side effects
Tylenol SinusAdvil Congestion ReliefZyrtec DSudafedAllegra DAdvil Allergy And Congestion ReliefBenadrylPhenylephrineNyquil Cold And FluAdvil Cold And Sinus

We haven’t found good data for Tylenol Sinus side effects.

FDA side effect reports for Tylenol Sinus »

We haven’t found good data for Advil Congestion Relief side effects.

FDA side effect reports for Advil Congestion Relief »

We haven’t found good data for Zyrtec D side effects.

FDA side effect reports for Zyrtec D »

We haven’t found good data for Sudafed side effects.

FDA side effect reports for Sudafed »
  • Headache 3%
  • Back pain 2%
  • Sleep difficulty 13%
  • Nausea 7%
  • Adverse effects 4%
  • Indigestion 3%
  • Dry mouth 3%
  • Dizziness 2%
  • Agitation 2%
More Allegra D side effects »

We haven’t found good data for Advil Allergy And Congestion Relief side effects.

FDA side effect reports for Advil Allergy And Congestion Relief »

We haven’t found good data for Benadryl side effects.

FDA side effect reports for Benadryl »

We haven’t found good data for Phenylephrine side effects.

FDA side effect reports for Phenylephrine »

We haven’t found good data for Nyquil Cold And Flu side effects.

FDA side effect reports for Nyquil Cold And Flu »

We haven’t found good data for Advil Cold And Sinus side effects.

FDA side effect reports for Advil Cold And Sinus »
How it works
Tylenol SinusAdvil Congestion ReliefZyrtec DSudafedAllegra DAdvil Allergy And Congestion ReliefBenadrylPhenylephrineNyquil Cold And FluAdvil Cold And Sinus
Tylenol Sinus (Acetaminophen / Phenylephrine) is a combination medicine that treats cold and allergy symptoms. Acetaminophen relieves pain and reduces fever. Phenylephrine is a decongestant that clears your sinuses.Advil Congestion Relief (Ibuprofen / Phenylephrine) is a combination medicine that treats cold and allergy symptoms. Ibuprofen is an NSAID that relieves swelling, pain, and fever. Phenylephrine is a decongestant that clears your sinuses.Zyrtec D (Cetirizine / Pseudoephedrine) is a combination medicine for allergies. Cetirizine (an antihistamine) prevents allergy symptoms like runny nose, sneezing, and itchy eyes or skin. Pseudoephedrine (a decongestant) clears your sinuses.Sudafed (Pseudoephedrine) is a decongestant. It narrows blood vessels and reduces swelling in your nasal passages to make breathing easier.Allegra D (Pseudoephedrine / Fexofenadine) is a combination medicine that relieves allergy symptoms. Fexofenadine (an antihistamine) prevents allergy symptoms like runny nose, sneezing, and itching. Pseudoephedrine (a decongestant) clears your sinuses.Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine) is a combination medicine that treats cold and allergy symptoms. Ibuprofen is an NSAID that relieves swelling, pain, and fever. Chlorpheniramine is an antihistamine that treats runny nose and watery eyes. Phenylephrine is a decongestant that clears your sinuses.Benadryl (Diphenhydramine) is an antihistamine. It blocks histamine, a chemical that causes congestion, itching, and other allergic reactions. It also makes you sleepy.Sudafed Pe (Phenylephrine) is a decongestant. It narrows blood vessels and reduces swelling in your nasal passages to make breathing easier.Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Doxylamine is an antihistamine that relieves a runny nose and makes you very sleepy.Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) is a combination medicine that relieves cold symptoms and sinus pressure. Ibuprofen (an NSAID) relieves pain and reduces fever. Pseudoephedrine (a decongestant) clears your sinuses.
Type of medication
Tylenol SinusAdvil Congestion ReliefZyrtec DSudafedAllegra DAdvil Allergy And Congestion ReliefBenadrylPhenylephrineNyquil Cold And FluAdvil Cold And Sinus
Over-the-counter
Over-the-counter
Prescription or OTC
Prescription or OTC
Prescription or OTC
Over-the-counter
Prescription or OTC
Prescription or OTC
Over-the-counter
Over-the-counter
Available as
Tylenol SinusAdvil Congestion ReliefZyrtec DSudafedAllegra DAdvil Allergy And Congestion ReliefBenadrylPhenylephrineNyquil Cold And FluAdvil Cold And Sinus
  • Pill
  • Pill
  • Extended release
  • Pill
  • Extended release
  • Liquid
  • Extended release
  • Pill
  • Pill
  • Oral solution
  • Cream, gel, or ointment
  • Pill
  • Nasal spray
  • Eye drops
  • Suppository
  • Pill
  • Liquid
  • Pill
Used for
Tylenol SinusAdvil Congestion ReliefZyrtec DSudafedAllegra DAdvil Allergy And Congestion ReliefBenadrylPhenylephrineNyquil Cold And FluAdvil Cold And Sinus
Risk factors for serious side effects
Tylenol SinusAdvil Congestion ReliefZyrtec DSudafedAllegra DAdvil Allergy And Congestion ReliefBenadrylPhenylephrineNyquil Cold And FluAdvil Cold And Sinus
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • History of high blood pressure
  • Taking MAO inhibitors
  • Women of childbearing age
Detailed Tylenol Sinus (Acetaminophen / Phenylephrine) risks & warnings »
  • History of stomach bleeding or ulcers
  • Age 60 years or older
  • Taking aspirin, NSAIDs, or blood thinners
  • Drinking more than 3 alcoholic beverages a day
  • Women of childbearing age
  • History of high blood pressure
  • Kidney disease
  • Heart failure
  • Liver disease
  • Taking high blood pressure medications
  • Age 65 years or older
  • History of heart problems
  • Age 65 years or older
  • Taking with aspirin
Detailed Advil Congestion Relief (Ibuprofen / Phenylephrine) risks & warnings »
  • History of high blood pressure
  • History of heart problems
  • Age 65 or older
  • History of seizure
  • Women of childbearing age
    • Age 65 years or older
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • Current kidney disease
    • Current liver disease
    Detailed Zyrtec D (Cetirizine / Pseudoephedrine) risks & warnings »
    • History of high blood pressure
    • History of heart problems
    • Age 65 years or older
    • History of seizures
    • Women of childbearing age
    Detailed Sudafed (Pseudoephedrine) risks & warnings »
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • History of high blood pressure
    • History of heart problems
    • Age 65 or older
    • History of seizure
    • Women of childbearing age
    Detailed Allegra D (Pseudoephedrine / Fexofenadine) risks & warnings »
    • History of stomach bleeding or ulcers
    • Age 60 years or older
    • Taking aspirin, NSAIDs, or blood thinners
    • Drinking more than 3 alcoholic beverages a day
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • Women of childbearing age
    • Kidney disease
    • Heart failure
    • Liver disease
    • Taking high blood pressure medications
    • Age 65 years or older
    • History of high blood pressure
    • History of heart problems
    • Age 65 years or older
    • Taking with aspirin
    Detailed Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine) risks & warnings »
    • Using other drugs with the same ingredients
    • Age 65 years or older
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • Children age 6 years and younger
    • Enlarged prostate
    • History of bladder problems
    • Glaucoma
    • Nursing mothers
    Detailed Benadryl (Diphenhydramine) risks & warnings »
    • History of high blood pressure
    • Taking MAO inhibitors
    • History of heart problems
    • Age 65 years or older
    • Women of childbearing age
    Detailed Sudafed Pe (Phenylephrine) risks & warnings »
    • Drinking more than 2 alcoholic beverages a day
    • Taking with other Tylenol-containing medicines
    • History of liver disease
    • Using other medications that affect serotonin
    • Taking with alcohol
    • Taking with other medicines that make you less alert
    • Age 65 years or older
    • Glaucoma
    • Benign prostatic hypertrophy (BPH)
    Detailed Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) risks & warnings »
    • History of stomach bleeding or ulcers
    • Age 60 years or older
    • Taking aspirin, NSAIDs, or blood thinners
    • Drinking more than 3 alcoholic beverages a day
    • Women of childbearing age
    • History of high blood pressure
    • Kidney disease
    • Heart failure
    • Liver disease
    • Taking high blood pressure medications
    • Age 65 years or older
    • History of heart problems
    • Age 65 years or older
    • Taking with aspirin
    Detailed Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) risks & warnings »
    Pregnancy

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    Interactions
    Tylenol SinusAdvil Congestion ReliefZyrtec DSudafedAllegra DAdvil Allergy And Congestion ReliefBenadrylPhenylephrineNyquil Cold And FluAdvil Cold And Sinus
    No interactions related info.
    • The pain reliever (ibuprofen) can interact with other medications and make health problems like stomach bleeding and ulcers worse.
    No interactions related info.No interactions related info.No interactions related info.
    • The pain reliever (ibuprofen) can interact with other medications and make health problems like stomach bleeding and ulcers worse.
    No interactions related info.No interactions related info.No interactions related info.
    • The pain reliever (ibuprofen) can interact with other medications and make health problems like stomach bleeding and ulcers worse.
    Alcohol
    Tylenol SinusAdvil Congestion ReliefZyrtec DSudafedAllegra DAdvil Allergy And Congestion ReliefBenadrylPhenylephrineNyquil Cold And FluAdvil Cold And Sinus
    No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.
    • While taking this, avoid alcohol and other drugs that make you drowsy.
    • Don't take it with alcohol or other drugs that make you sleepy.
    No alcohol related info.
    • Avoid using alcohol and other drugs that make you drowsy.
    No alcohol related info.
    Kidneys and liver
    Tylenol SinusAdvil Congestion ReliefZyrtec DSudafedAllegra DAdvil Allergy And Congestion ReliefBenadrylPhenylephrineNyquil Cold And FluAdvil Cold And Sinus
    • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it is a very common ingredient in pain and cold/flu combination medicines.
    • Advil Congestion Relief (Ibuprofen / Phenylephrine) contains ibuprofen, an NSAID that can lower kidney function or cause damage. Taking the lowest dose for the shortest amount of time lowers your risk. Your doctor should check your kidney function if you take Advil Congestion Relief (Ibuprofen / Phenylephrine) for any amount of time.
    • People with kidney or liver disease may need to take a lower dose of Zyrtec D (Cetirizine / Pseudoephedrine) to prevent overdose. Talk with your doctor to be sure you are using the correct dose.
    No kidneys and liver related info.No kidneys and liver related info.
    • Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine) contains ibuprofen, an NSAID that can lower kidney function or cause damage. Taking the lowest dose for the shortest amount of time lowers your risk. Your doctor should check your kidney function if you take Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine) for any amount of time.
    No kidneys and liver related info.No kidneys and liver related info.
    • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
    • Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) contains ibuprofen, an NSAID that can lower kidney function or cause damage. Taking the lowest dose for the shortest amount of time lowers your risk. Your doctor should check your kidney function if you take Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) for any amount of time.
    Pain
    Tylenol SinusAdvil Congestion ReliefZyrtec DSudafedAllegra DAdvil Allergy And Congestion ReliefBenadrylPhenylephrineNyquil Cold And FluAdvil Cold And Sinus
    • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than to other pain medications like aspirin or ibuprofen.
    • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it is a very common ingredient in pain and cold/flu combination medicines.
    • The pain reliever (ibuprofen) can interact with other medications and make health problems like stomach bleeding and ulcers worse.
    No pain related info.No pain related info.No pain related info.
    • The pain reliever (ibuprofen) can interact with other medications and make health problems like stomach bleeding and ulcers worse.
    No pain related info.No pain related info.
    • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
    • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
    • The pain reliever (ibuprofen) can interact with other medications and make health problems like stomach bleeding and ulcers worse.
    Sleep
    Tylenol SinusAdvil Congestion ReliefZyrtec DSudafedAllegra DAdvil Allergy And Congestion ReliefBenadrylPhenylephrineNyquil Cold And FluAdvil Cold And Sinus
    No sleep related info.No sleep related info.
    • The antihistamine (Cetirizine) in Zyrtec D (Cetirizine / Pseudoephedrine) causes less drowsiness than other medications like Benadryl.
    • The antihistamine (Cetirizine) can cause more drowsiness than similar antihistamines, like Allegra D (which contains Fexofenadine) and Claritin D (which contains Loratadine).
    • You might not sleep as well due to Pseudoephedrine's effects and you can also have strange dreams while taking it.
    • It can affect the quality of your sleep, so you can't take it too close to going to bed.
    • The antihistamine (fexofenadine) can cause dizziness, drowsiness, dry eyes/mouth, and constipation.
    No sleep related info.
    • Benadryl (Diphenhydramine) makes you more tired than Claritin, Allegra, or Zyrtec.
    • Benadryl (Diphenhydramine) makes you tired, so take it before you go to sleep.
    No sleep related info.No sleep related info.No sleep related info.
    Upsides and benefits
    Tylenol SinusAdvil Congestion ReliefZyrtec DSudafedAllegra DAdvil Allergy And Congestion ReliefBenadrylPhenylephrineNyquil Cold And FluAdvil Cold And Sinus
    • Tylenol Sinus (Acetaminophen / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a headache, and pain.
    • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
    • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than to other pain medications like aspirin or ibuprofen.
    • Advil Congestion Relief (Ibuprofen / Phenylephrine) is a combination medicine that relieves multiple cold and allergy symptoms. It's good to use if you have a stuffy nose, sinus pressure, and pain.
    • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
    • The antihistamine (Cetirizine) in Zyrtec D (Cetirizine / Pseudoephedrine) causes less drowsiness than other medications like Benadryl.
    • The decongestant (Pseudoephedrine) in Zyrtec D (Cetirizine / Pseudoephedrine) is stronger than other decongestants. It can also help relieve congestion-related headaches and ear pressure.
    • The stimulant effects of Pseudoephedrine can give you some extra energy during the day.
    • Doesn't give you rebound congestion (worse congestion symptoms after you stop taking the medicine) like decongestant nose sprays can.
    • It's available without a prescription, unlike other strong allergy medicines.
    • One of the best over-the-counter options to clear stuffy nose and help you breathe better.
    • Clears nasal congestion better than other decongestants like phenylephrine.
    • Can be helpful in relieving congestion-related headaches and pressure in your ears.
    • Available in regular and extended release forms.
    • Available without a prescription in the drugstore.
    • It has two medications that work in different ways to help relieve nasal symptoms.
    • The antihistamine (fexofenadine) is useful for relieving itchy eyes, runny nose, or constant sneezing.
    • The decongestant (pseudoephedrine) is very good at relieving congestion.
    • Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine) is a combination medicine that relieves multiple cold and allergy symptoms. It's good to use if you have a stuffy nose, sinus pressure, and pain.
    • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
    • Benadryl (Diphenhydramine) is often better than other antihistamines at treating allergy symptoms and hives.
    • It can provide quick relief of allergy symptoms for both kids and adults.
    • It makes you sleepy, so it'll help if your allergies are bothering you at night.
    • The effects wear off in 4 to 6 hours, so side effects don't last that long.
    • It comes as a tablet, capsule, liquid, and quick dissolving tablet.
    • Works to clear nasal congestion and helps you breathe better.
    • Helpful in relieving congestion-related headaches.
    • Has fewer side effects than other decongestants like pseudoephedrine.
    • It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
    • Doesn't give you rebound congestion (worse symptoms when you stop taking it) like nasal spray decongestants do.
    • Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have watery eyes, a cough, fever, and pain.
    • The cough medicine (dextromethorphan) works well and has very few side effects.
    • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
    • The antihistamine (doxylamine) will help you sleep.
    • Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) is a combination medicine that relieves cold symptoms. It's good to use if you have congestion, sore throat, headache, or fever.
    • Ibuprofen (a pain reliever) is more effective than acetaminophen at lowering fever and relieving sinus pain.
    • Pseudoephedrine (a decongestant) clears nose congestion to help you breathe better.
    Downsides and risks
    Tylenol SinusAdvil Congestion ReliefZyrtec DSudafedAllegra DAdvil Allergy And Congestion ReliefBenadrylPhenylephrineNyquil Cold And FluAdvil Cold And Sinus
    • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
    • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
    • You shouldn't use it if you have high blood pressure.
    • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it is a very common ingredient in pain and cold/flu combination medicines.
    • If you don't really need both of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
    • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
    • You shouldn't use it if you have high blood pressure.
    • The pain reliever (ibuprofen) can interact with other medications and make health problems like stomach bleeding and ulcers worse.
    • It's not safe to take ibuprofen if you're pregnant since it increases the risk of heart defects in babies.
    • You can have more side effects when using combination pills than when using single-ingredient medications.
    • The antihistamine (Cetirizine) can cause more drowsiness than similar antihistamines, like Allegra D (which contains Fexofenadine) and Claritin D (which contains Loratadine).
    • The decongestant (Pseudoephedrine) can make your heart race or give you anxious or restless feelings.
    • You might not sleep as well due to Pseudoephedrine's effects and you can also have strange dreams while taking it.
    • Pseudoephedrine can raise your blood pressure, so don't take it if you have high blood pressure or other heart conditions.
    • Although you don't need a prescription, you do need to show a photo ID to buy this from behind the pharmacy counter.
    • Pseudoephedrine (a decongestant) can make your heart race or make you feel anxious and restless.
    • It can affect the quality of your sleep, so you can't take it too close to going to bed.
    • Can raise blood pressure so check with your doctor before using it if you have high blood pressure or other heart conditions.
    • Sudafed (Pseudoephedrine) isn't as effective after using it for more than 4 days straight.
    • Need to show a photo ID to buy it in the drugstore and there is a limit on how much you can buy each visit.
    • Has more side effects than Allegra since it has pseudoephedrine in it.
    • The antihistamine (fexofenadine) can cause dizziness, drowsiness, dry eyes/mouth, and constipation.
    • The decongestant (pseudoephedrine) can make your blood pressure higher and can make it harder to sleep.
    • You must show a photo ID to buy this from behind the pharmacy counter. There's a maximum limit on how much you can buy in the pharmacy at a time.
    • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
    • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
    • You shouldn't use it if you have high blood pressure.
    • The pain reliever (ibuprofen) can interact with other medications and make health problems like stomach bleeding and ulcers worse.
    • It's not safe to take ibuprofen if you're pregnant since it increases the risk of heart defects in babies.
    • Benadryl (Diphenhydramine) makes you more tired than Claritin, Allegra, or Zyrtec.
    • You shouldn't drive after taking Benadryl (Diphenhydramine) until you know how it affects you.
    • Talk to a pediatrician before giving Benadryl (Diphenhydramine) to a child.
    • It can increase the risk of falls, so elderly people shouldn't use Benadryl (Diphenhydramine).
    • Don't use Benadryl (Diphenhydramine) if you are breastfeeding.
    • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine (Sudafed).
    • You shouldn't use it if you have high blood pressure.
    • Can make your heart race or make you feel anxious and restless.
    • Shouldn't use it before you want to sleep.
    • Not as effective after using it for 4 days in a row.
    • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
    • You shouldn't use it if you have high blood pressure.
    • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
    • If you don't need both of the medications in this combination, you'd be taking extra medicine and can have extra side effects for no reason.
    • The pain reliever (ibuprofen) can interact with other medications and make health problems like stomach bleeding and ulcers worse.
    • It's not safe to take ibuprofen if you're pregnant since it increases the risk of heart defects in babies.
    • Pseudoephedrine, the decongestant in Advil Cold And Sinus (Ibuprofen / Pseudoephedrine), can make your heart race or make you feel anxious and restless.
    Tips from our pharmacists for people taking the medication
    Tylenol SinusAdvil Congestion ReliefZyrtec DSudafedAllegra DAdvil Allergy And Congestion ReliefBenadrylPhenylephrineNyquil Cold And FluAdvil Cold And Sinus
    • Starts working in 30 minutes.
    • Phenylephrine (the decongestant ingredient) can make you restless, so don't take it too close to bedtime.
    • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
    • Follow age-specific dosing instructions on how much to take.
    • Let your doctor know if your symptoms don't improve in a few days.
    • Starts working in 30 minutes.
    • Don't take it if you have an allergy to aspirin since ibuprofen can cause a similar reaction.
    • Phenylephrine (the decongestant ingredient) can make you restless, so don't take it too close to bedtime.
    • Follow age-specific dosing instructions on how much to take. Don't take more than what's recommended on the package.
    • Let your doctor know if your symptoms don't improve in a few days.
    • Starts working in 30 minutes.
    • You need to show an ID to buy Zyrtec D (Cetirizine / Pseudoephedrine) in the drugstore because it contains Pseudoephedrine.
    • Don't cut, crush, or chew tablets; swallow them whole.
    • It's better to take Zyrtec D (Cetirizine / Pseudoephedrine) early in the morning or when you wake up, otherwise you can have trouble sleeping later.
    • Can cause an irregular or fast heartbeat, and can raise your blood pressure.
    • If you need to use it for more than a few weeks, talk with your doctor since a different medication might work better for you.
    • Starts working in 30 minutes.
    • You need to show an ID to buy Sudafed (Pseudoephedrine) in the drugstore because it contains pseudoephedrine.
    • Follow age-specific dosing instructions on how much to take. Don't take more than recommended on the package.
    • Don't take Sudafed (Pseudoephedrine) too close to bedtime since it can keep you awake.
    • Can cause an irregular or fast heartbeat, and can raise your blood pressure.
    • Talk to your doctor if your symptoms don't get better in 1 week.
    • It works best if you have nasal congestion and a runny nose.
    • Take on an empty stomach, 1 hour before eating or 2 hours after eating.
    • Shouldn't be used in kids younger than 12 years old.
    • Avoid taking it close to bedtime to prevent trouble sleeping.
    • Can cause dizziness, headache, or a fast heartbeat.
    • Talk to your doctor if you have high blood pressure or kidney problems before using it.
    • If symptoms get worse or you need to use it for more than a few weeks, talk with your doctor.
    • Don't take it if you have an allergy to aspirin since ibuprofen can cause a similar reaction.
    • Chlorpheniramine (the antihistamine ingredient in Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine)) can make you sleepy, so avoid activities that require you to be fully alert until you know how it affects you.
    • While taking this, avoid alcohol and other drugs that make you drowsy.
    • Phenylephrine (the decongestant ingredient) can make you restless, so don't take it too close to bedtime.
    • Let your doctor know if your symptoms don't improve in a few days.
    • Don't use in kids age 12 years or younger.
    • Take it as needed every 4 to 6 hours.
    • Benadryl (Diphenhydramine) can make you dehydrated, so avoid this side effect by drinking plenty of fluids.
    • Benadryl (Diphenhydramine) makes you tired, so take it before you go to sleep.
    • Don't take it with alcohol or other drugs that make you sleepy.
    • If you need to use it for more than a few weeks, talk with your doctor. A different medication might work better for you long-term.
    • If you only have itchy or watery eyes, try using just an antihistamine eye drop.
    • Starts working in 30 minutes.
    • Phenylephrine can make you restless, so don't take it too close to bedtime.
    • It's in other cold and flu combination medicines. Read labels closely so you don't accidentally double up and take too much of it in a day.
    • Follow age-specific dosing instructions on how much to take.
    • Let your doctor know if your symptoms don't improve in a few days.
    • Doxylamine (the antihistamine ingredient) can make you tired, so take it close to bedtime.
    • Follow age-specific dosing instructions on how much to take. Don't take more than recommended on the package.
    • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
    • Avoid using alcohol and other drugs that make you drowsy.
    • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
    • Starts working in 30 minutes.
    • You need to show an ID to buy Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) in the drugstore because it contains pseudoephedrine.
    • Don't take it if you have an allergy to aspirin since ibuprofen can cause a similar reaction.
    • Take it after eating to avoid getting an upset stomach.
    • Can cause an irregular or fast heartbeat, and can raise your blood pressure.
    • Be careful taking Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) if you have a history of bleeding problems or ulcers since it can make them worse.
    • Talk to your doctor if symptoms don't get better in 1 week.
    Learn more
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