Over-the-counterLower-cost generic available

Tylenol Regular Strength Alternatives

(Acetaminophen)

Over-the-counterLower-cost generic available
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Compare Tylenol Regular Strength (Acetaminophen) to alternatives

These medications are comparable to Tylenol Regular Strength (Acetaminophen) or used for similar purposes.

Tylenol Regular Strength
(Acetaminophen)

Mobic
(Meloxicam)

Lodine
(Etodolac)

Aleve
(Naproxen)

Relafen
(Nabumetone)

Aspirin

Tylenol #3
(Acetaminophen / Codeine)

Zorvolex
(Diclofenac)

Celebrex
(Celecoxib)

Advil
(Ibuprofen)

Relieves pain and fever. Tylenol Regular Strength (Acetaminophen) reduces fever and relieves pain well, but it doesn't lower inflammation and swelling.Relieves pain and inflammation. Mobic (Meloxicam) works well for treating pain and causes less upset stomach than other NSAIDs.Coming soon.Relieves pain, fever, and inflammation. Aleve (Naproxen) works well for mild to moderate pain and inflammation, and it lasts longer than other NSAIDs.Coming soon.Relieves pain, fever, and inflammation. Protects your heart and thins blood. A low dose of Aspirin (81mg) every day can protect your heart, but it's not the best medicine to take for pain, swelling, or fever.Treats mild to moderate pain. Tylenol #3 (Acetaminophen / Codeine) is a good option to treat pain and cough as needed when over-the-counter medicines can't control the symptoms, but must make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.Treats arthritis pain and swelling. Zorvolex (Diclofenac) is an okay medication used to treat pain and swelling caused by arthritis. However, because of the risk of heart attack, you should limit the amount you take.Relieves pain and inflammation. Celebrex (Celecoxib) works well for treating pain and causes less upset stomach than other NSAIDs.Relieves pain, fever, and inflammation. Advil (Ibuprofen) works well for mild to moderate pain and inflammation, but it doesn't last as long as other NSAIDs.
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Reviews & ratings
Filter group. All currently selected
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5.019019019019019Tylenol
Reviews for Tylenol Regular Strength (Acetaminophen)
77%
of people (All ages) say Tylenol Regular Strength (Acetaminophen) is worth it
37%
say it works well
3%
say it's a big hassle
999 reviews
Have you used Tylenol Regular Strength (Acetaminophen)?
Worth itNot sureNot worth it
Reviews for Mobic (Meloxicam)
56%
21% vs. Tylenol Regular Strength (Acetaminophen)
48%
+11% vs. Tylenol Regular Strength (Acetaminophen)
16%
13% vs. Tylenol Regular Strength (Acetaminophen)
103 reviews
Have you used Mobic (Meloxicam)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Lodine (Etodolac)?
Worth itNot sureNot worth it
Reviews for Aleve (Naproxen)
78%
+1% vs. Tylenol Regular Strength (Acetaminophen)
46%
+9% vs. Tylenol Regular Strength (Acetaminophen)
5%
2% vs. Tylenol Regular Strength (Acetaminophen)
937 reviews
Have you used Aleve (Naproxen)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Relafen (Nabumetone)?
Worth itNot sureNot worth it
Reviews for Aspirin
76%
1% vs. Tylenol Regular Strength (Acetaminophen)
41%
+4% vs. Tylenol Regular Strength (Acetaminophen)
6%
3% vs. Tylenol Regular Strength (Acetaminophen)
532 reviews
Have you used Aspirin?
Worth itNot sureNot worth it
Reviews for Tylenol #3 (Acetaminophen / Codeine)
70%
7% vs. Tylenol Regular Strength (Acetaminophen)
41%
+4% vs. Tylenol Regular Strength (Acetaminophen)
9%
6% vs. Tylenol Regular Strength (Acetaminophen)
558 reviews
Have you used Tylenol #3 (Acetaminophen / Codeine)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Zorvolex (Diclofenac)?
Worth itNot sureNot worth it
Reviews for Celebrex (Celecoxib)
56%
21% vs. Tylenol Regular Strength (Acetaminophen)
36%
1% vs. Tylenol Regular Strength (Acetaminophen)
13%
10% vs. Tylenol Regular Strength (Acetaminophen)
529 reviews
Have you used Celebrex (Celecoxib)?
Worth itNot sureNot worth it
Reviews for Advil (Ibuprofen)
88%
+11% vs. Tylenol Regular Strength (Acetaminophen)
51%
+14% vs. Tylenol Regular Strength (Acetaminophen)
4%
1% vs. Tylenol Regular Strength (Acetaminophen)
865 reviews
Have you used Advil (Ibuprofen)?
Worth itNot sureNot worth it
Side effects
TylenolMeloxicamLodineNaproxenRelafenAspirinAcetaminophen With CodeineDiclofenacCelebrexIbuprofen

We haven’t found good data for Tylenol side effects.

FDA side effect reports for Tylenol »
  • Gastrointestinal disorders 5%
  • Diarrhea 4%
  • Infection and infestations 3%
  • Accident household 3%
  • Swelling due to excess fluid 2%
  • Dyspeptic signs and symptoms 2%
  • Sore throat 2%
  • Dizziness 1%
  • Flu-like symptomsa-like symptoms 1%
More Meloxicam side effects »

We haven’t found good data for Lodine side effects.

FDA side effect reports for Lodine »

The Naproxen FDA package insert doesn’t have numbers about how common side effects are.

More about Naproxen side effects »

We haven’t found good data for Relafen side effects.

FDA side effect reports for Relafen »

We haven’t found good data for Aspirin side effects.

FDA side effect reports for Aspirin »

The Acetaminophen With Codeine FDA package insert doesn’t have numbers about how common side effects are.

More about Acetaminophen With Codeine side effects »
  • Constipation 4%
  • Diarrhea 3%
  • Abdominal pain upper 2%
  • Pain in extremity 2%
  • Itching 1%
  • Swelling due to excess fluid 1%
  • Passing gas 1%
More Diclofenac side effects »

We haven’t found good data for Celebrex side effects.

FDA side effect reports for Celebrex »

We haven’t found good data for Ibuprofen side effects.

FDA side effect reports for Ibuprofen »
How it works
TylenolMeloxicamLodineNaproxenRelafenAspirinAcetaminophen With CodeineDiclofenacCelebrexIbuprofen
Tylenol Regular Strength (Acetaminophen) reduces fever and relieves pain, but doesn't lower inflammation and swelling.Mobic (Meloxicam) is a non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain.Coming soon.Aleve (Naproxen) is a non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain.Coming soon.Aspirin is a salicylate and non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain. It also prevents blood platelets from forming clots, which thins your blood.Tylenol #3 (Acetaminophen / Codeine) is a combination pain medicine. Codeine is an opioid (similar to morphine) that works in the brain to lower pain perception. Acetaminophen is a non-opioid pain reliever and fever reducer.Zorvolex (Diclofenac) is a non-steroidal anti-inflammatory drug (NSAID). It stops your body from making chemicals that cause inflammation and pain.Celebrex (Celecoxib) is a non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain.Advil (Ibuprofen) is a non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain.
Type of medication
TylenolMeloxicamLodineNaproxenRelafenAspirinAcetaminophen With CodeineDiclofenacCelebrexIbuprofen
Pain reliever
Acetaminophen (APAP)
Over-the-counter
Pain reliever
Nonsteroidal anti-inflammatory drug (NSAID)
Prescription only
Coming soon.
Pain reliever
Nonsteroidal anti-inflammatory drug (NSAID)
Prescription or OTC
Coming soon.
Pain reliever
Salicylate
Anticoagulant
Anti-platelet
Over-the-counter
Pain reliever
Acetaminophen (APAP)
Opioid
Prescription only
Pain reliever
Nonsteroidal anti-inflammatory drug (NSAID)
Prescription only
Pain reliever
Nonsteroidal anti-inflammatory drug (NSAID)
Prescription only
Pain reliever
Nonsteroidal anti-inflammatory drug (NSAID)
Prescription or OTC
Available as
TylenolMeloxicamLodineNaproxenRelafenAspirinAcetaminophen With CodeineDiclofenacCelebrexIbuprofen
  • Pill
  • Extended release tablet
  • Chewable tablet
  • Dissolving tablet
  • Gelcap
  • Liquid
  • Suppository
  • Pill
  • Liquid
  • Pill
  • Extended release
  • Pill
  • Delayed release tablet
  • Liquid
  • Pill
  • Pill
  • Pill
  • Liquid
  • Pill
  • Pill
  • Pill
  • Chewable tablet
  • Oral suspension
Used for (click to learn more)
TylenolMeloxicamLodineNaproxenRelafenAspirinAcetaminophen With CodeineDiclofenacCelebrexIbuprofen
  • Juvenile rheumatoid arthritis Osteoarthritis Pain Rheumatoid arthritis
  • Osteoarthritis Rheumatoid arthritis
  • Osteoarthritis pain
Risk factors for serious side effects
TylenolMeloxicamLodineNaproxenRelafenAspirinAcetaminophen With CodeineDiclofenacCelebrexIbuprofen
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
Detailed Tylenol Regular Strength (Acetaminophen) risks & warnings »
  • History of heart attack
  • History of heart surgery
  • High blood pressure
  • High Cholesterol
  • Diabetes
  • Being Overweight or Obese
  • Smoking
  • History of stomach bleeding or ulcers
  • Age 65 or older
  • Hemophilia
  • von Willebrand's disease
  • Low blood platelet count
  • Also taking anticoagulant medication
  • Asthma
  • Rhinitis
  • Nasal Polyps
  • Aspirin Allergy
  • NSAID Allergy
  • Kidney Disease
  • Heart Failure
  • Liver Disease
  • Also taking diuretics
  • Also taking ACE inhibitors
  • Also taking Angiotensin Receptor Blockers (ARBs)
  • Age 65 or older
  • History of high blood pressure
  • Taking water pills (diuretics)
  • Late pregnancy (more than 30 weeks)
Detailed Mobic (Meloxicam) risks & warnings »
Coming soon.
  • History of heart problems
  • High blood pressure
  • High cholesterol
  • Diabetes
  • Smoking
  • History of stomach bleeding or ulcers
  • Age 60 years or older
  • Taking aspirin, NSAIDs, or blood thinners
  • Drinking more than 3 alcoholic beverages a day
  • Hemophilia
  • von Willebrand's disease
  • Low blood platelet count
  • Taking anticoagulant medications
  • Asthma
  • Rhinitis
  • Nasal polyps
  • Aspirin allergy
  • NSAID allergy
  • Kidney disease
  • Heart failure
  • Liver disease
  • Taking high blood pressure medications
  • Age 65 years or older
  • Women of childbearing age
Detailed Aleve (Naproxen) risks & warnings »
Coming soon.
  • Children 18 years or younger
  • Children recovering from viral infections
  • History of stomach bleeding or ulcers
  • Age 60 years or older
  • Taking Aspirin, NSAIDs, or blood thinners
  • Drinking more than 3 alcoholic beverages a day
  • Asthma
  • Rhinitis
  • Nasal polyps
  • Aspirin allergy
  • NSAID allergy
  • Women of childbearing age
Detailed Aspirin risks & warnings »
Coming soon.
  • History of heart problems
  • High blood pressure
  • High cholesterol
  • Diabetes
  • Being overweight or obese
  • Smoking
  • History of stomach bleeding or ulcers
  • Age 65 years or older
  • Bleeding disorder
  • Taking other blood-thinning medications
  • Asthma
  • Rhinitis
  • Nasal polyps
  • Aspirin allergy
  • NSAID allergy
  • Kidney problems
  • Heart failure
  • Liver disease
  • Taking diuretics
  • Taking ACE inhibitors or angiotensin receptor blockers (ARBs)
  • Age 65 or older
  • History of high blood pressure
  • Taking water pills (diuretics)
Detailed Zorvolex (Diclofenac) risks & warnings »
  • Long-term use
  • History of heart disease
  • History of heart bypass surgery (coronary artery bypass graft/CABG)
  • Age 65 or older
  • History of GI bleed or peptic ulcer disease
  • History of high blood pressure
  • Taking water pills (diuretics)
  • History of heart failure
    • History of asthma
    • Kidney Disease
    • Heart Failure
    • Liver Disease
    • Also taking diuretics
    • Also taking ACE inhibitors
    • Also taking Angiotensin Receptor Blockers (ARBs)
    • Age 65 or older
    • Late pregnancy (more than 30 weeks)
    Detailed Celebrex (Celecoxib) risks & warnings »
    • History of heart problems
    • High blood pressure
    • High cholesterol
    • Diabetes
    • Smoking
    • History of stomach bleeding or ulcers
    • Age 60 years or older
    • Taking aspirin, NSAIDs, or blood thinners
    • Drinking more than 3 alcoholic beverages a day
    • Hemophilia
    • von Willebrand's disease
    • Low blood platelet count
    • Taking anticoagulant medications
    • Asthma
    • Rhinitis
    • Nasal polyps
    • Aspirin allergy
    • NSAID allergy
    • Kidney disease
    • Heart failure
    • Liver disease
    • Taking high blood pressure medications
    • Age 65 years or older
    • Women of childbearing age
    Detailed Advil (Ibuprofen) risks & warnings »
    Pregnancy

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Alcohol
    TylenolMeloxicamLodineNaproxenRelafenAspirinAcetaminophen With CodeineDiclofenacCelebrexIbuprofen
    • Drinking alcohol while taking Tylenol Regular Strength (Acetaminophen) can damage your liver.
    • Heavy alcohol drinkers shouldn't use Tylenol Regular Strength (Acetaminophen) since it can cause serious liver damage.
    No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.
    • Avoid alcohol.
    • You should avoid alcohol while on Zorvolex (Diclofenac) since it can increase your risk of stomach issues.
    • Don't drink alcohol while using Zorvolex (Diclofenac).
    No alcohol related info.No alcohol related info.
    Food
    TylenolMeloxicamLodineNaproxenRelafenAspirinAcetaminophen With CodeineDiclofenacCelebrexIbuprofen
    No food related info.
    • Take Mobic (Meloxicam) only once a day. Take it with a meal or a snack to prevent an upset stomach.
    No food related info.
    • It needs to be taken with food to avoid getting an upset stomach.
    • Take it with a meal or a snack to prevent an upset stomach.
    No food related info.
    • Take with food to lower the chance of an upset stomach.
    • Take it with food to lower the chance of an upset stomach.
    • Take it with food to avoid getting diarrhea.
    • Take it with a meal or a snack to prevent an upset stomach.
    • It needs to be taken with food to avoid getting an upset stomach.
    • Take it with a meal or a snack to prevent upset stomach.
    Kidneys and liver
    TylenolMeloxicamLodineNaproxenRelafenAspirinAcetaminophen With CodeineDiclofenacCelebrexIbuprofen
    • Doesn't cause kidney damage and is safe to use if you have heart problems or if you're pregnant.
    • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it's a very common ingredient in pain and cold/flu combination medicines.
    • Can also affect your kidneys or cause permanent kidney damage if taken for a long time.
    • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
    • Mobic (Meloxicam), and similar medications in the NSAID family, can lower kidney function or cause permanent kidney damage. Taking the lowest dose for the shortest amount of time necessary can lower your risk for kidney problems. It is important to get lab tests to check your kidney function periodically if you use Mobic (Meloxicam) for long periods of time.
    No kidneys and liver related info.
    • It can cause serious kidney and stomach problems (like ulcers and bleeding) the longer you take it.
    • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
    • Aleve (Naproxen) is an NSAID that can lower kidney function or cause damage. Taking the lowest dose for the shortest amount of time lowers your risk. Your doctor should check your kidney function if you take Aleve (Naproxen) for any amount of time.
    No kidneys and liver related info.No kidneys and liver related info.
    • Don't take more than instructed to prevent liver damage.
    • Zorvolex (Diclofenac), and similar medications in the NSAID family, can lower kidney function or cause permanent kidney damage. Taking the lowest dose for the shortest amount of time necessary can lower your risk of kidney problems. It's important to get lab tests to check your kidney function periodically if you use Zorvolex (Diclofenac) for long periods of time.
    • Can also affect your kidneys or cause permanent kidney damage if taken for a long time.
    • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
    • Celebrex (Celecoxib), and similar medications in the NSAID family, can cause lower kidney function or cause permanent kidney damage. You're at higher risk for this if you've a history of kidney disease, heart failure, and liver disease. Taking Diuretic, ACE inhibitor, or Angiotensin Receptor Blocker (ARB) medications also increases your risk. If you are 65 or older you're also at a higher risk for these types of kidney problems.
    • It can cause serious kidney and stomach problems (like ulcers and bleeding) the longer you take it.
    • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
    • Advil (Ibuprofen) is an NSAID that can lower kidney function or cause damage. Taking the lowest dose for the shortest amount of time lowers your risk. Your doctor should check your kidney function if you take Advil (Ibuprofen) for any amount of time.
    Pain
    TylenolMeloxicamLodineNaproxenRelafenAspirinAcetaminophen With CodeineDiclofenacCelebrexIbuprofen
    • Works well to relieve pain and fevers.
    • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it's a very common ingredient in pain and cold/flu combination medicines.
    • Works well to relieve pain and inflammation from osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis.
    • Good for muscle aches and pains.
    • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
    No pain related info.
    • Works well to relieve pain, swelling, and fevers.
    • Starts relieving pain in 30 to 60 minutes.
    • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
    No pain related info.
    • Used in higher doses to relieve pain, swelling, and fever.
    • Combination pain medicine with an opioid component (codeine) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
    • Good for as-needed pain and control.
    • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
    • Works best if you take it as soon as you start feeling pain.
    • Pain relief lasts 4-6 hours.
    • Clinical studies show that Zorvolex (Diclofenac) is better at relieving arthritis pain than acetaminophen (Tylenol).
    • Can be used as needed to treat pain and swelling.
    • Can cause swelling in your legs, abdominal pain, constipation, diarrhea, and an upset stomach.
    • Relieves pain and inflammation for many types of arthritis, including osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis.
    • Good for treating muscle aches and pains, as well as menstrual cramps.
    • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
    • Works well to relieve pain, swelling, and fevers.
    • Starts relieving pain in 30 to 60 minutes.
    • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
    Sleep
    TylenolMeloxicamLodineNaproxenRelafenAspirinAcetaminophen With CodeineDiclofenacCelebrexIbuprofen
    No sleep related info.No sleep related info.No sleep related info.No sleep related info.No sleep related info.No sleep related info.
    • Can help you fall asleep easier.
    • Dizziness and drowsiness is common, but your body may adjust.
    No sleep related info.No sleep related info.No sleep related info.
    Upsides and benefits
    TylenolMeloxicamLodineNaproxenRelafenAspirinAcetaminophen With CodeineDiclofenacCelebrexIbuprofen
    • Works well to relieve pain and fevers.
    • Tylenol Regular Strength (Acetaminophen) causes less upset stomach, ulcers, bruising, and bleeding than other pain medications like aspirin, ibuprofen, and naproxen.
    • Doesn't cause kidney damage and is safe to use if you have heart problems or if you're pregnant.
    • Good for menstrual cramps, toothaches, body aches, and mild arthritis pain.
    • Although not without side effects, it's been around for a long time and is generally safe for short-term use.
    • Works well to relieve pain and inflammation from osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis.
    • Good for muscle aches and pains.
    • It lasts longer than Ibuprofen, so you can take it less often.
    • Causes less upset stomach than other NSAIDs, like Ibuprofen.
    • Can also caus less bruising or bleeding than other NSAIDs when taken at lower doses (7.5 mg per day or less).
    Coming soon
    • Lasts longer than Ibuprofen, so you can take it less often.
    • Aleve (Naproxen) works as well as Aspirin and Indomethacin to treat arthritis pain, and causes fewer stomach problems.
    • Works well to relieve pain, swelling, and fevers.
    • Good for menstrual cramps, toothaches, body aches, and mild arthritis pain.
    • Although not without side effects, it's been around for a long time and is generally safe for short-term use.
    Coming soon
    • When taking low doses (81 mg) every day, Aspirin provides protection for your heart and prevents heart attacks and stroke.
    • Used in higher doses to relieve pain, swelling, and fever.
    • Available over-the-counter in drugstores by itself and in combination with other cold and flu medications.
    • Combination pain medicine with an opioid component (codeine) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
    • Provides quick relieve for mild to moderate pain to improve quality of life.
    • Good for as-needed pain and control.
    • Generally well tolerated by people, especially if taken with food to lower risk of stomach upset.
    • Lower rates of misuse compared to pure opioid medicines.
    • Can help you fall asleep easier.
    • Clinical studies show that Zorvolex (Diclofenac) is better at relieving arthritis pain than acetaminophen (Tylenol).
    • Can be used as needed to treat pain and swelling.
    • Available as a generic.
    • Relieves pain and inflammation for many types of arthritis, including osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis.
    • Good for treating muscle aches and pains, as well as menstrual cramps.
    • Causes fewer stomach problems than other NSAIDs like Ibuprofen or Naproxen.
    • Lasts longer than Ibuprofen.
    • Ibuprofen works as well as aspirin in treating pain and causes fewer stomach problems.
    • Ibuprofen works better than acetaminophen (Tylenol) at lowering fever and relieving sinus pain.
    • Works well to relieve pain, swelling, and fevers.
    • Good for menstrual cramps, toothaches, body aches, and mild arthritis pain.
    • Although not without side effects, it's been around for a long time and is generally safe for short-term use.
    Downsides and risks
    TylenolMeloxicamLodineNaproxenRelafenAspirinAcetaminophen With CodeineDiclofenacCelebrexIbuprofen
    • Tylenol Regular Strength (Acetaminophen) doesn't treat pain as well as other medications like ibuprofen and naproxen.
    • Drinking alcohol while taking Tylenol Regular Strength (Acetaminophen) can damage your liver.
    • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it's a very common ingredient in pain and cold/flu combination medicines.
    • Heavy alcohol drinkers shouldn't use Tylenol Regular Strength (Acetaminophen) since it can cause serious liver damage.
    • The longer you take Mobic (Meloxicam), the more likely you are to have stomach problems, including inflammation, ulcers, and bleeding. This can also happen if you take Mobic (Meloxicam) on an empty stomach.
    • Like all NSAIDs, it can raise your risk of blood clots, heart attack, or a stroke.
    • Can also affect your kidneys or cause permanent kidney damage if taken for a long time.
    Coming soon
    • It needs to be taken with food to avoid getting an upset stomach.
    • Can't be taken by pregnant women.
    • It can cause serious kidney and stomach problems (like ulcers and bleeding) the longer you take it.
    • Like all NSAIDs, it can raise your risk of having blood clots, heart attack, or stroke.
    Coming soon
    • Not a preferred medication for treating pain, swelling, or fever due to its high risk of bleeding.
    • NSAIDs (like ibuprofen and naproxen) and acetaminophen (Tylenol) are better for treating pain and fever thank Aspirin.
    • Aspirin raises your risk of bleeding, especially when used with other blood thinner medications like warfarin (Coumadin).
    • Studies show that using higher doses of Aspirin (162 mg or more) every day raises your risk of stomach bleeding and doesn't provide any additional heart protection.
    • Dizziness and drowsiness is common, but your body may adjust.
    • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Acetaminophen with codeine if you need.
    • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
    • The non-opioid part of Acetaminophen with codeine, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
    • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
    • Avoid alcohol.
    • You should avoid alcohol while on Zorvolex (Diclofenac) since it can increase your risk of stomach issues.
    • If you're taking it on a regular basis, you'll need to get labs done to make sure your liver and kidneys aren't being affected.
    • The longer you take Celebrex (Celecoxib), the more likely you are to have stomach problems, including inflammation, ulcers, and bleeding. Can also happen if you take Celebrex (Celecoxib) on an empty stomach.
    • Like all NSAIDs, it can raise your risk of blood clots, heart attack, or a stroke.
    • Can also affect your kidneys or cause permanent kidney damage if taken for a long time.
    • Ibuprofen doesn't work as long as other NSAIDs, so follow the package directions on how often you can take it.
    • It needs to be taken with food to avoid getting an upset stomach.
    • Can't be taken by pregnant women.
    • It can cause serious kidney and stomach problems (like ulcers and bleeding) the longer you take it.
    • Like all NSAIDs, it can raise your risk of having blood clots, heart attack, or stroke.
    Tips from our pharmacists for people taking the medication
    TylenolMeloxicamLodineNaproxenRelafenAspirinAcetaminophen With CodeineDiclofenacCelebrexIbuprofen
    • Starts working in one hour.
    • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
    • Follow age-specific dosing instructions on how much to take. Adults should never take more than 3,000 milligrams (mg) in a single day.
    • Let your doctor know if your symptoms don't improve in a few days.
    • Take Mobic (Meloxicam) only once a day. Take it with a meal or a snack to prevent an upset stomach.
    • Can make you bruise or bleed more easily and it can also cause stomach ulcers.
    • Don't take it with other blood thinners, like aspirin, unless your doctor tells you it's safe.
    • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
    Coming soon
    • Starts relieving pain in 30 to 60 minutes.
    • Take it with a meal or a snack to prevent an upset stomach.
    • Can make you bruise or bleed more easily and it can also cause stomach ulcers.
    • Don't take it with other blood thinners, like aspirin, unless your doctor tells you it's safe.
    • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
    Coming soon
    • Using low doses (81mg) of Aspirin every day can lower your risk of heart attack and stroke, but it isn't good for everyone. Only take Aspirin daily if your doctor recommends it.
    • Higher Aspirin doses can be used to treat occasional pain, swelling, and fever. Using ibuprofen or acetaminophen (Tylenol) instead can lower your risk of serious bleeding.
    • Take with food to lower the chance of an upset stomach.
    • Don't use for kids younger than 18 years old.
    • Stop taking this right away and tell your doctor if you have ringing in your ears, unusual bleeding, or nausea or vomiting that doesn't go away.
    • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
    • Starts working in 30 minutes.
    • Works best if you take it as soon as you start feeling pain.
    • Pain relief lasts 4-6 hours.
    • Can make you dizzy or drowsy.
    • Avoid activities need you to be fully alert until you know how it affects you.
    • Take it with food to lower the chance of an upset stomach.
    • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and using laxatives can help.
    • Don't take more than instructed to prevent liver damage.
    • Use it for the shortest time possible, and at the lowest dose possible, to lower your chance of becoming addicted.
    • Talk to your doctor if it doesn't help enough for your pain, or if the side effects are really bad.
    • Take it with food to avoid getting diarrhea.
    • Don't drink alcohol while using Zorvolex (Diclofenac).
    • Don't take other anti-inflammatory medications (NSAIDs) without talking to your doctor or pharmacist.
    • Can cause swelling in your legs, abdominal pain, constipation, diarrhea, and an upset stomach.
    • Don't take antacids with magnesium since they can interact with Zorvolex (Diclofenac).
    • Take Zorvolex (Diclofenac) at the smallest dose possible for the shortest amount of time to prevent an increased risk of heart attack.
    • Starts working in 1 to 3 hours.
    • Take it with a meal or a snack to prevent an upset stomach.
    • Can make you bruise or bleed more easily and it can also cause stomach ulcers.
    • Don't take it with other blood thinners, like aspirin, unless your doctor tells you it's safe.
    • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
    • Take it with a meal or a snack to prevent upset stomach.
    • Starts relieving pain in 30 to 60 minutes.
    • Can make you bruise or bleed more easily and it can also cause stomach ulcers.
    • Don't take it with other blood thinners, like aspirin, unless your doctor tells you it's safe.
    • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
    Learn more
    More about TylenolSide effectsReviews & ratingsAlternativesFDA package insert
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