Prescription onlyNo lower cost generic available

Uloric Alternatives

(Febuxostat)

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Compare Uloric (Febuxostat) to alternatives

These medications are comparable to Uloric (Febuxostat) or used for similar purposes.

Uloric
(Febuxostat)

Zyloprim
(Allopurinol)

Benemid
(Probenecid)

Colcrys
(Colchicine)

Prevents gout attacks. Uloric (Febuxostat) is a once a day medication for chronic gout, but it takes a few weeks to kick in.Prevents gout flare-ups. Zyloprim (Allopurinol) works well to prevent gout attacks and is cheaper than some alternatives, but it takes a few weeks to kick in.Coming soon.Prevents and treats gout. Colcrys (Colchicine) is a second-choice treatment for gout attacks. Be careful how much you use since it causes a lot of side effects.
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Reviews & ratings
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Reviews for Zyloprim (Allopurinol)
71%
+71% vs. Uloric (Febuxostat)
52%
+52% vs. Uloric (Febuxostat)
5%
5% vs. Uloric (Febuxostat)

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Side effects
UloricAllopurinolBenemidColcrys
  • Liver function abnormalities 6%
  • Rash 1%
More Uloric side effects »

The Allopurinol FDA package insert doesn’t have numbers about how common side effects are.

More about Allopurinol side effects »

We haven’t found good data for Benemid side effects.

FDA side effect reports for Benemid »
  • Gastrointestinal disorders 6%
  • Gout 2%
  • Metabolic and nutrition disorders 1%
More Colcrys side effects »
How it works
UloricAllopurinolBenemidColcrys
Uloric (Febuxostat) is an antigout xanthine oxidase inhibitor. It decreases the build up of uric acid, the enzyme that causes gout.Zyloprim (Allopurinol) is a type of medicine called a xanthine oxidase inhibitor. It lowers uric acid levels in your blood, which prevents gout attacks and certain types of kidney stones.Coming soon.Colcrys (Colchicine) is a second choice antigout medication that prevents acute gout attacks by reducing inflammation.
Type of medication
UloricAllopurinolBenemidColcrys
Antigout
Xanthine oxidase inhibitor
Prescription only
Antigout
Xanthine oxidase inhibitor
Prescription only
Coming soon.
AntigoutPrescription only
Available as
UloricAllopurinolBenemidColcrys
  • Pill
  • Pill
  • Pill
  • Pill
Used for (click to learn more)
UloricAllopurinolBenemidColcrys
  • Antibiotic therapy; Adjunct Gonorrhea
Risk factors for serious side effects
UloricAllopurinolBenemidColcrys
        Detailed Uloric (Febuxostat) risks & warnings »
        Coming soon.Coming soon.Coming soon.
        Pregnancy category
        UloricAllopurinolBenemidColcrys
        CFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        CFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        BFDA pregnancy category (Probably safe)

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        See the FDA package insert
        CFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        Alcohol
        No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.
        Food
        • Take Uloric (Febuxostat) at the same time everyday, with or without food.
        • To help prevent attacks, avoid beer, sugary drinks, and foods like red meat, seafood, turkey, asparagus, cauliflower, spinach, and mushrooms.
        • Take with food or milk to prevent an upset stomach.
        No specific food-related info.
        • Take it with or without food.
        Kidneys and liver
        • You need to drink a lot of fluids while taking this to prevent kidney stones from forming.
        • Uloric (Febuxostat) can be used in people with mild to moderate kidney disease.
        • You should drink a lot of fluids to prevent kidney stones from forming while taking this medication.
        No specific kidneys and liver-related info.
        • Doses needs to be adjusted if you have kidney or liver problems.
        Sex
        No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.
        Sleep
        No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.
        Weight
        • Because people taking this medication have suffered fatal and non-fatal liver failure, it is important to have liver function blood work done before starting Uloric (Febuxostat). In addition, it is important to have these tests done anytime your doctor feels you may have liver injury. This can be the case if you become overly tired, begin to loose an unusual amount of weight, have severe pain on the right side of your abdomen, have dark urine, or a yellow appearance of your skin. Be sure to talk to a doctor if this occurs.
        No specific weight-related info.No specific weight-related info.No specific weight-related info.
        Upsides and benefits
        UloricAllopurinolBenemidColcrys
        • In one clinical trial, Uloric (Febuxostat) was shown to decrease uric acid to normal levels in over half of the people taking it. It worked better than Zyloprim (allopurinol).
        • You only need to take Uloric (Febuxostat) once a day.
        • Uloric (Febuxostat) can be used in people with mild to moderate kidney disease.
        • Works well to lower the amount of uric acid in the body to reduce gout attacks.
        • Available as a generic medication.
        Coming soon.
        • Is an antigout medication that has anti-inflammatory properties to help treat sudden gout attacks.
        • Lowers the risk of sudden gout attacks when taken as prescribed to prevent gout attacks.
        • Also treats Familial Mediterranean Fever.
        Downsides and risks
        UloricAllopurinolBenemidColcrys
        • Can increase the amount of gout attacks in the first few weeks.
        • You need to drink a lot of fluids while taking this to prevent kidney stones from forming.
        • While taking Uloric (Febuxostat), you'll have to get your blood checked often.
        • Doesn't come in a generic version.
        • Can actually increase the number of gout attacks in the first few weeks.
        • It can take 2 to 6 weeks to feel the full effects of the medication.
        • You should drink a lot of fluids to prevent kidney stones from forming while taking this medication.
        Coming soon.
        • Doesn't work as well as nonsteroidal anti-inflammatory drugs (NSAIDs) or corticosteroids to treat gout attacks.
        • Taking too much can cause serious side effects.
        • Doses needs to be adjusted if you have kidney or liver problems.
        • Doesn't have the ability to ease or treat pain.
        Tips from our pharmacists for people taking the medication
        UloricAllopurinolBenemidColcrys
        • In the first few months of taking Uloric (Febuxostat), you can still have gout attacks. Don’t give up since it takes a while to fully work. Your doctor can give you another medication to help until it's working well.
        • Take Uloric (Febuxostat) at the same time everyday, with or without food.
        • To make sure Uloric (Febuxostat) is working, have your blood checked often.
        • To help prevent attacks, avoid beer, sugary drinks, and foods like red meat, seafood, turkey, asparagus, cauliflower, spinach, and mushrooms.
        • Drink plenty of water while taking this medication.
        • Take with food or milk to prevent an upset stomach.
        • It takes at least 2 to 6 weeks to experience the full benefit of this medication.
        • Your doctor can run blood tests to make sure the medication is working as it should.
        Coming soon.
        • Take it with or without food.
        • At the first sign of a gout attack, take two tablets. Don't take more than three tablets a day in order to avoid serious side effects.
        • Wait at least 3 days before another using Colcrys (Colchicine) again.
        • Almost all people experience some nausea, vomiting, or diarrhea after taking Colcrys (Colchicine).
        • Let your doctor know of any serious nausea, vomiting, diarrhea, or if you have tingling in your fingers or toes.
        Learn more
        More about UloricSide effectsReviews & ratingsAlternativesFDA package insert
        More about AllopurinolSide effectsReviews & ratingsFDA package insert
        More about BenemidSide effectsFDA package insert
        More about ColcrysSide effectsReviews & ratingsFDA package insert