Over-the-counterLower-cost generic available

Unisom Sleepgels

(Diphenhydramine)

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Treats allergy symptoms and helps you sleep.

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Over-the-counterLower-cost generic available

Our pharmacists’ bottom line

Unisom Sleepgels (Diphenhydramine) is a good over-the-counter medication for nighttime allergies.

  • Unisom Sleepgels (Diphenhydramine) is often better than other antihistamines at treating allergy symptoms and hives.
  • It can provide quick relief of allergy symptoms for both kids and adults.
  • It makes you sleepy, so it'll help if your allergies are bothering you at night.
  • The effects wear off in 4 to 6 hours, so side effects don't last that long.
  • It comes as a tablet, capsule, liquid, and quick dissolving tablet.
  • Unisom Sleepgels (Diphenhydramine) makes you more tired than Claritin, Allegra, or Zyrtec.
  • You shouldn't drive after taking Unisom Sleepgels (Diphenhydramine) until you know how it affects you.
  • Talk to a pediatrician before giving Unisom Sleepgels (Diphenhydramine) to a child.
  • It can increase the risk of falls, so elderly people shouldn't use Unisom Sleepgels (Diphenhydramine).
  • Don't use Unisom Sleepgels (Diphenhydramine) if you are breastfeeding.

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Side effects for Unisom Sleepgels (Diphenhydramine)

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These are side effects of Unisom Sleepgels (Diphenhydramine) reported to the FDA by people taking it, and by doctors and pharmacists.

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What to expect when you take Unisom Sleepgels (Diphenhydramine)

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Tips from our pharmacists
  • Take Unisom Sleepgels (Diphenhydramine) at bedtime as needed if you're 12 years of age or older.
  • Unisom Sleepgels (Diphenhydramine) can make you dehydrated, so avoid this side effect by drinking plenty of fluids.
  • Don't take it with alcohol or other drugs that make you sleepy.
  • If you need to use it for more than a few weeks, talk with your doctor. A different medication might work better for you long-term.
  • Unisom comes in two different generic forms, doxylamine (Unisom SleepTabs) and diphenhydramine (other Unisom products). Both are antihistamines that help you sleep.

Risks and Warnings for Unisom Sleepgels (Diphenhydramine)

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    • Higher risk if:
    • Using other drugs with the same ingredients

    There are a variety of over-the-counter medications with the same ingredients as Unisom Sleepgels (Diphenhydramine). It's not safe to use more than one medication containing diphenhydramine (the ingredient in Unisom Sleepgels (Diphenhydramine)) at the same time. Read package labels carefully to make sure you take the right dose of these medications.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Unisom Sleepgels (Diphenhydramine)

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The FDA category for this medication is B. It is advised that you: Probably safe
Pregnancy
Alcohol
  • Tips from our pharmacists
  • Don't take it with alcohol or other drugs that make you sleepy.
Sleep
  • Tips from our pharmacists
  • Unisom comes in two different generic forms, doxylamine (Unisom SleepTabs) and diphenhydramine (other Unisom products). Both are antihistamines that help you sleep.
  • Risks from our pharmacists
  • People age 65 years and older have a higher risk of side effects from taking antihistamine medications like Unisom Sleepgels (Diphenhydramine). Watch for changes in vision, severe dry mouth, trouble urinating, or constipation. The drowsiness caused by Unisom Sleepgels (Diphenhydramine) can make you "unsteady" on your feet, leading to a higher chance of falls.