Over-the-counterLower-cost generic availableClass: Respiratory

Unisom Sleepgels 


Over-the-counterLower-cost generic availableClass: Respiratory
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Treats allergy symptoms and helps you sleep.

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Our bottom line

Unisom Sleepgels (Diphenhydramine) is a good over-the-counter medication for nighttime allergies.

Price and discounts
Best available price for 30 (25mg) capsules of diphenhydramine


  • Unisom Sleepgels (Diphenhydramine) is often better than other antihistamines at treating allergy symptoms and hives.
  • It can provide quick relief of allergy symptoms for both kids and adults.
  • It makes you sleepy, so it'll help if your allergies are bothering you at night.
  • The effects wear off in 4 to 6 hours, so side effects don't last that long.
  • It comes as a tablet, capsule, liquid, and quick dissolving tablet.


  • Unisom Sleepgels (Diphenhydramine) makes you more tired than Claritin, Allegra, or Zyrtec.
  • You shouldn't drive after taking Unisom Sleepgels (Diphenhydramine) until you know how it affects you.
  • Talk to a pediatrician before giving Unisom Sleepgels (Diphenhydramine) to a child.
  • It can increase the risk of falls, so elderly people shouldn't use Unisom Sleepgels (Diphenhydramine).
  • Don't use Unisom Sleepgels (Diphenhydramine) if you are breastfeeding.
How it works

Unisom Sleepgels (Diphenhydramine) is an antihistamine. It blocks histamine, a chemical that causes congestion, itching, and other allergic reactions. It also makes you sleepy.

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Side effect rates for Unisom Sleepgels (diphenhydramine)

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These are side effects of Unisom Sleepgels (diphenhydramine) reported to the FDA by people taking it, and by doctors and pharmacists.
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Risks and Warnings for Unisom Sleepgels (diphenhydramine)

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    • Higher risk if:
    • Using other drugs with the same ingredients

    There are a variety of over-the-counter medications with the same ingredients as Unisom Sleepgels (Diphenhydramine). It's not safe to use more than one medication containing diphenhydramine (the ingredient in Unisom Sleepgels (Diphenhydramine)) at the same time. Read package labels carefully to make sure you take the right dose of these medications.

Common concerns from people taking Unisom Sleepgels (diphenhydramine)

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  • Don't take it with alcohol or other drugs that make you sleepy.
  • Unisom Sleepgels (Diphenhydramine) makes you more tired than Claritin, Allegra, or Zyrtec.