Prescription onlyLower-cost generic available



  • Pill
  • Gallbladder stone
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Dissolves gallbladder stones.

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Prescription onlyLower-cost generic available

Our pharmacists’ bottom line

Actigall (Ursodiol) is a decent way to get rid of gallstones if surgery isn't an option for you.

  • Helps dissolve gallbladder stones without needing to have surgery.
  • Can take long time for gallstones to be fully dissolved.
  • May not work depending on the initial size of the gallstone.
  • Often causes upset stomach.
  • Can be pricey.
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Side effects for Actigall (Ursodiol)

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These are side effects of Actigall (Ursodiol) reported to the FDA by people taking it, and by doctors and pharmacists.

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What to expect when you start Actigall (Ursodiol)

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Tips from our pharmacists
  • Take with food to lessen upset stomach.
  • Can cause dizziness, headache, diarrhea, nausea, or vomiting.
  • Avoid taking aluminum-containing antacids since it doesn't let Actigall (Ursodiol) work as well.
  • It can take several months before the gallstone is completely dissolved.

Risks and Warnings for Actigall (Ursodiol)

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  • Bile acid sequestering agents (like Cholestyramine and Colestipol) and aluminum-based antacids can interfere with how well Actigall (Ursodiol) works by not letting it be absorbed by your body. Estrogens, oral contraceptives, and clofibrate (and perhaps other lipid-lowering drugs) can cause gallstones to be made and work against the effectiveness of Actigall (Ursodiol).

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Actigall (Ursodiol)

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The FDA category for this medication is B. It is advised that you: Probably safe
  • I am chronic ulcerative colitis patient with sclerosis cholangitis (for 25 years). Have taken the Urso for years with no side effects. This med along with reduced alcohol use has brought my liver values back to new normal.
    Age: 66
    Gender: man
    Taken for: Liver disease
    Duration taken: two years or more
  • Tips from our pharmacists
  • Take with food to lessen upset stomach.