Prescription onlyNo lower cost generic available

Vagifem

(Estradiol Vaginal Tablet)

  • Vaginal tablet
  • Vaginal dryness and inflammation
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Relieves vaginal dryness due to menopause.

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Prescription onlyNo lower cost generic available

Our pharmacists’ bottom line

Vagifem (Estradiol Vaginal Tablet) is an easy-to-use vaginal tablet and is a good alternative to oral estrogen pills and patches.

  • Vagifem (Estradiol Vaginal Tablet) relieves vaginal dryness and irritation to make sex more enjoyable.
  • Works locally in the vagina and doesn't expose the rest of your body to estrogen like pills do.
  • Generally works well with few side effects.
  • For painful sex, it can work better than over-the-counter vaginal lubricants because over time, Vagifem (Estradiol Vaginal Tablet) treats the cause of the problem (low estrogen levels), not just the symptoms (dryness).
  • Vaginal estrogens can weaken latex (rubber) condoms, cervical caps, and diaphrams. Don't use these within 72 hours after a dose.
  • Inserting the applicator can possibly cause discomfort or infection.
  • If you have your uterus, you might need to use Vagifem (Estradiol Vaginal Tablet) with another hormone called progestin to lower your risk of uterine cancer.
  • Can be expensive since it's only available as a brand name product.

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Side effects for Vagifem (Estradiol Vaginal Tablet)

From clinical trials of Vagifem / Atrophic vaginitis due to menopause (10 mcg) ( 308)

  • Vulvovaginal mycotic infectionVulvovaginal mycotic infection8% for Vagifem vs.3% for placebo
  • Vulvovaginal pruritusVulvovaginal pruritus8% for Vagifem vs.2% for placebo
  • Back painBack pain7% for Vagifem vs.2% for placebo
  • DiarrheaDiarrhea5% for Vagifem vs.0% for placebo

What to expect when you take Vagifem (Estradiol Vaginal Tablet)

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Tips from our pharmacists
  • Each applicator contains 1 pill to be placed in the vagina. Don't take this tablet by mouth.
  • Insert the applicator deeply into your vagina and press the plunger to release the pill.
  • Use 1 tablet once a day for 2 weeks, then 1 tablet twice a week.
  • Make sure you ask your doctor or pharmacist how to use the applicator.
  • Throw the applicator out after each use.
  • Most people don't have many side effects, but temporary headache, dizziness, bloating, and breast tenderness are possible.
  • Tell your doctor about any unusual vaginal bleeding.

Risks and Warnings for Vagifem (Estradiol Vaginal Tablet)

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    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Vagifem (Estradiol Vaginal Tablet)

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The FDA category for this medication is X. It is advised that you: Unsafe
Pregnancy
Sex
  • Upsides and downsides from our pharmacists
  • Vagifem (Estradiol Vaginal Tablet) relieves vaginal dryness and irritation to make sex more enjoyable.
  • For painful sex, it can work better than over-the-counter vaginal lubricants because over time, Vagifem (Estradiol Vaginal Tablet) treats the cause of the problem (low estrogen levels), not just the symptoms (dryness).