Prescription onlyNo lower cost generic available

Vagifem

(Estradiol Vaginal Tablet)

Prescription onlyNo lower cost generic available
  • Vaginal tablet
  • Vaginal dryness and inflammation
Back to: Full Site NavigationSkip to: side effects sectionSkip to: What to expect sectionSkip to: Risks and warnings sectionSkip to: Common concerns from users and pharmacists

Relieves vaginal dryness due to menopause.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Vagifem (Estradiol Vaginal Tablet) is an easy-to-use vaginal tablet and is a good alternative to oral estrogen pills and patches.

Coupons and discounts

Upsides

  • Vagifem (Estradiol Vaginal Tablet) relieves vaginal dryness and irritation to make sex more enjoyable.
  • Works locally in the vagina and doesn't expose the rest of your body to estrogen like pills do.
  • Generally works well with few side effects.
  • For painful sex, it can work better than over-the-counter vaginal lubricants because over time, Vagifem (Estradiol Vaginal Tablet) treats the cause of the problem (low estrogen levels), not just the symptoms (dryness).

Downsides

  • Vaginal estrogens can weaken latex (rubber) condoms, cervical caps, and diaphrams. Don't use these within 72 hours after a dose.
  • Inserting the applicator can possibly cause discomfort or infection.
  • If you have your uterus, you might need to use Vagifem (Estradiol Vaginal Tablet) with another hormone called progestin to lower your risk of uterine cancer.
  • Can be expensive since it's only available as a brand name product.
Skip side effects section. Skip to What to Expect and Pharmacists Tips section.

Side effect rates for Vagifem (Estradiol Vaginal Tablet)

308 From clinical trials of Vagifem / Atrophic vaginitis due to menopause (10 mcg)
  • Vulvovaginal mycotic infection
  • Vulvovaginal pruritus
  • Back pain
  • Diarrhea

Risks and Warnings for Vagifem (Estradiol Vaginal Tablet)

Skip risks section. Skip to common concerns section.
    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Vagifem (Estradiol Vaginal Tablet)

Final section. Do you want to return to drug navigation?
Pregnancy
Pain
  • For painful sex, it can work better than over-the-counter vaginal lubricants because over time, Vagifem (Estradiol Vaginal Tablet) treats the cause of the problem (low estrogen levels), not just the symptoms (dryness).