Prescription onlyClass: Women's health

Vagifem

(estradiol vaginal tablet)

Prescription onlyClass: Women's health
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Relieves vaginal dryness due to menopause.

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Our bottom line

Vagifem (Estradiol Vaginal Tablet) is an easy-to-use vaginal tablet and is a good alternative to oral estrogen pills and patches.

Prices and discounts
Lowest price for 8 10mcg tablets
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$56.51

Upsides

  • Vagifem (Estradiol Vaginal Tablet) relieves vaginal dryness and irritation to make sex more enjoyable.
  • Works locally in the vagina and doesn't expose the rest of your body to estrogen like pills do.
  • Generally works well with few side effects.
  • For painful sex, it can work better than over-the-counter vaginal lubricants because over time, Vagifem (Estradiol Vaginal Tablet) treats the cause of the problem (low estrogen levels), not just the symptoms (dryness).
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Downsides

  • Vaginal estrogens can weaken latex (rubber) condoms, cervical caps, and diaphrams. Don't use these within 72 hours after a dose.
  • Inserting the applicator can possibly cause discomfort or infection.
  • If you have your uterus, you might need to use Vagifem (Estradiol Vaginal Tablet) with another hormone called progestin to lower your risk of uterine cancer.
  • Can be expensive since it's only available as a brand name product.
Prices and discounts
Lowest price for 8 10mcg tablets
Determining your location...
$56.51
How it works

Vagifem (Estradiol Vaginal Tablet) is a vaginal tablet that replaces estrogen hormones in your vagina that your body loses during menopause. Estrogen helps rebuild and maintain vaginal tissue, relieving symptoms of vaginal dryness, soreness, irritation, and painful sex.

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Used for
  • Vaginal dryness and inflammation
Dosage forms
  • Vaginal tablet
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Side effect rates for Vagifem (estradiol vaginal tablet)

308 From clinical trials of Vagifem / Atrophic vaginitis due to menopause (10 mcg)
  • Vulvovaginal Mycotic infection
  • Vulvovaginal Pruritus
  • Back pain
  • Diarrhea

Risks and Warnings for Vagifem (estradiol vaginal tablet)

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    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Vagifem (estradiol vaginal tablet)

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Pregnancy
Pain
  • For painful sex, it can work better than over-the-counter vaginal lubricants because over time, Vagifem (Estradiol Vaginal Tablet) treats the cause of the problem (low estrogen levels), not just the symptoms (dryness).