Prescription onlyClass: Women's health

VagifemAlternatives

(estradiol vaginal tablet)

Prescription onlyClass: Women's health
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Compare Vagifem (estradiol vaginal tablet) to alternatives

These medications are comparable to Vagifem (estradiol vaginal tablet) or used for similar purposes.

Vagifem
(estradiol vaginal tablet)

Premarin
(conjugated estrogens)

Activella
(estradiol / norethindrone)

Prempro
(conjugated estrogens / medroxyprogesterone acetate)

Climara
(estradiol patch)

Provera
(medroxyprogesterone)

Premarin Vaginal Cream
(conjugated estrogens)

Estring
(estradiol vaginal ring)

Divigel
(estradiol gel)

Vivelle-Dot
(estradiol patch)

Relieves vaginal dryness due to menopause. Vagifem (Estradiol Vaginal Tablet) is an easy-to-use vaginal tablet and is a good alternative to oral estrogen pills and patches.Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis. Premarin (Conjugated Estrogens) relieves menopausal symptoms and prevents bone loss. It's an oral hormone replacement, so it can have a lot of side effects, and it's important to think through the benefits and potential hassles of this drug before using it.Relieves menopause symptoms and lowers your risk of osteoporosis. Activella (Estradiol / Norethindrone) is effective at treating symptoms related to menopause and preventing bone loss. The estrogen/progestin combo is a good options for women with an intact uterus.Coming soon.Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis. You only have to think about the Climara (Estradiol Patch) once a week, and it may have fewer side effects than oral estrogen pills.Regulates your menstrual cycle and supplements estrogen treatments for menopause. Provera (Medroxyprogesterone) works well to regulate your menstrual cycle and stop irregular bleeding. It also protects the uterus from estrogen's harmful effects.Relieves vaginal dryness and pain due to menopause. Premarin Vaginal Cream (Conjugated Estrogens) works well for vaginal problems caused by menopause, and it has fewer side effects than estrogen pills.Relieves vaginal dryness due to menopause. Estring (Estradiol Vaginal Ring) is a vaginal ring that may be less of a hassle than estrogen pills, gels, patches, or vaginal creams, but comes with the same side effects.Relieves hot flashes due to menopause. Divigel (Estradiol Gel) comes in 3 different strengths. It uses lower doses of estrogen than other hormone replacements and is easy to use and apply.Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis. The Vivelle-Dot (Estradiol Patch) needs to be replaced twice a week, but it comes in more strengths than other patches. It may have fewer side effects than oral estrogen pills.
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Reviews & ratings
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Have you used Vagifem (estradiol vaginal tablet)?
Worth itNot sureNot worth it
Reviews for Premarin (conjugated estrogens)
50%
-40% worse vs. Vagifem (estradiol vaginal tablet)
43%
-37% worse vs. Vagifem (estradiol vaginal tablet)
11%
-11% worse vs. Vagifem (estradiol vaginal tablet)
154 reviews
Have you used Premarin (conjugated estrogens)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Activella (estradiol / norethindrone)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Prempro (conjugated estrogens / medroxyprogesterone acetate)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Climara (estradiol patch)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Provera (medroxyprogesterone)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Premarin Vaginal Cream (conjugated estrogens)?
Worth itNot sureNot worth it
Reviews for Estring (estradiol vaginal ring)
63%
-27% worse vs. Vagifem (estradiol vaginal tablet)
39%
-41% worse vs. Vagifem (estradiol vaginal tablet)
18%
-18% worse vs. Vagifem (estradiol vaginal tablet)
Have you used Estring (estradiol vaginal ring)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Divigel (estradiol gel)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Vivelle-Dot (estradiol patch)?
Worth itNot sureNot worth it
Side effects
VagifemPremarinEstradiol NorethindronePremproClimaraProveraPremarin Vaginal CreamEstringDivigelVivelle-Dot
  • Vulvovaginal mycotic infection 5%
  • Vulvovaginal pruritus 6%
  • Back pain 5%
  • Diarrhea 5%
  • Headache 3%
  • Abdominal pain 3%
  • Ear, nose, or throat infection 1%
  • Moniliassis genital 3%
More Vagifem side effects »
  • Excessive vaginal bleeding 13%
  • Abdominal pain 5%
  • Breast pain 3%
  • Passing gas 4%
  • Pain 1%
  • Thick vaginal discharge 3%
  • Endometrial hyperplasia 5%
  • Vaginitis 5%
  • Sleep difficulty 1%
More Premarin side effects »
  • Breast pain 24%
  • Ear, nose, or throat infection 18%
  • Headache 16%
  • Sinus inflammation 7%
  • Sleep difficulty 6%
  • Back pain 6%
  • Post-menopausal bleeding 5%
  • Uterine fibroid 5%
  • Infection viral 4%
  • Moniliasis genital 4%
More Estradiol Norethindrone side effects »

We haven’t found good data for Prempro side effects.

FDA side effect reports for Prempro »
  • Breast pain 1%
  • Sinus inflammation 1%
  • Inflammation inside the nose 1%
  • Swelling due to excess fluid 7%
  • Abdominal pain 3%
  • Pain 1%
More Climara side effects »

We haven’t found good data for Provera side effects.

FDA side effect reports for Provera »
  • Any side effect 8%
  • Abdominal pain 5%
  • Back pain 2%
  • Excessive vaginal bleeding 14%
  • Joint pain 2%
  • Upper respiratory infection 1%
More Premarin Vaginal Cream side effects »
  • Headache 13%
  • Thick vaginal discharge 7%
  • Back pain 6%
  • Yeast infection 6%
  • Ear, nose, or throat infection 5%
  • Vaginitis 5%
  • Vaginal discomfort/pain 5%
  • Sinus inflammation 4%
  • Asymptomatic genital bacterial growth 4%
  • Abdominal pain 4%
More Estring side effects »
  • Common cold 2%
  • Ear, nose, or throat infection 4%
  • Metrorrhagia 2%
  • Breast tenderness 1%
More Divigel side effects »
  • Breast tenderness 17%
  • Low mood disorder 7%
  • Back pain 3%
  • Weight increased 7%
  • Indigestion 3%
More Vivelle-Dot side effects »
How it works
VagifemPremarinEstradiol NorethindronePremproClimaraProveraPremarin Vaginal CreamEstringDivigelVivelle-Dot
Vagifem (Estradiol Vaginal Tablet) is a vaginal tablet that replaces estrogen hormones in your vagina that your body loses during menopause. Estrogen helps rebuild and maintain vaginal tissue, relieving symptoms of vaginal dryness, soreness, irritation, and painful sex.Premarin (Conjugated Estrogens) is an oral medication that replaces estrogen hormones during and after menopause. Higher levels of estrogen lower menopause-related hot flashes, flushing, night sweats, vaginal problems, and bone loss.Activella (Estradiol / Norethindrone) contains two hormones that work to balance hormone changes in your body during and after menopause. Estradiol (an estrogen) reduces hot flashes and night sweats and prevents bone loss, but can also harm cells in the uterus after menopause. Norethindrone (a progestin) protects the uterus from damage.Coming soon.The Climara (Estradiol Patch) replaces an estrogen hormone, estradiol, that your body loses during and after menopause. Higher levels of estradiol relieve symptoms of low estrogen and menopause and prevent bone loss.Provera (Medroxyprogesterone) contains medroxyprogesterone, a progesterone hormone that works to balance hormone changes in the body. In premenopausal women, it prevents thickening of the uterus lining and regulates your menstrual cycle. It's also added to hormone therapy to protect the uterus from the harmful effects of estrogen.Premarin Vaginal Cream (Conjugated Estrogens) is a topical medication that replaces estrogen hormones in the vagina to rebuild vaginal tissue and make vaginal sex more comfortable.Estring (Estradiol Vaginal Ring) is a vaginal ring that replaces estrogen hormones in your vagina that your body loses during menopause. Estrogen helps rebuild and maintain vaginal tissue, relieving symptoms of vaginal dryness, soreness, irritation, and painful sex.Divigel (Estradiol Gel) replaces estrogen hormones in your vagina that your body loses during menopause. Estrogen helps relieve symptoms of menopause, such as hot flashes, night sweats, and vaginal problems.The Vivelle-Dot (Estradiol Patch) replaces an estrogen hormone, estradiol, that your body loses during and after menopause. Higher levels of estradiol relieve symptoms of low estrogen and menopause and prevent bone loss.
Type of medication
VagifemPremarinEstradiol NorethindronePremproClimaraProveraPremarin Vaginal CreamEstringDivigelVivelle-Dot
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Available as
VagifemPremarinEstradiol NorethindronePremproClimaraProveraPremarin Vaginal CreamEstringDivigelVivelle-Dot
  • Vaginal tablet
  • Pill
  • Pill
  • Pill
  • Patch
  • Pill
  • Vaginal cream, gel, or ointment
  • Vaginal ring
  • Cream, gel, or ointment
  • Patch
Used for
VagifemPremarinEstradiol NorethindronePremproClimaraProveraPremarin Vaginal CreamEstringDivigelVivelle-Dot
  • Vaginal Dryness And Inflammation
  • Hot Flashes And Night Sweats
  • Hot Flashes And Night Sweats
  • Menopause Moderate To Severe Abnormal Vasomotor Function Menopause Moderate To Severe Vaginal Atrophy Moderate To Severe Vulvar Atrophy Postmenopausal Osteoporosis
  • Hot Flashes And Night Sweats
  • Amenorrhea
  • Vaginal Dryness And Inflammation
  • Vaginal Dryness And Inflammation
  • Hot Flashes And Night Sweats
  • Hot Flashes And Night Sweats
Risk factors for serious side effects
VagifemPremarinEstradiol NorethindronePremproClimaraProveraPremarin Vaginal CreamEstringDivigelVivelle-Dot
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
  • Systemic lupus erythematosus (SLE)
  • Smoking
  • Obesity
  • High blood pressure
  • High blood sugar
  • High cholesterol
  • Age 50 or older
  • Women of childbearing age
Detailed Vagifem (estradiol vaginal tablet) risks & warnings »
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
  • Systemic lupus erythematosus (SLE)
  • Smoking
  • Obesity
  • High blood pressure
  • High blood sugar
  • High cholesterol
  • Age 50 or older
      • Prior severe allergic reaction to Premarin (Conjugated Estrogens)
      • Women of childbearing age
      • High levels of triglycerides
      Detailed Premarin (conjugated estrogens) risks & warnings »
      • Using estrogen for more than one year
      • Personal or family history of breast cancer
      • Duration of use
      • Personal or family history of blood clots
      • Obesity
      • Systemic lupus erythematosus (SLE)
      • Women of childbearing age
      • High levels of triglycerides
      • Family history of ovarian cancer
      Detailed Activella (estradiol / norethindrone) risks & warnings »
      Coming soon.
      • Using estrogen for more than one year
      • Personal or family history of breast cancer
      • Duration of use
      • Personal or family history of blood clots
      • Obesity
      • Systemic lupus erythematosus (SLE)
      • Smoking
      • Obesity
      • High blood pressure
      • High blood sugar
      • High cholesterol
      • Age 50 or older
      • Women of childbearing age
      • High levels of triglycerides
      Detailed Climara (estradiol patch) risks & warnings »
      • Personal or family history of breast cancer
      • Family history of ovarian cancer
      • Personal or family history of blood clots
      • Smoking
      • Obesity
      • Hypertension
      • Diabetes
      • High cholesterol
      • Systemic lupus erythematosus (SLE)
      • History of depression
      • History of liver problems
      • Women of childbearing age
      Detailed Provera (medroxyprogesterone) risks & warnings »
      • Using estrogen for more than one year
      • Personal or family history of breast cancer
      • Duration of use
      • Personal or family history of blood clots
      • Obesity
      • Systemic lupus erythematosus (SLE)
      • Smoking
      • Obesity
      • High blood pressure
      • High blood sugar
      • High cholesterol
      • Age 50 or older
          • Prior severe allergic reaction to Premarin Vaginal Cream (Conjugated Estrogens)
          • Women of childbearing age
          • High levels of triglycerides
          Detailed Premarin Vaginal Cream (conjugated estrogens) risks & warnings »
          • Using estrogen for more than one year
          • Personal or family history of breast cancer
          • Duration of use
          • Personal or family history of blood clots
          • Obesity
          • Systemic lupus erythematosus (SLE)
          • Smoking
          • Obesity
          • High blood pressure
          • High blood sugar
          • High cholesterol
          • Age 50 or older
          • Women of childbearing age
          • High levels of triglycerides
          Detailed Estring (estradiol vaginal ring) risks & warnings »
          • Using estrogen for more than one year
          • Personal or family history of breast cancer
          • Duration of use
          • Personal or family history of blood clots
          • Obesity
          • Systemic lupus erythematosus (SLE)
          • Smoking
          • Obesity
          • High blood pressure
          • High blood sugar
          • High cholesterol
          • Age 50 or older
          • Women of childbearing age
            Detailed Divigel (estradiol gel) risks & warnings »
            • Using estrogen for more than one year
            • Personal or family history of breast cancer
            • Duration of use
            • Personal or family history of blood clots
            • Obesity
            • Systemic lupus erythematosus (SLE)
            • Smoking
            • Obesity
            • High blood pressure
            • High blood sugar
            • High cholesterol
            • Age 50 or older
            • Women of childbearing age
            • High levels of triglycerides
            Detailed Vivelle-Dot (estradiol patch) risks & warnings »
            Pregnancy

            Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

            Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

            Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

            Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

            Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

            Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

            Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

            Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

            Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

            Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

            Alcohol
            VagifemPremarinEstradiol NorethindronePremproClimaraProveraPremarin Vaginal CreamEstringDivigelVivelle-Dot
            No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.
            • The gel is alcohol-based and flammable, so you shouldn't smoke while applying it.
            No alcohol related info.
            Pain
            VagifemPremarinEstradiol NorethindronePremproClimaraProveraPremarin Vaginal CreamEstringDivigelVivelle-Dot
            • For painful sex, it can work better than over-the-counter vaginal lubricants because over time, Vagifem (Estradiol Vaginal Tablet) treats the cause of the problem (low estrogen levels), not just the symptoms (dryness).
            • Get emergency care if you notice swelling or pain in your lower legs, sudden shortness of breath, or an unexplained severe headache.
            No pain related info.No pain related info.No pain related info.No pain related info.
            • For painful sex, it can work better than over-the-counter vaginal lubricants because Premarin Vaginal Cream (Conjugated Estrogens) treats the cause of the problem (low estrogen levels), not just the symptoms (dryness).
            • If you have severe vaginal dryness, you might have pain, bleeding, or infections from repeatedly inserting the applicator.
            No pain related info.No pain related info.No pain related info.
            Weight
            VagifemPremarinEstradiol NorethindronePremproClimaraProveraPremarin Vaginal CreamEstringDivigelVivelle-Dot
            No weight related info.
            • Can cause nausea, dizziness, bloating and breast tenderness.
            • Can cause nausea, dizziness, bloating, and breast tenderness.
            • Activella (Estradiol / Norethindrone) is a mixture of estrogen and progestin. It could cause a higher risk of ovarian cancer, especially if you have a family history of it. Your doctor can help you weigh the risks versus the benefits of this medication.
            No weight related info.
            • Can cause nausea, dizziness, bloating, and breast tenderness.
            • Can cause headache, weight gain, breast tenderness, or changes in mood.
            • Provera (Medroxyprogesterone) contains progestin. It could cause a higher risk of ovarian cancer, especially if you have a family history of it. Your doctor can help you weigh the risks versus the benefits of this medication.
            No weight related info.No weight related info.
            • Can cause nausea, dizziness, bloating, and breast tenderness.
            • Can cause nausea, dizziness, bloating, and breast tenderness.
            Upsides and benefits
            VagifemPremarinEstradiol NorethindronePremproClimaraProveraPremarin Vaginal CreamEstringDivigelVivelle-Dot
            • Vagifem (Estradiol Vaginal Tablet) relieves vaginal dryness and irritation to make sex more enjoyable.
            • Works locally in the vagina and doesn't expose the rest of your body to estrogen like pills do.
            • Generally works well with few side effects.
            • For painful sex, it can work better than over-the-counter vaginal lubricants because over time, Vagifem (Estradiol Vaginal Tablet) treats the cause of the problem (low estrogen levels), not just the symptoms (dryness).
            • Premarin (Conjugated Estrogens) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
            • Lowers your risk of fractures by keeping your bones healthy. Make sure you also take enough calcium and Vitamin D.
            • Improves mood, energy, and mental alertness for some people.
            • Does not expose your partner to estrogen during sexual acitivities like vaginal estrogen creams.
            • Can help relieve symptoms of prostate cancer or advanced breast cancer in some people.
            • Activella (Estradiol / Norethindrone) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
            • Good choice for women with intact uterus. The norethindrone (a progestin) protects against the risk of cancer in the uterus from estrogen treatment.
            • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
            • Improves mood, energy, and mental alertness for some people.
            • Mimvey brand is less expensive than other estrogen/progestin combination medicines.
            Coming soon
            • The Climara (Estradiol Patch) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen, like hot flashes and vaginal dryness.
            • The patch is good for people who don't want to take daily pills.
            • Can be worn while swimming, bathing, and showering.
            • By using a patch instead of a pill, there's a lower risk of side effects such as blood clots and stroke since lower amounts of estrogen are used in patches.
            • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
            • Improves mood, energy, and mental alertness for some people.
            • Provera (Medroxyprogesterone) can be used to treat multiple hormone problems in women.
            • After menopause, taking estrogen raises your risk of uterine cancer. However, taking progesterone, like in Provera (Medroxyprogesterone), along with estrogen gives you the positive effects of estrogen, but also prevents it from damaging your uterus.
            • Women taking an estrogen/progestin combination medications have a lower risk of uterine cancer.
            • Premarin Vaginal Cream (Conjugated Estrogens) relieves vaginal dryness and irritation to make sex more enjoyable.
            • Works locally in the vagina and doesn't expose the rest of your body to estrogen like pills do.
            • Premarin Vaginal Cream (Conjugated Estrogens) doesn't need to be used forever, so you can work with your doctor to see how long you’ll need to continue treatment.
            • For painful sex, it can work better than over-the-counter vaginal lubricants because Premarin Vaginal Cream (Conjugated Estrogens) treats the cause of the problem (low estrogen levels), not just the symptoms (dryness).
            • Estring (Estradiol Vaginal Ring) relieves vaginal dryness and irritation to make sex more enjoyable.
            • Works locally in the vagina and doesn't expose the rest of your body to estrogen like pills do.
            • Good option for people who don't want to take oral pills.
            • Generally works well with fewer side effects.
            • Many women think Estring (Estradiol Vaginal Ring) is easy to insert and comfortable to use.
            • In a 12-week study, Estring (Estradiol Vaginal Ring) worked well to improve vaginal problems, reduced pain during urination, and sudden urges to urinate.
            • Estring (Estradiol Vaginal Ring) slowly releases estrogen over the 90 days the ring is in place, so you only have to remove and insert a new one every three months.
            • Divigel (Estradiol Gel) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness).
            • Good for people who don't want to take daily pills.
            • The pre-measured packets are easy to use and can be taken anywhere.
            • Fewer side effects than pills since there are lower amounts of estrogen in topical gels.
            • In studies, when people used low doses of Divigel (Estradiol Gel), their symptoms started to improve in 5 weeks and they felt continued improvement over 8 to 12 weeks. People using the highest doses of Divigel (Estradiol Gel) felt better in just 2 weeks.
            • Divigel (Estradiol Gel) is available in 3 strengths.
            • Very few women (less than 1%) had skin irritation from the medicine.
            • Can lower your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
            • Improves mood, energy, and mental alertness for some people.
            • Comes in 4 different strengths.
            • The Vivelle-Dot (Estradiol Patch) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen, like hot flashes and vaginal dryness.
            • The patch is good for people who don't want to take daily pills.
            • Can be worn while swimming, bathing, and showering.
            • By using a patch instead of a pill, there's a lower risk of side effects such as blood clots and stroke since lower amounts of estrogen are used in patches.
            • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
            • Improves mood, energy, and mental alertness for some people.
            Downsides and risks
            VagifemPremarinEstradiol NorethindronePremproClimaraProveraPremarin Vaginal CreamEstringDivigelVivelle-Dot
            • Vaginal estrogens can weaken latex (rubber) condoms, cervical caps, and diaphrams. Don't use these within 72 hours after a dose.
            • Inserting the applicator can possibly cause discomfort or infection.
            • If you have your uterus, you might need to use Vagifem (Estradiol Vaginal Tablet) with another hormone called progestin to lower your risk of uterine cancer.
            • Can be expensive since it's only available as a brand name product.
            • More potential side effects than estrogen creams since it exposes your whole body to estrogen.
            • Increases your risk of uterine and breast cancer.
            • If you have your uterus, you have to take Premarin (Conjugated Estrogens) with another hormone called progestin to lower your risk of uterine cancer.
            • Increases your risk of developing blood clots and stroke.
            • Can't be used in people with liver problems.
            • Can be expensive since it's only available as a brand name product.
            • More potential side effects since it exposes your whole body to two hormones, estrogen and norethindrone (a progestin).
            • Increases your risk of developing blood clots and stroke.
            • You may get irregular bleeding and spotting that can last a few months to a year.
            Coming soon
            • Patch can fall off.
            • Increases your risk of uterine and breast cancer.
            • If you have your uterus, you have to use the Climara (Estradiol Patch) with another hormone called progestin to lower your risk of uterine cancer.
            • Increases your risk of developing blood clots and stroke.
            • Can worsen other health conditions, like high cholesterol, asthma, diabetes, fluid retention, and migraines.
            • Can't be used in people with liver problems.
            • You can't take Provera (Medroxyprogesterone) if you've had a hysterectomy (your uterus removed). You also can't take it if you're pregnant or breastfeeding, have unusual vaginal bleeding, or have a history of blood clots, certain kinds of cancer, stroke, heart attack, liver problems, or bleeding problems.
            • Vaginal estrogens can weaken latex (rubber) condoms, cervical caps, and diaphragms, so you can't rely on these for birth control for 72 hours after using Premarin Vaginal Cream (Conjugated Estrogens).
            • If you have severe vaginal dryness, you might have pain, bleeding, or infections from repeatedly inserting the applicator.
            • Some of the medicine can be absorbed into your partner's skin, so you can’t have vaginal sex right after using Premarin Vaginal Cream (Conjugated Estrogens).
            • Even though Premarin Vaginal Cream (Conjugated Estrogens) is used in the vagina, it's possible some of the estrogens will get into the rest of your body and cause side effects that happen more often with estrogen pills.
            • Estring (Estradiol Vaginal Ring) may not be the best estrogen product if you have a narrow vagina or frequent vaginal infections.
            • The ring can fall out without you noticing it.
            • Increases your risk of endometrial (uterine cancer).
            • If you have your uterus, you might need to use Estring (Estradiol Vaginal Ring) with another hormone called progestin to lower your risk of uterine cancer.
            • Can be expensive since it's only available as a brand name product.
            • Increases your risk of endometrial and breast cancer.
            • If you have your uterus, you have to use Divigel (Estradiol Gel) with another hormone called progestin to lower your risk of uterine cancer.
            • Increases your risk of developing blood clots and stroke.
            • Can't be used in people with liver problems.
            • It's possible to expose other people to the estrogen before it's absorbed by your skin.
            • Can be expensive since it's only available as a brand name product.
            • You need to replace the Vivelle-Dot (Estradiol Patch) twice a week, compared to other patches that are once a week.
            • Patch can fall off.
            • Increases your risk of uterine and breast cancer.
            • If you have your uterus, you have to use the Vivelle-Dot (Estradiol Patch) with another hormone called progestin to lower your risk of uterine cancer.
            • Increases your risk of developing blood clots and stroke.
            • Can worsen other health conditions, like high cholesterol, asthma, diabetes, fluid retention, and migraines.
            • Can't be used in people with liver problems.
            Tips from our pharmacists for people taking the medication
            VagifemPremarinEstradiol NorethindronePremproClimaraProveraPremarin Vaginal CreamEstringDivigelVivelle-Dot
            • Each applicator contains 1 pill to be placed in the vagina. Don't take this tablet by mouth.
            • Insert the applicator deeply into your vagina and press the plunger to release the pill.
            • Use 1 tablet once a day for 2 weeks, then 1 tablet twice a week.
            • Make sure you ask your doctor or pharmacist how to use the applicator.
            • Throw the applicator out after each use.
            • Most people don't have many side effects, but temporary headache, dizziness, bloating, and breast tenderness are possible.
            • Tell your doctor about any unusual vaginal bleeding.
            • Take Premarin (Conjugated Estrogens) at the same time each day. If you miss a dose, take it as soon as possible, but if it’s almost time for your next dose, take only that dose.
            • Use the lowest dose possible of Premarin (Conjugated Estrogens) and take it only as long as needed. Talk to your doctor regularly to see if you still need treatment. If you’re taking Premarin (Conjugated Estrogens) only for vaginal symptoms or to prevent bone loss, there are other medicines that can work better with fewer side effects (like a vaginal cream for menopause symptoms, or non-estrogen medicine for bone loss).
            • Can cause nausea, dizziness, bloating and breast tenderness.
            • Get emergency care if you notice swelling or pain in your lower legs, sudden shortness of breath, or an unexplained severe headache.
            • Tell your doctor about any unusual vaginal bleeding.
            • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
            • Can cause nausea, dizziness, bloating, and breast tenderness.
            • Tell your doctor about any unusual vaginal bleeding.
            • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
            Coming soon
            • Remove the patch by tearing the package by hand and not with scissors. Never cut the patch.
            • Apply the sticky side of the patch to clean, dry, hairless skin below your waistline on areas as instructed by the manufacturer (never on your breast).
            • Replace the patch every 7 days on a different area of your skin to lower your risk of skin irritation.
            • Fold together the sticky sides of used patches before throwing them away to avoid exposing others to the medicine. Don't flush them down the toilet.
            • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
            • Can cause nausea, dizziness, bloating, and breast tenderness.
            • Tell your doctor about any unusual vaginal bleeding.
            • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
            • The dose of Provera (Medroxyprogesterone) will be different depending on what you’re using it for, so take it exactly the way your doctor tells you.
            • Talk to your doctor every few months about using the lowest possible dose of Provera (Medroxyprogesterone). Since there can be a lot of long-term side effects, take it only as long as you need it.
            • Can cause headache, weight gain, breast tenderness, or changes in mood.
            • If you're taking Provera (Medroxyprogesterone) to regulate your period, you'll get withdrawal bleeding 3 to 7 days after stopping Provera (Medroxyprogesterone).
            • Your doctor will tell you how often to use Premarin Vaginal Cream (Conjugated Estrogens). If you're taking Premarin Vaginal Cream (Conjugated Estrogens) regularly, use it around the same time each day.
            • Attach the applicator to the tube. Once the dose is measured, insert the applicator deeply into your vagina, and press the plunger to release all the medicine. Clean the applicator after each use.
            • More effective if you use it at bedtime.
            • Consider wearing a panty liner after use.
            • Most people don't have many side effects, but temporary nausea, dizziness, bloating, and breast tenderness are possible.
            • Insert the ring as deeply as possible into your vagina. You shouldn't feel the ring once it's inserted.
            • The ring is good for 90 days in your vagina. If it falls out before the 90 days are up, just clean it with warm water and reinsert.
            • You don’t have to remove Estring (Estradiol Vaginal Ring) to treat a vaginal infection or have sex.
            • It can take up to 2 to 3 weeks to feel the full benefits.
            • Most people don't have many side effects, but temporary nausea, dizziness, bloating, and breast tenderness are possible.
            • Tell your doctor about any unusual vaginal bleeding.
            • Apply all of the gel in the packet to dry, clean, unbroken skin on the right or left upper thigh, alternating each day.
            • Don't put it on your face, breasts, vagina, or irritated skin.
            • Don't rub it in. Let the gel dry before dressing, and don't wash the application site for at least an hour.
            • Wash your hands well after applying the gel.
            • The gel is alcohol-based and flammable, so you shouldn't smoke while applying it.
            • Can cause nausea, dizziness, bloating, and breast tenderness.
            • Tell your doctor about any unusual vaginal bleeding.
            • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
            • Remove the patch by tearing the package by hand and not with scissors. Never cut the patch.
            • Apply the sticky side of the patch to clean, dry, hairless skin below your waistline on areas as instructed by the manufacturer (never on your breast).
            • Replace the patch twice a week (every 3-4 days) on a different area of your skin to lower your risk of skin irritation.
            • Fold together the sticky sides of used patches before throwing them away to avoid exposing others to the medicine. Don't flush them down the toilet.
            • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
            • Can cause nausea, dizziness, bloating, and breast tenderness.
            • Tell your doctor about any unusual vaginal bleeding.
            • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
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