(Hydrocodone / Ibuprofen)

Ibudone (Hydrocodone / Ibuprofen)

Prescription only

Advil (ibuprofen)

1 of 2 alternatives
Treats moderate to severe pain.

Ibudone (Hydrocodone / Ibuprofen) works well for moderate to severe pain, but it shouldn't be used long-term.

Relieves pain, fever, and swelling.

Advil (ibuprofen) works well for treating fever, inflammation, and a variety of mild to moderate pain conditions, but it doesn't last as long as other NSAIDs.

  • Effective option to relieve short-term moderate to severe pain.
  • Provides better pain control since Ibudone (Hydrocodone / Ibuprofen) is a combination medicine that works in two different ways.
  • Can cause less sleepiness than other similar medicines.
  • Available as a generic and comes in different strengths.
  • Advil (ibuprofen) is effective for treating fever, pain, and inflammation.
  • Good for relieving pain due to common conditions like menstrual cramps, toothaches, backaches, and sports-related injuries.
  • Advil (ibuprofen) is generally safe to use, cheap, and available over-the-counter.
  • Advil (ibuprofen) causes less stomach problems than its alternatives.
  • It comes in different flavored liquid forms that makes it easy for children to take.
  • Not used for long-term pain or for conditions like osteoarthritis or rheumatoid arthritis.
  • Can cause serious heart and stomach problems. The risk goes up the longer you take it, but problems can happen at any time. Don't take Ibudone (Hydrocodone / Ibuprofen) any longer than your doctor recommends.
  • Ibudone (Hydrocodone / Ibuprofen) raises your risk of bleeding, especially when taken with other blood-thinning medicines.
  • You can experience withdrawal symptoms if you suddenly stop taking Ibudone (Hydrocodone / Ibuprofen).
  • Not a good choice if you have high blood pressure or kidney, liver, or stomach problems.
  • Advil (ibuprofen) doesn't last as long as other NSAIDs, so you need to take it a few times a day to get relief of your symptoms.
  • It needs to be taken with food or millk to avoid getting an upset stomach.
  • Advil (ibuprofen) is not as safe as other alternatives for pregnant women and people who are age 60 or older.
  • It can cause serious complications like stomach bleeding and kidney problems if taken for a long period of time.
  • Like all NSAIDs, Advil (ibuprofen) can raise your risk of getting blood clots, a heart attack, or stroke.
Used for
Dosage forms
  • Pill
  • Pill
  • Chewable tablet
  • Suspension
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Side effects
6possible side effects
  • Headache
  • Somnolence
  • Constipation
  • Nausea
  • Dizziness
  • Dyspepsia
See more detailed side effects
The Advil (ibuprofen) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Heart attack or stroke

    History of cardiovascular disease

    ...and 2 more risk factors

  • Stomach bleeding

    History of stomach bleeding or ulcers

    ...and 1 more risk factors

  • Driving impairment

    Taking with alcohol

    ...and 1 more risk factors

  • Harm to fetus

    Women of childbearing age

  • Low blood pressure

    Age 65 years or older

  • Worsening kidney or liver function

    Heart failure

    ...and 2 more risk factors

  • Bleeding or bruising

    Blood-thinning medicines

    ...and 1 more risk factors

See more detailed risks and warnings
  • Heart attack and stroke

    History of heart problems

    ...and 1 more risk factors

  • Stomach bleeding

    History of stomach bleeding

    ...and 5 more risk factors

  • Severe allergic reaction


    ...and 3 more risk factors

  • Kidney damage

    Kidney disease

    ...and 5 more risk factors

  • Harm to fetus (unborn baby)

    Women who want to or can become pregnant

    ...and 1 more risk factors

See more detailed risks and warnings