Prescription onlyNo lower cost generic available

Viibryd

(Vilazodone)

  • Pill
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Treats depression.

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Prescription onlyNo lower cost generic available

Our pharmacists’ bottom line

Viibryd (Vilazodone) is a good option to treat depression, but it often causes stomach and intestinal problems, including diarrhea.

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Works well?Does it work?
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  • Viibryd (Vilazodone) improves depressive symptoms in people with major depressive disorder.
  • The dose of Viibryd (Vilazodone) doesn’t need to be changed if you have severe kidney disease.
  • Compared to other antidepressants, it has a lower risk of weight gain and causing problems with sexual function.
  • You shouldn’t take Viibryd (Vilazodone) if you have severe liver problems.
  • Can’t take Viibryd (Vilazodone) with drugs called monoamine oxidase inhibitors (MAOIs).
  • Need to avoid drinking alcohol while taking Viibryd (Vilazodone).

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Side effects for Viibryd (Vilazodone)

From clinical trials of Viibryd / Depression (40 mg) ( 869)

  • DiarrheaDiarrhea28% for Viibryd vs.9% for placebo
  • NauseaNausea23% for Viibryd vs.5% for placebo
  • DizzinessDizziness9% for Viibryd vs.5% for placebo
  • Dry mouthDry mouth8% for Viibryd vs.5% for placebo
  • Sleep difficultySleep difficulty6% for Viibryd vs.2% for placebo
  • Decreased libidoDecreased libido5% for Viibryd vs.0% for placebo
  • VomitingVomiting5% for Viibryd vs.1% for placebo
  • Lower sex driveLower sex drive4% for Viibryd vs.0% for placebo
  • FatigueFatigue4% for Viibryd vs.3% for placebo
  • Abnormal orgasmAbnormal orgasm4% for Viibryd vs.0% for placebo

Manufacturers don’t say how common these side effects are

  • Delayed ejaculation
  • Impotence
  • Sexual dysfunction

What to expect when you take Viibryd (Vilazodone)

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Tips from our pharmacists
  • Take Viibryd (Vilazodone) with food at the same time every day.
  • Your dose will need to be increased slowly over the first 3 weeks to reduce feelings of upset stomach.
  • It can take 4 to 6 weeks to see the full effects, so continue taking it even if you start to feel better.
  • Stopping Viibryd (Vilazodone) suddenly can cause withdrawal symptoms, including anxiety, irritability, headache, and dizziness. Gradually lower your dose over a 1 to 2 week period before stopping it completely.
  • Call your doctor right away if you notice new or worsening symptoms of aggressive or violent behavior, panic attacks, or other unusual changes in behavior or mood.

Risks and Warnings for Viibryd (Vilazodone)

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    • Higher risk if:
    • Age 18 years or younger

    Viibryd (Vilazodone) can increase the risk of suicidal thoughts or behavior. Watch for worsening depression or any unusual changes in mood or behavior, especially during the first few months of treatment, or when the dose changes. Report anything concerning to a doctor immediately. Viibryd (Vilazodone) is not approved for children younger than age 18 years.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Viibryd (Vilazodone)

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The FDA category for this medication is C. It is advised that you: Weigh risks vs. benefits
Pregnancy
Alcohol
  • Upsides and downsides from our pharmacists
  • Need to avoid drinking alcohol while taking Viibryd (Vilazodone).
  • Made me absolutely psychotic. Literally. I am a very aggreable and positive person to be around and this medicine caused me to be aggressive and impulsive. Mixed with minor amounts of alcohol caused rage filled blackouts/lkng for fights. :/
    Age: 33
    Gender: Woman
    Taken for: Major depressive disorder
Food
  • Tips from our pharmacists
  • Take Viibryd (Vilazodone) with food at the same time every day.
  • Take with food! Helps with the awful stomach side effects, & is imperative for the drug to work. Taking without food decreases efficiency. Viibryd, gave me constant "brain zaps" even when taken consistently, and worse when starting/ending.
    Age: 29
    Gender: Woman
    Taken for: Depression, anxiety
    Duration taken: A year or so
  • Helps to take with food and plenty of water. Mornings have personally worked best.
    Age: 30
    Gender: Woman
    Taken for: Major depressive disorder
  • Take with a small snack at bedtime. Never had any side effects.
    Age: 60
    Gender: Woman
    Taken for: Major depressive disorder
Kidneys & liver
  • Upsides and downsides from our pharmacists
  • The dose of Viibryd (Vilazodone) doesn’t need to be changed if you have severe kidney disease.
Sex
  • Upsides and downsides from our pharmacists
  • Compared to other antidepressants, it has a lower risk of weight gain and causing problems with sexual function.
  • This is absolutely the only depression drug I've ever taken that WORKS & didn't make me feel like a Zombie or tired all the time. I had more energy and there were NO Sexual side effects. I actually had a big increase in Libido.
    Age: 41
    Gender: Woman
    Duration taken: A few months
  • Higher doses led to anorgasmia (inability to ejaculate). Lowering the dose and supplementing with Ritalin has allowed successful treatment and ended the side-effects.
    Age: 41
    Gender: Man
    Taken for: Depression
    Duration taken: A year or so
  • I've been on multiple antidepressants and this is the only one I've noticed that truly has made a difference. I take 40mg daily in the morning. I had abnormal dreams/nightmares for the first few days of taking it/increasing dose but they subsided it was worth the wait. I have not had sexual side effects or weight gain/loss, though I do sweat more than I had previously.
    Age: 25
    Gender: Woman
    Taken for: Major depressive disorder
Sleep
  • Risks from our pharmacists
  • In some people, antidepressants like Viibryd (Vilazodone) can trigger a manic episode (increased energy, severe trouble sleeping, racing thoughts, reckless behavior, unusually grand ideas, excessive happiness/ irritability, talking faster or louder than usual). Let your doctor know if you've had any manic episodes in the past or were treated for bipolar disorder before taking Viibryd (Vilazodone).
  • Do take with food. I didn't experience GI issues, but it felt almost like I skipped the dose if I took it without food. Had a lot of trouble sleeping at first and with dose change - melatonin helped get through those periods
    Age: 19
    Gender: Woman
    Taken for: Major depressive disorder
  • I missed taking the 40mg one night and my started to act like a seizure when I'm about in a deep sleep. It kept me up until 4 in the morning. So, I cut my dose down from that day.
    Age: 16
    Gender: Woman
    Taken for: Major depressive disorder
    Duration taken: A month or so
  • I took it close to bedtime at first and experienced sleep paralysis which was very scary the first time. I began taking it in the morning and haven't had the problem since.
    Age: 31
    Gender: Woman
    Taken for: Major depressive disorder
    Duration taken: A few months
Weight gain or loss
  • Upsides and downsides from our pharmacists
  • Compared to other antidepressants, it has a lower risk of weight gain and causing problems with sexual function.
  • I've been on multiple antidepressants and this is the only one I've noticed that truly has made a difference. I take 40mg daily in the morning. I had abnormal dreams/nightmares for the first few days of taking it/increasing dose but they subsided it was worth the wait. I have not had sexual side effects or weight gain/loss, though I do sweat more than I had previously.
    Age: 25
    Gender: Woman
    Taken for: Major depressive disorder