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Viibryd Alternatives

(Vilazodone)

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Compare Viibryd (Vilazodone) to alternatives

These medications are comparable to Viibryd (Vilazodone) or used for similar purposes.

Viibryd
(Vilazodone)

Cymbalta
(Duloxetine)

Effexor
(Venlafaxine)

Lexapro
(Escitalopram)

Paxil
(Paroxetine)

Serzone
(Nefazodone)

Pristiq
(Desvenlafaxine)

Oleptro
(Trazodone)

Zoloft
(Sertraline)

Treats depression. Viibryd (Vilazodone) is a good option to treat depression, but it often causes stomach and intestinal problems, including diarrhea.Improves mood and relieves certain kinds of pain. Cymbalta (Duloxetine) is good for treating depression and anxiety, and may help with chronic pain. More likely than other antidepressants to cause problems if you drink or have high blood pressure.Improves mood and helps you relax. Effexor (Venlafaxine) is good for treating depression and anxiety. May work when other antidepressants haven't, it's but more likely to cause side effects and withdrawal symptoms than other antidepressants.Improves mood and helps you relax. Lexapro (Escitalopram) is good for treating depression and anxiety. Might be less likely to cause side effects than some antidepressants, but not the best choice for people with heart or liver problems.Improves mood and helps you relax. Paxil (Paroxetine) is good for treating depression and anxiety but it causes more weight gain, sleepiness, and withdrawal symptoms than other antidepressants.Coming soon.Improves mood. Pristiq (Desvenlafaxine) is basically the same medication as Effexor, which is cheaper because it's available as a generic.Improves mood and helps you sleep. Oleptro (Trazodone) works well as a sleep aid, but has more side effects when used at higher doses for treating depression.Improves mood and helps you relax. Zoloft (Sertraline) is good for treating depression and anxiety. It's more likely to cause insomnia and diarrhea than other antidepressants.
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Reviews & ratings
Button Group. All currently active
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5.442857142857143Viibryd
Reviews for Viibryd (Vilazodone)
67%
of people say Viibryd (Vilazodone) is worth it
59%
say it works well
13%
say it's a big hassle
Reviews for Cymbalta (Duloxetine)
59%
8% vs. Viibryd (Vilazodone)
49%
10% vs. Viibryd (Vilazodone)
24%
11% vs. Viibryd (Vilazodone)
Reviews for Effexor (Venlafaxine)
61%
6% vs. Viibryd (Vilazodone)
50%
9% vs. Viibryd (Vilazodone)
22%
9% vs. Viibryd (Vilazodone)
Reviews for Lexapro (Escitalopram)
59%
8% vs. Viibryd (Vilazodone)
46%
13% vs. Viibryd (Vilazodone)
15%
2% vs. Viibryd (Vilazodone)
Reviews for Paxil (Paroxetine)
52%
15% vs. Viibryd (Vilazodone)
39%
20% vs. Viibryd (Vilazodone)
23%
10% vs. Viibryd (Vilazodone)

Not enough reviews for this drug. Help someone out, leave a review!

Reviews for Pristiq (Desvenlafaxine)
48%
19% vs. Viibryd (Vilazodone)
45%
14% vs. Viibryd (Vilazodone)
25%
12% vs. Viibryd (Vilazodone)
Reviews for Oleptro (Trazodone)
72%
+5% vs. Viibryd (Vilazodone)
48%
11% vs. Viibryd (Vilazodone)
24%
11% vs. Viibryd (Vilazodone)
Reviews for Zoloft (Sertraline)
59%
8% vs. Viibryd (Vilazodone)
40%
19% vs. Viibryd (Vilazodone)
15%
2% vs. Viibryd (Vilazodone)
Side effects
ViibrydCymbaltaEffexorLexaproPaxilSerzonePristiqOleptroZoloft
  • Diarrhea 19%
  • Nausea 18%
  • Vomiting 4%
  • Dizziness 4%
  • Sleep difficulty 4%
  • Dry mouth 3%
  • Abnormal dreams 3%
  • Tingling sensation 2%
  • Fatigue 1%
  • Impotence 1%
More Viibryd side effects »
  • Nausea 15%
  • Dry mouth 8%
  • Drowsiness 8%
  • Constipation 7%
  • Somnolencee 7%
  • Decreased appetite 7%
  • Fatigued 6%
  • Sleep difficulty 5%
  • Dizziness 4%
  • Fatigue 4%
More Cymbalta side effects »
  • Nausea 42%
  • Drowsiness 22%
  • Dizziness 20%
  • Nervousness 17%
  • Sleep difficulty 16%
  • Loss of appetite 15%
  • Sweating 14%
  • Dry mouth 13%
  • Dry mouth 11%
  • Muscle weakness 10%
More Effexor side effects »
  • Ejaculation disorder 12%
  • Ejaculation disorder (primarily ejaculatory delay) 11%
  • Sleep difficulty 10%
  • Nausea 10%
  • Diarrhea 9%
  • Headache 7%
  • Drowsiness 6%
  • Fatigue 6%
  • Dizziness 5%
  • Lower sex drive 5%
More Lexapro side effects »
  • Abnormal ejaculation† 27%
  • Ejaculatory disturbance 26%
  • Nausea 22%
  • Dry mouth 19%
  • Drowsiness 17%
  • Lower sex drive 11%
  • Diarrhea 11%
  • Sleep difficulty 11%
  • Constipation 10%
  • Decreased libido 10%
More Paxil side effects »

We haven’t found good data for Serzone side effects.

FDA side effect reports for Serzone »
  • Nausea 31%
  • Excessive sweating 17%
  • Dry mouth 16%
  • Dizziness 11%
  • Constipation 10%
  • Impotence 10%
  • Sleep difficulty 9%
  • Decreased appetite 8%
  • Drowsiness 8%
  • Fatigue 7%
More Pristiq side effects »
  • Somnolence/sedation 27%
  • Drowsiness 21%
  • Dry mouth 14%
  • Dizziness/lightheadedness 13%
  • Dizziness 13%
  • Blurred vision 11%
  • Nausea 8%
  • Fatigue 7%
  • Skin condition/edema 6%
  • Headache 6%
More Oleptro side effects »
  • Nausea 19%
  • Ejaculation failure 18%
  • Sleep difficulty 16%
  • Diarrhea/loose stools 14%
  • Fatigue 9%
  • Loss of appetite 9%
  • Lower sex drive 9%
  • Sweating increased 9%
  • Dizziness 8%
  • Indigestion 8%
More Zoloft side effects »
How it works
ViibrydCymbaltaEffexorLexaproPaxilSerzonePristiqOleptroZoloft
Viibryd (Vilazodone) is an antidepressant that is both a selective serotonin reuptake inhibitor (SSRI) and a serotonin receptor agonist. It treats depression by adjusting the levels of serotonin in your brain.Cymbalta (Duloxetine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulates mood.Effexor (Venlafaxine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulate mood.Lexapro (Escitalopram) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Paxil (Paroxetine) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Coming soon.Pristiq (Desvenlafaxine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulates mood.Oleptro (Trazodone) is a serotonin reuptake inhibitor (SRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Zoloft (Sertraline) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases the activity of serotonin in the brain, which regulates mood.
Type of medication
ViibrydCymbaltaEffexorLexaproPaxilSerzonePristiqOleptroZoloft
Antidepressant
Partial serotonin receptor agonist
Prescription only
Antidepressant
Serotonin-norepinephrine reuptake inhibitor (SNRI)
Prescription only
Antidepressant
Serotonin-norepinephrine reuptake inhibitor (SNRI)
Prescription only
Antidepressant
Selective serotonin reuptake inhibitor (SSRI)
Prescription only
Antidepressant
Selective serotonin reuptake inhibitor (SSRI)
Prescription only
Coming soon.
Antidepressant
Serotonin-norepinephrine reuptake inhibitor (SNRI)
Prescription only
Antidepressant
Serotonin antagonist and reuptake inhibitor
Prescription only
Antidepressant
Selective serotonin reuptake inhibitor (SSRI)
Prescription only
Available as
ViibrydCymbaltaEffexorLexaproPaxilSerzonePristiqOleptroZoloft
  • Pill
  • Extended release
  • Pill
  • Extended release
  • Pill
  • Liquid
  • Pill
  • Extended release tablet
  • Liquid
  • Pill
  • Extended release
  • Pill
  • Extended release
  • Pill
  • Liquid
Used for (click to learn more)
ViibrydCymbaltaEffexorLexaproPaxilSerzonePristiqOleptroZoloft
  • Major depressive disorder
How well it works for depression
The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.
The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Viibryd (Vilazodone)

After 4 weeks using Start and Cymbalta (Duloxetine), here’s how much better people feel.

After 4 weeks using Start and Effexor (Venlafaxine), here’s how much better people feel.

After 4 weeks using Start and Lexapro (Escitalopram), here’s how much better people feel.

After 4 weeks using Start and Paxil (Paroxetine), here’s how much better people feel.

The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Serzone (Nefazodone)

After 4 weeks using Start and Pristiq (Desvenlafaxine), here’s how much better people feel.

The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Oleptro (Trazodone)

After 4 weeks using Start and Zoloft (Sertraline), here’s how much better people feel.

Risk factors for serious side effects
ViibrydCymbaltaEffexorLexaproPaxilSerzonePristiqOleptroZoloft
  • Age 18 years or younger
  • Taking Viibryd (Vilazodone) with MAOIs
  • Taking Viibryd (Vilazodone) with Zyvox or methylene blue
  • Taking Viibryd (Vilazodone) with other drugs that increase serotonin
  • Taking Viibryd (Vilazodone) with NSAIDs, warfarin, aspirin, or other drugs that affect clotting
  • Women of childbearing age
  • History of glaucoma
  • History of bipolar disorder (mixed/mania)
Detailed Viibryd (Vilazodone) risks & warnings »
Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.
Pregnancy category
ViibrydCymbaltaEffexorLexaproPaxilSerzonePristiqOleptroZoloft
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
DFDA pregnancy category (Weigh risks vs. benefits)

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
Alcohol
  • Need to avoid drinking alcohol while taking Viibryd (Vilazodone).
No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.
Food
  • Take Viibryd (Vilazodone) with food at the same time every day.
  • Take with food to avoid upset stomach.
  • You can take the extended-release form once a day with food either in the morning or in the evening at about the same time each day.
  • Take with food to avoid upset stomach.
  • Take with food to avoid upset stomach.
No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.
Kidneys and liver
  • The dose of Viibryd (Vilazodone) doesn’t need to be changed if you have severe kidney disease.
  • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.
Sex
  • Compared to other antidepressants, it has a lower risk of weight gain and causing problems with sexual function.
No specific sex-related info.
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
  • Can cause more sexual side effects like low libido and an inability to orgasm or ejaculate than most antidepressants.
No specific sex-related info.
  • Can cause sexual side effects (usually low libido or the inability to have an orgasm or ejaculate).
  • Fewer sexual side effects than many other antidepressants.
  • Seek medical attention for unwanted, persistent erection.
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
Sleep
  • In some people, antidepressants like Viibryd (Vilazodone) can trigger a manic episode (increased energy, severe trouble sleeping, racing thoughts, reckless behavior, unusually grand ideas, excessive happiness/ irritability, talking faster or louder than usual). Let your doctor know if you've had any manic episodes in the past or were treated for bipolar disorder before taking Viibryd (Vilazodone).
No specific sleep-related info.
  • Causes more sleepiness than other antidepressants, so it's good for people who have trouble sleeping.
No specific sleep-related info.
  • It causes drowsiness, so it's good for people who have trouble sleeping.
No specific sleep-related info.No specific sleep-related info.
  • Commonly used in lower doses to help treat sleep problems (insomnia).
  • Safer sleep medication than others (benzodiazepines or Unisom) for people age 65 and older.
  • Has been used for sleep and depression for a long time. There's a lot of information available about how it works and how safe it is.
  • Comes as a generic medication and is cheaper than many other sleep aides.
  • Causes less drowsiness than other antidepressants.
Weight
  • Compared to other antidepressants, it has a lower risk of weight gain and causing problems with sexual function.
No specific weight-related info.No specific weight-related info.
  • More likely to cause minor weight gain (1 to 5 pounds) than other antidepressants.
  • More likely to cause minor weight gain (1 to 5 pounds) or make you feel sick if you miss a dose than other antidepressants.
  • Can cause weight gain, which can be helpful if you've recently lost weight or have a low appetite.
No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.
Upsides and benefits
ViibrydCymbaltaEffexorLexaproPaxilSerzonePristiqOleptroZoloft
  • Viibryd (Vilazodone) improves depressive symptoms in people with major depressive disorder.
  • The dose of Viibryd (Vilazodone) doesn’t need to be changed if you have severe kidney disease.
  • Compared to other antidepressants, it has a lower risk of weight gain and causing problems with sexual function.
  • Lowers relapse rates for depression.
  • Can relieve some types of chronic pain. Might be particularly good at pain relief for people who are also depressed.
  • Effective at relieving depression and anxiety symptoms.
  • Causes more sleepiness than other antidepressants, so it's good for people who have trouble sleeping.
  • Might work when other antidepressants haven't worked since it affects two chemicals in the brain that impact your mood. Many other antidepressants affect only serotonin, but not norepinephrine too.
  • Effective at relieving depression and anxiety symptoms.
  • Lowers relapse rates of depression.
  • Causes less sleepiness than some other antidepressants.
  • Effective at relieving depression and anxiety symptoms.
  • Lowers relapse rates of depression.
  • Lowers relapse rates of depression and anxiety disorders, including OCD, panic disorder, social anxiety disorder, and generalized anxiety disorder.
  • It causes drowsiness, so it's good for people who have trouble sleeping.
  • Can cause weight gain, which can be helpful if you've recently lost weight or have a low appetite.
  • Effective at relieving depression and anxiety symptoms.
Coming soon.
  • Effective at relieving symptoms and lowering relapse rates for depression.
  • Commonly used in lower doses to help treat sleep problems (insomnia).
  • Safer sleep medication than others (benzodiazepines or Unisom) for people age 65 and older.
  • Fewer sexual side effects than many other antidepressants.
  • Has been used for sleep and depression for a long time. There's a lot of information available about how it works and how safe it is.
  • Comes as a generic medication and is cheaper than many other sleep aides.
  • Effective at lowering symptoms and relapse rates of depression and anxiety disorders.
  • Causes less drowsiness than other antidepressants.
Downsides and risks
ViibrydCymbaltaEffexorLexaproPaxilSerzonePristiqOleptroZoloft
  • You shouldn’t take Viibryd (Vilazodone) if you have severe liver problems.
  • Can’t take Viibryd (Vilazodone) with drugs called monoamine oxidase inhibitors (MAOIs).
  • Need to avoid drinking alcohol while taking Viibryd (Vilazodone).
  • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
  • Not the best option for people with high blood pressure.
  • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • Overdosing on this medication could be fatal.
  • It's more likely to cause nausea and vomiting or make you feel sick if you miss a dose than other antidepressants. Also causes more sleepiness than others.
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
  • Not the best option for people with high blood pressure.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
  • More likely to cause minor weight gain (1 to 5 pounds) than other antidepressants.
  • Can cause an irregular heartbeat if you take a high dose (20 mg a day, or more).
  • Not a good option for you if you have heart or liver problems.
  • The first antidepressant you try doesn't always work, and might have side effects you really don't like. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
  • More likely to cause minor weight gain (1 to 5 pounds) or make you feel sick if you miss a dose than other antidepressants.
  • Can harm an unborn child, so you can't take it if you're pregnant.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than age 24.
  • Can cause more sexual side effects like low libido and an inability to orgasm or ejaculate than most antidepressants.
Coming soon.
  • Similar to Effexor, without any extra benefits in clinical studies.
  • Can cause sexual side effects (usually low libido or the inability to have an orgasm or ejaculate).
  • Not available in generic form, so it's more expensive.
  • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • Not as effective as other medications for depression.
  • More sedating than other antidepressants.
  • Causes more side effects when used at higher doses for depression. Includes sleepiness, dizziness, upset stomach, and irregular heartbeat.
  • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • More likely to cause diarrhea than other antidepressants.
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
Tips from our pharmacists for people taking the medication
ViibrydCymbaltaEffexorLexaproPaxilSerzonePristiqOleptroZoloft
  • Take Viibryd (Vilazodone) with food at the same time every day.
  • Your dose will need to be increased slowly over the first 3 weeks to reduce feelings of upset stomach.
  • It can take 4 to 6 weeks to see the full effects, so continue taking it even if you start to feel better.
  • Stopping Viibryd (Vilazodone) suddenly can cause withdrawal symptoms, including anxiety, irritability, headache, and dizziness. Gradually lower your dose over a 1 to 2 week period before stopping it completely.
  • Call your doctor right away if you notice new or worsening symptoms of aggressive or violent behavior, panic attacks, or other unusual changes in behavior or mood.
  • Full effects in 8 to 12 weeks for mood, 2 weeks for pain.
  • Take with food to avoid upset stomach.
  • Stop taking slowly to avoid withdrawal symptoms.
  • You can take the extended-release form once a day with food either in the morning or in the evening at about the same time each day.
  • Extended-release capsules should be swallowed whole. If you can’t swallow pills, open the capsule, sprinkle it on a spoonful of applesauce and then swallow it without chewing.
  • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
  • Stop taking it slowly to avoid getting withdrawal symptoms.
  • Take with food to avoid upset stomach.
  • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
  • Stop taking it slowly to avoid getting withdrawal symptoms.
  • The controlled-release (CR) tablet can cause less nausea than other forms.
  • Don’t crush, break, or chew the Paxil (Paroxetine) controlled-release tablet or the Pexeva film-coated tablets.
  • It’s best to take Paxil (Paroxetine) in the morning, except Brisdelle, which can be taken at bedtime.
  • Take with food to avoid upset stomach.
  • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
  • Stop taking it slowly to avoid getting withdrawal symptoms.
Coming soon.
  • Takes 8 to 12 weeks to see full effects on mood.
  • Can cause sweating and high blood pressure.
  • Stop taking slowly to avoid withdrawal symptoms.
  • Makes you sleepy. Take at bedtime.
  • Can cause temporary dry mouth and upset stomach.
  • Seek medical attention for unwanted, persistent erection.
  • It interacts with St. John's Wort and Tryptophan.
  • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
  • Stop taking it slowly to avoid getting withdrawal symptoms.
Learn more
More about ViibrydSide effectsReviews & ratingsAlternativesFDA package insert
More about CymbaltaSide effectsReviews & ratingsFDA package insert
More about EffexorSide effectsReviews & ratingsFDA package insert
More about LexaproSide effectsReviews & ratingsFDA package insert
More about PaxilSide effectsReviews & ratingsFDA package insert
More about SerzoneSide effectsFDA package insert
More about PristiqSide effectsReviews & ratingsFDA package insert
More about OleptroSide effectsReviews & ratingsFDA package insert
More about ZoloftSide effectsReviews & ratingsFDA package insert