Prescription onlyNo lower cost generic available

Vytorin

(Ezetimibe / Simvastatin)

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Lowers cholesterol.

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Prescription onlyNo lower cost generic available

Our pharmacists’ bottom line

Vytorin is expensive and is no more effective than simvastatin by itself.

Worth it?Is it worth it?
Works well?Does it work?
Hassle?Is it a hassle?
  • A 2-in-1 cholesterol-lowering combination medicine.
  • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
  • In clinical studies, simvastatin/ezetimibe hasn't controlled cholesterol better than simvastatin alone.
  • There's no generic available, so it can be expensive.

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Side effects for Vytorin (Ezetimibe / Simvastatin)

From clinical trials of Vytorin / High cholesterol ( 1791)

  • HeadacheHeadache6% for Vytorin vs.0% for placebo
  • HeadacheHeadache6% for Vytorin vs.5% for placebo
  • Any side effectAny side effect5% for Vytorin vs.2% for placebo
  • Increased altIncreased alt4% for Vytorin vs.0% for placebo
  • Muscle painMuscle pain4% for Vytorin vs.0% for placebo
  • Ear, nose, or throat infectionEar, nose, or throat infection4% for Vytorin vs.0% for placebo
  • Muscle painMuscle pain4% for Vytorin vs.2% for placebo
  • Ear, nose, or throat infectionEar, nose, or throat infection4% for Vytorin vs.3% for placebo
  • DiarrheaDiarrhea3% for Vytorin vs.0% for placebo
  • DiarrheaDiarrhea3% for Vytorin vs.2% for placebo

What to expect when you take Vytorin (Ezetimibe / Simvastatin)

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Tips from our pharmacists
  • Take it in the evening.
  • Avoid grapefruit and grapefruit juice while taking this medicine.
  • Can cause headaches or diarrhea.
  • Call your doctor if you develop muscle pain.
  • Also taking Welchol or Questran? Take this medicine at least 2 hours before or 4 hours after.

Risks and Warnings for Vytorin (Ezetimibe / Simvastatin)

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    • Higher risk if:
    • Asian patients taking high-dose niacin

    People on Vytorin (Ezetimibe / Simvastatin) have reported muscle pain which may lead to muscle breakdown and kidney damage, especially in people of Asian ancestry who are also taking niacin. This has been very rare. Talk to your doctor if you suddenly develop muscle pain and a fever and you don't know why.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Vytorin (Ezetimibe / Simvastatin)

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The FDA category for this medication is X. It is advised that you: Unsafe
Pregnancy
Alcohol
  • Risks from our pharmacists
  • People who take Vytorin (Ezetimibe / Simvastatin) have reported liver damage, especially if taken with statins or if you drink large amounts of alcohol. This has been rare. Talk to your doctor if you've ever had liver disease as they may discuss alternatives, or they may monitor your liver with blood tests.
Kidneys & liver
  • Risks from our pharmacists
  • People on Vytorin (Ezetimibe / Simvastatin) have reported muscle pain which may lead to muscle breakdown and kidney damage, especially in people of Asian ancestry who are also taking niacin. This has been very rare. Talk to your doctor if you suddenly develop muscle pain and a fever and you don't know why.
Sleep
  • Take medication at sleep time after 6 months cholesterol and triglycerides did improve
    Age: 62
    Gender: Man
    Taken for: High cholesterol