Prescription onlyClass: Cardiovascular

Welchol 

(colesevelam)

Prescription onlyClass: Cardiovascular
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Lowers cholesterol and helps lower blood sugars.

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Our bottom line

Can be taken as a tablet or as a sprinkled packet that's mixed with water, juice, or diet soft drinks.|Welchol (colesevelam) may be a good option for people who have high cholesterol and diabetes.|Welchol (colesevelam) is another option for people that can't tolerate statin medications.|It's able to be used in children over the age of 10.

Price and discounts
Prices and coupons for 180 (625mg) tablets of colesevelam

Upsides

  • Can be taken as a tablet or a sprinkled packet that's mixed with water, juice, or diet soft drinks.
  • Welchol (colesevelam) may be good for people with high cholesterol and diabetes since it can help with both conditions.
  • Welchol (colesevelam) is a good option for people that can't tolerate statins.

Downsides

  • Welchol (colesevelam) can make you feel really constipated.
  • Welchol (colesevelam) doesn't lower cholesterol as well as other drugs.
  • It interacts with many other medications by reducing their absorption in the body.
  • Welchol (colesevelam) can increase the amount of triglycerides (fats) in some people, so your doctor may perform blood work to check your triglyceride levels.
  • It's not recommended for use in children under 10 years of age.
How it works

Welchol (colesevelam) is a bile acid sequestrant that reduces the amount of cholesterol your body absorbs from food.

What to expect when you take Welchol (colesevelam) for High cholesterol

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Side effect rates for Welchol (colesevelam)

2025 From clinical trials of Welchol / Diabetes
  • Constipation
  • Low blood sugar
  • Indigestion
  • Nausea
  • High blood pressure
  • Back pain

Risks and Warnings for Welchol (colesevelam)

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    • Higher risk if:
    • Gastrointestinal tract surgery
    • Gastroparesis
    • Gastric motility disorders

    Welchol (colesevelam) can lead to constipation, so in people with gastrointestinal issues (such as gastroparesis/GI motility disorders), this can lead to problems like bowel obstruction. Therefore, it's important that your doctor knows about these problems before they prescribe Welchol (colesevelam).

Common concerns from people taking Welchol (colesevelam)

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Pregnancy
Interactions
  • It interacts with many other medications by reducing their absorption in the body.
  • Many medications interact with Welchol (colesevelam), so check with your doctor or pharmacist which ones need to be taken at different times of the day.