Wellbutrin

(Bupropion)

3.4/ 5 average rating with 1164 reviewsforWellbutrin
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Improves mood.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Wellbutrin (Bupropion) is good for treating depression and has fewer sexual side effects than other antidepressants, but you need to be okay with avoiding alcohol.

Quick facts about Wellbutrin
  • Drug class: Mental health
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (bupropion)
Prices and discounts
Lowest price for 60 75mg tablets
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$19.91

Upsides

  • Effective at relieving depression symptoms.
  • Causes fewer sexual side effects than other antidepressants. Can actually boost sex drive for some people.
  • Can be taken with other antidepressants to counteract their sexual side effects.
  • Has some stimulant effects, so it can be energizing.
  • Can help with ADHD symptoms.
  • Also used to suppress appetite and help you quit smoking.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.

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What to expect from Wellbutrin, on one page

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People’s experience with Wellbutrin

1164reviews so far. What do you think?

Downsides

  • Wellbutrin (Bupropion) can be stimulating, so it can cause anxiety or insomnia the first few days you're taking it.
  • Generally not as good as other antidepressants for people who have anxiety.
  • It's less likely to cause weight gain than other antidepressants.
  • Has a higher risk of causing seizures, especially if you have a seizure disorder, eating disorder, or if you drink alcohol. So, it's not a good medication if you drink a lot.
  • It contains the same ingredient as a medication that helps you to stop smoking, (Zyban), so these two meds can't be used together.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.

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What to expect from Wellbutrin, on one page

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Prices and discounts
Lowest price for 60 75mg tablets
Determining your location...
$19.91
How it works

Wellbutrin (Bupropion) is an atypical antidepressant. Researchers don't know exactly how it works, but it seems to change dopamine and norepinephrine activity in the brain, which regulate mood.

Quick facts about Wellbutrin
  • Drug class: Mental health
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (bupropion)

Used for

Dosage forms

  • Pill
  • Extended release
People’s experience with Wellbutrin

1164reviews so far. What do you think?

What to expect when you take Wellbutrin (Bupropion) for Depression

Skip what to expect section. Skip to side effects section.
Skip side effects section. Skip to risks and warnings section.

Side effect rates for Wellbutrin (Bupropion)

From 508 clinical trials of Wellbutrin when taken for depression (300mg to 600mg per day)
  • Agitation
  • Dry mouth
  • Constipation
  • Headache/migraine
  • Nausea/vomiting
  • Dizziness
  • Excessive sweating
  • Tremor
  • Sleepiness
  • Insomnia

Risks and Warnings for Wellbutrin (Bupropion)

Skip risks section. Skip to common concerns section.
    • Higher risk if:
    • Age 24 years or younger

    Wellbutrin (Bupropion) may increase the risk of suicidal thoughts or behavior. Watch for worsening depression or any unusual changes in mood or behavior, especially during the first few months of treatment or when the dose changes. Report anything concerning to a doctor immediately. Wellbutrin (Bupropion) is not approved for use in children younger than age 18.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Wellbutrin (Bupropion)

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Pregnancy
Alcohol
  • Has a higher risk of causing seizures, especially if you have a seizure disorder, eating disorder, or if you drink alcohol. So, it's not a good medication if you drink a lot.
  • Reviewed Wellbutrinon 9/1/2016I did not drink alcohol for the first 2 months, and then drank at home before going out. No negative effects. I feel like myself for the first time in years.
    26
    Woman
    Depression
  • Reviewed Wellbutrinon 12/9/2016take the warning about alcohol use seriously and please don't drink with this medication or at least seriously minimize your drinking habits. there can be serious consequences of drinking with this medication including big mood disturbances and loss of the progress you had before drinking.
    20
    Woman
    Depression
  • Reviewed Wellbutrinon 4/25/2017Take the alcohol warning seriously, alcohol has a heavier affect on you when you're taking this medication.
    19
    Woman
    Two years or more
    Depression
Food
  • Reviewed WellbutrinThis is make or break medication. You'll know fast it works (days). If you feel ANY paranoia, rage, racing thoughts, or any of its top side effects, discontinue with doctor guidance IMMEDIATELY. For ADD, this is nothing like real ADD meds!
    20
    Man
    A month or so
    Depression
Kidneys and liver
  • Wellbutrin (Bupropion) is processed by the kidney and liver. If you have kidney or liver problems, you may need a different dose to prevent increased risk for side effects.
Pain
  • Reviewed Wellbutrinon 5/1/2017I'm not sure yet but it does seem like I have a better outlook on life since starting a few weeks ago. Mild low grade headaches so far that are not relieved with OTC pain relievers. Dry mouth and difficulty staying asleep. Hopefully these lesson with adjustment.
    40
    Woman
    A couple weeks
    Sexual dysfunction from taking SSRI antidepressant
  • Reviewed Wellbutrinon 7/9/2017I was getting UTIs constantly. I was having pain & pressure constantly even after the infection went away. I went to the ER in pain & was diagnosed with urinary retention. No one mentioned it is a side effect of wellbutrin. I read about it & went off wellbutrin cold turkey. Within 24 hours, my pain subsided. Beware of this side effect!
    43
    Woman
    A year or so
    Depression
Sleep
  • Reviewed Wellbutrinon 1/10/2016DIFFICULTY GETTING TO SLEEP & STAYING ASLEEP AT NIGHT
    61
    Woman
    A year or so
  • Reviewed WellbutrinI take it at night, haven't noticed sleep problems. First day I was amped up but that went away, still have low low sex drive and a healthy appetite :(
    35
    Woman
    A year or so
    Depression
  • Reviewed Wellbutrinon 11/9/2016Very tired all the time get anxiety attacks and depression attacks sometimes
    20
    Woman
    Depression
Weight
  • It's less likely to cause weight gain than other antidepressants.
  • Reviewed WellbutrinI started taking it and immediately lost my appetite to the point I had to force myself to eat. I lost 90 pounds in about 6-12 months. For me, it has been the best medication I have taken so far. It helped my mood, my depression and weight.
    65
    Woman
    Two years or more
  • Reviewed Wellbutrinon 7/22/2016Really helps my depression and effectiveness of Zoloft. Having trouble keeping weight off even though I work out daily.
    17
    Woman
    Depression
  • Reviewed Wellbutrinon 7/25/2016Lost weight at first but that subsided.
    42
    Woman
    Depression