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Prescription onlyLower-cost generic available
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  • Extended release
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Improves mood.

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Our bottom line

Wellbutrin (Bupropion) is good for treating depression and has fewer sexual side effects than other antidepressants, but you need to be okay with avoiding alcohol.

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  • Effective at relieving depression symptoms.
  • Causes fewer sexual side effects than other antidepressants. Can actually boost sex drive for some people.
  • Can be taken with other antidepressants to counteract their sexual side effects.
  • Has some stimulant effects, so it can be energizing.
  • Can help with ADHD symptoms.
  • Also used to suppress appetite and help you quit smoking.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
People say this drug is:
1077 reviews


  • Wellbutrin (Bupropion) can be stimulating, so it can cause anxiety or insomnia the first few days you're taking it.
  • Generally not as good as other antidepressants for people who have anxiety.
  • It's less likely to cause weight gain than other antidepressants.
  • Has a higher risk of causing seizures, especially if you have a seizure disorder, eating disorder, or if you drink alcohol. So, it's not a good medication if you drink a lot.
  • It contains the same ingredient as a medication that helps you to stop smoking, (Zyban), so these two meds can't be used together.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.

What to expect when you take Wellbutrin (Bupropion) for Depression

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Side effect rates for Wellbutrin (Bupropion)

508 From clinical trials of Wellbutrin / Depression (300mg to 600mg per day)
  • Agitation
  • Dry mouth
  • Constipation
  • Headache/migraine
  • Nausea/vomiting
  • Excessive sweating
  • Dizziness
  • Tremor
  • Sleepiness
  • Sleep difficulty

Risks and Warnings for Wellbutrin (Bupropion)

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    • Higher risk if:
    • Age 24 years or younger

    Wellbutrin (Bupropion) may increase the risk of suicidal thoughts or behavior. Watch for worsening depression or any unusual changes in mood or behavior, especially during the first few months of treatment or when the dose changes. Report anything concerning to a doctor immediately. Wellbutrin (Bupropion) is not approved for use in children younger than age 18.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Wellbutrin (Bupropion)

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  • Has a higher risk of causing seizures, especially if you have a seizure disorder, eating disorder, or if you drink alcohol. So, it's not a good medication if you drink a lot.
  • take the warning about alcohol use seriously and please don't drink with this medication or at least seriously minimize your drinking habits. there can be serious consequences of drinking with this medication including big mood disturbances and loss of the progress you had before drinking.
  • I did not drink alcohol for the first 2 months, and then drank at home before going out. No negative effects. I feel like myself for the first time in years.
  • This is make or break medication. You'll know fast it works (days). If you feel ANY paranoia, rage, racing thoughts, or any of its top side effects, discontinue with doctor guidance IMMEDIATELY. For ADD, this is nothing like real ADD meds!
Kidneys and liver
  • Wellbutrin (Bupropion) is processed by the kidney and liver. If you have kidney or liver problems, you may need a different dose to prevent increased risk for side effects.
  • Trouble sleeping and speedy feeling at first. After a few days, that went away and over weeks my mood improved. No sexual side effects!
  • Very tired all the time get anxiety attacks and depression attacks sometimes
  • I take it at night, haven't noticed sleep problems. First day I was amped up but that went away, still have low low sex drive and a healthy appetite :(
  • It's less likely to cause weight gain than other antidepressants.
  • Stimulated appetite and sex drive and weight loss.
  • Lost weight very quickly. Be aware of your heart condition, it accelerates you. Messed a little with my period.
  • It's work ok. I'm not having weight gain. Helps me to get out of a strong depression. I'm taking about few months however.