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Wellbutrin Alternatives

(Bupropion)

Prescription onlyLower-cost generic available
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  • Extended release
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Compare Wellbutrin (Bupropion) to alternatives

These medications are comparable to Wellbutrin (Bupropion) or used for similar purposes.

Wellbutrin
(Bupropion)

Buspar
(Buspirone)

Cymbalta
(Duloxetine)

Celexa
(Citalopram)

Zoloft
(Sertraline)

Remeron
(Mirtazapine)

Oleptro
(Trazodone)

Paxil
(Paroxetine)

Lexapro
(Escitalopram)

Prozac
(Fluoxetine)

Effexor
(Venlafaxine)

Improves mood. Wellbutrin (Bupropion) is good for treating depression and has fewer sexual side effects than other antidepressants, but you need to be okay with avoiding alcohol.Helps you relax. Buspar (Buspirone) is effective for treating Generalized Anxiety Disorder (GAD), and less effective for short-term use.Improves mood and relieves certain kinds of pain. Cymbalta (Duloxetine) is good for treating depression and anxiety, and may help with chronic pain. More likely than other antidepressants to cause problems if you drink or have high blood pressure.Improves mood and helps you relax. Celexa (Citalopram) is good for treating depression and anxiety. Might be less likely to cause side effects than some antidepressants, but not the best choice for people with heart or liver problems.Improves mood and helps you relax. Zoloft (Sertraline) is good for treating depression and anxiety. It's more likely to cause insomnia and diarrhea than other antidepressants.Improves mood. Remeron (Mirtazapine) is okay for treating depression and good for sleep. More likely to cause weight gain than any other antidepressant.Improves mood and helps you sleep. Oleptro (Trazodone) works well as a sleep aid, but has more side effects when used at higher doses for treating depression.Improves mood and helps you relax. Paxil (Paroxetine) is good for treating depression and anxiety but it causes more weight gain, sleepiness, and withdrawal symptoms than other antidepressants.Improves mood and helps you relax. Lexapro (Escitalopram) is good for treating depression and anxiety. Might be less likely to cause side effects than some antidepressants, but not the best choice for people with heart or liver problems.Improves mood and helps you relax. Prozac (Fluoxetine) is good for treating depression and anxiety. It's more energizing than other antidepressants, but may not be the best choice for people who have trouble sleeping.Improves mood and helps you relax. Effexor (Venlafaxine) is good for treating depression and anxiety. May work when other antidepressants haven't, it's but more likely to cause side effects and withdrawal symptoms than other antidepressants.
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Reviews & ratings
Filter group. All currently selected
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4.66Wellbutrin
Reviews for Wellbutrin (Bupropion)
60%
of people (All ages) say Wellbutrin (Bupropion) is worth it
40%
say it works well
13%
say it's a big hassle
1164 reviews
Have you used Wellbutrin (Bupropion)?
Worth itNot sureNot worth it
Reviews for Buspar (Buspirone)
46%
14% vs. Wellbutrin (Bupropion)
45%
+5% vs. Wellbutrin (Bupropion)
22%
9% vs. Wellbutrin (Bupropion)
Have you used Buspar (Buspirone)?
Worth itNot sureNot worth it
Reviews for Cymbalta (Duloxetine)
58%
2% vs. Wellbutrin (Bupropion)
49%
+9% vs. Wellbutrin (Bupropion)
24%
11% vs. Wellbutrin (Bupropion)
496 reviews
Have you used Cymbalta (Duloxetine)?
Worth itNot sureNot worth it
Reviews for Celexa (Citalopram)
61%
+1% vs. Wellbutrin (Bupropion)
51%
+11% vs. Wellbutrin (Bupropion)
16%
3% vs. Wellbutrin (Bupropion)
520 reviews
Have you used Celexa (Citalopram)?
Worth itNot sureNot worth it
Reviews for Zoloft (Sertraline)
59%
1% vs. Wellbutrin (Bupropion)
41%
+1% vs. Wellbutrin (Bupropion)
15%
2% vs. Wellbutrin (Bupropion)
1472 reviews
Have you used Zoloft (Sertraline)?
Worth itNot sureNot worth it
Reviews for Remeron (Mirtazapine)
45%
15% vs. Wellbutrin (Bupropion)
39%
1% vs. Wellbutrin (Bupropion)
26%
13% vs. Wellbutrin (Bupropion)
152 reviews
Have you used Remeron (Mirtazapine)?
Worth itNot sureNot worth it
Reviews for Oleptro (Trazodone)
73%
+13% vs. Wellbutrin (Bupropion)
49%
+9% vs. Wellbutrin (Bupropion)
24%
11% vs. Wellbutrin (Bupropion)
Have you used Oleptro (Trazodone)?
Worth itNot sureNot worth it
Reviews for Paxil (Paroxetine)
52%
8% vs. Wellbutrin (Bupropion)
39%
1% vs. Wellbutrin (Bupropion)
24%
11% vs. Wellbutrin (Bupropion)
694 reviews
Have you used Paxil (Paroxetine)?
Worth itNot sureNot worth it
Reviews for Lexapro (Escitalopram)
61%
+1% vs. Wellbutrin (Bupropion)
48%
+8% vs. Wellbutrin (Bupropion)
15%
2% vs. Wellbutrin (Bupropion)
1063 reviews
Have you used Lexapro (Escitalopram)?
Worth itNot sureNot worth it
Reviews for Prozac (Fluoxetine)
62%
+2% vs. Wellbutrin (Bupropion)
40%
Same vs. Wellbutrin (Bupropion)
16%
3% vs. Wellbutrin (Bupropion)
1319 reviews
Have you used Prozac (Fluoxetine)?
Worth itNot sureNot worth it
Reviews for Effexor (Venlafaxine)
62%
+2% vs. Wellbutrin (Bupropion)
51%
+11% vs. Wellbutrin (Bupropion)
23%
10% vs. Wellbutrin (Bupropion)
577 reviews
Have you used Effexor (Venlafaxine)?
Worth itNot sureNot worth it
Side effects
WellbutrinBusparCymbaltaCelexaZoloftRemeronOleptroPaxilLexaproProzacEffexor
  • Tremor 13%
  • Dry mouth 10%
  • Agitation 10%
  • Constipation 9%
  • Excessive sweating 7%
  • Dizziness 6%
  • Blurred vision 5%
  • Nausea/vomiting 4%
  • Headache/migraine 4%
  • Menstrual complaints 4%
More Wellbutrin side effects »

The Buspar FDA package insert doesn’t have numbers about how common side effects are.

More about Buspar side effects »

The Cymbalta FDA package insert doesn’t have numbers about how common side effects are.

More about Cymbalta side effects »
  • Abnormal ejaculation 5%
More Celexa side effects »
  • Nausea 19%
  • Ejaculation failure 18%
  • Sleep difficulty 16%
  • Diarrhea/loose stools 14%
  • Fatigue 9%
  • Loss of appetite 9%
  • Lower sex drive 9%
  • Sweating increased 9%
  • Dizziness 8%
  • Indigestion 8%
More Zoloft side effects »

The Remeron FDA package insert doesn’t have numbers about how common side effects are.

More about Remeron side effects »

The Oleptro FDA package insert doesn’t have numbers about how common side effects are.

More about Oleptro side effects »
  • Nausea 22%
  • Dry mouth 19%
  • Drowsiness 14%
  • Diarrhea 11%
  • Sweating 10%
  • Dizziness 9%
  • Constipation 7%
  • Blurred vision 6%
  • Decreased appetite 4%
More Paxil side effects »
  • Sleep difficulty 10%
  • Diarrhea 9%
  • Drowsiness 8%
  • Dry mouth 6%
  • Dizziness 5%
  • Indigestion 5%
  • Constipation 5%
  • Fatigue 4%
More Lexapro side effects »

The Prozac FDA package insert doesn’t have numbers about how common side effects are.

More about Prozac side effects »
  • Nausea 42%
  • Drowsiness 22%
  • Dizziness 20%
  • Nervousness 17%
  • Loss of appetite 15%
  • Sweating 14%
  • Muscle weakness 14%
  • Sleep difficulty 13%
  • Anxiety 7%
  • Vomiting 7%
More Effexor side effects »
How it works
WellbutrinBusparCymbaltaCelexaZoloftRemeronOleptroPaxilLexaproProzacEffexor
Wellbutrin (Bupropion) is an atypical antidepressant. Researchers don't know exactly how it works, but it seems to change dopamine and norepinephrine activity in the brain, which regulate mood.Buspar (Buspirone) is an anti-anxiety medication. It's used to stabilize chemicals in the brain that control mood and nervousness.Cymbalta (Duloxetine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulates mood.Celexa (Citalopram) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Zoloft (Sertraline) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases the activity of serotonin in the brain, which regulates mood.Remeron (Mirtazapine) is an atypical antidepressant. It stimulates your body to make certain chemicals in the brain, such as serotonin and norepinephrine, which regulate mood.Oleptro (Trazodone) is a serotonin reuptake inhibitor (SRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Paxil (Paroxetine) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Lexapro (Escitalopram) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Prozac (Fluoxetine) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Effexor (Venlafaxine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulate mood.
Type of medication
WellbutrinBusparCymbaltaCelexaZoloftRemeronOleptroPaxilLexaproProzacEffexor
Antidepressant
Norepinephrine-dopamine reuptake inhibitor
Prescription only
Anti-anxiety
Azaspirodecanedione
Prescription only
Antidepressant
Serotonin-norepinephrine reuptake inhibitor (SNRI)
Prescription only
Antidepressant
Selective serotonin reuptake inhibitor (SSRI)
Prescription only
Antidepressant
Selective serotonin reuptake inhibitor (SSRI)
Prescription only
Antidepressant
Noradrenergic and specific serotonergic antidepressant
Prescription only
Antidepressant
Serotonin antagonist and reuptake inhibitor
Prescription only
Antidepressant
Selective serotonin reuptake inhibitor (SSRI)
Prescription only
Antidepressant
Selective serotonin reuptake inhibitor (SSRI)
Prescription only
Antidepressant
Selective serotonin reuptake inhibitor (SSRI)
Prescription only
Antidepressant
Serotonin-norepinephrine reuptake inhibitor (SNRI)
Prescription only
Available as
WellbutrinBusparCymbaltaCelexaZoloftRemeronOleptroPaxilLexaproProzacEffexor
  • Pill
  • Extended release
  • Pill
  • Extended release
  • Pill
  • Oral solution
  • Pill
  • Liquid
  • Pill
  • Dissolving tablet
  • Pill
  • Extended release
  • Pill
  • Extended release tablet
  • Liquid
  • Pill
  • Liquid
  • Pill
  • Delayed release capsule
  • Liquid
  • Pill
  • Extended release
Used for (click to learn more)
WellbutrinBusparCymbaltaCelexaZoloftRemeronOleptroPaxilLexaproProzacEffexor
Risk factors for serious side effects
WellbutrinBusparCymbaltaCelexaZoloftRemeronOleptroPaxilLexaproProzacEffexor
  • Age 24 years or younger
  • History of depression
  • History of bipolar disorder
  • At risk for bipolar disorder
  • Withdrawing from nicotine
Detailed risks & warnings »
  • Taking with MAOIs
  • Taking with Zyvox or methylene blue
  • Taking with or converting from benzodiazepine medicines
  • Duration of treatment
Detailed risks & warnings »
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Cymbalta (Duloxetine) suddenly
  • History of high blood pressure
  • Taking other blood-thinning drugs
Detailed risks & warnings »
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • History of bipolar disorder
  • At risk for bipolar disorder
  • Stopping Celexa (Citalopram) suddenly
Detailed risks & warnings »
  • Under 24 years old
  • Interactions with other medications
  • Stopping Zoloft (Sertraline) suddenly
  • Taking with blood-thinning drugs
  • Elderly
Detailed risks & warnings »
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • History of heart problems
  • History of liver problems
  • Higher dose
Detailed risks & warnings »
  • Age 24 years or younger
  • History of seizures
  • Alcoholism
  • Eating disorder
  • Higher dose
Detailed risks & warnings »
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Paxil (Paroxetine) suddenly
  • Taking other blood-thinning drugs
  • History of bipolar disorder
Detailed risks & warnings »
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Lexapro (Escitalopram) suddenly
  • Higher dose
  • History of heart problems
Detailed risks & warnings »
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Prozac (Fluoxetine) suddenly
  • History of heart problems
  • History of liver problems
Detailed risks & warnings »
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Effexor (Venlafaxine) suddenly
  • History of high blood pressure
  • Taking other blood-thinning drugs
Detailed risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
WellbutrinBusparCymbaltaCelexaZoloftRemeronOleptroPaxilLexaproProzacEffexor
No interactions related info.No interactions related info.No interactions related info.No interactions related info.
  • It interacts with St. John's Wort and Tryptophan.
No interactions related info.No interactions related info.No interactions related info.No interactions related info.No interactions related info.No interactions related info.
Alcohol
WellbutrinBusparCymbaltaCelexaZoloftRemeronOleptroPaxilLexaproProzacEffexor
  • Has a higher risk of causing seizures, especially if you have a seizure disorder, eating disorder, or if you drink alcohol. So, it's not a good medication if you drink a lot.
  • Avoid alcohol when taking Buspar (Buspirone).
No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.
Food
WellbutrinBusparCymbaltaCelexaZoloftRemeronOleptroPaxilLexaproProzacEffexor
No food related info.
  • Be consistent in taking Buspar (Buspirone) with or without food.
  • Take with food to avoid upset stomach.
  • Take with food to avoid upset stomach.
No food related info.No food related info.No food related info.
  • Take with food to avoid upset stomach.
  • Take with food to avoid upset stomach.
  • Take in the morning with food to avoid side effects.
No food related info.
Kidneys and liver
WellbutrinBusparCymbaltaCelexaZoloftRemeronOleptroPaxilLexaproProzacEffexor
  • Wellbutrin (Bupropion) is processed by the kidney and liver. If you have kidney or liver problems, you may need a different dose to prevent increased risk for side effects.
No kidneys and liver related info.
  • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
  • Not a good option for you if you have heart or liver problems.
No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.
  • Not a good option for you if you have heart or liver problems.
No kidneys and liver related info.No kidneys and liver related info.
Pain
WellbutrinBusparCymbaltaCelexaZoloftRemeronOleptroPaxilLexaproProzacEffexor
No pain related info.No pain related info.
  • Full effects in 8 to 12 weeks for mood, 2 weeks for pain.
No pain related info.No pain related info.No pain related info.No pain related info.No pain related info.No pain related info.No pain related info.No pain related info.
Sex
WellbutrinBusparCymbaltaCelexaZoloftRemeronOleptroPaxilLexaproProzacEffexor
No sex related info.No sex related info.No sex related info.
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
No sex related info.No sex related info.No sex related info.
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
Sleep
WellbutrinBusparCymbaltaCelexaZoloftRemeronOleptroPaxilLexaproProzacEffexor
No sleep related info.
  • Can cause drowsiness or dizziness when you start taking Buspar (Buspirone). Be extremely careful of activities that require mental alertness, such as driving.
No sleep related info.No sleep related info.
  • Causes less drowsiness than other antidepressants.
  • Zoloft (Sertraline) may increase the risk of low sodium levels in the blood (hyponatremia). Watch out for symptoms including headache, difficulty concentrating, memory problems, confusion, weakness, and unsteadiness, which may lead to falls. Talk to a doctor right away before developing more serious symptoms, such as hallucination, fainting, coma, and death.
No sleep related info.No sleep related info.
  • It causes drowsiness, so it's good for people who have trouble sleeping.
No sleep related info.No sleep related info.No sleep related info.
Weight
WellbutrinBusparCymbaltaCelexaZoloftRemeronOleptroPaxilLexaproProzacEffexor
  • It's less likely to cause weight gain than other antidepressants.
No weight related info.No weight related info.
  • Can cause minor weight gain (1 to 5 pounds).
No weight related info.
  • More likely to cause minor weight gain (1 to 5 pounds) and raise cholesterol than any other antidepressant.
  • Can increase appetite and weight.
  • Remeron (Mirtazapine) can increase appetite and cause you to gain weight.
No weight related info.
  • Can cause weight gain, which can be helpful if you've recently lost weight or have a low appetite.
  • More likely to cause minor weight gain (1 to 5 pounds) or make you feel sick if you miss a dose than other antidepressants.
  • More likely to cause minor weight gain (1 to 5 pounds) than other antidepressants.
No weight related info.No weight related info.
Upsides and benefits
WellbutrinBusparCymbaltaCelexaZoloftRemeronOleptroPaxilLexaproProzacEffexor
  • Effective at relieving depression symptoms.
  • Causes fewer sexual side effects than other antidepressants. Can actually boost sex drive for some people.
  • Can be taken with other antidepressants to counteract their sexual side effects.
  • Has some stimulant effects, so it can be energizing.
  • Can help with ADHD symptoms.
  • Also used to suppress appetite and help you quit smoking.
  • Buspar (Buspirone) works very well to control the symptoms of generalized anxiety syndrome (GAD).
  • Buspar (Buspirone) doesn't cause physical dependence or withdrawal symptoms.
  • Buspar (Buspirone) is only available as a generic, so the price can be pretty cheap.
  • Lowers relapse rates for depression.
  • Can relieve some types of chronic pain. Might be particularly good at pain relief for people who are also depressed.
  • Causes less sleepiness compared to other antidepressants.
  • Effective at lowering symptoms and relapse rates of depression and anxiety disorders.
  • Causes less drowsiness than other antidepressants.
  • Effective at relieving some depression symptoms.
  • Starts to work more quickly than most antidepressants.
  • Might be a good option for people who have insomnia with their depression, because it can make you very sleepy.
  • Good option for people who are underweight or frail, because it can help you gain weight.
  • Commonly used in lower doses to help treat sleep problems (insomnia).
  • Safer sleep medication than others (benzodiazepines or Unisom) for people age 65 and older.
  • Fewer sexual side effects than many other antidepressants.
  • Has been used for sleep and depression for a long time. There's a lot of information available about how it works and how safe it is.
  • Comes as a generic medication and is cheaper than many other sleep aides.
  • Lowers relapse rates of depression and anxiety disorders, including OCD, panic disorder, social anxiety disorder, and generalized anxiety disorder.
  • It causes drowsiness, so it's good for people who have trouble sleeping.
  • Can cause weight gain, which can be helpful if you've recently lost weight or have a low appetite.
  • Causes less sleepiness than some other antidepressants.
  • Lowers relapse rates of depression.
  • Lowers relapse rates of depression and bulimia nervosa.
  • Causes less sleepiness than other antidepressants.
  • It's more energizing than other antidepressants, so it's good for people who have low energy.
  • It has been used to treat depression for a long time, so there's a lot of information available about how it works and how safe it is.
  • Causes more sleepiness than other antidepressants, so it's good for people who have trouble sleeping.
  • Might work when other antidepressants haven't worked since it affects two chemicals in the brain that impact your mood. Many other antidepressants affect only serotonin, but not norepinephrine too.
  • Lowers relapse rates of depression.
Downsides and risks
WellbutrinBusparCymbaltaCelexaZoloftRemeronOleptroPaxilLexaproProzacEffexor
  • Wellbutrin (Bupropion) can be stimulating, so it can cause anxiety or insomnia the first few days you're taking it.
  • Generally not as good as other antidepressants for people who have anxiety.
  • It's less likely to cause weight gain than other antidepressants.
  • Has a higher risk of causing seizures, especially if you have a seizure disorder, eating disorder, or if you drink alcohol. So, it's not a good medication if you drink a lot.
  • It contains the same ingredient as a medication that helps you to stop smoking, (Zyban), so these two meds can't be used together.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
  • Buspar (Buspirone) can take as long as four weeks to become fully effective.
  • Not as effective for short-term anxiety conditions or panic disorders.
  • Most people find that it loses effectiveness over long periods of time.
  • Can cause drowsiness or dizziness when you start taking Buspar (Buspirone). Be extremely careful of activities that require mental alertness, such as driving.
  • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
  • Not the best option for people with high blood pressure.
  • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • Can cause minor weight gain (1 to 5 pounds).
  • Celexa (Citalopram) can cause an irregular heartbeat if you take a high dose (40 mg a day, or more).
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24 years.
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
  • Not a good option for you if you have heart or liver problems.
  • More likely to cause diarrhea than other antidepressants.
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
  • More likely to cause minor weight gain (1 to 5 pounds) and raise cholesterol than any other antidepressant.
  • Not as effective as other medications for depression.
  • More sedating than other antidepressants.
  • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • Causes more side effects when used at higher doses for depression. Includes sleepiness, dizziness, upset stomach, and irregular heartbeat.
  • Not as effective as other medications for depression.
  • More sedating than other antidepressants.
  • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • Can cause more sexual side effects like low libido and an inability to orgasm or ejaculate than most antidepressants.
  • More likely to cause minor weight gain (1 to 5 pounds) or make you feel sick if you miss a dose than other antidepressants.
  • Can harm an unborn child, so you can't take it if you're pregnant.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than age 24.
  • More likely to cause minor weight gain (1 to 5 pounds) than other antidepressants.
  • Can cause an irregular heartbeat if you take a high dose (20 mg a day, or more).
  • The first antidepressant you try doesn't always work, and might have side effects you really don't like. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
  • Not a good option for you if you have heart or liver problems.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
  • Can increase feelings of anxiety or cause headaches during the first few weeks of taking it. These effects should go away over time.
  • More likely than other antidepressants to interact with other medications you're taking.
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
  • Overdosing on this medication could be fatal.
  • It's more likely to cause nausea and vomiting or make you feel sick if you miss a dose than other antidepressants. Also causes more sleepiness than others.
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
  • Not the best option for people with high blood pressure.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
Tips from our pharmacists for people taking the medication
WellbutrinBusparCymbaltaCelexaZoloftRemeronOleptroPaxilLexaproProzacEffexor
  • Wellbutrin (Bupropion) makes you energized, so take it in the morning to avoid difficulty sleeping later that night.
  • There are no sexual side effects from this medication.
  • The extended-release tablet shell can show up unchanged in your stool, but don't worry since the medication was still absorbed by your body.
  • Take doses at about the same time each day.
  • It can take several weeks to get the full effect.
  • Don't eat or drink grapefruit juice when using Buspar (Buspirone).
  • Don't use Buspar (Buspirone) within two weeks of using an MAO inhibitor (like Eldepryl, Parnate, or Marplan).
  • Be consistent in taking Buspar (Buspirone) with or without food.
  • Avoid alcohol when taking Buspar (Buspirone).
  • Take with food to avoid upset stomach.
  • Full effects in 8 to 12 weeks for mood, 2 weeks for pain.
  • Stop taking slowly to avoid withdrawal symptoms.
  • Take with food to avoid upset stomach.
  • It interacts with St. John's Wort and Tryptophan.
  • Can increase appetite and weight.
  • Makes you sleepy. Take at bedtime.
  • Takes 8 to 12 weeks to see full effects on mood.
  • Stop taking slowly to avoid withdrawal symptoms.
  • Can cause temporary dry mouth and upset stomach.
  • Seek medical attention for unwanted, persistent erection.
  • Makes you sleepy. Take at bedtime.
  • The controlled-release (CR) tablet can cause less nausea than other forms.
  • Don’t crush, break, or chew the Paxil (Paroxetine) controlled-release tablet or the Pexeva film-coated tablets.
  • It’s best to take Paxil (Paroxetine) in the morning, except Brisdelle, which can be taken at bedtime.
  • Take with food to avoid upset stomach.
  • Take with food to avoid upset stomach.
  • Take in the morning with food to avoid side effects.
  • You can take the extended-release form once a day with food either in the morning or in the evening at about the same time each day.
  • Extended-release capsules should be swallowed whole. If you can’t swallow pills, open the capsule, sprinkle it on a spoonful of applesauce and then swallow it without chewing.
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