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Wellbutrin Alternatives

(Bupropion)

  • Pill
  • Extended release
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Compare Wellbutrin (Bupropion) to alternatives

These medications are comparable to Wellbutrin (Bupropion) or used for similar purposes.

Wellbutrin
(Bupropion)

Buspar
(Buspirone)

Cymbalta
(Duloxetine)

Celexa
(Citalopram)

Zoloft
(Sertraline)

Remeron
(Mirtazapine)

Oleptro
(Trazodone)

Paxil
(Paroxetine)

Lexapro
(Escitalopram)

Prozac
(Fluoxetine)

Effexor
(Venlafaxine)

Improves mood. Wellbutrin (Bupropion) is good for treating depression and has fewer sexual side effects than other antidepressants, but you need to be okay with avoiding alcohol.Helps you relax. Buspar (Buspirone) is effective for treating Generalized Anxiety Disorder (GAD), and less effective for short-term use.Improves mood and relieves certain kinds of pain. Cymbalta (Duloxetine) is good for treating depression and anxiety, and may help with chronic pain. More likely than other antidepressants to cause problems if you drink or have high blood pressure.Improves mood and helps you relax. Celexa (Citalopram) is good for treating depression and anxiety. Might be less likely to cause side effects than some antidepressants, but not the best choice for people with heart or liver problems.Improves mood and helps you relax. Zoloft (Sertraline) is good for treating depression and anxiety. It's more likely to cause insomnia and diarrhea than other antidepressants.Improves mood. Remeron (Mirtazapine) is okay for treating depression and good for sleep. More likely to cause weight gain than any other antidepressant.Improves mood and helps you sleep. Oleptro (Trazodone) works well as a sleep aid, but has more side effects when used at higher doses for treating depression.Improves mood and helps you relax. Paxil (Paroxetine) is good for treating depression and anxiety but it causes more weight gain, sleepiness, and withdrawal symptoms than other antidepressants.Improves mood and helps you relax. Lexapro (Escitalopram) is good for treating depression and anxiety. Might be less likely to cause side effects than some antidepressants, but not the best choice for people with heart or liver problems.Improves mood and helps you relax. Prozac (Fluoxetine) is good for treating depression and anxiety. It's more energizing than other antidepressants, but may not be the best choice for people who have trouble sleeping.Improves mood and helps you relax. Effexor (Venlafaxine) is good for treating depression and anxiety. May work when other antidepressants haven't, it's but more likely to cause side effects and withdrawal symptoms than other antidepressants.
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Reviews & ratings
Button Group. All currently active
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4.610027855153203Wellbutrin
Reviews for Wellbutrin (Bupropion)
58%
of people say Wellbutrin (Bupropion) is worth it
38%
say it works well
13%
say it's a big hassle
Reviews for Buspar (Buspirone)
51%
7% vs. Wellbutrin (Bupropion)
47%
+9% vs. Wellbutrin (Bupropion)
28%
15% vs. Wellbutrin (Bupropion)
Reviews for Cymbalta (Duloxetine)
59%
+1% vs. Wellbutrin (Bupropion)
49%
+11% vs. Wellbutrin (Bupropion)
24%
11% vs. Wellbutrin (Bupropion)
Reviews for Celexa (Citalopram)
60%
+2% vs. Wellbutrin (Bupropion)
50%
+12% vs. Wellbutrin (Bupropion)
15%
2% vs. Wellbutrin (Bupropion)
Reviews for Zoloft (Sertraline)
59%
+1% vs. Wellbutrin (Bupropion)
40%
+2% vs. Wellbutrin (Bupropion)
15%
2% vs. Wellbutrin (Bupropion)
Reviews for Remeron (Mirtazapine)
47%
11% vs. Wellbutrin (Bupropion)
42%
+4% vs. Wellbutrin (Bupropion)
26%
13% vs. Wellbutrin (Bupropion)
Reviews for Oleptro (Trazodone)
72%
+14% vs. Wellbutrin (Bupropion)
48%
+10% vs. Wellbutrin (Bupropion)
24%
11% vs. Wellbutrin (Bupropion)
Reviews for Paxil (Paroxetine)
52%
6% vs. Wellbutrin (Bupropion)
39%
+1% vs. Wellbutrin (Bupropion)
23%
10% vs. Wellbutrin (Bupropion)
Reviews for Lexapro (Escitalopram)
59%
+1% vs. Wellbutrin (Bupropion)
46%
+8% vs. Wellbutrin (Bupropion)
15%
2% vs. Wellbutrin (Bupropion)
Reviews for Prozac (Fluoxetine)
61%
+3% vs. Wellbutrin (Bupropion)
40%
+2% vs. Wellbutrin (Bupropion)
16%
3% vs. Wellbutrin (Bupropion)
Reviews for Effexor (Venlafaxine)
61%
+3% vs. Wellbutrin (Bupropion)
50%
+12% vs. Wellbutrin (Bupropion)
22%
9% vs. Wellbutrin (Bupropion)
Side effects
WellbutrinBusparCymbaltaCelexaZoloftRemeronOleptroPaxilLexaproProzacEffexor
  • Tremor 13%
  • Dry mouth 10%
  • Agitation 10%
  • Constipation 9%
  • Excessive sweating 7%
  • Dizziness 6%
  • Blurred vision 5%
  • Nausea/vomiting 4%
  • Headache/migraine 4%
  • Menstrual complaints 4%
More Wellbutrin side effects »
  • Dizziness 9%
  • Nervousness 4%
  • Headache 3%
  • Nausea 3%
  • Drowsiness 1%
More Buspar side effects »
  • Nausea 15%
  • Dry mouth 8%
  • Drowsiness 8%
  • Constipation 7%
  • Somnolencee 7%
  • Decreased appetite 7%
  • Fatigued 6%
  • Sleep difficulty 5%
  • Dizziness 4%
  • Fatigue 4%
More Cymbalta side effects »
  • Drowsiness 8%
  • Nausea 7%
  • Dry mouth 6%
  • Abnormal ejaculation 5%
  • Ejaculation disorder 5%
  • Diarrhea 3%
  • Tremor 2%
  • Sweating increased 2%
  • Fatigue 2%
  • Loss of appetite 2%
More Celexa side effects »
  • Nausea 19%
  • Ejaculation failure 18%
  • Sleep difficulty 16%
  • Diarrhea/loose stools 14%
  • Fatigue 9%
  • Loss of appetite 9%
  • Lower sex drive 9%
  • Sweating increased 9%
  • Dizziness 8%
  • Indigestion 8%
More Zoloft side effects »
  • Drowsiness 36%
  • Increased appetite 15%
  • Dry mouth 10%
  • Weight gain 10%
  • Constipation 6%
  • Dizziness 4%
  • Muscle weakness 3%
  • Abnormal dreams 3%
  • Flu syndrome 2%
  • Thinking abnormal 2%
More Remeron side effects »
  • Somnolence/sedation 27%
  • Drowsiness 21%
  • Dry mouth 14%
  • Dizziness/lightheadedness 13%
  • Dizziness 13%
  • Blurred vision 11%
  • Nausea 8%
  • Fatigue 7%
  • Skin condition/edema 6%
  • Headache 6%
More Oleptro side effects »
  • Abnormal ejaculation† 27%
  • Ejaculatory disturbance 26%
  • Nausea 22%
  • Dry mouth 19%
  • Drowsiness 17%
  • Lower sex drive 11%
  • Diarrhea 11%
  • Sleep difficulty 11%
  • Constipation 10%
  • Decreased libido 10%
More Paxil side effects »
  • Ejaculation disorder 12%
  • Ejaculation disorder (primarily ejaculatory delay) 11%
  • Sleep difficulty 10%
  • Nausea 10%
  • Diarrhea 9%
  • Headache 7%
  • Drowsiness 6%
  • Fatigue 6%
  • Dizziness 5%
  • Lower sex drive 5%
More Lexapro side effects »
  • Rash 57%
  • Sleep difficulty 20%
  • Nausea 18%
  • Muscle weakness 12%
  • Drowsiness 10%
  • Tremor 9%
  • Dry mouth 9%
  • Lower sex drive 9%
  • Loss of appetite 7%
  • Anxiety 7%
More Prozac side effects »
  • Nausea 42%
  • Drowsiness 22%
  • Dizziness 20%
  • Nervousness 17%
  • Sleep difficulty 16%
  • Loss of appetite 15%
  • Sweating 14%
  • Dry mouth 13%
  • Dry mouth 11%
  • Muscle weakness 10%
More Effexor side effects »
How it works
WellbutrinBusparCymbaltaCelexaZoloftRemeronOleptroPaxilLexaproProzacEffexor
Wellbutrin (Bupropion) is an atypical antidepressant. Researchers don't know exactly how it works, but it seems to change dopamine and norepinephrine activity in the brain, which regulate mood.Buspar (Buspirone) is an anti-anxiety medication. It's used to stabilize chemicals in the brain that control mood and nervousness.Cymbalta (Duloxetine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulates mood.Celexa (Citalopram) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Zoloft (Sertraline) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases the activity of serotonin in the brain, which regulates mood.Remeron (Mirtazapine) is an atypical antidepressant. It stimulates your body to make certain chemicals in the brain, such as serotonin and norepinephrine, which regulate mood.Oleptro (Trazodone) is a serotonin reuptake inhibitor (SRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Paxil (Paroxetine) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Lexapro (Escitalopram) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Prozac (Fluoxetine) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Effexor (Venlafaxine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulate mood.
Type of medication
WellbutrinBusparCymbaltaCelexaZoloftRemeronOleptroPaxilLexaproProzacEffexor
Antidepressant
Norepinephrine-dopamine reuptake inhibitor
Prescription only
Anti-anxiety
Azaspirodecanedione
Prescription only
Antidepressant
Serotonin-norepinephrine reuptake inhibitor (SNRI)
Prescription only
Antidepressant
Selective serotonin reuptake inhibitor (SSRI)
Prescription only
Antidepressant
Selective serotonin reuptake inhibitor (SSRI)
Prescription only
Antidepressant
Noradrenergic and specific serotonergic antidepressant
Prescription only
Antidepressant
Serotonin antagonist and reuptake inhibitor
Prescription only
Antidepressant
Selective serotonin reuptake inhibitor (SSRI)
Prescription only
Antidepressant
Selective serotonin reuptake inhibitor (SSRI)
Prescription only
Antidepressant
Selective serotonin reuptake inhibitor (SSRI)
Prescription only
Antidepressant
Serotonin-norepinephrine reuptake inhibitor (SNRI)
Prescription only
Available as
WellbutrinBusparCymbaltaCelexaZoloftRemeronOleptroPaxilLexaproProzacEffexor
  • Pill
  • Extended release
  • Pill
  • Extended release
  • Pill
  • Oral solution
  • Pill
  • Liquid
  • Pill
  • Dissolving tablet
  • Pill
  • Extended release
  • Pill
  • Extended release tablet
  • Liquid
  • Pill
  • Liquid
  • Pill
  • Delayed release capsule
  • Liquid
  • Pill
  • Extended release
Used for (click to learn more)
WellbutrinBusparCymbaltaCelexaZoloftRemeronOleptroPaxilLexaproProzacEffexor
How well it works for depression
The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.

After 4 weeks using Start and Wellbutrin (Bupropion), here’s how much better people feel.

The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Buspar (Buspirone)

After 4 weeks using Start and Cymbalta (Duloxetine), here’s how much better people feel.

After 4 weeks using Start and Celexa (Citalopram), here’s how much better people feel.

After 4 weeks using Start and Zoloft (Sertraline), here’s how much better people feel.

After 4 weeks using Start and Remeron (Mirtazapine), here’s how much better people feel.

The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Oleptro (Trazodone)

After 4 weeks using Start and Paxil (Paroxetine), here’s how much better people feel.

After 4 weeks using Start and Lexapro (Escitalopram), here’s how much better people feel.

After 4 weeks using Start and Prozac (Fluoxetine), here’s how much better people feel.

After 4 weeks using Start and Effexor (Venlafaxine), here’s how much better people feel.

Risk factors for serious side effects
WellbutrinBusparCymbaltaCelexaZoloftRemeronOleptroPaxilLexaproProzacEffexor
  • Age 24 years or younger
  • History of depression
  • History of bipolar disorder
  • At risk for bipolar disorder
  • Withdrawing from nicotine
  • History of seizures
  • Alcoholism
  • Eating disorder
  • Higher dose
  • Drug interactions
  • History of bipolar disorder
  • At risk for bipolar disorder
  • Current kidney problems
  • Current liver problems
    Detailed Wellbutrin (Bupropion) risks & warnings »
    Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.
    Pregnancy category
    WellbutrinBusparCymbaltaCelexaZoloftRemeronOleptroPaxilLexaproProzacEffexor
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    BFDA pregnancy category (Probably safe)

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    DFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    Alcohol
    • Has a higher risk of causing seizures, especially if you have a seizure disorder, eating disorder, or if you drink alcohol. So, it's not a good medication if you drink a lot.
    • Avoid alcohol when taking Buspar (Buspirone).
    No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.
    Food
    No specific food-related info.
    • Be consistent in taking Buspar (Buspirone) with or without food.
    • Take with food to avoid upset stomach.
    • Take with food to avoid upset stomach.
    No specific food-related info.No specific food-related info.No specific food-related info.
    • Take with food to avoid upset stomach.
    • Take with food to avoid upset stomach.
    • Take in the morning with food to avoid side effects.
    • You can take the extended-release form once a day with food either in the morning or in the evening at about the same time each day.
    Kidneys and liver
    • Wellbutrin (Bupropion) is processed by the kidney and liver. If you have kidney or liver problems, you may need a different dose to prevent increased risk for side effects.
    No specific kidneys and liver-related info.
    • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
    No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.
    Sex
    • Causes fewer sexual side effects than other antidepressants. Can actually boost sex drive for some people.
    • Can be taken with other antidepressants to counteract their sexual side effects.
    • There are no sexual side effects from this medication.
    No specific sex-related info.No specific sex-related info.
    • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
    • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
    No specific sex-related info.
    • Fewer sexual side effects than many other antidepressants.
    • Seek medical attention for unwanted, persistent erection.
    • Can cause more sexual side effects like low libido and an inability to orgasm or ejaculate than most antidepressants.
    • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
    • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
    • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
    Sleep
    • Wellbutrin (Bupropion) makes you energized, so take it in the morning to avoid difficulty sleeping later that night.
    • Can cause drowsiness or dizziness when you start taking Buspar (Buspirone). Be extremely careful of activities that require mental alertness, such as driving.
    No specific sleep-related info.No specific sleep-related info.
    • Causes less drowsiness than other antidepressants.
    No specific sleep-related info.
    • Commonly used in lower doses to help treat sleep problems (insomnia).
    • Safer sleep medication than others (benzodiazepines or Unisom) for people age 65 and older.
    • Has been used for sleep and depression for a long time. There's a lot of information available about how it works and how safe it is.
    • Comes as a generic medication and is cheaper than many other sleep aides.
    • It causes drowsiness, so it's good for people who have trouble sleeping.
    No specific sleep-related info.No specific sleep-related info.
    • Causes more sleepiness than other antidepressants, so it's good for people who have trouble sleeping.
    Weight
    • It's less likely to cause weight gain than other antidepressants.
    • Wellbutrin (Bupropion) may cause weight loss. Talk to your doctor if weight loss is not desirable.
    No specific weight-related info.No specific weight-related info.
    • Can cause minor weight gain (1 to 5 pounds).
    No specific weight-related info.
    • More likely to cause minor weight gain (1 to 5 pounds) and raise cholesterol than any other antidepressant.
    • Good option for people who are underweight or frail, because it can help you gain weight.
    • Can increase appetite and weight.
    No specific weight-related info.
    • More likely to cause minor weight gain (1 to 5 pounds) or make you feel sick if you miss a dose than other antidepressants.
    • Can cause weight gain, which can be helpful if you've recently lost weight or have a low appetite.
    • More likely to cause minor weight gain (1 to 5 pounds) than other antidepressants.
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    WellbutrinBusparCymbaltaCelexaZoloftRemeronOleptroPaxilLexaproProzacEffexor
    • Effective at relieving depression symptoms.
    • Causes fewer sexual side effects than other antidepressants. Can actually boost sex drive for some people.
    • Can be taken with other antidepressants to counteract their sexual side effects.
    • Has some stimulant effects, so it can be energizing.
    • Can help with ADHD symptoms.
    • Also used to suppress appetite and help you quit smoking.
    • Buspar (Buspirone) works very well to control the symptoms of generalized anxiety syndrome (GAD).
    • Buspar (Buspirone) doesn't cause physical dependence or withdrawal symptoms.
    • Buspar (Buspirone) is only available as a generic, so the price can be pretty cheap.
    • Lowers relapse rates for depression.
    • Can relieve some types of chronic pain. Might be particularly good at pain relief for people who are also depressed.
    • Causes less sleepiness compared to other antidepressants.
    • Effective at lowering symptoms and relapse rates of depression and anxiety disorders.
    • Causes less drowsiness than other antidepressants.
    • Effective at relieving some depression symptoms.
    • Starts to work more quickly than most antidepressants.
    • Might be a good option for people who have insomnia with their depression, because it can make you very sleepy.
    • Good option for people who are underweight or frail, because it can help you gain weight.
    • Commonly used in lower doses to help treat sleep problems (insomnia).
    • Safer sleep medication than others (benzodiazepines or Unisom) for people age 65 and older.
    • Fewer sexual side effects than many other antidepressants.
    • Has been used for sleep and depression for a long time. There's a lot of information available about how it works and how safe it is.
    • Comes as a generic medication and is cheaper than many other sleep aides.
    • Lowers relapse rates of depression and anxiety disorders, including OCD, panic disorder, social anxiety disorder, and generalized anxiety disorder.
    • It causes drowsiness, so it's good for people who have trouble sleeping.
    • Can cause weight gain, which can be helpful if you've recently lost weight or have a low appetite.
    • Causes less sleepiness than some other antidepressants.
    • Lowers relapse rates of depression.
    • Lowers relapse rates of depression and bulimia nervosa.
    • Causes less sleepiness than other antidepressants.
    • It's more energizing than other antidepressants, so it's good for people who have low energy.
    • It has been used to treat depression for a long time, so there's a lot of information available about how it works and how safe it is.
    • Causes more sleepiness than other antidepressants, so it's good for people who have trouble sleeping.
    • Might work when other antidepressants haven't worked since it affects two chemicals in the brain that impact your mood. Many other antidepressants affect only serotonin, but not norepinephrine too.
    • Lowers relapse rates of depression.
    Downsides and risks
    WellbutrinBusparCymbaltaCelexaZoloftRemeronOleptroPaxilLexaproProzacEffexor
    • Wellbutrin (Bupropion) can be stimulating, so it can cause anxiety or insomnia the first few days you're taking it.
    • Generally not as good as other antidepressants for people who have anxiety.
    • It's less likely to cause weight gain than other antidepressants.
    • Has a higher risk of causing seizures, especially if you have a seizure disorder, eating disorder, or if you drink alcohol. So, it's not a good medication if you drink a lot.
    • It contains the same ingredient as a medication that helps you to stop smoking, (Zyban), so these two meds can't be used together.
    • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
    • Buspar (Buspirone) can take as long as four weeks to become fully effective.
    • Not as effective for short-term anxiety conditions or panic disorders.
    • Most people find that it loses effectiveness over long periods of time.
    • Can cause drowsiness or dizziness when you start taking Buspar (Buspirone). Be extremely careful of activities that require mental alertness, such as driving.
    • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
    • Not the best option for people with high blood pressure.
    • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
    • Can cause minor weight gain (1 to 5 pounds).
    • Celexa (Citalopram) can cause an irregular heartbeat if you take a high dose (40 mg a day, or more).
    • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24 years.
    • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
    • Not a good option for you if you have heart or liver problems.
    • More likely to cause diarrhea than other antidepressants.
    • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
    • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
    • More likely to cause minor weight gain (1 to 5 pounds) and raise cholesterol than any other antidepressant.
    • Not as effective as other medications for depression.
    • More sedating than other antidepressants.
    • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
    • Causes more side effects when used at higher doses for depression. Includes sleepiness, dizziness, upset stomach, and irregular heartbeat.
    • Not as effective as other medications for depression.
    • More sedating than other antidepressants.
    • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
    • Can cause more sexual side effects like low libido and an inability to orgasm or ejaculate than most antidepressants.
    • More likely to cause minor weight gain (1 to 5 pounds) or make you feel sick if you miss a dose than other antidepressants.
    • Can harm an unborn child, so you can't take it if you're pregnant.
    • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than age 24.
    • More likely to cause minor weight gain (1 to 5 pounds) than other antidepressants.
    • Can cause an irregular heartbeat if you take a high dose (20 mg a day, or more).
    • The first antidepressant you try doesn't always work, and might have side effects you really don't like. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
    • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
    • Not a good option for you if you have heart or liver problems.
    • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
    • Can increase feelings of anxiety or cause headaches during the first few weeks of taking it. These effects should go away over time.
    • More likely than other antidepressants to interact with other medications you're taking.
    • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
    • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
    • Overdosing on this medication could be fatal.
    • It's more likely to cause nausea and vomiting or make you feel sick if you miss a dose than other antidepressants. Also causes more sleepiness than others.
    • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
    • Not the best option for people with high blood pressure.
    • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
    Tips from our pharmacists for people taking the medication
    WellbutrinBusparCymbaltaCelexaZoloftRemeronOleptroPaxilLexaproProzacEffexor
    • Wellbutrin (Bupropion) makes you energized, so take it in the morning to avoid difficulty sleeping later that night.
    • There are no sexual side effects from this medication.
    • The extended-release tablet shell can show up unchanged in your stool, but don't worry since the medication was still absorbed by your body.
    • Take doses at about the same time each day.
    • It can take several weeks to get the full effect.
    • Don't eat or drink grapefruit juice when using Buspar (Buspirone).
    • Don't use Buspar (Buspirone) within two weeks of using an MAO inhibitor (like Eldepryl, Parnate, or Marplan).
    • Be consistent in taking Buspar (Buspirone) with or without food.
    • Avoid alcohol when taking Buspar (Buspirone).
    • Take with food to avoid upset stomach.
    • Full effects in 8 to 12 weeks for mood, 2 weeks for pain.
    • Stop taking slowly to avoid withdrawal symptoms.
    • Take with food to avoid upset stomach.
    • It interacts with St. John's Wort and Tryptophan.
    • Can increase appetite and weight.
    • Makes you sleepy. Take at bedtime.
    • Takes 8 to 12 weeks to see full effects on mood.
    • Stop taking slowly to avoid withdrawal symptoms.
    • Can cause temporary dry mouth and upset stomach.
    • Seek medical attention for unwanted, persistent erection.
    • Makes you sleepy. Take at bedtime.
    • The controlled-release (CR) tablet can cause less nausea than other forms.
    • Don’t crush, break, or chew the Paxil (Paroxetine) controlled-release tablet or the Pexeva film-coated tablets.
    • It’s best to take Paxil (Paroxetine) in the morning, except Brisdelle, which can be taken at bedtime.
    • Take with food to avoid upset stomach.
    • Take with food to avoid upset stomach.
    • Take in the morning with food to avoid side effects.
    • You can take the extended-release form once a day with food either in the morning or in the evening at about the same time each day.
    • Extended-release capsules should be swallowed whole. If you can’t swallow pills, open the capsule, sprinkle it on a spoonful of applesauce and then swallow it without chewing.
    Learn more
    More about WellbutrinSide effectsReviews & ratingsAlternativesFDA package insert
    More about BusparSide effectsReviews & ratingsFDA package insert
    More about CymbaltaSide effectsReviews & ratingsFDA package insert
    More about CelexaSide effectsReviews & ratingsFDA package insert
    More about ZoloftSide effectsReviews & ratingsFDA package insert
    More about RemeronSide effectsReviews & ratingsFDA package insert
    More about OleptroSide effectsReviews & ratingsFDA package insert
    More about PaxilSide effectsReviews & ratingsFDA package insert
    More about LexaproSide effectsReviews & ratingsFDA package insert
    More about ProzacSide effectsReviews & ratingsFDA package insert
    More about EffexorSide effectsReviews & ratingsFDA package insert