Prescription onlyLower-cost generic availableClass: Mental health

XanaxAlternatives

(alprazolam)

Prescription onlyLower-cost generic availableClass: Mental health
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Compare Xanax (alprazolam) to alternatives

These medications are comparable to Xanax (alprazolam) or used for similar purposes.

Xanax
(alprazolam)

Klonopin
(clonazepam)

Valium
(diazepam)

Ativan
(lorazepam)

Helps you relax. Xanax (Alprazolam) is okay for occasional or short-term use (up to 4 weeks) for anxiety, and longer-term for panic attacks. More likely to cause withdrawal symptoms compared to similar drugs.Controls seizures and helps you relax. Klonopin (Clonazepam) is okay for occasional or short-term use (up to 4 weeks) for anxiety, and to treat seizures. Less severe withdrawal symptoms compared to similar drugs.Helps you relax. Valium (Diazepam) is okay for occasional or short-term use (up to 4 weeks) for anxiety and for pain and sleeplessness from muscle spasm. Less severe withdrawal symptoms compared to similar drugs.Helps you relax. Ativan (Lorazepam) is okay for occasional or short-term use (up to 4 weeks) for anxiety and sleep. Less likely to have drug interactions, but more likely to cause withdrawal symptoms compared to similar drugs.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.35Xanax
Reviews for Xanax (alprazolam)
74%
of people (All ages) say Xanax (alprazolam) is worth it
55%
say it works well
13%
say it's a big hassle
1287 reviews
Have you used Xanax (alprazolam)?
Worth itNot sureNot worth it
Reviews for Klonopin (clonazepam)
70%
-4% worse vs. Xanax (alprazolam)
52%
-3% worse vs. Xanax (alprazolam)
14%
-1% worse vs. Xanax (alprazolam)
767 reviews
Have you used Klonopin (clonazepam)?
Worth itNot sureNot worth it
Reviews for Valium (diazepam)
70%
-4% worse vs. Xanax (alprazolam)
53%
-2% worse vs. Xanax (alprazolam)
15%
-2% worse vs. Xanax (alprazolam)
976 reviews
Have you used Valium (diazepam)?
Worth itNot sureNot worth it
Reviews for Ativan (lorazepam)
71%
-3% worse vs. Xanax (alprazolam)
51%
-4% worse vs. Xanax (alprazolam)
15%
-2% worse vs. Xanax (alprazolam)
642 reviews
Have you used Ativan (lorazepam)?
Worth itNot sureNot worth it
Side effects
XanaxKlonopinValiumAtivan
  • Drowsiness 34%
  • Fatigue and tiredness 6%
  • Impaired coordination 23%
  • Irritability 3%
  • Memory impairment 11%
  • Increased appetite 10%
More Xanax side effects »
  • Drowsiness 50%
  • Lack of muscle coordination 30%
  • Behavior problems 25%
  • Ear, nose, or throat infection 6%
  • Fatigue 5%
  • Low mood disorder 6%
  • Dizziness 1%
  • Vaginal inflammation 3%
  • Sinus inflammation 1%
  • Inflammation inside the nose 2%
More Klonopin side effects »

The Valium FDA package insert doesn’t have numbers about how common side effects are.

More about Valium side effects »
  • Relaxation or sleepiness 16%
  • Dizziness 7%
  • Weakness 4%
  • Unsteadiness 3%
More Ativan side effects »
How it works
XanaxKlonopinValiumAtivan
Xanax (Alprazolam) is a fast-acting benzodiazepine. It affects neurotransmitters in the brain and calms the nervous system. This reduces anxiety and can cause sleepiness.Klonopin (Clonazepam) is a fast-acting benzodiazepine. It affects neurotransmitters in the brain and calms the nervous system. This reduces anxiety and muscle spasms, and causes sleepiness.Valium (Diazepam) is a fast-acting benzodiazepine. It affects neurotransmitters in the brain and calms the nervous system. This reduces anxiety and muscle spasms, and causes sleepiness.Ativan (Lorazepam) is a fast-acting benzodiazepine. It affects neurotransmitters in the brain and calms the nervous system. This reduces anxiety and can cause sleepiness.
Type of medication
XanaxKlonopinValiumAtivan
Prescription only
Prescription only
Prescription only
Prescription only
Available as
XanaxKlonopinValiumAtivan
  • Pill
  • Extended release
  • Dissolving tablet
  • Liquid
  • Pill
  • Dissolving tablet
  • Pill
  • Liquid
  • Rectal gel
  • Pill
  • Liquid
Used for
XanaxKlonopinValiumAtivan
Risk factors for serious side effects
XanaxKlonopinValiumAtivan
  • History of drug abuse
  • Taking with alcohol or drugs
  • Taking more than 4 mg/day or longer than 12 weeks
  • Stopping Xanax (Alprazolam) suddenly
  • Severely depressed
  • Taking with alcohol or drugs
  • First trimester of pregnancy
  • Current liver problems
Detailed Xanax (alprazolam) risks & warnings »
  • Taking more than the prescribed dose
  • Taking longer than 4 weeks
  • History of drug abuse
  • Long-term use
    • Alcohol
    • Taking other medicines that make you less alert
      Detailed Klonopin (clonazepam) risks & warnings »
      • Taking more than the prescribed dose
      • Taking longer than 4 weeks
      • History of drug abuse
      • Long-term use
        • Alcohol
        • Taking other medicines that make you less alert
          • Current liver problems
          Detailed Valium (diazepam) risks & warnings »
          • Taking more than the prescribed dose
          • Taking longer than 4 weeks
          • History of drug abuse
          • Long-term use
            • Alcohol
            • Taking other medicines that make you less alert
              Detailed Ativan (lorazepam) risks & warnings »
              Pregnancy

              Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              Interactions
              XanaxKlonopinValiumAtivan
              No interactions related info.No interactions related info.No interactions related info.
              • Less likely to have drug interactions compared to other benzodiazepines, so it might be a better option if you're taking multiple medications.
              Alcohol
              XanaxKlonopinValiumAtivan
              • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
              • Not safe to use with alcohol.
              • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
              • Not safe to use with alcohol.
              • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
              • Not safe to use with alcohol.
              • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
              • Not safe to use with alcohol.
              Kidneys and liver
              XanaxKlonopinValiumAtivan
              • Processed by the liver, so might not be the best choice if you have liver problems.
              No kidneys and liver related info.
              • Processed by the liver, so might not be the best choice if you have liver problems.
              No kidneys and liver related info.
              Sleep
              XanaxKlonopinValiumAtivan
              • Can cause memory problems, drowsiness, dizziness, and confusion.
              • Can cause temporary dizziness and drowsiness.
              • Can cause memory problems, drowsiness, dizziness, and confusion.
              • Can cause dizziness, drowsiness, and salivation.
              • Can cause memory problems, drowsiness, dizziness, and confusion.
              • Can cause temporary dizziness and drowsiness.
              • Can cause memory problems, drowsiness, dizziness, and confusion.
              • Can cause temporary dizziness and drowsiness.
              Upsides and benefits
              XanaxKlonopinValiumAtivan
              • Effective at relieving short-term anxiety.
              • Effective longer-term for panic attacks.
              • Can be used together with antidepressants to manage anxiety disorders. Especially helpful for anxiety symptoms while you wait for an antidepressant to kick in (it can take several weeks).
              • Effective at relieving short-term anxiety and sleeplessness.
              • Can be used together with antidepressants to manage anxiety disorders. Especially helpful for anxiety symptoms while you wait for an antidepressant to kick in (it can take several weeks).
              • Can be used alone or with other medicines to treat seizures.
              • Less severe withdrawal symptoms compared to other benzodiazepines.
              • Effective at relieving short-term anxiety and sleeplessness.
              • Can be used together with antidepressants to manage anxiety disorders. Especially helpful for anxiety symptoms while you wait for an antidepressant to kick in (it can take several weeks).
              • Effective at relieving muscle spasms caused by a variety of conditions.
              • Less severe withdrawal symptoms compared to other benzodiazepines.
              • Effective at relieving short-term anxiety and sleeplessness.
              • Can be used together with antidepressants to manage anxiety disorders. Especially helpful for anxiety symptoms while you wait for an antidepressant to kick in (it can take several weeks).
              • Less likely to have drug interactions compared to other benzodiazepines, so it might be a better option if you're taking multiple medications.
              Downsides and risks
              XanaxKlonopinValiumAtivan
              • Processed by the liver, so might not be the best choice if you have liver problems.
              • Can cause memory problems, drowsiness, dizziness, and confusion.
              • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
              • Compared to other benzodiazepines, more likely to cause withdrawal if you take it for a long time and then stop suddenly.
              • Can cause memory problems, drowsiness, dizziness, and confusion.
              • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
              • Most people find that it gets less effective over time.
              • Processed by the liver, so might not be the best choice if you have liver problems.
              • Can cause memory problems, drowsiness, dizziness, and confusion.
              • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
              • Most people find that it gets less effective over time.
              • Can cause memory problems, drowsiness, dizziness, and confusion.
              • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
              • Compared to other benzodiazepines, more likely to cause withdrawal if you take it for a long time and then stop suddenly.
              • Most people find that it gets less effective over time.
              Tips from our pharmacists for people taking the medication
              XanaxKlonopinValiumAtivan
              • Good for short-term relief of anxiety symptoms.
              • Starts working in 45 minutes when swallowed.
              • Can cause temporary dizziness and drowsiness.
              • Addictive. Long-term use can cause dependence or abuse.
              • Not safe to use with alcohol.
              • For the first week, avoid activities that require you to be alert.
              • Can cause dizziness, drowsiness, and salivation.
              • Report any confusion or inability to control muscle movements to your doctor.
              • Not safe to use with alcohol.
              • Good for short-term relief of anxiety symptoms.
              • Starts working in 30 minutes when swallowed.
              • Helpful with muscle spasms.
              • Can cause temporary dizziness and drowsiness.
              • Addictive. Long-term use can cause dependence or abuse.
              • Not safe to use with alcohol.
              • Good for short-term relief of anxiety symptoms.
              • Starts working in 45 minutes when swallowed.
              • Starts working in 10 to 20 minutes when dissolved under your tongue.
              • Can cause temporary dizziness and drowsiness.
              • Addictive. Long-term use can cause dependence or abuse.
              • Not safe to use with alcohol.
              Learn more
              More about XanaxSide effectsReviews & ratingsAlternativesFDA package insert
              Have you used Xanax (alprazolam)?
              Worth itNot sureNot worth it
              More about KlonopinSide effectsReviews & ratingsFDA package insert
              Have you used Klonopin (clonazepam)?
              Worth itNot sureNot worth it
              More about ValiumSide effectsReviews & ratingsFDA package insert
              Have you used Valium (diazepam)?
              Worth itNot sureNot worth it
              More about AtivanSide effectsReviews & ratingsFDA package insert
              Have you used Ativan (lorazepam)?
              Worth itNot sureNot worth it