Prescription onlyNo lower cost generic available

Xarelto Alternatives

(Rivaroxaban)

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Compare Xarelto (Rivaroxaban) to alternatives

These medications are comparable to Xarelto (Rivaroxaban) or used for similar purposes.

Xarelto
(Rivaroxaban)

Arixtra
(Fondaparinux)

Coumadin
(Warfarin)

Eliquis
(Apixaban)

Lovenox
(Enoxaparin)

Pradaxa
(Dabigatran)

Heparin

Prevents blood clots. Xarelto (Rivaroxaban) is a good medication for preventing blood clots. It doesn't require regular blood tests or changing doses often. It can be expensive and there's no way to reverse the medication's effects.Coming soon.Prevents blood clots. Coumadin (Warfarin) is an old, cheap, and effective medicine to prevent blood clots, but it requires some monitoring, dose adjustments, and even lifestyle changes.Prevents blood clots. Eliquis (Apixaban) is an easy to use and effective way to prevent blood clots from forming in your veins.Prevents blood clots. Lovenox (Enoxaparin) is a good anticoagulant that reduces the risk of death or bleeding, and blood clots are less likely to happen. However, it is only available as an injection which isn't great if you're afraid of needles.Prevents blood clots. Pradaxa (Dabigatran) is a good medication for preventing blood clots. It doesn't require regular blood tests or changing doses often. It can be expensive and there's no way to reverse the medication's effects.Prevents blood clots. Heparin is a good anticoagulant that prevents blood clots. However, you'll need to get frequent blood tests to make sure it's working well.
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Reviews & ratings
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Reviews for Coumadin (Warfarin)
61%
+17% vs. Xarelto (Rivaroxaban)
54%
+10% vs. Xarelto (Rivaroxaban)
21%
10% vs. Xarelto (Rivaroxaban)

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Side effects
XareltoArixtraCoumadinEliquisLovenoxPradaxaHeparin
  • Back pain 3%
More Xarelto side effects »

We haven’t found good data for Arixtra side effects.

FDA side effect reports for Arixtra »

The Coumadin FDA package insert doesn’t have numbers about how common side effects are.

More about Coumadin side effects »
  • All bleeding 6%
  • Nosebleed 3%
  • Nonmajor bleeding 2%
  • Collection of blood 1%
More Eliquis side effects »
  • Injection site hematoma 7%
  • Fever 2%
  • Confusion 1%
  • Nausea 1%
More Lovenox side effects »

The Pradaxa FDA package insert doesn’t have numbers about how common side effects are.

More about Pradaxa side effects »

We haven’t found good data for Heparin side effects.

FDA side effect reports for Heparin »
How it works
XareltoArixtraCoumadinEliquisLovenoxPradaxaHeparin
Xarelto (Rivaroxaban) is an anticoagulant that stops the formation of blood clots.Coming soon.Coumadin (Warfarin) is an anticoagulant blood thinner. It lowers chemicals called clotting factors so that it's harder for your body to form blood clots.Eliquis (Apixaban) is a factor Xa inhibitor anticoagulant and prevents the formation of blood clots in your veins.Lovenox (Enoxaparin) is an anticoagulant that prevents certain blood-clotting proteins from working. By stopping blood clots from forming, there's a lower chance of having a stroke or blood clots travel to your lungs.Pradaxa (Dabigatran) is an anticoagulant that stops the formation of blood clots.Heparin is an anticoagulant that binds with proteins and platelets to stop blood clots from being made and traveling to the brain, heart, and lungs.
Type of medication
XareltoArixtraCoumadinEliquisLovenoxPradaxaHeparin
Anticoagulant
Factor Xa inhibitor
Prescription only
Coming soon.
Anticoagulant
Vitamin K antagonist
Prescription only
Anticoagulant
Factor Xa inhibitor
Prescription only
Anticoagulant
Heparin
Prescription only
Anticoagulant
Thrombin inhibitor
Prescription only
Anticoagulant
Heparin
Prescription only
Available as
XareltoArixtraCoumadinEliquisLovenoxPradaxaHeparin
  • Pill
  • Injection
  • Pill
  • Pill
  • Injection
  • Pill
  • Injection
Used for (click to learn more)
XareltoArixtraCoumadinEliquisLovenoxPradaxaHeparin
  • Deep venous thrombosis
Risk factors for serious side effects
XareltoArixtraCoumadinEliquisLovenoxPradaxaHeparin
  • Stopping Xarelto (Rivaroxaban) too soon
  • Artificial heart valve
  • Spinal puncture (spinal tap)
  • Getting anesthesia in the spine (epidural anesthesia)
  • History of bleeding problems
  • Severe high blood pressure
  • Age 65 or older
  • Drug interactions
  • Taking NSAIDs, aspirin, or other blood-thinning medicines
  • Current kidney problems
  • Current liver problems
Detailed Xarelto (Rivaroxaban) risks & warnings »
Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.
Pregnancy category
XareltoArixtraCoumadinEliquisLovenoxPradaxaHeparin
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
BFDA pregnancy category (Probably safe)

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

See the FDA package insert
XFDA pregnancy category (Unsafe)

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

See the FDA package insert
BFDA pregnancy category (Probably safe)

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

See the FDA package insert
BFDA pregnancy category (Probably safe)

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

See the FDA package insert
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
Alcohol
No specific alcohol-related info.No specific alcohol-related info.
  • Many lifestyle factors can affect how well warfarin works, such as diet, alcohol, and activity level, so it's important that you try to stay consistent with your behaviors.
No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.
Food
  • Xarelto (Rivaroxaban) doesn't have as many food interactions as compared to other anticoagulants like warfarin (Coumadin).
  • Take Xarelto (Rivaroxaban) with food and a full glass of water.
No specific food-related info.
  • Eat foods containing consistent amounts of Vitamin K.
  • Take twice a day, with or without food, at the same time each day.
No specific food-related info.No specific food-related info.No specific food-related info.
Kidneys and liver
  • Xarelto (Rivaroxaban) is processed by the kidney and liver. If you have kidney or liver problems, talk to your doctor about possibly switching to a different medicine to prevent increased risk for side effects.
No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.
  • It doesn't work as well as other medications for "thinning the blood" if you are overweight, underweight, or if you have kidney disease.
No specific kidneys and liver-related info.No specific kidneys and liver-related info.
Sex
No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.
Sleep
No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.
Weight
No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.
Upsides and benefits
XareltoArixtraCoumadinEliquisLovenoxPradaxaHeparin
  • Studies have shown that Xarelto (Rivaroxaban) works just as well as other blood thinners (anticoagulants) in preventing strokes and reducing bleeding.
  • Xarelto (Rivaroxaban) doesn't require regular blood testing or frequent dose adjustments.
  • Xarelto (Rivaroxaban) doesn't have as many food interactions as compared to other anticoagulants like warfarin (Coumadin).
Coming soon.
  • Oral blood-thinning medicine that prevents blood clots from forming or getting bigger.
  • Prevents complications of blood clots that can cause extreme discomfort or death. Examples include stroke (blood clots in the brain), pulmonary embolism (blood clots in the lungs causing trouble breathing), or deep vein thrombosis (blood clots in the legs causing pain and blood vessel damage).
  • Has an antidote, Vitamin K, in case of a major accidental bleeding.
  • Coumadin (Warfarin) has been around for a long time, so we know a lot about how well it works and what the risks are.
  • It's dirt cheap.
  • Eliquis (Apixaban) is very effective in reducing the threat of stroke in people with Afib or other clotting disorders.
  • Eliquis (Apixaban) doesn't require regular blood testing and doesn't have dietary restrictions.
  • If you've had clots in your legs or lungs before, Eliquis (Apixaban) can lower the risk of these forming again.
  • In a study that compared Lovenox (Enoxaparin) to other medications used to stop blood clots, there was a lower risk of clots coming back, with similar rates of major bleeding and mortality.
  • You don't need to go in for lab tests to check whether it's working, unlike other medications like warfarin that require regular blood draws.
  • Available in generic so it can be cheaper than other "blood thinners".
  • Good option if you're pregnant or have cancer.
  • Clinical studies have shown that the risk of stroke and blood clots is lower than with warfarin, another popular "blood thinner" (anticoagulant).
  • Doesn't require regular blood tests or frequent dose changes.
  • In studies comparing Pradaxa (Dabigatran) to other "blood thinners", it worked just as well in preventing strokes and was better in lowering the risk of bleeding.
  • Safe to use in pregnancy and if you're breast feeding.
  • There are other medications that can help stop unexpected bleeding while taking Heparin.
  • Available as a generic medication.
  • Usually used in the hospital, but can be given at home too.
Downsides and risks
XareltoArixtraCoumadinEliquisLovenoxPradaxaHeparin
  • Xarelto (Rivaroxaban) can increase your risk of bleeding. Call your doctor right away if there is blood in your phlegm, urine, or stool (look for black, tarry stools).
  • Xarelto (Rivaroxaban) isn't available as a generic medication.
  • There are no antidotes to stop bleeding caused by taking too much Xarelto (Rivaroxaban).
  • Can't take during pregnancy.
Coming soon.
  • Raises your risk of bleeding and bruising.
  • Requires routine blood testing (called an INR) to see how well the medicine is working for you and to make the dose just right for you.
  • Many lifestyle factors can affect how well warfarin works, such as diet, alcohol, and activity level, so it's important that you try to stay consistent with your behaviors.
  • Lots of interactions with other drugs or supplements. Always check with your doctor or pharmacist before starting any new meds.
  • You can bruise easier and if you cut yourself, it'll take longer to stop the bleeding. Always look for signs of internal bleeding, such as dark urine or blood in your stool.
  • Can't be used if you have artificial heart valves.
  • Never stop taking Eliquis (Apixaban) without talking to your doctor first.
  • Eliquis (Apixaban) isn't available as a generic, so it can be pricey.
  • It is only available as an injection, so it's not great if you're afraid of needles.
  • While surprise bleeding episodes can be treated while taking Lovenox (Enoxaparin), they won't completely work.
  • It doesn't work as well as other medications for "thinning the blood" if you are overweight, underweight, or if you have kidney disease.
  • Not available as generic.
  • There are no antidotes to stop bleeding caused by taking too much Pradaxa (Dabigatran).
  • Can't take during pregnancy.
  • You'll need to get labs/blood draws done on a regular basis to make sure the drug is working and to make sure you don't get unexpected side effects.
  • You can be at higher risk for bleeding or clotting while taking Heparin compared to other anticoagulants.
Tips from our pharmacists for people taking the medication
XareltoArixtraCoumadinEliquisLovenoxPradaxaHeparin
  • Xarelto (Rivaroxaban) is an anticoagulant, so it's important not to miss a dose. Don't stop taking this medication without talking to your doctor first.
  • When taking Xarelto (Rivaroxaban), you can bleed more easily, so use a soft toothbrush and an electric razor to avoid cutting yourself.
  • Take Xarelto (Rivaroxaban) with food and a full glass of water.
  • You can crush the tablets and mix with applesauce.
Coming soon.
  • Thins your blood to prevent clots from forming or getting bigger. Doesn't break up existing clots.
  • The amount you need depends on your diet, other medical problems, and genes.
  • Take it exactly as instructed.
  • Can raise your risk of bleeding or bruising.
  • Requires regular blood tests to get your dose right.
  • Interacts with a lot of medicines and supplements. Don't start any new meds without talking to your doctor.
  • Eat foods containing consistent amounts of Vitamin K.
  • Tell your doctor immediately if you fell or if you have unusual bleeding, bruising, swelling, or changes in vision and coordination.
  • Get a medical bracelet so that people know you're on a blood thinner during an emergency situation.
  • Take twice a day, with or without food, at the same time each day.
  • Needs to be stopped prior to dental procedures or surgery.
  • You can bruise easier and if you have a cut, it can take longer for bleeding to stop.
  • Do not take with other drugs that affect your blood, like aspirin, ibuprofen, warfarin, or SSRIs.
  • Call a doctor immediately if you have dizziness, weakness, or a really bad headache.
  • Rotate the spot where you inject Lovenox (Enoxaparin) every day.
  • While on this, it can take longer to stop bleeding and you are more likely to bruise or bleed more easily.
  • Avoid taking certain anti-inflammatory drugs (like NSAIDs) because they can make you more likely to bleed.
  • Can cause swelling in your legs, diarrhea, and nausea.
  • Pradaxa (Dabigatran) is an anticoagulant, so it's important not to miss a dose. Don't stop taking this medication without talking to your doctor first.
  • When taking Pradaxa (Dabigatran), you can bleed more easily, so use a soft toothbrush and an electric razor to avoid cutting yourself.
  • Take this exactly as your doctor or pharmacist tells you to.
  • Take with a full glass of water. Swallow the capsule whole. Don't chew, break, or open the capsule.
  • Make sure to change where you inject Heparin every time.
  • Don't take aspirin or other anti-inflammatory medications without talking to your doctor first.
  • You will have to do regular blood draws or labs to make sure that Heparin is working for you.
Learn more
More about XareltoSide effectsReviews & ratingsAlternativesFDA package insert
More about ArixtraSide effectsFDA package insert
More about CoumadinSide effectsReviews & ratingsFDA package insert
More about EliquisSide effectsReviews & ratingsFDA package insert
More about LovenoxSide effectsReviews & ratingsFDA package insert
More about PradaxaSide effectsReviews & ratingsFDA package insert
More about HeparinSide effectsReviews & ratingsFDA package insert