Prescription onlyClass: Cardiovascular

XareltoAlternatives

(rivaroxaban)

Prescription onlyClass: Cardiovascular
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Compare Xarelto (rivaroxaban) to alternatives

These medications are comparable to Xarelto (rivaroxaban) or used for similar purposes.

Xarelto
(rivaroxaban)

Arixtra
(fondaparinux)

Coumadin
(warfarin)

Eliquis
(apixaban)

Lovenox
(enoxaparin)

Pradaxa
(dabigatran)

heparin

Prevents blood clots. Xarelto (rivaroxaban) is a good medication for preventing blood clots. It doesn't require regular blood tests or changing doses often. However, it can be expensive and there's no way to reverse the medication's effects.Coming soon.Prevents blood clots. Coumadin (warfarin) is a cheap and effective medicine that prevents new blood clots. It requires regular blood tests and you'll need to eat, exercise, and take your medicines consistently.Prevents blood clots. Eliquis (Apixaban) is an easy to use and effective way to prevent blood clots from forming in your veins.Prevents blood clots. Lovenox (Enoxaparin) is a good anticoagulant that reduces the risk of death or bleeding, and blood clots are less likely to happen. However, it is only available as an injection which isn't great if you're afraid of needles.Prevents blood clots. Pradaxa (Dabigatran) is a good medication for preventing blood clots. It doesn't require regular blood tests or changing doses often. It can be expensive and there's no way to reverse the medication's effects.Prevents blood clots. Heparin is a good anticoagulant that prevents blood clots. However, you'll need to get frequent blood tests to make sure it's working well.
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Reviews & ratings
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Not enough reviews for this drug. Help someone out, leave a review!

Have you used Xarelto (rivaroxaban)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Arixtra (fondaparinux)?
Worth itNot sureNot worth it
Reviews for Coumadin (warfarin)
61%
+16% better vs. Xarelto (rivaroxaban)
54%
+9% better vs. Xarelto (rivaroxaban)
21%
-12% worse vs. Xarelto (rivaroxaban)
513 reviews
Have you used Coumadin (warfarin)?
Worth itNot sureNot worth it

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Have you used Eliquis (apixaban)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Lovenox (enoxaparin)?
Worth itNot sureNot worth it

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Have you used Pradaxa (dabigatran)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Heparin?
Worth itNot sureNot worth it
Side effects
XareltoArixtraCoumadinEliquisLovenoxPradaxaHeparin
  • Major bleeding needing transfusion 4%
  • Bleeding in the stomach & intestines 2%
  • Complaints of bleeding 28%
  • Clinically relevant but not major bleeding 9%
  • Back pain 3%
  • Upper abdominal pain 2%
  • Joint arthritis 1%
  • Any bleeding event after hip or knee replacement surgery 6%
  • Any side effect causing stopping of xarelto (rivaroxaban) 4%
  • Wound drainage 3%
More Xarelto side effects »

We haven’t found good data for Arixtra side effects.

FDA side effect reports for Arixtra »

The Coumadin FDA package insert doesn’t have numbers about how common side effects are.

More about Coumadin side effects »
  • Bleeding 2%
  • Major bleed 2%
  • Nonmajor bleeding 2%
  • All bleed 12%
  • All bleeding 7%
  • Nausea 3%
  • Low red blood cells 3%
  • Nosebleed 3%
  • Bruise 2%
  • Blood in urine 2%
More Eliquis side effects »
  • Injection site hematoma 7%
  • Excessive bleeding 7%
  • Major hemorrhage 4%
  • Nausea 1%
  • Confusion 1%
  • Fever 2%
More Lovenox side effects »
  • Gi side effect 35%
  • Any side effect 21%
  • Any bleed 20%
  • Indigestion 8%
  • Major gastrointestinal bleed 6%
  • Gi bleed 3%
  • Major bleed 3%
  • Gastritis-like symptoms 3%
  • Gastrointestinal bleed 2%
  • Life-threatening bleed 2%
More Pradaxa side effects »

We haven’t found good data for Heparin side effects.

FDA side effect reports for Heparin »
How it works
XareltoArixtraCoumadinEliquisLovenoxPradaxaHeparin
Xarelto (rivaroxaban) is an anticoagulant that stops blood clots from forming.Coming soon.Coumadin (warfarin) prevents blood clots from forming. It doesn't break up clots that already exist. It can only stop new ones from forming or old ones from getting bigger.Eliquis (Apixaban) is a factor Xa inhibitor anticoagulant and prevents the formation of blood clots in your veins.Lovenox (Enoxaparin) is an anticoagulant that prevents certain blood-clotting proteins from working. By stopping blood clots from forming, there's a lower chance of having a stroke or blood clots travel to your lungs.Pradaxa (Dabigatran) is an anticoagulant that stops the formation of blood clots.Heparin is an anticoagulant that binds with proteins and platelets to stop blood clots from being made and traveling to the brain, heart, and lungs.
Type of medication
XareltoArixtraCoumadinEliquisLovenoxPradaxaHeparin
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Available as
XareltoArixtraCoumadinEliquisLovenoxPradaxaHeparin
  • Pill
  • Injection
  • Pill
  • Pill
  • Injection
  • Pill
  • Injection
Used for
XareltoArixtraCoumadinEliquisLovenoxPradaxaHeparin
  • Deep Venous Thrombosis
Risk factors for serious side effects
XareltoArixtraCoumadinEliquisLovenoxPradaxaHeparin
  • Stopping Xarelto (rivaroxaban) too soon
  • Artificial heart valve
  • Spinal puncture (spinal tap)
  • Getting anesthesia in the spine (epidural anesthesia)
  • History of bleeding problems
  • Severe high blood pressure
  • Age 65 or older
  • Drug interactions
  • Taking NSAIDs, aspirin, or other blood-thinning medicines
  • Current kidney problems
  • Current liver problems
Detailed Xarelto (rivaroxaban) risks & warnings »
Coming soon.
  • Coumadin (warfarin) dose too high
  • Age greater than 65 year
  • History of stomach bleeding
  • High blood pressure
  • Kidney or liver problems
  • Drug interactions
  • Change in lifestyle or diet
  • Alcohol use
  • Certain genetic factors
  • Women of childbearing age
      Detailed Coumadin (warfarin) risks & warnings »
      • Stopping Eliquis (Apixaban) early
      • Spinal puncture (spinal tap)
      • Getting anesthesia in the spine (epidural anesthesia)
      • History of bleeding problems
      • Severe high blood pressure
      • Older age
      • Artificial heart valve
      • Current kidney problems
      • Current liver problems
      Detailed Eliquis (apixaban) risks & warnings »
      • Spinal puncture (spinal tap)
      • Getting anesthesia in the spine (epidural anesthesia)
      • Taking NSAIDs or other blood thinning medicines
      • History of bleeding problems
      • Severe high blood pressure
      • Older age
      • Stopping Lovenox (Enoxaparin) early
      • Heparin-induced thrombocytopenia
      Detailed Lovenox (enoxaparin) risks & warnings »
      • Stopping Pradaxa (Dabigatran) too soon
      • Spinal tap
      • Anesthesia along the spine (epidural anesthesia)
      • Taking NSAIDs, aspirin, or other blood-thinning medicines
      • Drug interactions
      • Taking with NSAIDs, aspirin, or other blood-thinning medicines
        • Artificial heart valve
        Detailed Pradaxa (dabigatran) risks & warnings »
        • History of bleeding problems
        • Severe high blood pressure
        • Older age
        • Heparin-induced thrombocytopenia
        Detailed Heparin risks & warnings »
        Pregnancy

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Interactions
        XareltoArixtraCoumadinEliquisLovenoxPradaxaHeparin
        • Xarelto (rivaroxaban) doesn't interact with as many types of food as other blood thinners like warfarin (Coumadin).
        No interactions related info.
        • A lot of other drugs and supplements interact with Coumadin (warfarin), so you'll need to check with your doctor or pharmacist before starting any new medicines.
        • Coumadin (warfarin) interacts with many drugs and supplements. This can increase your risk of bleeding or of developing a new blood clot. If you start a new medication or change your diet, let your doctor know so they can change your dose if necessary.
        No interactions related info.No interactions related info.No interactions related info.No interactions related info.
        Food
        XareltoArixtraCoumadinEliquisLovenoxPradaxaHeparin
        • Like all blood thinners, it will take a little longer for your blood to clot if you start bleeding while you're taking Xarelto (rivaroxaban). Call your doctor if you notice bleeding that won't stop, a bruise that won't go away or gets worse, pink or brown urine, bright red or dark tarry stool, nose bleeds, or if you start coughing up blood.
        No food related info.No food related info.
        • Take twice a day, with or without food, at the same time each day.
        • Available in generic so it can be cheaper than other "blood thinners".
        No food related info.No food related info.
        Kidneys and liver
        XareltoArixtraCoumadinEliquisLovenoxPradaxaHeparin
        • Xarelto (rivaroxaban) is processed by the kidney and liver. If you have kidney or liver problems, talk to your doctor about possibly switching to a different medicine to avoid other side effects.
        No kidneys and liver related info.No kidneys and liver related info.
        • Eliquis (Apixaban) is processed by the kidney and liver. If you have kidney or liver problems, talk to your doctor about possibly switching to a different medicine to prevent increased risk for side effects.
        No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.
        Upsides and benefits
        XareltoArixtraCoumadinEliquisLovenoxPradaxaHeparin
        • Studies show that Xarelto (rivaroxaban) works just as well as other blood thinners (anticoagulants) in preventing strokes and stopping clots from froming.
        • Xarelto (rivaroxaban) doesn't require regular blood tests or frequent dose changes.
        • Xarelto (rivaroxaban) doesn't interact with as many types of food as other blood thinners like warfarin (Coumadin).
        Coming soon
        • Coumadin (warfarin) is available as a generic, so it should be less expensive than the brand version.
        • In case you start bleeding too much while using Coumadin (warfarin), your doctor can give you another drug that reverses Coumadin (warfarin)'s effects.
        • Coumadin (warfarin) comes in numerous strengths.
        • Coumadin (warfarin) has been around for a long time and is one of the most commonly used 'blood thinner' medicines.
        • Eliquis (Apixaban) is very effective in reducing the threat of stroke in people with Afib or other clotting disorders.
        • Eliquis (Apixaban) doesn't require regular blood testing and doesn't have dietary restrictions.
        • If you've had clots in your legs or lungs before, Eliquis (Apixaban) can lower the risk of these forming again.
        • In a study that compared Lovenox (Enoxaparin) to other medications used to stop blood clots, there was a lower risk of clots coming back, with similar rates of major bleeding and mortality.
        • You don't need to go in for lab tests to check whether it's working, unlike other medications like warfarin that require regular blood draws.
        • Available in generic so it can be cheaper than other "blood thinners".
        • Good option if you're pregnant or have cancer.
        • Clinical studies have shown that the risk of stroke and blood clots is lower than with warfarin, another popular "blood thinner" (anticoagulant).
        • Doesn't require regular blood tests or frequent dose changes.
        • In studies comparing Pradaxa (Dabigatran) to other "blood thinners", it worked just as well in preventing strokes and was better in lowering the risk of bleeding.
        • Safe to use in pregnancy and if you're breast feeding.
        • There are other medications that can help stop unexpected bleeding while taking Heparin.
        • Available as a generic medication.
        • Usually used in the hospital, but can be given at home too.
        Downsides and risks
        XareltoArixtraCoumadinEliquisLovenoxPradaxaHeparin
        • Xarelto (rivaroxaban) can increase your risk of bleeding, so call your doctor right away if you see blood in your spit, urine, or stool (look for black, tarry stools or bright red blood).
        • Xarelto (rivaroxaban) isn't available as a generic medication.
        • There are no antidotes to stop bleeding caused by taking too much Xarelto (rivaroxaban).
        • You can't take Xarelto (rivaroxaban) if you are pregnant.
        Coming soon
        • Raises your risk of bleeding and bruising.
        • Requires regular blood work, such as an INR, to make sure Coumadin (warfarin) is working correctly.
        • Your daily dose of Coumadin (warfarin) can change if you change your diet, exercise patterns, or use of alcohol.
        • A lot of other drugs and supplements interact with Coumadin (warfarin), so you'll need to check with your doctor or pharmacist before starting any new medicines.
        • You can bruise easier and if you cut yourself, it'll take longer to stop the bleeding. Always look for signs of internal bleeding, such as dark urine or blood in your stool.
        • Can't be used if you have artificial heart valves.
        • Never stop taking Eliquis (Apixaban) without talking to your doctor first.
        • Eliquis (Apixaban) isn't available as a generic, so it can be pricey.
        • It is only available as an injection, so it's not great if you're afraid of needles.
        • While surprise bleeding episodes can be treated while taking Lovenox (Enoxaparin), they won't completely work.
        • It doesn't work as well as other medications for "thinning the blood" if you are overweight, underweight, or if you have kidney disease.
        • Not available as generic.
        • There are no antidotes to stop bleeding caused by taking too much Pradaxa (Dabigatran).
        • Can't take during pregnancy.
        • You'll need to get labs/blood draws done on a regular basis to make sure the drug is working and to make sure you don't get unexpected side effects.
        • You can be at higher risk for bleeding or clotting while taking Heparin compared to other anticoagulants.
        Tips from our pharmacists for people taking the medication
        XareltoArixtraCoumadinEliquisLovenoxPradaxaHeparin
        • Xarelto (rivaroxaban) prevents blood from clotting, so it's important not to miss a dose. If you miss your daily dose, take it as soon as you remember that day. Just don't take two doses close to each other.
        • If you completely forget to take a dose, call your doctor right away.
        • When taking Xarelto (rivaroxaban), you can bleed more easily, so use a soft toothbrush and an electric razor to avoid cutting yourself.
        • You can crush the pills and mix it with a spoonful of applesauce, but make sure to eat some food and drink a glass of water right away.
        Coming soon
        • Prevents clots from forming or getting bigger. It doesn't break up clots that already exist.
        • Take Coumadin (warfarin) exactly as your doctor tells you.
        • Once you're taking Coumadin (warfarin), it'll take longer for your body to heal if you get cut or bruised. Call your doctor if you notice any unusual bleeding or bruising.
        • Carry a list of your medications with you or wear a medical bracelet that says you're on Coumadin (warfarin) in case you have a medical emergency.
        • Your doctor will check your blood regularly for the first few months that you're taking Coumadin (warfarin).
        • To get the best results, don't fall behind on taking your other medicines and eat the same amount of vegetables each day.
        • Take twice a day, with or without food, at the same time each day.
        • Needs to be stopped prior to dental procedures or surgery.
        • You can bruise easier and if you have a cut, it can take longer for bleeding to stop.
        • Do not take with other drugs that affect your blood, like aspirin, ibuprofen, warfarin, or SSRIs.
        • Call a doctor immediately if you have dizziness, weakness, or a really bad headache.
        • Rotate the spot where you inject Lovenox (Enoxaparin) every day.
        • While on this, it can take longer to stop bleeding and you are more likely to bruise or bleed more easily.
        • Avoid taking certain anti-inflammatory drugs (like NSAIDs) because they can make you more likely to bleed.
        • Can cause swelling in your legs, diarrhea, and nausea.
        • Pradaxa (Dabigatran) is an anticoagulant, so it's important not to miss a dose. Don't stop taking this medication without talking to your doctor first.
        • When taking Pradaxa (Dabigatran), you can bleed more easily, so use a soft toothbrush and an electric razor to avoid cutting yourself.
        • Take this exactly as your doctor or pharmacist tells you to.
        • Take with a full glass of water. Swallow the capsule whole. Don't chew, break, or open the capsule.
        • Make sure to change where you inject Heparin every time.
        • Don't take aspirin or other anti-inflammatory medications without talking to your doctor first.
        • You will have to do regular blood draws or labs to make sure that Heparin is working for you.
        Learn more
        More about XareltoSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Xarelto (rivaroxaban)?
        Worth itNot sureNot worth it
        More about ArixtraSide effectsFDA package insert
        Have you used Arixtra (fondaparinux)?
        Worth itNot sureNot worth it
        More about CoumadinSide effectsReviews & ratingsFDA package insert
        Have you used Coumadin (warfarin)?
        Worth itNot sureNot worth it
        More about EliquisSide effectsReviews & ratingsFDA package insert
        Have you used Eliquis (apixaban)?
        Worth itNot sureNot worth it
        More about LovenoxSide effectsReviews & ratingsFDA package insert
        Have you used Lovenox (enoxaparin)?
        Worth itNot sureNot worth it
        More about PradaxaSide effectsReviews & ratingsFDA package insert
        Have you used Pradaxa (dabigatran)?
        Worth itNot sureNot worth it
        More about HeparinSide effectsReviews & ratingsFDA package insert
        Have you used Heparin?
        Worth itNot sureNot worth it