Prescription onlyLower-cost generic available

Xyzal Alternatives

(Levocetirizine)

Prescription onlyLower-cost generic available
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Compare Xyzal (Levocetirizine) to alternatives

These medications are comparable to Xyzal (Levocetirizine) or used for similar purposes.

Xyzal
(Levocetirizine)

Allegra
(Fexofenadine)

Benadryl
(Diphenhydramine)

Clarinex
(Desloratadine)

Claritin
(Loratadine)

Zyrtec
(Cetirizine)

Treats allergy symptoms. Xyzal (Levocetirizine) is good for treating allergy symptoms, but it can cause drowsiness.Treats allergy symptoms. Allegra (Fexofenadine) relieves allergy symptoms without making you feel drowsy.Treats allergy symptoms and helps you sleep. Benadryl (Diphenhydramine) is great for allergies, but curl up on the couch after taking it and get ready for a nap.Treats allergy symptoms. Clarinex (Desloratadine) is a good option for once-daily allergy relief. It doesn't make you feel sleepy, but you need a prescription.Treats allergy symptoms. Claritin (Loratadine) is a once-daily allergy relief medication that doesn't make you feel sleepy.Treats allergy symptoms. Zyrtec (Cetirizine) is a once-daily allergy relief medication that won't make you feel too sleepy.
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Reviews & ratings
Filter group. All currently selected
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Not enough reviews for this drug. Help someone out, leave a review!

Have you used Xyzal (Levocetirizine)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Allegra (Fexofenadine)?
Worth itNot sureNot worth it
Reviews for Benadryl (Diphenhydramine)
85%
+10% vs. Xyzal (Levocetirizine)
57%
18% vs. Xyzal (Levocetirizine)
8%
+5% vs. Xyzal (Levocetirizine)
267 reviews
Have you used Benadryl (Diphenhydramine)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Clarinex (Desloratadine)?
Worth itNot sureNot worth it
Reviews for Claritin (Loratadine)
74%
1% vs. Xyzal (Levocetirizine)
38%
37% vs. Xyzal (Levocetirizine)
6%
+7% vs. Xyzal (Levocetirizine)
1514 reviews
Have you used Claritin (Loratadine)?
Worth itNot sureNot worth it
Reviews for Zyrtec (Cetirizine)
76%
+1% vs. Xyzal (Levocetirizine)
46%
29% vs. Xyzal (Levocetirizine)
7%
+6% vs. Xyzal (Levocetirizine)
1218 reviews
Have you used Zyrtec (Cetirizine)?
Worth itNot sureNot worth it
Side effects
XyzalAllegraBenadrylClarinexClaritinZyrtec
  • Drowsiness 4%
  • Common cold 3%
  • Fatigue 2%
  • Fever 2%
  • Dry mouth 2%
  • Vomiting 1%
  • Diarrhea 1%
  • Sore throat 1%
More Xyzal side effects »
  • Vomiting 3%
  • Headache 3%
  • Cough 3%
  • Back pain 2%
  • Ear, nose, or throat infection 2%
  • Diarrhea 1%
  • Fever 1%
  • Runny nose 1%
  • Dizziness 1%
  • Stomach discomfort 1%
More Allegra side effects »

We haven’t found good data for Benadryl side effects.

FDA side effect reports for Benadryl »
  • Fever 12%
  • Diarrhea 12%
  • Ear, nose, or throat infection 8%
  • Fatigue 4%
  • Middle ear inflammation 4%
  • Sore throat 3%
  • Nausea 3%
  • Loss of appetite 3%
  • Vomiting 3%
  • Runny nose 2%
More Clarinex side effects »

We haven’t found good data for Claritin side effects.

FDA side effect reports for Claritin »

We haven’t found good data for Zyrtec side effects.

FDA side effect reports for Zyrtec »
How it works
XyzalAllegraBenadrylClarinexClaritinZyrtec
Xyzal (Levocetirizine) is an antihistamine. It blocks histamine, a chemical that causes congestion, itching, and other allergic reactions.Allegra (Fexofenadine) is an antihistamine. It blocks histamine, a chemical that causes congestion, itching, and other allergic reactions.Benadryl (Diphenhydramine) is an antihistamine. It blocks histamine, a chemical that causes congestion, itching, and other allergic reactions. It also makes you sleepy.Clarinex (Desloratadine) is an antihistamine. It blocks histamine, a chemical that causes congestion, itching, and other allergic reactions.Claritin (Loratadine) is an antihistamine. It blocks histamine, a chemical that causes congestion, itching, and other allergic reactions. Antihistamines can also make you sleepy, but Loratadine is a low-drowsiness version.Zyrtec (Cetirizine) is an antihistamine. It blocks histamine, a chemical that causes congestion, itching, and other allergic reactions. Antihistamines can also make you sleepy, but Zyrtec is a low-drowsiness version.
Type of medication
XyzalAllegraBenadrylClarinexClaritinZyrtec
Antihistamine
2nd generation
Prescription only
Antihistamine
2nd generation
Prescription or OTC
Antihistamine
1st generation
Prescription or OTC
Antihistamine
2nd generation
Prescription only
Antihistamine
2nd generation
Prescription or OTC
Antihistamine
2nd generation
Prescription or OTC
Available as
XyzalAllegraBenadrylClarinexClaritinZyrtec
  • Pill
  • Liquid
  • Pill
  • Dissolving tablet
  • Liquid
  • Pill
  • Oral solution
  • Cream, gel, or ointment
  • Pill
  • Dissolving tablet
  • Liquid
  • Pill
  • Chewable tablet
  • Orally disintegrating tablet
  • Liquid
  • Pill
  • Liquid capsule
  • Dissolving tablet
  • Liquid
Used for (click to learn more)
XyzalAllegraBenadrylClarinexClaritinZyrtec
Risk factors for serious side effects
XyzalAllegraBenadrylClarinexClaritinZyrtec
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Current kidney problems
  • Age 65 or older
  • Enlarged prostate
  • Spinal cord conditions
Detailed Xyzal (Levocetirizine) risks & warnings »
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • History of phenylketonuria (PKU)
Detailed Allegra (Fexofenadine) risks & warnings »
  • Using other drugs with the same ingredients
  • Age 65 years or older
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Children age 6 years and younger
  • Enlarged prostate
  • History of bladder problems
  • Glaucoma
  • Nursing mothers
Detailed Benadryl (Diphenhydramine) risks & warnings »
Coming soon.
    • Age 65 or older
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • History of phenylketonuria (PKU)
    Detailed Claritin (Loratadine) risks & warnings »
      • Age 65 or older
      • Taking with alcohol
      • Taking other medicines that make you less alert
      • Current kidney disease
      • Current liver disease
      Detailed Zyrtec (Cetirizine) risks & warnings »
      Pregnancy

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

      The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

      Alcohol
      XyzalAllegraBenadrylClarinexClaritinZyrtec
      No alcohol related info.No alcohol related info.
      • Don't take it with alcohol or other drugs that make you sleepy.
      No alcohol related info.No alcohol related info.No alcohol related info.
      Food
      XyzalAllegraBenadrylClarinexClaritinZyrtec
      • Can be taken with or without food.
      • Some forms of Allegra (Fexofenadine) contain aspartame (phenylalanine). People who have phenylketonuria (PKU) can't break down the amino acid phenylalanine. It builds up and causes serious medical problems. If you have PKU, check to see which products you can use.
      No food related info.No food related info.
      • Claritin (Loratadine) contains aspartame (phenylalanine). People who have phenylketonuria (PKU) can't break down the amino acid phenylalanine. It builds up and causes serious medical problems. If you have PKU, don't use this product.
      No food related info.
      Kidneys and liver
      XyzalAllegraBenadrylClarinexClaritinZyrtec
      • Xyzal (Levocetirizine) is processed by the kidney. If you have kidney problems, you may need a different dose to prevent increased risk for side effects. Don't use Xyzal (Levocetirizine) if you have end-stage renal disease or are on hemodialysis. Children ages 6 months to 11 years with kidney problems shouldn't use Xyzal (Levocetirizine).
      • The dose needs to be adjusted for people with kidney problems.
      No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.
      • People with kidney or liver disease may need to take a lower dose of Zyrtec (Cetirizine) to prevent overdose. Talk with your doctor to be sure you are using the correct dose.
      Sleep
      XyzalAllegraBenadrylClarinexClaritinZyrtec
      • Can cause drowsiness.
      • Xyzal (Levocetirizine) can cause dizziness or drowsiness. Don't drink alcohol or take other allergy medications while on this.
      • Won't make you feel drowsy like some antihistamine medicines.
      • Can make you feel dizzy or sleepy, so you can take it at bedtime.
      • Benadryl (Diphenhydramine) makes you more tired than Claritin, Allegra, or Zyrtec.
      • Benadryl (Diphenhydramine) makes you tired, so take it before you go to sleep.
      • Preferred for older people since it causes little to no drowsiness compared to other antihistamines like Diphenhydramine (Benadryl).
      • Works faster than other non-drowsy antihistamines like Loratadine (Claritin).
      • Can give you a headache or diarrhea, but it rarely causes drowsiness or dizziness.
      • Can make you feel sleepy, so take it at bedtime if needed.
      • Can make you feel sleepy, so take it at bedtime if needed.
      Upsides and benefits
      XyzalAllegraBenadrylClarinexClaritinZyrtec
      • Xyzal (Levocetirizine) is taken once a day to help with allergy symptoms.
      • Available as a generic in both liquid and tablets.
      • Can be taken with or without food.
      • Children can take lower doses of Xyzal (Levocetirizine).
      • Relieves allergy symptoms, like sneezing, runny nose, and itching.
      • Approved to be used in kids and adults age 6 months and older.
      • Won't make you feel drowsy like some antihistamine medicines.
      • Available over-the-counter without a prescription.
      • Comes in many forms, such as a tablet, liquid, or quick-dissolving tablet.
      • It's okay to take with most other medications since it has very few interactions.
      • Benadryl (Diphenhydramine) is often better than other antihistamines at treating allergy symptoms and hives.
      • It makes you sleepy, so it'll help if your allergies are bothering you at night.
      • The effects wear off in 4 to 6 hours, so side effects don't last that long.
      • It comes as a tablet, capsule, liquid, and quick dissolving tablet.
      • It can provide quick relief of allergy symptoms for both kids and adults.
      • Relieves allergy symptoms like sneezing, runny nose, congestion, hives, or itchy skin.
      • Preferred for older people since it causes little to no drowsiness compared to other antihistamines like Diphenhydramine (Benadryl).
      • Works faster than other non-drowsy antihistamines like Loratadine (Claritin).
      • Available as a liquid or fast-dissolving tablet for people who don't like swallowing pills.
      • Side effects are rare and usually mild.
      • Relieves allergy symptoms like sneezing and runny nose just as well as other antihistamines, but with less sedation (drowsiness).
      • Also treats hives and itchy skin.
      • Available over the counter without a prescription.
      • Comes as a tablet, liquid, or quick-dissolving tablet.
      • Can provide quick relief of allergy symptoms for both kids and adults.
      • Okay to take with most other medications because it doesn't have many interactions.
      • Side effects are rare and usually mild.
      • Zyrtec (Cetirizine) works as well as other antihistamines to treat sneezing and runny nose, but causes less sedation.
      • Works well to also treat hives and itchy skin.
      • Zyrtec (Cetirizine) is available over the counter without a prescription.
      • It comes as a tablet, liquid, and quick-dissolving tablet.
      • It's okay to take with most other medications because it has few drug interactions.
      • Most people don't get any side effects from Zyrtec (Cetirizine).
      • It can provide quick relief of allergy symptoms for both kids and adults.
      Downsides and risks
      XyzalAllegraBenadrylClarinexClaritinZyrtec
      • Can cause drowsiness.
      • Don't take Xyzal (Levocetirizine) if you have poor kidney function.
      • Xyzal (Levocetirizine) is similar to Zyrtec, another allergy medication, so if you can't take Zyrtec, you won't be able to take Xyzal (Levocetirizine).
      • For some people, the effects Allegra (Fexofenadine) has on allergies will wear off over time.
      • May not work as well as the first-generation antihistamines, like diphenhydramine (Benadryl).
      • The dose needs to be adjusted for people with kidney problems.
      • Benadryl (Diphenhydramine) makes you more tired than Claritin, Allegra, or Zyrtec.
      • You shouldn't drive after taking Benadryl (Diphenhydramine) until you know how it affects you.
      • Talk to a pediatrician before giving Benadryl (Diphenhydramine) to a child.
      • It can increase the risk of falls, so elderly people shouldn't use Benadryl (Diphenhydramine).
      • Don't use Benadryl (Diphenhydramine) if you are breastfeeding.
      • May not work as fast as the other antihistamines that make you sleepy (like Benadryl).
      • Not a good medication for pregnant women to take.
      • For some people, its effectiveness on treating allergies wears off over time.
      • Some people find that other more sedating antihistamines (like Zyrtec or Benadryl) are more effective for them.
      • Not for kids under 2 years.
      • The Reditabs version contains aspartame (phenylalanine).
      • If you have daily allergy symptoms, a prescription nasal steroid spray might be better for you long-term.
      • Although it works fast, its effectiveness wears off for some people over time.
      • Zyrtec (Cetirizine) can be slightly more sedating than Allegra or Claritin.
      • Some people find that other more sedating antihistamines, like Benadryl, are more effective for them than Zyrtec (Cetirizine).
      • If you have daily allergy symptoms, a prescription nasal steroid spray might be better for you long-term.
      Tips from our pharmacists for people taking the medication
      XyzalAllegraBenadrylClarinexClaritinZyrtec
      • Xyzal (Levocetirizine) can cause dizziness or drowsiness. Don't drink alcohol or take other allergy medications while on this.
      • It's recommended to take Xyzal (Levocetirizine) in the evening.
      • Talk to your doctor if you experience urinary problems. You may need to switch to another allergy medication.
      • Starts working in 1 to 2 hours depending on what dosage form you're taking.
      • Works best when taken regularly, even before symptoms are expected to appear.
      • Can make you feel dizzy or sleepy, so you can take it at bedtime.
      • Follow age-specific dosing and don't take more than recommended.
      • If symptoms get worse or you need to use it for more than a few weeks, talk with your doctor.
      • Take it as needed every 4 to 6 hours.
      • Benadryl (Diphenhydramine) can make you dehydrated, so avoid this side effect by drinking plenty of fluids.
      • Benadryl (Diphenhydramine) makes you tired, so take it before you go to sleep.
      • Don't take it with alcohol or other drugs that make you sleepy.
      • If you need to use it for more than a few weeks, talk with your doctor. A different medication might work better for you long-term.
      • If you only have itchy or watery eyes, try using just an antihistamine eye drop.
      • Starts working in an hour.
      • Take it once a day when needed.
      • Works the best if used regularly during allergy season.
      • Can give you a headache or diarrhea, but it rarely causes drowsiness or dizziness.
      • Take it only once a day.
      • Starts working in a few hours.
      • Avoid possible side effects by drinking plenty of non-caffeinated liquids.
      • If you need to use it for more than a few weeks, talk with your doctor about trying a nasal steroid instead, which might work better for you long-term.
      • Using an antihistamine eye drop might work better to help itchy or watery eyes.
      • Can make you feel sleepy, so take it at bedtime if needed.
      • Starts working in a few hours. Only take it once a day.
      • Avoid some of the side effects by drinking plenty of non-caffeinated liquids.
      • If you need to use it for more than a few weeks, talk with your doctor about trying a nasal steroid instead since it might work better for you long-term.
      • Using an antihistamine eye drop instead can also work better to treat itchy or watery eyes.
      • Can make you feel sleepy, so take it at bedtime if needed.
      Learn more
      More about XyzalSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Xyzal (Levocetirizine)?
      Worth itNot sureNot worth it
      More about AllegraSide effectsReviews & ratingsFDA package insert
      Have you used Allegra (Fexofenadine)?
      Worth itNot sureNot worth it
      More about BenadrylSide effectsReviews & ratingsFDA package insert
      Have you used Benadryl (Diphenhydramine)?
      Worth itNot sureNot worth it
      More about ClarinexSide effectsReviews & ratingsFDA package insert
      Have you used Clarinex (Desloratadine)?
      Worth itNot sureNot worth it
      More about ClaritinSide effectsReviews & ratingsFDA package insert
      Have you used Claritin (Loratadine)?
      Worth itNot sureNot worth it
      More about ZyrtecSide effectsReviews & ratingsFDA package insert
      Have you used Zyrtec (Cetirizine)?
      Worth itNot sureNot worth it