Zanaflex

(tizanidine)

4.3/ 5 average rating with 26 reviewsforZanaflex
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Relaxes your muscles.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Zanaflex (tizanidine) isn't a first-choice treatment for muscle spasticity. Try other options before using this.

Quick facts about Zanaflex
  • Drug class: Musculoskeletal
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (tizanidine)
Prices and discounts
Lowest price for 90 4mg tablets
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$21.55
  • Price before coupon
    $41.78
  • Lowest price with coupon
    $21.55
  • Savings
    48%

Upsides

  • Relieves muscle spasticity.
  • Available as a generic.
  • Available in a tablet or capsule form. It also comes in a capsule that can be opened and sprinkled in applesauce for people that can't swallow pills.

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What to expect from Zanaflex, on one page

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People’s experience with Zanaflex

26reviews so far. What do you think?

Downsides

  • This isn't a first-choice muscle relaxing medication. Other drugs work better and have fewer side effects.
  • Takes over an hour to kick in and only lasts 3 to 6 hours.
  • Zanaflex (tizanidine) can lower blood pressure, so be careful if you are already on a blood pressure medication.
  • Need to be consistent every day in taking this with or without food.
  • Elderly individuals have more side effects when taking Zanaflex (tizanidine).

Get the newsletter!

Sign up and get Pill Talk, the latest in health & medicine news from Iodine

Get our free fact sheet

What to expect from Zanaflex, on one page

Download Fact Sheet
Prices and discounts
Lowest price for 90 4mg tablets
Determining your location...
$21.55
  • Price before coupon
    $41.78
  • Lowest price with coupon
    $21.55
  • Savings
    48%
How it works

Zanaflex (tizanidine) is an alpha2-adrenergic agonist that works in the nervous system to calm down muscle spasticity.

Quick facts about Zanaflex
  • Drug class: Musculoskeletal
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (tizanidine)

Dosage forms

  • Pill
People’s experience with Zanaflex

26reviews so far. What do you think?

What to expect when you take Zanaflex (tizanidine) for Muscle spasticity

Skip what to expect section. Skip to side effects section.
Skip side effects section. Skip to risks and warnings section.

Side effect rates for Zanaflex (tizanidine)

From 525 clinical trials of Zanaflex when taken for muscle spasticity (multiple doses)
  • Dry mouth
  • Sleepiness
  • Weakness
  • Dizziness
  • Urinary tract infection
  • General infection
  • Liver test abnormality
  • Constipation
  • Vomiting
  • Speech disorder

Risks and Warnings for Zanaflex (tizanidine)

Skip risks section. Skip to common concerns section.
    • Higher risk if:
    • Taking maximum doses of Zanaflex (tizanidine)

    Zanaflex (tizanidine) can damage your liver. You'll need to get blood tests done to check how your liver is functioning if you're taking this regularly.

Common concerns from people taking Zanaflex (tizanidine)

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Food
  • Can be taken with or without food, but you need to be consistent since food affects how the medication is absorbed and works.
  • Need to be consistent every day in taking this with or without food.
Kidneys and liver
  • Reviewed Zanaflexon 3/30/2017Watch out for signs of liver toxicity. They resolve quickly when use is topped, but can be somewhat unpleasant.
    24
    Man
    A month or so
    Headache (long-term)
Pain
  • Reviewed ZanaflexI took it for back pain, the pain is still there and it has not helped the pain, but I have not had a anxiety attack! This is a big thing for me as I have had them every day for years! It does not help me sleep but I am not tired.
    47
    Woman
    A month or so
Sleep
  • Taking Zanaflex (tizanidine) can make you feel sleepy and dizzy, especially if you're taking other medications that can also make you feel sleepy, or if you're taking recreational drugs or drinking too much alcohol. Avoid driving or doing other tasks that require concentration until you know how this medication affects you.
  • Can cause dizziness, fatigue, drowsiness, and dry mouth.
  • Reviewed Zanaflexon 1/2/2017does cause drowsiness but since I tend to suffer from insomnia, works great at bedtime. It also works to help control breakthrough migraines.
    53
    Woman
    Spasticity