Prescription onlyClass: Musculoskeletal

Zanaflex Alternatives

(Tizanidine)

Prescription onlyClass: Musculoskeletal
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Compare Zanaflex (Tizanidine) to alternatives

These medications are comparable to Zanaflex (Tizanidine) or used for similar purposes.

Zanaflex
(Tizanidine)

Lioresal
(Baclofen)

Valium
(Diazepam)

Flexeril
(Cyclobenzaprine)

Soma
(Carisoprodol)

Relaxes your muscles. Zanaflex (Tizanidine) isn't a first-choice treatment for muscle spasms. Try other options before using this.Relaxes your muscles. Lioresal (Baclofen) is effective for long term spastic conditions, such as multiple sclerosis, spinal cord injury, and others.Helps you relax. Valium (Diazepam) is okay for occasional or short-term use (up to 4 weeks) for anxiety and for pain and sleeplessness from muscle spasm. Less severe withdrawal symptoms compared to similar drugs.Relaxes your muscles. Flexeril (Cyclobenzaprine) is widely used to treat muscle spasms and is available as a generic, but it shouldn't be used long-term.Relaxes your muscles. Soma (Carisoprodol) is widely used to treat muscle spasms and is available as a generic, but it's not considered a first-choice treatment for muscle spasms. It's also not meant for long-term therapy.
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Reviews & ratings
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Have you used Zanaflex (Tizanidine)?
Worth itNot sureNot worth it
Reviews for Lioresal (Baclofen)
61%
-20% worse vs. Zanaflex (Tizanidine)
55%
-18% worse vs. Zanaflex (Tizanidine)
15%
+4% better vs. Zanaflex (Tizanidine)
Have you used Lioresal (Baclofen)?
Worth itNot sureNot worth it
Reviews for Valium (Diazepam)
70%
-11% worse vs. Zanaflex (Tizanidine)
53%
-20% worse vs. Zanaflex (Tizanidine)
15%
+4% better vs. Zanaflex (Tizanidine)
976 reviews
Have you used Valium (Diazepam)?
Worth itNot sureNot worth it
Reviews for Flexeril (Cyclobenzaprine)
66%
-15% worse vs. Zanaflex (Tizanidine)
37%
-36% worse vs. Zanaflex (Tizanidine)
14%
+5% better vs. Zanaflex (Tizanidine)
1064 reviews
Have you used Flexeril (Cyclobenzaprine)?
Worth itNot sureNot worth it
Reviews for Soma (Carisoprodol)
61%
-20% worse vs. Zanaflex (Tizanidine)
39%
-34% worse vs. Zanaflex (Tizanidine)
9%
+10% better vs. Zanaflex (Tizanidine)
220 reviews
Have you used Soma (Carisoprodol)?
Worth itNot sureNot worth it
Side effects
ZanaflexBaclofenValiumFlexerilSoma

We haven’t found good data for Zanaflex side effects.

FDA side effect reports for Zanaflex »

We haven’t found good data for Baclofen side effects.

FDA side effect reports for Baclofen »

The Valium FDA package insert doesn’t have numbers about how common side effects are.

More about Valium side effects »
  • Dry mouth 4%
  • Dizziness 1%
  • Fatigue 1%
  • Nausea 2%
  • Drowsiness 100%
  • Headache nos 17%
  • Dry throat 8%
  • Acne nos 6%
  • Disturbance in attention 6%
More Flexeril side effects »
  • Drowsiness 7%
  • Dizziness 6%
  • Hedache 3%
  • Central nervous system reactions 2%
More Soma side effects »
How it works
ZanaflexBaclofenValiumFlexerilSoma
Zanaflex (Tizanidine) is a muscle relaxer. It works in the nervous system to calm down muscle spasms without interfering with normal muscle function.Lioresal (Baclofen) is a muscle relaxer. It works in the nervous system to calm down muscle spasms without interfering with normal muscle function.Valium (Diazepam) is a fast-acting benzodiazepine. It affects neurotransmitters in the brain and calms the nervous system. This reduces anxiety and muscle spasms, and causes sleepiness.Flexeril (Cyclobenzaprine) is a muscle relaxer. It works in the brain to help calm down muscle spasms without interfering with normal muscle function.Soma (Carisoprodol) is a muscle relaxant. It works in the brain to help calm down muscle spasms.
Type of medication
ZanaflexBaclofenValiumFlexerilSoma
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Available as
ZanaflexBaclofenValiumFlexerilSoma
  • Pill
  • Pill
  • Dissolving tablet
  • Pill
  • Liquid
  • Rectal gel
  • Pill
  • Extended release
  • Pill
Used for
ZanaflexBaclofenValiumFlexerilSoma
Risk factors for serious side effects
ZanaflexBaclofenValiumFlexerilSoma
    • Age 65 years or older
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • Age 65 or greater
      Detailed Zanaflex (Tizanidine) risks & warnings »
      • Stopping Lioresal (Baclofen) too quickly
      • Taking with alcohol
      • Taking other medicines that make you less alert
      • Age 65 or greater
      • Higher dose
      • Using other medicines that can cause seizures
      • History of seizures
      • Alcoholism
      • Eating disorders
      • Brain infections
      Detailed Lioresal (Baclofen) risks & warnings »
      • Taking more than the prescribed dose
      • Taking longer than 4 weeks
      • History of drug abuse
      • Long-term use
        • Alcohol
        • Taking other medicines that make you less alert
          • Current liver problems
          Detailed Valium (Diazepam) risks & warnings »
          • Taking monoamine oxidase inhibitors (MAOI) 14 days before starting
          • Taking other medications for your mood
          • Alcohol or drug use
          • Age over 65
          • Taking tramadol
          Detailed Flexeril (Cyclobenzaprine) risks & warnings »
          • Taking other medications that also cause sleepiness
          • Recreational drug use
          • Excessive alcohol use
          • Prior history of drug abuse
          • Prior history of overdoses of drugs of abuse, recreational drugs or alcohol
          Detailed Soma (Carisoprodol) risks & warnings »
          Pregnancy

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Alcohol
          ZanaflexBaclofenValiumFlexerilSoma
          • Don't drink alcohol while using this.
          • Don't drink alcohol while using this.
          • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
          • Not safe to use with alcohol.
          • Don't drink alcohol while on this medication.
          • Don't drink alcohol while on this medication.
          Food
          ZanaflexBaclofenValiumFlexerilSoma
          • Can be taken with or without food, but you need to be consistent in how you take it every day.
          • Need to be consistent every day in taking this with or without food.
          • Can be taken with or without food, but you need to be consistent since food affects how the medication is absorbed and works.
          No food related info.No food related info.No food related info.No food related info.
          Kidneys and liver
          ZanaflexBaclofenValiumFlexerilSoma
          No kidneys and liver related info.No kidneys and liver related info.
          • Processed by the liver, so might not be the best choice if you have liver problems.
          No kidneys and liver related info.No kidneys and liver related info.
          Pain
          ZanaflexBaclofenValiumFlexerilSoma
          No pain related info.
          • Relieves pain associated with muscle spasms.
          No pain related info.
          • Can relieve pain associated with muscle spasms.
          • Can cause stomach pain, nausea and vomiting.
          Sleep
          ZanaflexBaclofenValiumFlexerilSoma
          • Can cause dizziness, fatigue, drowsiness, and dry mouth.
          • Can cause extreme drowsiness or dizziness if you are taking meds for high blood pressure.
          • Can cause extreme drowsiness or dizziness if you're taking it with high blood pressure medications.
          • Can cause memory problems, drowsiness, dizziness, and confusion.
          • Can cause temporary dizziness and drowsiness.
          • Taking Flexeril (Cyclobenzaprine) may make you feel dizzy or sleepy for the first few days, especially if you drink a lot of alcohol or take recreational drugs. Your body should adjust to this, however, avoid driving or other activities requiring concentration until you know how your body responds to the medication. Talk to your doctor or pharmacist if these symptoms bother you.
          No sleep related info.
          Upsides and benefits
          ZanaflexBaclofenValiumFlexerilSoma
          • Relieves muscle spasms well.
          • Can be taken with or without food, but you need to be consistent in how you take it every day.
          • Available as a generic.
          • Available in a tablet or capsule form. It also comes in a capsule that can be opened and sprinkled in applesauce for people that can't swallow pills.
          • Lioresal (Baclofen) is effective for treating muscle spasms, as well as being an effective muscle relaxant.
          • Can be used long term.
          • Relieves pain associated with muscle spasms.
          • A better option for seniors compared to other muscle relaxants since it has less side effects than the other meds.
          • Lioresal (Baclofen) is available as a generic and is a relatively inexpensive medication.
          • Effective at relieving short-term anxiety and sleeplessness.
          • Can be used together with antidepressants to manage anxiety disorders. Especially helpful for anxiety symptoms while you wait for an antidepressant to kick in (it can take several weeks).
          • Effective at relieving muscle spasms caused by a variety of conditions.
          • Less severe withdrawal symptoms compared to other benzodiazepines.
          • Can relieve pain associated with muscle spasms.
          • Available as a generic medication.
          • Can be used by pregnant women.
          • Available in generic.
          • Available in two different strengths, although the smaller strength is only available as brand name and thus more expensive.
          Downsides and risks
          ZanaflexBaclofenValiumFlexerilSoma
          • This isn't a first-choice muscle relaxing medication. Other drugs work better and have fewer side effects.
          • Zanaflex (Tizanidine) can lower blood pressure, so be careful if you are already on a blood pressure medication.
          • Need to be consistent every day in taking this with or without food.
          • Elderly individuals have more side effects when taking Zanaflex (Tizanidine).
          • Can't stop taking this abruptly if you use it regularly.
          • If taking regularly, you shouldn't stop taking Lioresal (Baclofen) abruptly. You'll need to get off of it slowly.
          • Be careful if taking other drugs that affect your ability to stay awake, since Lioresal (Baclofen) can make you much more tired.
          • Processed by the liver, so might not be the best choice if you have liver problems.
          • Can cause memory problems, drowsiness, dizziness, and confusion.
          • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
          • Most people find that it gets less effective over time.
          • Can cause dizziness and sleepiness.
          • Not meant for long-term therapy.
          • Not recommended in elderly patients, people with glaucoma, or in people with recent heart issues (like rhythm problems, heart failure, or heart attack).
          • Not first line for treating muscle spasms.
          • Can cause dizziness and sleepiness.
          • Not meant for long term therapy.
          • Can cause dependence and withdrawal symptoms if you stop taking it suddenly.
          Tips from our pharmacists for people taking the medication
          ZanaflexBaclofenValiumFlexerilSoma
          • Can cause dizziness, fatigue, drowsiness, and dry mouth.
          • Avoid activities requiring mental alertness (like driving) until you know how it affects you.
          • Can cause extreme drowsiness or dizziness if you are taking meds for high blood pressure.
          • Side effects are more prevalent in the elderly.
          • Don't drink alcohol while using this.
          • Can be taken with or without food, but you need to be consistent since food affects how the medication is absorbed and works.
          • Can cause dizziness and fatigue.
          • Avoid activities requiring mental alertness (like driving) until you know how it affects you.
          • Can cause extreme drowsiness or dizziness if you're taking it with high blood pressure medications.
          • Side effects are more prevalent in the elderly.
          • Don't drink alcohol while using this.
          • Can be taken as needed or 'around-the-clock'. Ask your doctor about what'll work best for you.
          • If taking regularly, you need to work with your doctor to get off the medication slowly (also called tapering) to avoid withdrawal symptoms.
          • Good for short-term relief of anxiety symptoms.
          • Starts working in 30 minutes when swallowed.
          • Helpful with muscle spasms.
          • Can cause temporary dizziness and drowsiness.
          • Addictive. Long-term use can cause dependence or abuse.
          • Not safe to use with alcohol.
          • Can cause dizziness, fatigue, and sleepiness.
          • Take the medication at the same time each day.
          • Not to be used for long-term treatment.
          • Don't drink alcohol while on this medication.
          • Can cause dizziness, fatigue, and sleepiness.
          • Take the medication at the same time each day.
          • Not to be used for long-term treatment (2 to 3 weeks maximum)
          • Don't drink alcohol while on this medication.
          • Can cause stomach pain, nausea and vomiting.
          Learn more
          More about ZanaflexSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Zanaflex (Tizanidine)?
          Worth itNot sureNot worth it
          More about BaclofenSide effectsReviews & ratingsFDA package insert
          Have you used Lioresal (Baclofen)?
          Worth itNot sureNot worth it
          More about ValiumSide effectsReviews & ratingsFDA package insert
          Have you used Valium (Diazepam)?
          Worth itNot sureNot worth it
          More about FlexerilSide effectsReviews & ratingsFDA package insert
          Have you used Flexeril (Cyclobenzaprine)?
          Worth itNot sureNot worth it
          More about SomaSide effectsReviews & ratingsFDA package insert
          Have you used Soma (Carisoprodol)?
          Worth itNot sureNot worth it