Prescription or OTCLower-cost generic available


(Omeprazole / Sodium Bicarbonate)

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Relieves heartburn, ulcers, and acid tummy.

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Prescription or OTCLower-cost generic available

Our bottom line

Zegerid (Omeprazole / Sodium Bicarbonate) gives you long-lasting heartburn relief. Choose the cheapest proton pump inhibitor because they all work equally well for heartburn.


  • Most people can take Zegerid without any noticeable day-to-day side effects.
  • Zegerid lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
  • Available as both a generic and over-the-counter option, so it's pretty affordable.
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  • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
  • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
  • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Zegerid long-term.
  • Although the generic is affordable, other medications might still be cheaper than Zegerid.
  • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Zegerid.

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What to expect when you take Zegerid (Omeprazole / Sodium Bicarbonate)

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Tips from our pharmacists
  • Take 1 hour before a meal.
  • Don't chew or crush capsules; swallow them whole.
  • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Zegerid.
  • If you've been having heartburn for 3 months or more, talk to your doctor before taking Zegerid. Get a check-up to make sure you aren't having a more serious stomach problem.
  • Talk to your doctor if you're still having heartburn after two weeks of use. Don't keep taking Zegerid; get checked-out first.
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Side effects for Zegerid (Omeprazole / Sodium Bicarbonate)

Manufacturers don’t say how common these side effects are

  • Abnormally large breasts in males
  • Agranulocytosis
  • Amenorrhoea
  • Aplastic anaemia
  • Asphyxia
  • Asthma
  • Bleeding under the skin
  • Blood disorder
  • Body shaking
  • Body temperature increased
  • Breast feeding
  • Cholestasis
  • Cogwheel rigidity
  • Colon atonic
  • Coloring of the skin
  • Constipation
  • Constricted pupil
  • Corneal deposits
  • Cough
  • Dangerously high body temperature
  • Death
  • Deep skin swelling
  • Dependence physiological
  • Dermatitis contact
  • Dermatitis exfoliative
  • Difficulty swallowing
  • Dilated pupil
  • Dizziness
  • Drooling
  • Drowsiness
  • Dry mouth
  • Edema cerebral
  • Electroencephalogram abnormal
  • Eosinophilia
  • Excessive bruising or bleeding
  • Extrapyramidal symptoms
  • Eye deviation
  • Eye retina disorder
  • Feeling jittery
  • Flu
  • Gait shuffling
  • Grand mal convulsion
  • Headache
  • Hepatocellular injury
  • High blood sugar
  • Hives
  • Hyperactive muscle reflexes
  • Hypersensitivity
  • Ileus paralytic
  • Impotence
  • Increased appetite
  • Infection
  • Itching
  • Jaundice cholestatic
  • Keratopathy
  • Laryngeal oedema
  • Leaking fluid from nipples
  • Leg or ankle swelling
  • Life-threatening fever and muscle rigidity
  • Lockjaw
  • Low blood cell count
  • Low blood pressure
  • Low blood sugar
  • Low red blood cell count
  • Low red blood cells
  • Low white blood cells
  • Lupus, autoimmune disorder
  • Lupus, autoimmune disorder
  • Malignant syndrome nos
  • Menstruation irregular
  • Mitral valve incompetence
  • Motor restlessness
  • Movements involuntary
  • Muscle rigidity
  • Muscle spasms
  • Muscle twitching
  • Nasal congestion
  • Obstipation
  • Opisthotonus
  • Orofacial dyskinesia
  • Paralyzed intestines
  • Persistent and painful erection
  • Petit mal epilepsy
  • Phaeochromocytoma
  • Pigmentation skin
  • Pregnancy test false positive
  • Pregnancy test positive
  • Protrusion tongue
  • Pseudoparkinsonism
  • Rash
  • Redness
  • Relaxation or sleepiness
  • Restlessness
  • Retinitis pigmentosa
  • Scaly, itchy rash
  • Sensitivity to light
  • Serious allergic reaction
  • Shortness of breath
  • Skin disorder
  • Sleep difficulty
  • Stopped heart and circulation
  • Stupor
  • Sudden death
  • Sugar in urine
  • Swelling due to excess fluid
  • Tenderness
  • Throat sore
  • Throat tightness
  • Torticollis
  • Tremor
  • Tremulousness
  • Urinary retention
  • Vision blurred
  • Weight increased
  • Yellow skin or eyes

Risks and Warnings for Zegerid (Omeprazole / Sodium Bicarbonate)

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  • Heartburn and feelings of upset stomach can be warning signs of a more serious stomach problem or cancer. If you need to take Zegerid (Omeprazole / Sodium Bicarbonate) for 2 weeks or more go see a doctor. It's safest to get checked out to make sure you do not have a serious stomach condition.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Zegerid (Omeprazole / Sodium Bicarbonate)

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The FDA category for this medication is C. It is advised that you: Weigh risks vs. benefits
  • Tips from our pharmacists
  • Take 1 hour before a meal.