Prescription or OTCLower-cost generic availableClass: Gastrointestinal


(omeprazole / sodium bicarbonate)

Prescription or OTCLower-cost generic availableClass: Gastrointestinal
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Relieves heartburn, ulcers, and acid tummy.

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Our bottom line

Zegerid (Omeprazole / Sodium Bicarbonate) gives you long-lasting heartburn relief. Choose the cheapest proton pump inhibitor because they all work equally well for heartburn.

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Prices and coupons for 30 (40mg/1100mg) capsules of omeprazole / sodium bicarbonate


  • Most people can take Zegerid without any noticeable day-to-day side effects.
  • Zegerid lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
  • Available as both a generic and over-the-counter option, so it's pretty affordable.
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  • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
  • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
  • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Zegerid long-term.
  • Although the generic is affordable, other medications might still be cheaper than Zegerid.
  • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Zegerid.
How it works

Zegerid (Omeprazole / Sodium Bicarbonate) is a type of antacid called a proton pump inhibitor. It blocks the release of acid in your stomach, which treats heartburn and helps ulcers heal.

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Side effect rates for Zegerid (omeprazole / sodium bicarbonate)

Risks and Warnings for Zegerid (omeprazole / sodium bicarbonate)

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  • Heartburn and feelings of upset stomach can be warning signs of a more serious stomach problem or cancer. If you need to take Zegerid (Omeprazole / Sodium Bicarbonate) for 2 weeks or more go see a doctor. It's safest to get checked out to make sure you do not have a serious stomach condition.

Common concerns from people taking Zegerid (omeprazole / sodium bicarbonate)

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  • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Zegerid.
  • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Zegerid.
  • Take 1 hour before a meal.